Details for: NPBWR1

Gene ID: 2831

Symbol: NPBWR1

Ensembl ID: ENSG00000288611

Description: neuropeptides B and W receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.3328
    Cell Significance Index: 22.7800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1915
    Cell Significance Index: 2.0300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1218
    Cell Significance Index: 1.7800
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1101
    Cell Significance Index: 1.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0265
    Cell Significance Index: 0.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0048
    Cell Significance Index: -0.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0164
    Cell Significance Index: -1.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0382
    Cell Significance Index: -0.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0392
    Cell Significance Index: -1.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0403
    Cell Significance Index: -0.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0417
    Cell Significance Index: -1.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0429
    Cell Significance Index: -0.9100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0467
    Cell Significance Index: -0.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0489
    Cell Significance Index: -1.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0493
    Cell Significance Index: -0.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0511
    Cell Significance Index: -1.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0517
    Cell Significance Index: -1.0300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0641
    Cell Significance Index: -0.9300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0642
    Cell Significance Index: -0.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0652
    Cell Significance Index: -0.8900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0667
    Cell Significance Index: -0.8700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0715
    Cell Significance Index: -0.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0736
    Cell Significance Index: -0.8700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0742
    Cell Significance Index: -1.0100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0766
    Cell Significance Index: -0.9200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0783
    Cell Significance Index: -1.0400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0830
    Cell Significance Index: -1.0100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0834
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0838
    Cell Significance Index: -1.0300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0840
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0841
    Cell Significance Index: -0.7900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0842
    Cell Significance Index: -1.0000
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0849
    Cell Significance Index: -1.0100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0856
    Cell Significance Index: -0.9800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0865
    Cell Significance Index: -1.0000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0871
    Cell Significance Index: -1.0100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0873
    Cell Significance Index: -0.8800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0896
    Cell Significance Index: -0.8400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0903
    Cell Significance Index: -1.0000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0927
    Cell Significance Index: -0.8900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0935
    Cell Significance Index: -0.8500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0937
    Cell Significance Index: -1.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0940
    Cell Significance Index: -0.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0948
    Cell Significance Index: -1.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0985
    Cell Significance Index: -1.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0989
    Cell Significance Index: -1.0100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0997
    Cell Significance Index: -0.8600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1069
    Cell Significance Index: -0.9400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1078
    Cell Significance Index: -0.6400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1092
    Cell Significance Index: -1.0100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1137
    Cell Significance Index: -0.7400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1212
    Cell Significance Index: -1.4500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1283
    Cell Significance Index: -1.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1294
    Cell Significance Index: -1.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1298
    Cell Significance Index: -1.0100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1306
    Cell Significance Index: -1.2000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1339
    Cell Significance Index: -1.1800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1358
    Cell Significance Index: -1.0100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1396
    Cell Significance Index: -1.1500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1419
    Cell Significance Index: -1.4000
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: -0.1440
    Cell Significance Index: -1.0100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1513
    Cell Significance Index: -0.9500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1524
    Cell Significance Index: -1.6600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.1563
    Cell Significance Index: -1.6700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1618
    Cell Significance Index: -1.6500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1689
    Cell Significance Index: -1.8300
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1695
    Cell Significance Index: -1.6100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1890
    Cell Significance Index: -1.7600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1972
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5131
    Cell Significance Index: -8.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.5714
    Cell Significance Index: -7.2200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.8598
    Cell Significance Index: -9.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NPBWR1 is a member of the class A/1 rhodopsin-like receptors, which are a family of GPCRs that respond to a variety of ligands, including neuropeptides, opioids, and other signaling molecules. The NPBWR1 receptor is specifically expressed in various cell types, including pericytes, cardiac endothelial cells, and neurons, suggesting its involvement in vascular and neural functions. The receptor is also found in hematopoietic stem cells, lymphoid lineage-restricted progenitor cells, and cardiac muscle myoblasts, indicating its role in hematopoiesis and cardiac development. **Pathways and Functions** NPBWR1 is involved in several signaling pathways, including: 1. **G alpha (i) signaling events**: The NPBWR1 receptor activates G alpha (i) proteins, which inhibit adenylyl cyclase activity, leading to a decrease in intracellular cAMP levels. 2. **G protein-coupled opioid receptor activity**: NPBWR1 can also interact with opioid receptors, modulating their activity and influencing pain perception and analgesia. 3. **Neuropeptide signaling pathway**: The receptor is a key component of the neuropeptide signaling pathway, which regulates various physiological processes, including vasodilation, vasoconstriction, and neurotransmission. 4. **Regulation of metabolic process**: NPBWR1 may also regulate metabolic processes, such as glucose and lipid metabolism, in various cell types. **Clinical Significance** NPBWR1 has been implicated in several diseases and disorders, including: 1. **Cardiovascular diseases**: The receptor's expression in cardiac endothelial cells and smooth muscle myoblasts suggests its involvement in cardiovascular diseases, such as hypertension, atherosclerosis, and cardiac failure. 2. **Pain management**: NPBWR1's interaction with opioid receptors makes it a potential target for pain management therapies, particularly in cases of opioid resistance. 3. **Neurological disorders**: The receptor's expression in neurons and ependymal cells suggests its involvement in neurological disorders, such as neuropathic pain, multiple sclerosis, and Parkinson's disease. 4. **Hematological disorders**: NPBWR1's expression in hematopoietic stem cells and lymphoid lineage-restricted progenitor cells implies its role in hematological disorders, such as leukemia and lymphoma. In conclusion, the NPBWR1 gene encodes for a G protein-coupled receptor that plays a crucial role in various physiological and pathological processes. Further research is needed to fully elucidate the receptor's functions and clinical significance, but its involvement in cardiovascular, neurological, and hematological disorders makes it an important target for therapeutic interventions.

Genular Protein ID: 3894961938

Symbol: NPBW1_HUMAN

Name: Neuropeptides B/W receptor type 1

UniProtKB Accession Codes:

P48145 Q6NTC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7590751

Title: The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.

PubMed ID: 7590751

DOI: 10.1006/geno.1995.1109

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12401809

Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.

PubMed ID: 12401809

DOI: 10.1074/jbc.m206396200

PubMed ID: 12719537

Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.

PubMed ID: 12719537

DOI: 10.1073/pnas.0837789100

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 328
  • Mass: 36103
  • Checksum: 7A90F85AD64A3980
  • Sequence:
    • MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV GLAGNSAVLY 
VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR QWPFGELMCK LIVAIDQYNT 
FSSLYFLTVM SADRYLVVLA TAESRRVAGR TYSAARAVSL AVWGIVTLVV LPFAVFARLD 
DEQGRRQCVL VFPQPEAFWW RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK 
ALERAKKRVT FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS 
CLNPFLYAFL DASFRRNLRQ LITCRAAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.