Details for: NPBWR1

Gene ID: 2831

Symbol: NPBWR1

Ensembl ID: ENSG00000288611

Description: neuropeptides B and W receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.71
    Marker Score: 999
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2290
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1838
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.84
    Marker Score: 443
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11484
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 407
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3089
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 183
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 106
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.08
    Marker Score: 98
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 75.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 192
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.01
    Marker Score: 51
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.01
    Marker Score: 43
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 47
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 24
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 106
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 47

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Other Information

**Key characteristics:** - NPBWR1 is a single-pass transmembrane protein that is expressed in the plasma membrane. - It is a member of the neuropeptide B/W receptor family. - It is a ligand for the G protein-coupled opioid receptor (GPCR). **Pathways and functions:** - NPBWR1 is involved in the regulation of synaptic transmission. - It is a ligand for the GPCR, which is expressed in the central nervous system. - When NPBWR1 binds to the GPCR, it activates the receptor and triggers intracellular signaling events that lead to the inhibition of synaptic transmission. **Clinical significance:** - Mutations in NPBWR1 have been linked to a number of neurodegenerative diseases, including multiple sclerosis and amyotrophic lateral sclerosis. - These diseases are characterized by the loss of neurons, which is thought to be due to a combination of genetic and environmental factors. - NPBWR1 is a potential target for therapeutic intervention in these diseases.

Genular Protein ID: 3894961938

Symbol: NPBW1_HUMAN

Name: Neuropeptides B/W receptor type 1

UniProtKB Accession Codes:

P48145 Q6NTC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7590751

Title: The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.

PubMed ID: 7590751

DOI: 10.1006/geno.1995.1109

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12401809

Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.

PubMed ID: 12401809

DOI: 10.1074/jbc.m206396200

PubMed ID: 12719537

Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.

PubMed ID: 12719537

DOI: 10.1073/pnas.0837789100

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 328
  • Mass: 36103
  • Checksum: 7A90F85AD64A3980
  • Sequence:
    • MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV GLAGNSAVLY 
VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR QWPFGELMCK LIVAIDQYNT 
FSSLYFLTVM SADRYLVVLA TAESRRVAGR TYSAARAVSL AVWGIVTLVV LPFAVFARLD 
DEQGRRQCVL VFPQPEAFWW RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK 
ALERAKKRVT FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS 
CLNPFLYAFL DASFRRNLRQ LITCRAAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.