Details for: GPR17

Gene ID: 2840

Symbol: GPR17

Ensembl ID: ENSG00000144230

Description: G protein-coupled receptor 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5166
    Cell Significance Index: 8.8300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1400
    Cell Significance Index: 1.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1173
    Cell Significance Index: 9.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0046
    Cell Significance Index: -1.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0072
    Cell Significance Index: -3.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0088
    Cell Significance Index: -1.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0112
    Cell Significance Index: -3.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0122
    Cell Significance Index: -0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0148
    Cell Significance Index: -2.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0164
    Cell Significance Index: -2.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0165
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0185
    Cell Significance Index: -3.9000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0195
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0196
    Cell Significance Index: -3.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0286
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0299
    Cell Significance Index: -3.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0302
    Cell Significance Index: -0.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0325
    Cell Significance Index: -3.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0374
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0457
    Cell Significance Index: -2.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0465
    Cell Significance Index: -3.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0467
    Cell Significance Index: -0.6300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0475
    Cell Significance Index: -0.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0543
    Cell Significance Index: -2.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0568
    Cell Significance Index: -0.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0597
    Cell Significance Index: -3.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0598
    Cell Significance Index: -0.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0624
    Cell Significance Index: -2.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0628
    Cell Significance Index: -3.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0636
    Cell Significance Index: -2.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0660
    Cell Significance Index: -0.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0675
    Cell Significance Index: -3.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0725
    Cell Significance Index: -3.6700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0753
    Cell Significance Index: -0.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0802
    Cell Significance Index: -1.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0920
    Cell Significance Index: -2.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0950
    Cell Significance Index: -4.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0991
    Cell Significance Index: -2.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1005
    Cell Significance Index: -3.5300
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1011
    Cell Significance Index: -1.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1043
    Cell Significance Index: -2.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1050
    Cell Significance Index: -2.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1083
    Cell Significance Index: -2.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1097
    Cell Significance Index: -3.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1105
    Cell Significance Index: -3.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1106
    Cell Significance Index: -4.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1110
    Cell Significance Index: -1.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1111
    Cell Significance Index: -3.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1139
    Cell Significance Index: -3.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1181
    Cell Significance Index: -3.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1198
    Cell Significance Index: -3.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1236
    Cell Significance Index: -1.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1281
    Cell Significance Index: -3.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1301
    Cell Significance Index: -3.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1306
    Cell Significance Index: -2.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1311
    Cell Significance Index: -1.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1329
    Cell Significance Index: -3.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1335
    Cell Significance Index: -3.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1373
    Cell Significance Index: -3.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1393
    Cell Significance Index: -3.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1393
    Cell Significance Index: -2.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1405
    Cell Significance Index: -3.3700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1432
    Cell Significance Index: -3.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1449
    Cell Significance Index: -3.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1523
    Cell Significance Index: -3.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1558
    Cell Significance Index: -2.5000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1573
    Cell Significance Index: -2.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1664
    Cell Significance Index: -3.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1664
    Cell Significance Index: -6.8200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1679
    Cell Significance Index: -2.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1713
    Cell Significance Index: -4.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1717
    Cell Significance Index: -3.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1720
    Cell Significance Index: -3.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1732
    Cell Significance Index: -4.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1754
    Cell Significance Index: -3.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1763
    Cell Significance Index: -3.5400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1839
    Cell Significance Index: -3.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1845
    Cell Significance Index: -3.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1851
    Cell Significance Index: -3.6600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1931
    Cell Significance Index: -1.6700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1935
    Cell Significance Index: -2.8200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1944
    Cell Significance Index: -2.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1944
    Cell Significance Index: -3.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1952
    Cell Significance Index: -4.0500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1963
    Cell Significance Index: -2.8500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2005
    Cell Significance Index: -2.6000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2008
    Cell Significance Index: -2.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2039
    Cell Significance Index: -3.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2083
    Cell Significance Index: -3.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2095
    Cell Significance Index: -3.5900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2095
    Cell Significance Index: -2.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR17, also known as G protein-coupled receptor 17, is a GPCR that exhibits a unique combination of characteristics. Its structure is composed of seven transmembrane domains, which are typical of GPCRs. However, GPR17 also possesses a distinct ligand-binding domain, allowing it to recognize and respond to various ligands, including uracil nucleotides and cysteinyl leukotrienes. This receptor is primarily expressed in cells of the immune system, such as erythrocytes, cardiac endothelial cells, and oligodendrocyte precursor cells. Its expression is also found in other cell types, including goblet cells, cardiac muscle myoblasts, and neoplastic cells. **Pathways and Functions:** GPR17's signaling pathways are multifaceted and involve various G proteins, including Gαi and Gαq. These pathways are implicated in immune regulation, cellular differentiation, and inflammation. Specifically, GPR17 is involved in: 1. **Chemokine-mediated signaling pathway**: GPR17 recognizes chemokines, such as cysteinyl leukotrienes, and activates Gαi proteins, leading to the inhibition of chemokine-induced inflammation. 2. **Leukotriene receptors**: GPR17 is a leukotriene receptor, and its activation leads to the activation of Gαq proteins, resulting in the production of pro-inflammatory mediators. 3. **Negative regulation of inflammatory response**: GPR17's signaling pathways can dampen the inflammatory response to antigenic stimuli, highlighting its role in maintaining immune homeostasis. 4. **Oligodendrocyte differentiation**: GPR17 is involved in the differentiation of oligodendrocyte precursor cells, suggesting its importance in the development of the central nervous system. **Clinical Significance:** GPR17's role in immune regulation and inflammation has significant implications for various diseases, including: 1. **Inflammatory disorders**: GPR17's ability to regulate inflammation makes it a potential target for the treatment of inflammatory diseases, such as asthma and rheumatoid arthritis. 2. **Neurological disorders**: GPR17's involvement in oligodendrocyte differentiation and central nervous system development suggests its potential role in neurological disorders, such as multiple sclerosis. 3. **Cancer**: GPR17's expression in neoplastic cells and its involvement in cellular differentiation imply its potential role in cancer development and progression. In conclusion, GPR17 is a complex GPCR that plays a multifaceted role in immune regulation, cellular differentiation, and inflammation. Further research is necessary to fully elucidate its mechanisms of action and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2868901717

