Details for: GNAL

Gene ID: 2774

Symbol: GNAL

Ensembl ID: ENSG00000141404

Description: G protein subunit alpha L

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.1323
    Cell Significance Index: -25.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.6531
    Cell Significance Index: -25.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.7469
    Cell Significance Index: -25.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5526
    Cell Significance Index: -25.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.5640
    Cell Significance Index: 290.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4824
    Cell Significance Index: -25.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.8710
    Cell Significance Index: 222.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.4846
    Cell Significance Index: 74.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7656
    Cell Significance Index: -10.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.5398
    Cell Significance Index: 99.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.9920
    Cell Significance Index: 268.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5087
    Cell Significance Index: 71.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9528
    Cell Significance Index: 700.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8937
    Cell Significance Index: 1309.7400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.2901
    Cell Significance Index: 16.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2311
    Cell Significance Index: 75.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8696
    Cell Significance Index: 174.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7288
    Cell Significance Index: 12.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6538
    Cell Significance Index: 13.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6537
    Cell Significance Index: 18.2700
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.6130
    Cell Significance Index: 4.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5748
    Cell Significance Index: 29.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5677
    Cell Significance Index: 13.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4436
    Cell Significance Index: 84.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4097
    Cell Significance Index: 81.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2542
    Cell Significance Index: 478.5800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.2311
    Cell Significance Index: 2.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1614
    Cell Significance Index: 145.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1467
    Cell Significance Index: 64.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1242
    Cell Significance Index: 78.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0841
    Cell Significance Index: 129.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0705
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0642
    Cell Significance Index: 1.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0636
    Cell Significance Index: 7.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0395
    Cell Significance Index: 72.8700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0355
    Cell Significance Index: 0.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0264
    Cell Significance Index: 4.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0256
    Cell Significance Index: 2.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0173
    Cell Significance Index: 7.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0167
    Cell Significance Index: 0.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0104
    Cell Significance Index: 0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0046
    Cell Significance Index: -0.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0059
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0063
    Cell Significance Index: -0.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0082
    Cell Significance Index: -0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0093
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0124
    Cell Significance Index: -7.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0145
    Cell Significance Index: -1.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0159
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0255
    Cell Significance Index: -0.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0280
    Cell Significance Index: -0.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0309
    Cell Significance Index: -22.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0314
    Cell Significance Index: -17.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0345
    Cell Significance Index: -26.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0408
    Cell Significance Index: -22.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0506
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0638
    Cell Significance Index: -10.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0695
    Cell Significance Index: -4.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0752
    Cell Significance Index: -21.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0819
    Cell Significance Index: -17.2500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0862
    Cell Significance Index: -0.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0939
    Cell Significance Index: -2.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0974
    Cell Significance Index: -12.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0990
    Cell Significance Index: -6.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1129
    Cell Significance Index: -15.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1138
    Cell Significance Index: -1.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1147
    Cell Significance Index: -7.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1295
    Cell Significance Index: -3.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1385
    Cell Significance Index: -4.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1736
    Cell Significance Index: -22.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1761
    Cell Significance Index: -13.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1823
