Details for: PCDH11X

Gene ID: 27328

Symbol: PCDH11X

Ensembl ID: ENSG00000102290

Description: protocadherin 11 X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 186.1838
    Cell Significance Index: -28.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 116.9358
    Cell Significance Index: -29.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.5126
    Cell Significance Index: -28.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 9.7354
    Cell Significance Index: 546.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8433
    Cell Significance Index: -10.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.2709
    Cell Significance Index: 188.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.0029
    Cell Significance Index: 96.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.8622
    Cell Significance Index: 146.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.4625
    Cell Significance Index: 53.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.3734
    Cell Significance Index: 145.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.2857
    Cell Significance Index: 657.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2295
    Cell Significance Index: 799.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5065
    Cell Significance Index: 18.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1198
    Cell Significance Index: 224.6300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.7626
    Cell Significance Index: 9.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2609
    Cell Significance Index: 162.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.2549
    Cell Significance Index: 5.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2520
    Cell Significance Index: 6.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.2268
    Cell Significance Index: 4.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1973
    Cell Significance Index: 2.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1842
    Cell Significance Index: 6.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1072
    Cell Significance Index: 2.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1043
    Cell Significance Index: 20.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0871
    Cell Significance Index: 0.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0345
    Cell Significance Index: 1.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0076
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0030
    Cell Significance Index: -0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0208
    Cell Significance Index: -9.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0284
    Cell Significance Index: -18.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0288
    Cell Significance Index: -12.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0334
    Cell Significance Index: -24.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0336
    Cell Significance Index: -6.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0376
    Cell Significance Index: -28.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0402
    Cell Significance Index: -6.8600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0455
    Cell Significance Index: -0.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0521
    Cell Significance Index: -28.4400
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0720
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0774
    Cell Significance Index: -9.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0843
    Cell Significance Index: -12.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0971
    Cell Significance Index: -1.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1202
    Cell Significance Index: -3.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1400
    Cell Significance Index: -17.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1741
    Cell Significance Index: -23.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1754
    Cell Significance Index: -22.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1798
    Cell Significance Index: -20.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2181
    Cell Significance Index: -25.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2219
    Cell Significance Index: -25.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2321
    Cell Significance Index: -27.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2497
    Cell Significance Index: -25.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2811
    Cell Significance Index: -18.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2815
    Cell Significance Index: -29.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2869
    Cell Significance Index: -2.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2932
    Cell Significance Index: -3.7000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3169
    Cell Significance Index: -3.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3177
    Cell Significance Index: -23.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3351
    Cell Significance Index: -8.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3519
    Cell Significance Index: -24.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3619
    Cell Significance Index: -27.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3637
    Cell Significance Index: -22.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3744
    Cell Significance Index: -17.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3818
    Cell Significance Index: -22.9200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3920
    Cell Significance Index: -2.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3980
    Cell Significance Index: -20.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4134
    Cell Significance Index: -26.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4392
    Cell Significance Index: -26.9300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4479
    Cell Significance Index: -19.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4483
    Cell Significance Index: -5.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4490
    Cell Significance Index: -15.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4578
    Cell Significance Index: -9.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5043
    Cell Significance Index: -22.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5712
    Cell Significance Index: -12.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5960
    Cell Significance Index: -31.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6192
    Cell Significance Index: -28.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6227
    Cell Significance Index: -32.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6268
    Cell Significance Index: -12.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6404
    Cell Significance Index: -16.4600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.6518
    Cell Significance Index: -6.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6524
    Cell Significance Index: -12.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6612
    Cell Significance Index: -18.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6682
    Cell Significance Index: -24.5300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6705
    Cell Significance Index: -6.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.6881
    Cell Significance Index: -7.1900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.7329
    Cell Significance Index: -9.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7330
    Cell Significance Index: -25.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7711
    Cell Significance Index: -20.2800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7730
    Cell Significance Index: -24.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7800
    Cell Significance Index: -16.2800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.7828
    Cell Significance Index: -8.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8134
    Cell Significance Index: -28.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8200
    Cell Significance Index: -23.5100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8605
    Cell Significance Index: -11.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8663
    Cell Significance Index: -18.4500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8669
    Cell Significance Index: -17.6400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.8759
    Cell Significance Index: -5.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PCDH11X is a transmembrane protein with an extracellular domain that mediates homophilic cell adhesion, meaning it interacts with identical molecules on adjacent cells. The gene is characterized by its high expression levels in the brain, particularly in areas involved in motor control and learning. PCDH11X is also expressed in the lungs and placenta, where it may play a role in maintaining tissue integrity and development. **Pathways and Functions** PCDH11X is involved in several cellular processes, including: 1. **Homophilic cell adhesion**: PCDH11X mediates adhesion between adjacent cells, which is essential for maintaining tissue structure and function. 2. **Calcium ion binding**: The extracellular domain of PCDH11X contains calcium-binding motifs, which may regulate cell adhesion and signaling. 3. **Cell signaling**: PCDH11X may participate in signaling pathways that regulate cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of PCDH11X has been implicated in several neurological and psychiatric disorders, including: 1. **Autism spectrum disorder (ASD)**: Studies have shown that individuals with ASD have altered expression levels of PCDH11X in brain regions involved in social behavior and communication. 2. **Schizophrenia**: PCDH11X has been linked to schizophrenia, with altered expression levels in brain regions involved in cognitive processing and neural circuitry. 3. **Developmental disorders**: PCDH11X may play a role in developmental disorders, such as intellectual disability and epilepsy, where disruptions in brain development and function are common. In addition to its potential role in neurological disorders, PCDH11X may also be relevant to other diseases, such as: 1. **Cancer**: PCDH11X has been implicated in cancer, where it may play a role in cell adhesion and migration. 2. **Cardiovascular disease**: PCDH11X may contribute to cardiovascular disease, where disruptions in cell adhesion and signaling pathways are common. Overall, further research is needed to fully understand the functions and clinical significance of PCDH11X, but its involvement in neurological and psychiatric disorders highlights its potential as a therapeutic target.