Symbol: GPR17_HUMAN

Name: Uracil nucleotide/cysteinyl leukotriene receptor

UniProtKB Accession Codes:

Q13304 A8K9L0 B2R9X0 Q8N5S7 Q9UDZ6 Q9UE21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8558062

Title: New members of the chemokine receptor gene family.

PubMed ID: 8558062

DOI: 10.1002/jlb.59.1.18

PubMed ID: 9523551

Title: A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21.

PubMed ID: 9523551

DOI: 10.1046/j.1471-4159.1998.70041357.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16990797

Title: The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.

PubMed ID: 16990797

DOI: 10.1038/sj.emboj.7601341

Sequence Information:

  • Length: 367
  • Mass: 40989
  • Checksum: 132FBE97BE83C60C
  • Sequence:
    • MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM 
LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF 
SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC 
AFLWVVVAVA MAPLLVSPQT VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY 
LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ 
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS 
LSAKSEL

Genular Protein ID: 811193597

Symbol: G4XH68_HUMAN

Name: N/A

UniProtKB Accession Codes:

G4XH68

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 339
  • Mass: 37827
  • Checksum: BD2AEDB2FEBF15E1
  • Sequence:
    • MNGLEVAPPG LITNFSLATA EQCGQETPLE NMLFASFYLL DFILALVGNT LALWLFIRDH 
KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG EIACRLTGFL FYLNMYASIY 
FLTCISADRF LAIVHPVKSL KLRRPLYAHL ACAFLWVVVA VAMAPLLVSP QTVQTNHTVV 
CLQLYREKAS HHALVSLAVA FTFPFITTVT CYLLIIRSLR QGLRVEKRLK TKAVRMIAIV 
LAIFLVCFVP YHVNRSVYVL HYRSHGASCA TQRILALANR ITSCLTSLNG ALDPIMYFFV 
AEKFRHALCN LLCGKRLKGP PPSFEGKTNE SSLSAKSEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.