Details for: GNAL

Gene ID: 2774

Symbol: GNAL

Ensembl ID: ENSG00000141404

Description: G protein subunit alpha L

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.23
    Marker Score: 109036
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.5
    Marker Score: 19199
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.42
    Marker Score: 10031
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.36
    Marker Score: 89642
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.36
    Marker Score: 10903
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.34
    Marker Score: 34974
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.26
    Marker Score: 83344
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.11
    Marker Score: 6014
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.94
    Marker Score: 7485
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17938
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.84
    Marker Score: 18963
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6675.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.54
    Marker Score: 1705
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.5
    Marker Score: 2512
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168755
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.42
    Marker Score: 2882
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.37
    Marker Score: 465
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.33
    Marker Score: 512
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1231
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18235
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.14
    Marker Score: 1990
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2624
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.08
    Marker Score: 4541
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 679
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.06
    Marker Score: 616
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.94
    Marker Score: 303
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.94
    Marker Score: 1171
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 547
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.91
    Marker Score: 285
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5137
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.89
    Marker Score: 371
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.88
    Marker Score: 3658
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.87
    Marker Score: 18535
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.86
    Marker Score: 762
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.85
    Marker Score: 975
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.84
    Marker Score: 5025
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.81
    Marker Score: 2021
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.78
    Marker Score: 969
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.78
    Marker Score: 947
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3198
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.74
    Marker Score: 497
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.74
    Marker Score: 516
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.74
    Marker Score: 216
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 211
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 348
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5399
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.7
    Marker Score: 2334
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.7
    Marker Score: 211
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.68
    Marker Score: 186
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.67
    Marker Score: 1033
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.66
    Marker Score: 2268
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.66
    Marker Score: 747
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.66
    Marker Score: 5633
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.65
    Marker Score: 165
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 545
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 307
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.6
    Marker Score: 449
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.59
    Marker Score: 391
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.59
    Marker Score: 742.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.59
    Marker Score: 762
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.59
    Marker Score: 1289
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.58
    Marker Score: 494
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.58
    Marker Score: 4998
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.55
    Marker Score: 307
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.55
    Marker Score: 335
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.54
    Marker Score: 733
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.54
    Marker Score: 2905
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.54
    Marker Score: 783
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.52
    Marker Score: 770
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.52
    Marker Score: 175
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.51
    Marker Score: 1826
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.5
    Marker Score: 950
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.5
    Marker Score: 581
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.5
    Marker Score: 269
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 292
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.48
    Marker Score: 140
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.48
    Marker Score: 3604
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.47
    Marker Score: 570
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 125
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.47
    Marker Score: 9251

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Other Information

**Key characteristics:** - GNAL is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the G protein-coupled receptor (GPCR) family. - GNAL is a ligand for G protein-coupled receptors (GPCRs), including GABAB. **Pathways and functions:** - GNAL is primarily a ligand for G protein-coupled receptors (GPCRs), particularly for G protein-coupled receptor alpha B (GABAB). - It is involved in the activation of the adenylate cyclase activating pathway, which is a major second messenger pathway in the nervous system. - GNAL also modulates the G-protein-coupled receptor binding process, influencing the trafficking of GPCRs. - It is crucial for the regulation of various neuronal processes, including synaptic plasticity, learning and memory, and cognition. **Clinical significance:** - Mutations in the GNAL gene have been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. - GNAL inhibitors are being investigated as potential therapeutics for these disorders, as they could potentially enhance the activity of GPCRs and improve neuronal function. **Additional points:** - GNAL is a highly conserved protein with a similar sequence in mammals and other vertebrates. - It is a key regulator of neuronal excitability, and its dysfunction can lead to neuropsychiatric disorders. - GNAL is a promising target for the development of novel therapeutic interventions for neurological diseases.

Genular Protein ID: 4000738685

Symbol: GNAL_HUMAN

Name: Guanine nucleotide-binding protein G(olf) subunit alpha

UniProtKB Accession Codes:

P38405 B7ZA26 Q86XU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 2 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8243272

Title: Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.

PubMed ID: 8243272

DOI: 10.1210/endo.133.6.8243272

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23994616

Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.

PubMed ID: 23994616

DOI: 10.1016/j.bbamcr.2013.08.009

PubMed ID: 23222958

Title: Mutations in GNAL cause primary torsion dystonia.

PubMed ID: 23222958

DOI: 10.1038/ng.2496

Sequence Information:

  • Length: 381
  • Mass: 44308
  • Checksum: 9A73D2982FF9C9A3
  • Sequence:
    • MGCLGGNSKT TEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA GESGKSTIVK 
QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI IPPVPLANPE NQFRSDYIKS 
IAPITDFEYS QEFFDHVKKL WDDEGVKACF ERSNEYQLID CAQYFLERID SVSLVDYTPT 
DQDLLRCRVL TSGIFETRFQ VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY 
NMVIREDNNT NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP 
EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF TCAVDTENIR 
RVFNDCRDII QRMHLKQYEL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.