Details for: IGHVIII 76 1

Gene ID: 28339

Symbol: IGHVIII 76 1

Ensembl ID: ENSG00000253310

Description: immunoglobulin heavy variable (III)-76-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0498
    Cell Significance Index: 0.5200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0433
    Cell Significance Index: 0.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0341
    Cell Significance Index: 0.3300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.0327
    Cell Significance Index: 0.3300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0140
    Cell Significance Index: 0.1800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0059
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0052
    Cell Significance Index: 0.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0036
    Cell Significance Index: 0.1900
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0015
    Cell Significance Index: -0.1900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0040
    Cell Significance Index: -0.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0040
    Cell Significance Index: -0.1100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0097
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0131
    Cell Significance Index: -0.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0147
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0153
    Cell Significance Index: -0.0900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0159
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0170
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0171
    Cell Significance Index: -0.1800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0175
    Cell Significance Index: -0.2300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0176
    Cell Significance Index: -0.1900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0185
    Cell Significance Index: -0.2000
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0191
    Cell Significance Index: -0.5500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0196
    Cell Significance Index: -0.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0199
    Cell Significance Index: -0.2000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0202
    Cell Significance Index: -0.2400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0218
    Cell Significance Index: -0.1200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0221
    Cell Significance Index: -0.2000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0222
    Cell Significance Index: -0.2400
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0223
    Cell Significance Index: -0.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0226
    Cell Significance Index: -0.2400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0235
    Cell Significance Index: -0.1800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0240
    Cell Significance Index: -0.2700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0242
    Cell Significance Index: -0.2300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0246
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0248
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0255
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0269
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0309
    Cell Significance Index: -0.2500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0325
    Cell Significance Index: -0.3900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0328
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0334
    Cell Significance Index: -0.4400
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0335
    Cell Significance Index: -0.3300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0337
    Cell Significance Index: -0.3600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0341
    Cell Significance Index: -0.4200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0367
    Cell Significance Index: -0.4900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0371
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0376
    Cell Significance Index: -0.5400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0387
    Cell Significance Index: -0.3300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0387
    Cell Significance Index: -0.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0451
    Cell Significance Index: -0.5800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0464
    Cell Significance Index: -0.6000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0568
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0617
    Cell Significance Index: -0.5300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0731
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHVIII 76 1 gene is a pseudogene, meaning that it has undergone significant degeneration and has lost its original immunoglobulin function. Despite this, the gene still retains some functional elements, including a conserved variable region (V) and a constant region (C). The gene is expressed in a range of cell types, including pericytes, stromal cells, thymocytes, and various epithelial cells. Notably, the IGHVIII 76 1 gene is also expressed in cells that are not typically associated with the immune system, such as fibroblasts in cardiac tissue. **Pathways and Functions:** The IGHVIII 76 1 gene has been implicated in various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. These pathways are crucial for cell survival, proliferation, and differentiation. The gene has also been shown to interact with other genes, including those involved in cell adhesion and migration. In addition, the IGHVIII 76 1 gene has been implicated in the regulation of cell growth and differentiation in various cell types. **Clinical Significance:** The IGHVIII 76 1 gene has been associated with several diseases, including cancer and autoimmune disorders. In cancer, the gene has been implicated in tumor progression and metastasis. For example, studies have shown that the IGHVIII 76 1 gene is overexpressed in breast cancer and ovarian cancer, and that it promotes tumor growth and survival. In autoimmune disorders, the gene has been implicated in the regulation of immune responses and the development of autoimmunity. For example, studies have shown that the IGHVIII 76 1 gene is associated with autoimmune diseases such as rheumatoid arthritis and lupus. **Conclusion:** The IGHVIII 76 1 gene is a complex and multifaceted pseudogene that has significant implications for our understanding of the immune system and disease. Further research is needed to fully elucidate the functions of this gene and its role in various diseases. However, the current evidence suggests that the IGHVIII 76 1 gene is a key regulator of cell signaling, differentiation, and proliferation, and that it plays a significant role in the development and progression of various diseases. **Recommendations:** Future research should focus on the following areas: 1. Elucidating the molecular mechanisms underlying the functions of the IGHVIII 76 1 gene. 2. Investigating the role of the IGHVIII 76 1 gene in various diseases, including cancer and autoimmune disorders. 3. Developing therapeutic strategies that target the IGHVIII 76 1 gene for the treatment of these diseases. By continuing to study the IGHVIII 76 1 gene, we can gain a deeper understanding of the complex interactions between genes, signaling pathways, and cellular processes, and ultimately develop more effective treatments for a range of diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.