Details for: DHDH

Gene ID: 27294

Symbol: DHDH

Ensembl ID: ENSG00000104808

Description: dihydrodiol dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 25.1374
    Cell Significance Index: -3.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.2576
    Cell Significance Index: -3.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.3537
    Cell Significance Index: -3.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.1268
    Cell Significance Index: -3.9400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.2824
    Cell Significance Index: 10.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2413
    Cell Significance Index: 236.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8150
    Cell Significance Index: 48.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5998
    Cell Significance Index: 31.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5838
    Cell Significance Index: 16.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4774
    Cell Significance Index: 51.9300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4774
    Cell Significance Index: 3.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3949
    Cell Significance Index: 356.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3831
    Cell Significance Index: 8.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3415
    Cell Significance Index: 33.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2886
    Cell Significance Index: 19.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2451
    Cell Significance Index: 4.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2157
    Cell Significance Index: 35.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1891
    Cell Significance Index: 4.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1615
    Cell Significance Index: 7.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1508
    Cell Significance Index: 2.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1437
    Cell Significance Index: 1.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1417
    Cell Significance Index: 8.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1077
    Cell Significance Index: 0.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1072
    Cell Significance Index: 74.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0775
    Cell Significance Index: 15.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0704
    Cell Significance Index: 1.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0683
    Cell Significance Index: 7.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0646
    Cell Significance Index: 0.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0495
    Cell Significance Index: 1.7400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0429
    Cell Significance Index: 0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0429
    Cell Significance Index: 0.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0407
    Cell Significance Index: 0.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0358
    Cell Significance Index: 0.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0313
    Cell Significance Index: 11.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0251
    Cell Significance Index: 0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0216
    Cell Significance Index: 0.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0197
    Cell Significance Index: 0.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0185
    Cell Significance Index: 0.4000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0166
    Cell Significance Index: 0.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0161
    Cell Significance Index: 7.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0152
    Cell Significance Index: 0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0067
    Cell Significance Index: 1.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0065
    Cell Significance Index: 0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0044
    Cell Significance Index: 0.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0039
    Cell Significance Index: 0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0013
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0035
    Cell Significance Index: -1.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0067
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0113
    Cell Significance Index: -3.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0117
    Cell Significance Index: -0.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0141
    Cell Significance Index: -0.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0157
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0180
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0192
    Cell Significance Index: -4.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0196
    Cell Significance Index: -1.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0205
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0212
    Cell Significance Index: -2.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0237
    Cell Significance Index: -1.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0268
    Cell Significance Index: -3.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0317
    Cell Significance Index: -2.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0326
    Cell Significance Index: -0.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0332
    Cell Significance Index: -3.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0338
    Cell Significance Index: -2.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0349
    Cell Significance Index: -3.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0358
    Cell Significance Index: -0.3300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0368
    Cell Significance Index: -0.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0382
    Cell Significance Index: -1.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0403
    Cell Significance Index: -1.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0423
    Cell Significance Index: -1.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0452
    Cell Significance Index: -1.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0468
    Cell Significance Index: -1.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0468
    Cell Significance Index: -3.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0497
    Cell Significance Index: -2.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0500
    Cell Significance Index: -2.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0546
    Cell Significance Index: -1.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0554
    Cell Significance Index: -4.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0574
    Cell Significance Index: -3.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0631
    Cell Significance Index: -2.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0631
    Cell Significance Index: -1.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0648
    Cell Significance Index: -2.1200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0656
    Cell Significance Index: -0.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0673
    Cell Significance Index: -4.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0679
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0699
    Cell Significance Index: -2.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0703
    Cell Significance Index: -1.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0741
    Cell Significance Index: -2.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0743
    Cell Significance Index: -2.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DHDH is a dihydrodiol dehydrogenase enzyme, which plays a crucial role in the catabolic process of D-xylose, a five-carbon sugar. The gene is highly expressed in enterocytes of the colon, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, granulocyte monocyte progenitor cells, tuft cells of the colon, absorptive cells, BEST4+ intestinal epithelial cells, human intestinal crypt stem cells of the colon, and small intestine goblet cells. This widespread expression suggests that DHDH may be involved in various cellular processes, including metabolism, immune response, and neurodevelopment. **Pathways and Functions:** DHDH is implicated in several key pathways, including: 1. **D-xylose 1-dehydrogenase (NADP+) activity**: This enzyme catalyzes the conversion of D-xylose to xylitol, a key step in the catabolic process of D-xylose. 2. **D-xylose catabolic process**: DHDH is essential for the degradation of D-xylose, a process that is critical for maintaining proper glucose homeostasis and energy metabolism. 3. **Nucleotide binding**: Although the exact mechanism is unclear, DHDH may be involved in the regulation of nucleotide metabolism, which is crucial for various cellular processes, including DNA synthesis and repair. 4. **Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity**: This enzyme catalyzes the conversion of trans-1,2-dihydrobenzene-1,2-diol to benzene-1,2-diol, a reaction that is involved in the detoxification of certain environmental pollutants. **Clinical Significance:** The clinical significance of DHDH is multifaceted and warrants further investigation. Some potential implications of DHDH dysregulation include: 1. **Immunological disorders**: Alterations in DHDH expression or activity may contribute to the development of immune-related disorders, such as autoimmune diseases or inflammatory bowel disease. 2. **Metabolic disorders**: DHDH dysregulation may lead to metabolic imbalances, including glucose intolerance or insulin resistance, which are hallmarks of various metabolic disorders. 3. **Neurodevelopmental disorders**: The expression of DHDH in GABAergic interneurons and forebrain radial glial cells suggests that this gene may play a role in neurodevelopmental processes, including the development of neurodegenerative diseases. 4. **Cancer**: The expression of DHDH in certain cancer cells, including those of the colon and small intestine, raises the possibility that this gene may be involved in cancer development or progression. In conclusion, DHDH is a gene of emerging significance in immunology and immunology-related pathways. Further research is necessary to fully elucidate the mechanisms of DHDH and its clinical implications, ultimately leading to a better understanding of the complex relationships between this gene and various diseases.

Genular Protein ID: 2573623422

Symbol: DHDH_HUMAN

Name: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

UniProtKB Accession Codes:

Q9UQ10

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 4 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10477285

Title: Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases.

PubMed ID: 10477285

DOI: 10.1042/bj3420721

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 334
  • Mass: 36382
  • Checksum: 1E2E11DF0B55214B
  • Sequence:
    • MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE 
LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL 
MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY 
CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV 
SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM 
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.