Details for: TNFRSF21

Gene ID: 27242

Symbol: TNFRSF21

Ensembl ID: ENSG00000146072

Description: TNF receptor superfamily member 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.4976
    Cell Significance Index: -27.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.0544
    Cell Significance Index: -26.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.2236
    Cell Significance Index: -24.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.7677
    Cell Significance Index: -26.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.1900
    Cell Significance Index: -24.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.6691
    Cell Significance Index: -27.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0565
    Cell Significance Index: -26.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.8488
    Cell Significance Index: 303.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0482
    Cell Significance Index: 28.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2740
    Cell Significance Index: 60.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1412
    Cell Significance Index: 407.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0159
    Cell Significance Index: 363.4000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9839
    Cell Significance Index: 12.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6727
    Cell Significance Index: 205.6700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.4588
    Cell Significance Index: 18.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3142
    Cell Significance Index: 263.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1412
    Cell Significance Index: 32.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0477
    Cell Significance Index: 946.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8853
    Cell Significance Index: 24.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8761
    Cell Significance Index: 18.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7848
    Cell Significance Index: 11.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7067
    Cell Significance Index: 76.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7004
    Cell Significance Index: 42.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6616
    Cell Significance Index: 131.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6480
    Cell Significance Index: 105.3900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.5567
    Cell Significance Index: 3.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4923
    Cell Significance Index: 56.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4792
    Cell Significance Index: 47.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4177
    Cell Significance Index: 149.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4170
    Cell Significance Index: 8.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4068
    Cell Significance Index: 11.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3978
    Cell Significance Index: 8.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3702
    Cell Significance Index: 16.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3470
    Cell Significance Index: 24.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3147
    Cell Significance Index: 171.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1944
    Cell Significance Index: 4.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1852
    Cell Significance Index: 1.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1692
    Cell Significance Index: 19.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0386
    Cell Significance Index: 5.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0085
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0070
    Cell Significance Index: 1.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0107
    Cell Significance Index: -1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0131
    Cell Significance Index: -24.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0175
    Cell Significance Index: -32.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0180
    Cell Significance Index: -7.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0206
    Cell Significance Index: -31.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0225
    Cell Significance Index: -30.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0266
    Cell Significance Index: -16.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0279
    Cell Significance Index: -15.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0281
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0352
    Cell Significance Index: -2.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0391
    Cell Significance Index: -5.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0392
    Cell Significance Index: -5.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0487
    Cell Significance Index: -10.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0567
    Cell Significance Index: -25.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0579
    Cell Significance Index: -0.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0703
    Cell Significance Index: -4.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0820
    Cell Significance Index: -23.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0879
    Cell Significance Index: -4.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1257
    Cell Significance Index: -14.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1510
    Cell Significance Index: -6.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1550
    Cell Significance Index: -5.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1550
    Cell Significance Index: -7.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1617
    Cell Significance Index: -5.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2110
    Cell Significance Index: -24.8800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2132
    Cell Significance Index: -1.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2172
    Cell Significance Index: -27.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2226
    Cell Significance Index: -16.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2729
    Cell Significance Index: -28.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2932
    Cell Significance Index: -15.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3013
    Cell Significance Index: -18.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3058
    Cell Significance Index: -24.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3244
    Cell Significance Index: -5.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3255
    Cell Significance Index: -8.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3282
    Cell Significance Index: -25.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3306
    Cell Significance Index: -10.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3352
    Cell Significance Index: -7.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3612
    Cell Significance Index: -23.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3746
    Cell Significance Index: -7.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4020
    Cell Significance Index: -28.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4181
    Cell Significance Index: -13.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4250
    Cell Significance Index: -5.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4322
    Cell Significance Index: -27.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4338
    Cell Significance Index: -11.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4389
    Cell Significance Index: -6.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4709
    Cell Significance Index: -24.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4824
    Cell Significance Index: -16.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5089
    Cell Significance Index: -12.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5409
    Cell Significance Index: -10.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5558
    Cell Significance Index: -7.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5689
    Cell Significance Index: -19.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5697
    Cell Significance Index: -16.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5713
    Cell Significance Index: -7.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5833
    Cell Significance Index: -20.2700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5933
    Cell Significance Index: -8.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5988
    Cell Significance Index: -11.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The TNFRSF21 gene encodes a transmembrane protein that belongs to the TNFRSF family, characterized by the presence of a type I TNF receptor domain. 2. **Expression:** The gene is widely expressed in various cell types, including immune cells, epithelial cells, and neurons, suggesting a multifaceted role in maintaining tissue homeostasis and regulating immune responses. 3. **Signaling pathways:** The TNFRSF21 protein is involved in several signaling pathways, including the adaptive immune response, apoptotic process, and cellular responses to stress and heat shock. **Pathways and Functions:** 1. **Adaptive immune response:** The TNFRSF21 protein is involved in regulating B cell proliferation, differentiation, and apoptosis, highlighting its role in shaping the adaptive immune response. 2. **Apoptotic process:** The gene is also implicated in regulating apoptosis in various cell types, including neurons and oligodendrocytes, suggesting a role in maintaining tissue homeostasis. 3. **Cellular stress responses:** The TNFRSF21 protein is activated by heat shock and other forms of cellular stress, indicating its involvement in regulating cellular responses to stress. 4. **Neurodevelopment:** The gene is expressed in neurons and plays a role in regulating oligodendrocyte differentiation and myelination, highlighting its importance in neurodevelopment and function. 5. **Regulation of lipid metabolism:** The TNFRSF21 protein is also involved in regulating lipid metabolism by modulating the activity of PPARα, a nuclear receptor that regulates fatty acid metabolism. **Clinical Significance:** The TNFRSF21 gene has been implicated in various diseases, including autoimmune disorders, cancer, and neurodegenerative diseases. For example: 1. **Autoimmune disorders:** The gene has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, suggesting its role in regulating immune responses and maintaining tissue homeostasis. 2. **Cancer:** The TNFRSF21 protein has been implicated in cancer progression and metastasis, highlighting its potential as a therapeutic target. 3. **Neurodegenerative diseases:** The gene has been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's, suggesting its role in regulating neuronal function and survival. In conclusion, the TNFRSF21 gene is a multifaceted regulator of immune response, cellular homeostasis, and tissue development. Its expression in various cell types and involvement in multiple signaling pathways underscore its importance in maintaining tissue homeostasis and regulating immune responses. Further research is needed to fully elucidate the functional significance of this gene and its potential applications in disease treatment.

