Details for: GLDC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.4139
Cell Significance Index: -19.4900 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 6.8325
Cell Significance Index: 8.8400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.0886
Cell Significance Index: -20.0800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9605
Cell Significance Index: 587.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.0284
Cell Significance Index: 54.1600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.8140
Cell Significance Index: 58.1000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.2794
Cell Significance Index: -2.8000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.1981
Cell Significance Index: 174.1600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9596
Cell Significance Index: 53.8500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.9107
Cell Significance Index: 15.3400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9035
Cell Significance Index: 63.9000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.7112
Cell Significance Index: 1311.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.6104
Cell Significance Index: 939.6600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5552
Cell Significance Index: 111.3700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3485
Cell Significance Index: 9.7400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.3368
Cell Significance Index: 8.4000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.3079
Cell Significance Index: 418.6600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2296
Cell Significance Index: 14.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2164
Cell Significance Index: 149.6600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2162
Cell Significance Index: 41.1400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.1820
Cell Significance Index: 3.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1243
Cell Significance Index: 234.0800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0928
Cell Significance Index: 50.7000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0914
Cell Significance Index: 16.4700 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0880
Cell Significance Index: 1.4800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0872
Cell Significance Index: 5.3500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0583
Cell Significance Index: 1.6800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0567
Cell Significance Index: 25.0900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0266
Cell Significance Index: 9.5400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0226
Cell Significance Index: 20.4300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0125
Cell Significance Index: 7.9200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0043
Cell Significance Index: 0.7000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0063
Cell Significance Index: -0.2200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0112
Cell Significance Index: -8.2000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0210
Cell Significance Index: -0.3100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0256
Cell Significance Index: -2.7900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0306
Cell Significance Index: -23.1900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0369
Cell Significance Index: -27.3600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0377
Cell Significance Index: -3.7300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0411
Cell Significance Index: -25.6500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0447
Cell Significance Index: -20.2900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0490
Cell Significance Index: -27.6200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0504
Cell Significance Index: -1.2600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0538
Cell Significance Index: -3.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0655
Cell Significance Index: -18.8400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0691
Cell Significance Index: -8.5000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0826
Cell Significance Index: -4.2900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0903
Cell Significance Index: -11.5700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0965
Cell Significance Index: -2.0900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1149
Cell Significance Index: -13.3900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1149
Cell Significance Index: -1.6500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1202
Cell Significance Index: -25.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1209
Cell Significance Index: -5.4800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1210
Cell Significance Index: -2.5100 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.1217
Cell Significance Index: -0.9300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1379
Cell Significance Index: -18.9400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1427
Cell Significance Index: -9.8700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1490
Cell Significance Index: -9.6200 - Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.1509
Cell Significance Index: -0.7900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1663
Cell Significance Index: -28.3900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1677
Cell Significance Index: -21.6700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1806
Cell Significance Index: -21.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1833
Cell Significance Index: -19.0900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1880
Cell Significance Index: -3.9900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1945
Cell Significance Index: -19.8700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2201
Cell Significance Index: -25.2200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2268
Cell Significance Index: -5.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2527
Cell Significance Index: -20.0100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2594
Cell Significance Index: -8.2600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2598
Cell Significance Index: -19.9400 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2775
Cell Significance Index: -1.8800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2787
Cell Significance Index: -4.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2875
Cell Significance Index: -21.4300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2887
Cell Significance Index: -19.4200 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3360
Cell Significance Index: -5.8100 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.3370
Cell Significance Index: -2.0000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3447
Cell Significance Index: -8.8600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3461
Cell Significance Index: -7.3700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3663
Cell Significance Index: -19.2300 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.3665
Cell Significance Index: -3.1700 - Cell Name: glioblast (CL0000030)
Fold Change: -0.3726
Cell Significance Index: -2.3400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3738
Cell Significance Index: -19.4700 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.4042
Cell Significance Index: -3.1700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4303
Cell Significance Index: -20.2300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4382
Cell Significance Index: -15.3500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4402
Cell Significance Index: -19.4700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4528
Cell Significance Index: -7.7600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4739
Cell Significance Index: -13.5300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4754
Cell Significance Index: -9.5500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4930
Cell Significance Index: -31.0700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.4947
Cell Significance Index: -15.6500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5037
Cell Significance Index: -7.6500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5147
Cell Significance Index: -16.8500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5192
Cell Significance Index: -19.6600 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.5548
Cell Significance Index: -5.0000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5563
Cell Significance Index: -11.0000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5730
Cell Significance Index: -6.5100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5771
Cell Significance Index: -12.0800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5804
Cell Significance Index: -20.1700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5922
Cell Significance Index: -24.2600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2809795149
Symbol: GCSP_HUMAN
Name: Glycine cleavage system P protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1996985
Title: Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia.
PubMed ID: 1996985
PubMed ID: 1993704
Title: The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures.
PubMed ID: 1993704
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18088087
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28244183
Title: Nonketotic Hyperglycinemia: functional assessment of missense variants in GLDC to understand phenotypes of the disease.
PubMed ID: 28244183
DOI: 10.1002/humu.23208
PubMed ID: 1634607
Title: Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia.
PubMed ID: 1634607
DOI: 10.1172/jci115831
PubMed ID: 11286506
Title: Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH).
PubMed ID: 11286506
PubMed ID: 11592811
Title: Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis.
PubMed ID: 11592811
PubMed ID: 28737873
Title: Two novel mutations in the glycine decarboxylase gene in a boy with classic nonketotic hyperglycinemia: case report.
PubMed ID: 28737873
Sequence Information:
- Length: 1020
- Mass: 112730
- Checksum: 8FAEA7D56BEB17B2
- Sequence:
MQSCARAWGL RLGRGVGGGR RLAGGSGPCW APRSRDSSSG GGDSAAAGAS RLLERLLPRH DDFARRHIGP GDKDQREMLQ TLGLASIDEL IEKTVPANIR LKRPLKMEDP VCENEILATL HAISSKNQIW RSYIGMGYYN CSVPQTILRN LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ TMVCDITGLD MANASLLDEG TAAAEALQLC YRHNKRRKFL VDPRCHPQTI AVVQTRAKYT GVLTELKLPC EMDFSGKDVS GVLFQYPDTE GKVEDFTELV ERAHQSGSLA CCATDLLALC ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRESL VRMMPGRMVG VTRDATGKEV YRLALQTREQ HIRRDKATSN ICTAQALLAN MAAMFAIYHG SHGLEHIARR VHNATLILSE GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL GRAAQRQINF RLFEDGTLGI SLDETVNEKD LDDLLWIFGC ESSAELVAES MGEECRGIPG SVFKRTSPFL THQVFNSYHS ETNIVRYMKK LENKDISLVH SMIPLGSCTM KLNSSSELAP ITWKEFANIH PFVPLDQAQG YQQLFRELEK DLCELTGYDQ VCFQPNSGAQ GEYAGLATIR AYLNQKGEGH RTVCLIPKSA HGTNPASAHM AGMKIQPVEV DKYGNIDAVH LKAMVDKHKE NLAAIMITYP STNGVFEENI SDVCDLIHQH GGQVYLDGAN MNAQVGICRP GDFGSDVSHL NLHKTFCIPH GGGGPGMGPI GVKKHLAPFL PNHPVISLKR NEDACPVGTV SAAPWGSSSI LPISWAYIKM MGGKGLKQAT ETAILNANYM AKRLETHYRI LFRGARGYVG HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA GTLMVEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH SLTCVTSSHW DRPYSREVAA FPLPFVKPEN KFWPTIARID DIYGDQHLVC TCPPMEVYES PFSEQKRASS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.