Details for: GPR17

Gene ID: 2840

Symbol: GPR17

Ensembl ID: ENSG00000144230

Description: G protein-coupled receptor 17

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.13
    Marker Score: 1180
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.94
    Marker Score: 3677
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.59
    Marker Score: 10557
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19685
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7489
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3633
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.09
    Marker Score: 1345
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32718
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5307
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.87
    Marker Score: 492
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 733
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.76
    Marker Score: 1582
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.73
    Marker Score: 1187
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.71
    Marker Score: 9455
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 327
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 203
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1172
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 255
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 150
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 233
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.43
    Marker Score: 224
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 217
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.3
    Marker Score: 178
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.29
    Marker Score: 226
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.25
    Marker Score: 5660
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 104
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.24
    Marker Score: 441
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.22
    Marker Score: 274
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.17
    Marker Score: 613
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 213
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 359.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.12
    Marker Score: 294
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 142
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.11
    Marker Score: 250
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1
    Marker Score: 426.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 23.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 23.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.06
    Marker Score: 94
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: immature Schwann cell (CL0002377)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 68
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.04
    Marker Score: 20

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Other Information

**Key characteristics:** - It is a G protein-coupled receptor that is expressed in a variety of cell types. - It is a member of the GPCR superfamily, which are involved in a variety of cellular processes, including inflammation, immunity, and development. - It is a key regulator of inflammation and immunity. **Pathways and functions:** - It is a key regulator of inflammation and immunity. - It is expressed in cells that are involved in inflammation, such as endothelial cells, macrophages, and neutrophils. - It is activated by a variety of inflammatory stimuli, including lipopolysaccharide (LPS), zymosin, and histamine. - Activation of GPR17 triggers a cascade of intracellular events that leads to the production of pro-inflammatory cytokines and chemokines. - These cytokines and chemokines can recruit immune cells to the site of inflammation and promote inflammation. **Clinical significance:** - Mutations in GPR17 have been linked to a number of human diseases, including asthma, inflammatory bowel disease, and rheumatoid arthritis. - Inhibition of GPR17 has been shown to be effective in reducing inflammation and pain. **Additional notes:** - GPR17 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. - It is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 2868901717

Symbol: GPR17_HUMAN

Name: Uracil nucleotide/cysteinyl leukotriene receptor

UniProtKB Accession Codes:

Q13304 A8K9L0 B2R9X0 Q8N5S7 Q9UDZ6 Q9UE21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8558062

Title: New members of the chemokine receptor gene family.

PubMed ID: 8558062

DOI: 10.1002/jlb.59.1.18

PubMed ID: 9523551

Title: A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21.

PubMed ID: 9523551

DOI: 10.1046/j.1471-4159.1998.70041357.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16990797

Title: The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.

PubMed ID: 16990797

DOI: 10.1038/sj.emboj.7601341

Sequence Information:

  • Length: 367
  • Mass: 40989
  • Checksum: 132FBE97BE83C60C
  • Sequence:
    • MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM 
LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF 
SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC 
AFLWVVVAVA MAPLLVSPQT VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY 
LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ 
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS 
LSAKSEL

Genular Protein ID: 811193597

Symbol: G4XH68_HUMAN

Name: N/A

UniProtKB Accession Codes:

G4XH68

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 339
  • Mass: 37827
  • Checksum: BD2AEDB2FEBF15E1
  • Sequence:
    • MNGLEVAPPG LITNFSLATA EQCGQETPLE NMLFASFYLL DFILALVGNT LALWLFIRDH 
KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG EIACRLTGFL FYLNMYASIY 
FLTCISADRF LAIVHPVKSL KLRRPLYAHL ACAFLWVVVA VAMAPLLVSP QTVQTNHTVV 
CLQLYREKAS HHALVSLAVA FTFPFITTVT CYLLIIRSLR QGLRVEKRLK TKAVRMIAIV 
LAIFLVCFVP YHVNRSVYVL HYRSHGASCA TQRILALANR ITSCLTSLNG ALDPIMYFFV 
AEKFRHALCN LLCGKRLKGP PPSFEGKTNE SSLSAKSEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.