Genular Protein ID: 2559199575

Symbol: TNR21_HUMAN

Name: Tumor necrosis factor receptor superfamily member 21

UniProtKB Accession Codes:

O75509 B2RDI9 Q0D2P5 Q96D86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714541

Title: Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.

PubMed ID: 9714541

DOI: 10.1016/s0014-5793(98)00791-1

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19654028

Title: Functional analysis of the posttranslational modifications of the death receptor 6.

PubMed ID: 19654028

DOI: 10.1016/j.bbamcr.2009.07.008

PubMed ID: 21725297

Title: Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination.

PubMed ID: 21725297

DOI: 10.1038/nm.2373

PubMed ID: 22761420

Title: Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein.

PubMed ID: 22761420

DOI: 10.1074/jbc.m112.362038

PubMed ID: 23559013

Title: A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death.

PubMed ID: 23559013

DOI: 10.1038/cddis.2013.110

PubMed ID: 28743875

Title: Hepatitis C Virus Exploits Death Receptor 6-mediated Signaling Pathway to Facilitate Viral Propagation.

PubMed ID: 28743875

DOI: 10.1038/s41598-017-06740-9

PubMed ID: 34012073

Title: The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

PubMed ID: 34012073

DOI: 10.1038/s41422-021-00506-9

PubMed ID: 21463639

Title: The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP).

PubMed ID: 21463639

DOI: 10.1016/j.jmb.2011.03.048

PubMed ID: 22525750

Title: S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.

PubMed ID: 22525750

DOI: 10.1107/s0907444912004490

Sequence Information:

  • Length: 655
  • Mass: 71845
  • Checksum: 48939391C4852A33
  • Sequence:
    • MGTSPSSSTA LASCSRIARR ATATMIAGSL LLLGFLSTTT AQPEQKASNL IGTYRHVDRA 
TGQVLTCDKC PAGTYVSEHC TNTSLRVCSS CPVGTFTRHE NGIEKCHDCS QPCPWPMIEK 
LPCAALTDRE CTCPPGMFQS NATCAPHTVC PVGWGVRKKG TETEDVRCKQ CARGTFSDVP 
SSVMKCKAYT DCLSQNLVVI KPGTKETDNV CGTLPSFSSS TSPSPGTAIF PRPEHMETHE 
VPSSTYVPKG MNSTESNSSA SVRPKVLSSI QEGTVPDNTS SARGKEDVNK TLPNLQVVNH 
QQGPHHRHIL KLLPSMEATG GEKSSTPIKG PKRGHPRQNL HKHFDINEHL PWMIVLFLLL 
VLVVIVVCSI RKSSRTLKKG PRQDPSAIVE KAGLKKSMTP TQNREKWIYY CNGHGIDILK 
LVAAQVGSQW KDIYQFLCNA SEREVAAFSN GYTADHERAY AALQHWTIRG PEASLAQLIS 
ALRQHRRNDV VEKIRGLMED TTQLETDKLA LPMSPSPLSP SPIPSPNAKL ENSALLTVEP 
SPQDKNKGFF VDESEPLLRC DSTSSGSSAL SRNGSFITKE KKDTVLRQVR LDPCDLQPIF 
DDMLHFLNPE ELRVIEEIPQ AEDKLDRLFE IIGVKSQEAS QTLLDSVYSH LPDLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.