Details for: GPR4

Gene ID: 2828

Symbol: GPR4

Ensembl ID: ENSG00000177464

Description: G protein-coupled receptor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251805
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.96
    Marker Score: 576
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1632
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.75
    Marker Score: 1919
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.69
    Marker Score: 315
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 196
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 360
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 294
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 375
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.56
    Marker Score: 485
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.55
    Marker Score: 157
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.55
    Marker Score: 804
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.54
    Marker Score: 778
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.54
    Marker Score: 283
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.54
    Marker Score: 577
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.53
    Marker Score: 483
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.51
    Marker Score: 197
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.5
    Marker Score: 474
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.5
    Marker Score: 500
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.5
    Marker Score: 116
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.49
    Marker Score: 614
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.48
    Marker Score: 434
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.47
    Marker Score: 113
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.46
    Marker Score: 534
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.46
    Marker Score: 111
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.45
    Marker Score: 235
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.42
    Marker Score: 423
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.41
    Marker Score: 823
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.41
    Marker Score: 390
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.4
    Marker Score: 102
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4
    Marker Score: 669.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.38
    Marker Score: 669
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 163
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5844
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.36
    Marker Score: 94
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.34
    Marker Score: 236
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.33
    Marker Score: 661
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.32
    Marker Score: 189
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.32
    Marker Score: 156
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 132
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.31
    Marker Score: 80
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.31
    Marker Score: 127
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.26
    Marker Score: 2313
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.24
    Marker Score: 56
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.23
    Marker Score: 145
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1384
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.23
    Marker Score: 161
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 128
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 45
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2
    Marker Score: 200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.18
    Marker Score: 135
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.17
    Marker Score: 166
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.17
    Marker Score: 170
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 159
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 150
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.14
    Marker Score: 30
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 242
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.13
    Marker Score: 160
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.12
    Marker Score: 219
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 116.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1
    Marker Score: 25

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Other Information

**Key characteristics:** - G protein-coupled receptor 4 (GPR4) is a transmembrane protein with a single extracellular domain and a single transmembrane domain. - It is expressed in a variety of cell types, including granulocyte monocyte progenitor cells, goblet cells, fallopian tube secretory epithelial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, cerebral cortex endothelial cells, intestinal crypt stem cells of colon, transit amplifying cells, and abnormal cells. - It is a ligand-gated channel that is sensitive to the neuromodulator substance 2-arachidonoylglycerol (2-AG). - It is a negative regulator of angiogenesis, meaning that it inhibits the growth of new blood vessels. - It is a positive regulator of Rho protein signal transduction, meaning that it enhances the activity of Rho proteins. - It is involved in the regulation of cell adhesion, migration, and signaling. **Pathways and functions:** - GPR4 is involved in the activation of the adenylate cyclase-activating g protein-coupled receptor signaling pathway, the Class a/1 (rhodopsin-like receptors) pathway, the Gpcr downstream signaling pathway, and the positive regulation of Rho protein signal transduction. - It is involved in the regulation of cell adhesion by interacting with cell adhesion molecules such as cadherins and integrins. - It is involved in the regulation of vascular permeability by interacting with the vascular endothelial growth factor (VEGF) receptor. - It is involved in the response to acidic pH by interacting with the ion channel G protein-coupled receptor 7 (GPCR7). **Clinical significance:** - Mutations in GPR4 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. - GPR4 inhibitors are being investigated as potential drugs for these diseases.

Genular Protein ID: 2385697917

Symbol: GPR4_HUMAN

Name: G-protein coupled receptor 4

UniProtKB Accession Codes:

P46093 A8K3T3 B0M0K1 Q6NWM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7832990

Title: Isolation of three novel human genes encoding G protein-coupled receptors.

PubMed ID: 7832990

DOI: 10.1089/dna.1995.14.25

PubMed ID: 8595909

Title: Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3.

PubMed ID: 8595909

DOI: 10.1006/geno.1995.0013

PubMed ID: 7498459

Title: Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.

PubMed ID: 7498459

DOI: 10.1016/0014-5793(95)01196-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11535583

Title: Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.

PubMed ID: 11535583

DOI: 10.1074/jbc.m008057200

PubMed ID: 16498716

Title:

PubMed ID: 16498716

PubMed ID: 12955148

Title: Proton-sensing G-protein-coupled receptors.

PubMed ID: 12955148

DOI: 10.1038/nature01905

PubMed ID: 17462861

Title: Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms.

PubMed ID: 17462861

DOI: 10.1016/j.cellsig.2007.03.009

PubMed ID: 20211729

Title: Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.

PubMed ID: 20211729

DOI: 10.1016/j.phrs.2010.02.013

PubMed ID: 22110680

Title: Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.

PubMed ID: 22110680

DOI: 10.1371/journal.pone.0027586

PubMed ID: 32058960

Title: The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.

PubMed ID: 32058960

DOI: 10.1016/j.isci.2020.100848

Sequence Information:

  • Length: 362
  • Mass: 40982
  • Checksum: 6C75D97C36204541
  • Sequence:
    • MGNHTWEGCH VDSRVDHLFP PSLYIFVIGV GLPTNCLALW AAYRQVQQRN ELGVYLMNLS 
IADLLYICTL PLWVDYFLHH DNWIHGPGSC KLFGFIFYTN IYISIAFLCC ISVDRYLAVA 
HPLRFARLRR VKTAVAVSSV VWATELGANS APLFHDELFR DRYNHTFCFE KFPMEGWVAW 
MNLYRVFVGF LFPWALMLLS YRGILRAVRG SVSTERQEKA KIKRLALSLI AIVLVCFAPY 
HVLLLSRSAI YLGRPWDCGF EERVFSAYHS SLAFTSLNCV ADPILYCLVN EGARSDVAKA 
LHNLLRFLAS DKPQEMANAS LTLETPLTSK RNSTAKAMTG SWAATPPSQG DQVQLKMLPP 
AQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.