Details for: DESI1

Gene ID: 27351

Symbol: DESI1

Ensembl ID: ENSG00000100418

Description: desumoylating isopeptidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 142.2737
    Cell Significance Index: -22.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.4169
    Cell Significance Index: -22.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.0901
    Cell Significance Index: -26.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3154
    Cell Significance Index: -23.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1677
    Cell Significance Index: -21.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4790
    Cell Significance Index: -19.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2924
    Cell Significance Index: -24.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0115
    Cell Significance Index: 208.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0658
    Cell Significance Index: 240.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4161
    Cell Significance Index: 41.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0476
    Cell Significance Index: 54.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0329
    Cell Significance Index: 167.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7908
    Cell Significance Index: 10.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7627
    Cell Significance Index: 21.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7597
    Cell Significance Index: 150.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7091
    Cell Significance Index: 70.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7063
    Cell Significance Index: 141.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6639
    Cell Significance Index: 18.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6600
    Cell Significance Index: 17.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6279
    Cell Significance Index: 342.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6081
    Cell Significance Index: 109.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5683
    Cell Significance Index: 26.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4965
    Cell Significance Index: 23.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4671
    Cell Significance Index: 10.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4631
    Cell Significance Index: 56.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4202
    Cell Significance Index: 11.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3841
    Cell Significance Index: 45.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3530
    Cell Significance Index: 244.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3406
    Cell Significance Index: 122.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3336
    Cell Significance Index: 15.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3233
    Cell Significance Index: 41.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2834
    Cell Significance Index: 20.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2431
    Cell Significance Index: 33.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2405
    Cell Significance Index: 6.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2299
    Cell Significance Index: 101.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1954
    Cell Significance Index: 14.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1807
    Cell Significance Index: 3.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1533
    Cell Significance Index: 11.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1415
    Cell Significance Index: 24.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1200
    Cell Significance Index: 22.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0933
    Cell Significance Index: 3.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0646
    Cell Significance Index: 0.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0498
    Cell Significance Index: 1.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0380
    Cell Significance Index: 28.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0361
    Cell Significance Index: 32.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0275
    Cell Significance Index: 3.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0201
    Cell Significance Index: 37.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0043
    Cell Significance Index: 6.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 5.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0003
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0188
    Cell Significance Index: -11.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0257
    Cell Significance Index: -11.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0296
    Cell Significance Index: -3.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0429
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0453
    Cell Significance Index: -3.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0623
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0663
    Cell Significance Index: -13.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0712
    Cell Significance Index: -3.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0741
    Cell Significance Index: -21.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0875
    Cell Significance Index: -10.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0944
    Cell Significance Index: -5.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0944
    Cell Significance Index: -3.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1070
    Cell Significance Index: -15.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1140
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1269
    Cell Significance Index: -14.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1334
    Cell Significance Index: -8.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1392
    Cell Significance Index: -3.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1549
    Cell Significance Index: -2.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1610
    Cell Significance Index: -3.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1713
    Cell Significance Index: -4.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1804
    Cell Significance Index: -9.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1861
    Cell Significance Index: -3.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1951
    Cell Significance Index: -10.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2116
    Cell Significance Index: -3.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2176
    Cell Significance Index: -22.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2326
    Cell Significance Index: -18.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2459
    Cell Significance Index: -5.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2849
    Cell Significance Index: -7.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3192
    Cell Significance Index: -5.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3361
    Cell Significance Index: -5.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3602
    Cell Significance Index: -10.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3792
    Cell Significance Index: -23.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3797
    Cell Significance Index: -8.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4118
    Cell Significance Index: -11.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4374
    Cell Significance Index: -15.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4746
    Cell Significance Index: -7.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5112
    Cell Significance Index: -16.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5135
    Cell Significance Index: -13.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5173
    Cell Significance Index: -4.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5206
    Cell Significance Index: -11.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5290
    Cell Significance Index: -17.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5358
    Cell Significance Index: -19.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5359
    Cell Significance Index: -27.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5375
    Cell Significance Index: -7.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5509
    Cell Significance Index: -19.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5637
    Cell Significance Index: -14.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DESI1 is a member of the desumoylating enzyme family, which is involved in the removal of N-terminal sumoylation from proteins. This process is crucial for regulating protein stability, localization, and activity. DESI1 exhibits long-chain fatty acyl-coa hydrolase activity, which suggests its involvement in lipid metabolism and cellular homeostasis. The enzyme's ability to bind to importin-alpha family proteins and regulate proteasomal ubiquitin-dependent protein catabolic processes highlights its role in protein quality control and immune response. **Pathways and Functions:** DESI1's involvement in various cellular pathways underscores its significance in maintaining cellular homeostasis. Notably, its role in desumoylation and protein modification by small protein removal (SPR) processes suggests its capacity to regulate protein degradation and turnover. DESI1's interaction with importin-alpha family proteins and its ability to export proteins from the nucleus imply its involvement in nuclear transport and regulation of protein activity. Furthermore, its expression in epithelial cells and immune cells highlights its role in maintaining tissue homeostasis and immune system function. **Clinical Significance:** The clinical significance of DESI1 lies in its potential role as a biomarker for immune system dysregulation. Alterations in DESI1 expression or activity have been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune diseases. For instance, DESI1's expression has been found to be elevated in certain types of cancer, suggesting its potential as a prognostic marker. Additionally, DESI1's involvement in regulating protein degradation and modification implies its potential as a therapeutic target for diseases characterized by protein misregulation. In conclusion, DESI1 is a multifunctional protein that plays a crucial role in regulating protein degradation, modification, and localization. Its expression in various cell types and involvement in multiple pathways underscore its significance in maintaining cellular homeostasis and immune system function. Further research is necessary to fully elucidate the clinical significance of DESI1 and its potential as a biomarker or therapeutic target for immune system-related diseases. **Future Directions:** Further studies are needed to investigate the mechanisms underlying DESI1's regulation of protein degradation and modification. Additionally, the clinical significance of DESI1 should be further explored through studies examining its expression and activity in various disease states. The development of DESI1 as a biomarker or therapeutic target will require careful consideration of its expression patterns, localization, and functional significance in different cell types and disease contexts. **References:** (Insert relevant references to support the discussion) Note: This response is based on the provided information and may require additional research to fully support the claims made.

Genular Protein ID: 2168383573

Symbol: DESI1_HUMAN

Name: Palmitoyl protein thioesterase DESI1

UniProtKB Accession Codes:

Q6ICB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 4 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29666234

Title: Nuclear export of ubiquitinated proteins via the UBIN-POST system.

PubMed ID: 29666234

DOI: 10.1073/pnas.1711017115

PubMed ID: 35427157

Title: Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration.

PubMed ID: 35427157

DOI: 10.1126/sciadv.abj8633

Sequence Information:

  • Length: 168
  • Mass: 18263
  • Checksum: D902AF6FE5DDA31A
  • Sequence:
    • MEPPNLYPVK LYVYDLSKGL ARRLSPIMLG KQLEGIWHTS IVVHKDEFFF GSGGISSCPP 
GGTLLGPPDS VVDVGSTEVT EEIFLEYLSS LGESLFRGEA YNLFEHNCNT FSNEVAQFLT 
GRKIPSYITD LPSEVLSTPF GQALRPLLDS IQIQPPGGSS VGRPNGQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.