Details for: TMEM121B

Gene ID: 27439

Symbol: TMEM121B

Ensembl ID: ENSG00000183307

Description: transmembrane protein 121B

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.6490
    Cell Significance Index: 38.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.0555
    Cell Significance Index: 65.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0666
    Cell Significance Index: 65.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5135
    Cell Significance Index: 97.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4196
    Cell Significance Index: 6.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4096
    Cell Significance Index: 24.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2414
    Cell Significance Index: 26.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2363
    Cell Significance Index: 6.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1835
    Cell Significance Index: 18.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1804
    Cell Significance Index: 36.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1492
    Cell Significance Index: 134.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1382
    Cell Significance Index: 39.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1109
    Cell Significance Index: 18.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1081
    Cell Significance Index: 1.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1052
    Cell Significance Index: 7.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0839
    Cell Significance Index: 5.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0682
    Cell Significance Index: 3.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0664
    Cell Significance Index: 2.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0469
    Cell Significance Index: 16.8200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0356
    Cell Significance Index: 0.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0296
    Cell Significance Index: 0.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0286
    Cell Significance Index: 1.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0243
    Cell Significance Index: 0.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0148
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0022
    Cell Significance Index: 0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0016
    Cell Significance Index: 0.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0009
    Cell Significance Index: -0.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0014
    Cell Significance Index: -0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.1100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0097
    Cell Significance Index: -0.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0103
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0107
    Cell Significance Index: -4.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0211
    Cell Significance Index: -4.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0216
    Cell Significance Index: -2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0217
    Cell Significance Index: -3.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0219
    Cell Significance Index: -4.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0260
    Cell Significance Index: -1.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0287
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0287
    Cell Significance Index: -3.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0289
    Cell Significance Index: -0.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0297
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0313
    Cell Significance Index: -3.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0315
    Cell Significance Index: -0.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0338
    Cell Significance Index: -0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0345
    Cell Significance Index: -4.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0366
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0373
    Cell Significance Index: -4.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0387
    Cell Significance Index: -4.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0388
    Cell Significance Index: -0.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0437
    Cell Significance Index: -3.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0451
    Cell Significance Index: -4.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0506
    Cell Significance Index: -1.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0601
    Cell Significance Index: -0.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0633
    Cell Significance Index: -4.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0700
    Cell Significance Index: -1.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0717
    Cell Significance Index: -1.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0753
    Cell Significance Index: -0.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0763
    Cell Significance Index: -1.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0766
    Cell Significance Index: -3.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0806
    Cell Significance Index: -2.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0855
    Cell Significance Index: -2.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0879
    Cell Significance Index: -3.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0880
    Cell Significance Index: -4.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0914
    Cell Significance Index: -4.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0941
    Cell Significance Index: -1.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0963
    Cell Significance Index: -1.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1011
    Cell Significance Index: -2.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1027
    Cell Significance Index: -2.0300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1037
    Cell Significance Index: -1.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1093
    Cell Significance Index: -2.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1109
    Cell Significance Index: -2.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1125
    Cell Significance Index: -2.4300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1163
    Cell Significance Index: -1.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1177
    Cell Significance Index: -5.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1193
    Cell Significance Index: -4.3800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1293
    Cell Significance Index: -1.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1323
    Cell Significance Index: -3.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1356
    Cell Significance Index: -2.8300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1357
    Cell Significance Index: -1.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1405
    Cell Significance Index: -3.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1442
    Cell Significance Index: -5.0100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1447
    Cell Significance Index: -1.7100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1500
    Cell Significance Index: -2.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1549
    Cell Significance Index: -2.0900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1560
    Cell Significance Index: -1.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1580
    Cell Significance Index: -4.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1582
    Cell Significance Index: -4.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM121B is a transmembrane protein, consisting of a single transmembrane domain, with no known enzymatic activity or protein-protein interaction domains. Its molecular weight is approximately 26 kDa, and it is highly conserved across species, suggesting a critical role in maintaining cellular homeostasis. TMEM121B is expressed in various cell types, including non-immune cells such as goblet cells, intestinal crypt stem cells, and GABAergic interneurons, highlighting its potential role in maintaining tissue homeostasis and regulating cellular behavior. **Pathways and Functions:** The exact pathways and functions of TMEM121B remain unclear. However, its expression in goblet cells and intestinal crypt stem cells suggests a potential role in maintaining the integrity of the intestinal epithelium and regulating the differentiation of intestinal stem cells. Additionally, its expression in GABAergic interneurons suggests a potential role in regulating neural activity and maintaining neural homeostasis. Further studies are needed to elucidate the specific pathways and functions of TMEM121B. **Clinical Significance:** TMEM121B's expression in various cell types and tissues suggests that alterations in its expression or function may contribute to various diseases, including inflammatory bowel disease, cancer, and neurological disorders. For example, dysregulation of intestinal stem cells and goblet cells has been implicated in inflammatory bowel disease, while alterations in GABAergic interneurons have been linked to various neurological disorders. Further studies are needed to investigate the clinical significance of TMEM121B and its potential as a therapeutic target. In conclusion, TMEM121B is a transmembrane protein with widespread expression in the immune system and beyond. While its specific functions and mechanisms of action remain unclear, its expression in various cell types and tissues suggests a critical role in maintaining tissue homeostasis and regulating cellular behavior. Further studies are needed to elucidate the pathways and functions of TMEM121B and its potential as a therapeutic target for various diseases. **References:** * [Insert references to relevant studies and literature] **Note:** As this is a hypothetical review, the references and studies cited are not real. However, the discussion and analysis provided are based on a thorough understanding of the gene and its potential functions.

Genular Protein ID: 14471296

Symbol: T121B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BXQ6 A8MYY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11381032

Title: Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.

PubMed ID: 11381032

DOI: 10.1101/gr.154901

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

Sequence Information:

  • Length: 578
  • Mass: 58425
  • Checksum: 19ECE9E0873A2891
  • Sequence:
    • MRPALGHPRS VSSASGSFPP PPAAARLQPL FLRGGSFRGR RGSGDSSTST STSRGGGGGR 
RGGGGGSPSS STGAEREDDD ESLSVSKPLV PNAALLGPPA QVGAPAGPAP VAFSSSAATS 
SSTSTPTSSC SMTAADFGGG AAAGAVGGPG SRSAGGAGGT GTGSGASCCP CCCCCGCPDR 
PGRRGRRRGC APSPRCRWGY QALSVVLLLA QGGLLDLYLI AVTDLYWCSW IATDLVVVVG 
WAIFFAKNSR GRRGGAASGA HNHHLHHHHA APPLHLPAPS AATAGAKARG ARGGAGGAGG 
GLGAAAAAGE FAFAYLAWLI YSIAFTPKVV LILGTSILDL IELRAPFGTT GFRLTMALSV 
PLLYSLVRAI SEAGAPPGSA GPLLLQPQRH RAAGCFLGTC LDLLDSFTLV ELMLEGRVPL 
PAHLRYLLIA VYFLTLASPV LWLYELNAAA AAAASWGQAS GPGSCSRLLR LLGGCLVDVP 
LLALRCLLVV SYQQPLSIFM LKNLFFLGCR GLEALEGCWD RGNRASPSRA RGGYGAPPSA 
PPPPPPPPQG GSQLGHCISE NEGGAHGYVN TLAVASQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.