    Cell Significance Index: -8.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1875
    Cell Significance Index: -4.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1893
    Cell Significance Index: -13.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2145
    Cell Significance Index: -24.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2156
    Cell Significance Index: -25.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2226
    Cell Significance Index: -25.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2243
    Cell Significance Index: -22.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2245
    Cell Significance Index: -4.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2258
    Cell Significance Index: -2.4600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.2269
    Cell Significance Index: -1.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2286
    Cell Significance Index: -23.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2534
    Cell Significance Index: -15.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2986
    Cell Significance Index: -2.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3016
    Cell Significance Index: -23.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3132
    Cell Significance Index: -23.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3209
    Cell Significance Index: -4.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3637
    Cell Significance Index: -15.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3706
    Cell Significance Index: -19.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3766
    Cell Significance Index: -7.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3773
    Cell Significance Index: -17.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3807
    Cell Significance Index: -24.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3948
    Cell Significance Index: -12.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3953
    Cell Significance Index: -12.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4185
    Cell Significance Index: -5.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4300
    Cell Significance Index: -8.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4501
    Cell Significance Index: -7.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5157
    Cell Significance Index: -10.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-Protein Subunit**: The GNAL gene encodes for the alpha-L subunit of G-proteins, which is a key component of heterotrimeric G-proteins. 2. **Receptor Binding**: The alpha-L subunit binds to GPCRs, allowing for the activation of G-proteins and the subsequent transmission of signals to downstream effectors. 3. **Signaling Pathways**: The alpha-L subunit is involved in various signaling pathways, including the adenylate cyclase-activating dopamine receptor signaling pathway, the opioid signaling pathway, and the olfactory signaling pathway. 4. **Expression in Neurons**: The alpha-L subunit is specifically expressed in Purkinje cells, GABAergic cortical interneurons, and other neurons involved in sensory perception and neurotransmission. **Pathways and Functions:** The alpha-L subunit of G-proteins plays a crucial role in various signaling pathways, including: 1. **Activation of GABA_b Receptors**: The alpha-L subunit of G-proteins is involved in the activation of GABA_b receptors, which are inhibitory receptors that regulate neuronal excitability. 2. **Adenylate Cyclase-Activating Dopamine Receptor Signaling Pathway**: The alpha-L subunit of G-proteins is involved in the activation of adenylate cyclase, an enzyme that converts ATP into cyclic AMP (cAMP), a secondary messenger molecule that regulates various cellular processes. 3. **Opioid Signaling Pathway**: The alpha-L subunit of G-proteins is involved in the opioid signaling pathway, which regulates pain perception and analgesia. 4. **Olfactory Signaling Pathway**: The alpha-L subunit of G-proteins is involved in the olfactory signaling pathway, which regulates olfactory perception and processing. **Clinical Significance:** Dysregulation of the alpha-L subunit of G-proteins has been implicated in various neurological disorders, including: 1. **Neurodegenerative Diseases**: Dysregulation of the alpha-L subunit of G-proteins has been implicated in neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. 2. **Mental Health Disorders**: Dysregulation of the alpha-L subunit of G-proteins has been implicated in mental health disorders, such as depression and anxiety disorders. 3. **Pain Perception**: Dysregulation of the alpha-L subunit of G-proteins has been implicated in pain perception and analgesia, making it a potential target for pain management therapies. In conclusion, the GNAL gene encodes for the alpha-L subunit of guanine nucleotide-binding proteins, which plays a crucial role in neuronal signaling and has implications for various neurological disorders. Further research is needed to fully understand the function and clinical significance of the alpha-L subunit of G-proteins.

Genular Protein ID: 4000738685

Symbol: GNAL_HUMAN

Name: Guanine nucleotide-binding protein G(olf) subunit alpha

UniProtKB Accession Codes:

P38405 B7ZA26 Q86XU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 1 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8243272

Title: Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.

PubMed ID: 8243272

DOI: 10.1210/endo.133.6.8243272

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23994616

Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.

PubMed ID: 23994616

DOI: 10.1016/j.bbamcr.2013.08.009

PubMed ID: 23222958

Title: Mutations in GNAL cause primary torsion dystonia.

PubMed ID: 23222958

DOI: 10.1038/ng.2496

Sequence Information:

  • Length: 381
  • Mass: 44308
  • Checksum: 9A73D2982FF9C9A3
  • Sequence:
    • MGCLGGNSKT TEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA GESGKSTIVK 
QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI IPPVPLANPE NQFRSDYIKS 
IAPITDFEYS QEFFDHVKKL WDDEGVKACF ERSNEYQLID CAQYFLERID SVSLVDYTPT 
DQDLLRCRVL TSGIFETRFQ VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY 
NMVIREDNNT NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP 
EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF TCAVDTENIR 
RVFNDCRDII QRMHLKQYEL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.