Genular Protein ID: 42473342

Symbol: PC11X_HUMAN

Name: Protocadherin-11 X-linked

UniProtKB Accession Codes:

Q9BZA7 A6NIQ4 Q2TJH0 Q2TJH1 Q2TJH3 Q5JVZ0 Q70LR8 Q70LS7 Q70LS8 Q70LS9 Q70LT7 Q70LT8 Q70LT9 Q70LU0 Q70LU1 Q96RV4 Q96RW0 Q9BZA6 Q9H4E0 Q9P2M0 Q9P2X5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 25 Ensembl 7 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644456

Title: Identification of a novel protocadherin gene (PCDH11) on the human XY homology region in Xq21.3.

PubMed ID: 10644456

DOI: 10.1006/geno.1999.6042

PubMed ID: 11003707

Title: Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain.

PubMed ID: 11003707

DOI: 10.1007/s003350010177

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 14727141

Title: Protocadherin X (PCDHX) and Y (PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains.

PubMed ID: 14727141

DOI: 10.1007/s00335-003-3028-7

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1347
  • Mass: 147558
  • Checksum: 0227FA6C521FDA84
  • Sequence:
    • MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS LIPNKSLTTA 
MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI PRDEHCFYEV EVAILPDEIF 
RLVKIRFLIE DINDNAPLFP ATVINISIPE NSAINSKYTL PAAVDPDVGI NGVQNYELIK 
SQNIFGLDVI ETPEGDKMPQ LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT 
DTNDNHPVFK ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF 
HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND NVPSIDIRYI 
VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT DHEIPFRLRP VFSNQFLLET 
AAYLDYESTK EYAIKLLAAD AGKPPLNQSA MLFIKVKDEN DNAPVFTQSF VTVSIPENNS 
PGIQLTKVSA MDADSGPNAK INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI 
LAKDNGVPPL TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG 
DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR VSRSSSAKVT 
INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA VDNDTGMNAE VRYSIVGGNT 
RDLFAIDQET GNITLMEKCD VTDLGLHRVL VKANDLGQPD SLFSVVIVNL FVNESVTNAT 
LINELVRKST EAPVTPNTEI ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP 
HLKAAQKNKQ NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG 
NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI QPETPLNSKH 
HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT FEVPVSVHTR PPMKEVVRSC 
TPMKESTTME IWIHPQPQRK SEGKVAGKSQ RRVTFHLPEG SQESSSDGGL GDHDAGSLTS 
TSHGLPLGYP QEEYFDRATP SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT 
QECLIYGHSD ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP 
VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA QAAAISHSSP 
LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA TSQFYTMSER LHPSDDSIKV 
IPLTTFTPRQ QARPSRGDSP IMEEHPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.