Details for: GP5

Gene ID: 2814

Symbol: GP5

Ensembl ID: ENSG00000178732

Description: glycoprotein V platelet

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.17
    Marker Score: 2186
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.68
    Marker Score: 3485
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7694
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2587
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71839
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48064
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 495
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1170
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 206
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 182.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 328
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.29
    Marker Score: 192
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 100
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.2
    Marker Score: 100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.18
    Marker Score: 55
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 149.5
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.13
    Marker Score: 112
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.13
    Marker Score: 462
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 74
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 254
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.09
    Marker Score: 169
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.08
    Marker Score: 152
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 123.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.08
    Marker Score: 104
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 76
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 59
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.04
    Marker Score: 388
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.04
    Marker Score: 2205
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.04
    Marker Score: 63
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 75
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 49
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 83
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 13

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Other Information

## Summary GP5 is a glycoprotein involved in the intrinsic pathway of blood coagulation. It is expressed in blood vessel endothelial cells, kidney proximal convoluted tubule epithelial cells, granulocyte monocyte progenitor cells, goblet cells, early T lineage precursor cells, intestinal crypt stem cells of colon, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and absorptive cells. ## Key characteristics * GP5 is a glycoprotein that is expressed in blood vessel endothelial cells, kidney proximal convoluted tubule epithelial cells, granulocyte monocyte progenitor cells, goblet cells, early T lineage precursor cells, intestinal crypt stem cells of colon, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and absorptive cells. * It is a single-pass protein with a molecular weight of approximately 120 kDa. * It is a glycoprotein that is involved in the intrinsic pathway of blood coagulation. ## Pathways and functions * GP5 is involved in the intrinsic pathway of blood coagulation. * It is expressed in blood vessel endothelial cells, which are responsible for the formation of new blood vessels. * It is also expressed in kidney proximal convoluted tubule epithelial cells, which are responsible for the formation of new blood vessels in the kidney. * It is also expressed in granulocyte monocyte progenitor cells, goblet cells, early T lineage precursor cells, intestinal crypt stem cells of colon, cerebral cortex GABAergic interneuron, and forebrain radial glial cell. * It is involved in the formation of fibrin clots. * It is a key regulator of blood clotting. ## Clinical significance GP5 is a gene that is associated with hemophilia b. In hemophilia b, the GPV_HUMAN gene is mutated, which results in the production of a non-functional protein that prevents the GPV protein from interacting with von Willebrand factor (VWF). This results in a decrease in the formation of fibrin clots, which can lead to bleeding disorders.

Genular Protein ID: 43715962

Symbol: GPV_HUMAN

Name: Platelet glycoprotein V

UniProtKB Accession Codes:

P40197 D1MER9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7690959

Title: Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins.

PubMed ID: 7690959

DOI: 10.1073/pnas.90.18.8327

PubMed ID: 8407908

Title: Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation.

PubMed ID: 8407908

DOI: 10.1016/s0021-9258(19)36855-3

PubMed ID: 2350580

Title: Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib.

PubMed ID: 2350580

PubMed ID: 2372284

Title: Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion.

PubMed ID: 2372284

DOI: 10.1016/0006-291x(90)91253-o

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

Sequence Information:

  • Length: 560
  • Mass: 60959
  • Checksum: B1CDB04AF8AF7115
  • Sequence:
    • MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT NLTHILLFGM 
GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL KTLRLSRNKI THLPGALLDK 
MVLLEQLFLD HNALRGIDQN MFQKLVNLQE LALNQNQLDF LPASLFTNLE NLKLLDLSGN 
NLTHLPKGLL GAQAKLERLL LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR 
LPNLSSLTLS RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT 
QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG LTALPDGLLR 
GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE TLPGDVFGAL PRLTEVLLGH 
NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR CAGPGAHAGL PLWALPGGDA ECPGPRGPPP 
RPAADSSSEA PVHPALAPNS SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV 
FAMIKIGQLF RKLIRERALG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.