Details for: GLDC

Gene ID: 2731

Symbol: GLDC

Ensembl ID: ENSG00000178445

Description: glycine decarboxylase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.76
    Marker Score: 5064
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.33
    Marker Score: 4030
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.67
    Marker Score: 2190
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.48
    Marker Score: 1448
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.1
    Marker Score: 6871
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.05
    Marker Score: 3883
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.99
    Marker Score: 1532
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.66
    Marker Score: 4190
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.59
    Marker Score: 8540
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.53
    Marker Score: 3118
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.53
    Marker Score: 6593
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5
    Marker Score: 5880
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169053
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.39
    Marker Score: 3282
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.38
    Marker Score: 4910
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.35
    Marker Score: 921
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.28
    Marker Score: 47359
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.28
    Marker Score: 8208
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2
    Marker Score: 5034
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.17
    Marker Score: 1653
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.13
    Marker Score: 10695
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 671
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17228
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 660
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.03
    Marker Score: 1288
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21596
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 651
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5302
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 376
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.9
    Marker Score: 181
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.89
    Marker Score: 947
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 405
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.81
    Marker Score: 1248
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.81
    Marker Score: 821
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3254
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.76
    Marker Score: 258
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.76
    Marker Score: 424
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.71
    Marker Score: 1893
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.7
    Marker Score: 314
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.7
    Marker Score: 601
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 324
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.67
    Marker Score: 5106
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.66
    Marker Score: 436
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 556
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.64
    Marker Score: 24279
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 205
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.62
    Marker Score: 765
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.62
    Marker Score: 953
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.57
    Marker Score: 333
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.57
    Marker Score: 607
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.55
    Marker Score: 206
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.54
    Marker Score: 141
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.54
    Marker Score: 169.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.54
    Marker Score: 577
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.52
    Marker Score: 231
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.49
    Marker Score: 651
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 150
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 459
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.45
    Marker Score: 310
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.44
    Marker Score: 128
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.44
    Marker Score: 163
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.44
    Marker Score: 158
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.43
    Marker Score: 197
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.43
    Marker Score: 226
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.42
    Marker Score: 704
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.41
    Marker Score: 120
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.41
    Marker Score: 8059
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 217
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.37
    Marker Score: 102
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.37
    Marker Score: 148
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.37
    Marker Score: 475
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.36
    Marker Score: 1681
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 397
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.34
    Marker Score: 226.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.34
    Marker Score: 2250
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 174
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.33
    Marker Score: 122

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Other Information

**Key characteristics:** - GLDC is an enzyme in the glyoxylate metabolism pathway, which is responsible for the breakdown of amino acids and proteins. - It is a multi-functional enzyme that can act as a carboxylase, dehydrogenase, and lyase. - It is involved in the regulation of energy production and the maintenance of cellular homeostasis. **Pathways and functions:** - GLDC is involved in multiple pathways, including cellular response to leukemia inhibitory factor (a cytokine that inhibits immune responses), electron transfer, and glycine catabolism. - It is a key enzyme in the regulation of the antioxidant defense system, protecting cells from damage caused by reactive oxygen species. - It is also involved in the synthesis of pyridoxal, a precursor for various biomolecules, including neurotransmitters and enzymes. **Clinical significance:** - Mutations in GLDC have been linked to certain eye diseases, such as macular dystrophy and cataracts. - Dysfunction of GLDC can lead to the accumulation of glycine and disrupt cellular processes, resulting in various health problems. - Therefore, targeting GLDC has emerged as a potential therapeutic strategy for these eye diseases.

Genular Protein ID: 2809795149

Symbol: GCSP_HUMAN

Name: Glycine cleavage system P protein

UniProtKB Accession Codes:

P23378 Q2M2F8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SABIO-RK 1 SAM 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1996985

Title: Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia.

PubMed ID: 1996985

DOI: 10.1016/0006-291x(91)91545-n

PubMed ID: 1993704

Title: The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures.

PubMed ID: 1993704

DOI: 10.1016/s0021-9258(18)49991-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28244183

Title: Nonketotic Hyperglycinemia: functional assessment of missense variants in GLDC to understand phenotypes of the disease.

PubMed ID: 28244183

DOI: 10.1002/humu.23208

PubMed ID: 1634607

Title: Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia.

PubMed ID: 1634607

DOI: 10.1172/jci115831

PubMed ID: 11286506

Title: Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH).

PubMed ID: 11286506

DOI: 10.1006/mgme.2001.3158

PubMed ID: 11592811

Title: Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis.

PubMed ID: 11592811

DOI: 10.1006/mgme.2001.3224

PubMed ID: 28737873

Title: Two novel mutations in the glycine decarboxylase gene in a boy with classic nonketotic hyperglycinemia: case report.

PubMed ID: 28737873

DOI: 10.5546/aap.2017.eng.e225

Sequence Information:

  • Length: 1020
  • Mass: 112730
  • Checksum: 8FAEA7D56BEB17B2
  • Sequence:
    • MQSCARAWGL RLGRGVGGGR RLAGGSGPCW APRSRDSSSG GGDSAAAGAS RLLERLLPRH 
DDFARRHIGP GDKDQREMLQ TLGLASIDEL IEKTVPANIR LKRPLKMEDP VCENEILATL 
HAISSKNQIW RSYIGMGYYN CSVPQTILRN LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ 
TMVCDITGLD MANASLLDEG TAAAEALQLC YRHNKRRKFL VDPRCHPQTI AVVQTRAKYT 
GVLTELKLPC EMDFSGKDVS GVLFQYPDTE GKVEDFTELV ERAHQSGSLA CCATDLLALC 
ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRESL VRMMPGRMVG VTRDATGKEV 
YRLALQTREQ HIRRDKATSN ICTAQALLAN MAAMFAIYHG SHGLEHIARR VHNATLILSE 
GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL GRAAQRQINF RLFEDGTLGI SLDETVNEKD 
LDDLLWIFGC ESSAELVAES MGEECRGIPG SVFKRTSPFL THQVFNSYHS ETNIVRYMKK 
LENKDISLVH SMIPLGSCTM KLNSSSELAP ITWKEFANIH PFVPLDQAQG YQQLFRELEK 
DLCELTGYDQ VCFQPNSGAQ GEYAGLATIR AYLNQKGEGH RTVCLIPKSA HGTNPASAHM 
AGMKIQPVEV DKYGNIDAVH LKAMVDKHKE NLAAIMITYP STNGVFEENI SDVCDLIHQH 
GGQVYLDGAN MNAQVGICRP GDFGSDVSHL NLHKTFCIPH GGGGPGMGPI GVKKHLAPFL 
PNHPVISLKR NEDACPVGTV SAAPWGSSSI LPISWAYIKM MGGKGLKQAT ETAILNANYM 
AKRLETHYRI LFRGARGYVG HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA 
GTLMVEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH SLTCVTSSHW 
DRPYSREVAA FPLPFVKPEN KFWPTIARID DIYGDQHLVC TCPPMEVYES PFSEQKRASS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.