Details for: MCHR1

Gene ID: 2847

Symbol: MCHR1

Ensembl ID: ENSG00000128285

Description: melanin concentrating hormone receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.39
    Marker Score: 2405.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.6
    Marker Score: 3247
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.56
    Marker Score: 2960
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.48
    Marker Score: 645
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19913
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.23
    Marker Score: 1169
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.2
    Marker Score: 720
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.08
    Marker Score: 1204
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2471
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.93
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.87
    Marker Score: 921
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.68
    Marker Score: 302
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.67
    Marker Score: 387
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 495
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.58
    Marker Score: 575
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.54
    Marker Score: 1098
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.48
    Marker Score: 762
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.47
    Marker Score: 457
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.41
    Marker Score: 194
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.37
    Marker Score: 197
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.36
    Marker Score: 121
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.36
    Marker Score: 1390
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.26
    Marker Score: 403
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 125
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.24
    Marker Score: 2446
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.22
    Marker Score: 135
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.22
    Marker Score: 204
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.17
    Marker Score: 204
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.16
    Marker Score: 177
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 326
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.15
    Marker Score: 620
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.15
    Marker Score: 210
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 113
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 549
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 132
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.12
    Marker Score: 331
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7440
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.12
    Marker Score: 486
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 121
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 830
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.09
    Marker Score: 3514
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.08
    Marker Score: 1618
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.08
    Marker Score: 114
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.08
    Marker Score: 2875
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.08
    Marker Score: 1157
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 65
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 132
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.07
    Marker Score: 678
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.07
    Marker Score: 148
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.06
    Marker Score: 581
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.06
    Marker Score: 249
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.06
    Marker Score: 454
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.05
    Marker Score: 181
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 82
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 16

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Other Information

**Key characteristics:** * MCHR1 is a member of the G protein-coupled receptor family of cell surface receptors. * It is a transmembrane protein that is composed of 14 extracellular repeats of a 33-amino acid sequence and seven intracellular repeats of a 21-amino acid sequence. * It is a ligand-gated ion channel that is expressed in the plasma membrane of endothelial cells. * It is a G protein-coupled receptor that is activated by melanin-concentrating hormone (MCH). **Pathways and functions:** * MCHR1 is involved in the regulation of blood vessel permeability. * It is expressed in blood vessel endothelial cells, where it is responsible for the regulation of blood flow. * It is also expressed in cardiac endothelial cells, where it is involved in the regulation of cardiac function. * It is expressed in pancreatic D cells, where it is involved in the regulation of pancreatic secretion. * It is expressed in cardiac muscle myoblasts, where it is involved in the regulation of cardiac contractility. * It is expressed in B cells, where it is involved in the regulation of immune responses. * It is expressed in lymphoid lineage restricted progenitor cells, where it is involved in the development of lymphoid tissue. * It is expressed in goblet cells, where it is involved in the regulation of mucus secretion. * It is expressed in plasma cells, where it is involved in the regulation of fluid and electrolyte balance. **Clinical significance:** MCHR1 mutations have been linked to a number of human diseases, including diabetes, heart disease, and cancer. These mutations can lead to the loss of MCHR1 function, which can result in the development of these diseases.

Genular Protein ID: 574814931

Symbol: MCHR1_HUMAN

Name: G-protein coupled receptor 24

UniProtKB Accession Codes:

Q99705 B2RBX6 Q5R3J1 Q96S47 Q9BV08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10441476

Title: Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.

PubMed ID: 10441476

DOI: 10.1006/bbrc.1999.1104

PubMed ID: 15941924

Title: Mutation analysis of the MCHR1 gene in human obesity.

PubMed ID: 15941924

DOI: 10.1530/eje.1.01917

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8977118

Title: Characterization of a human gene related to genes encoding somatostatin receptors.

PubMed ID: 8977118

DOI: 10.1016/s0014-5793(96)01160-x

PubMed ID: 10421367

Title: Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.

PubMed ID: 10421367

DOI: 10.1038/22313

PubMed ID: 16945926

Title: Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.

PubMed ID: 16945926

DOI: 10.1074/jbc.m602889200

PubMed ID: 15166293

Title: Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.

PubMed ID: 15166293

DOI: 10.1038/oby.2004.89

PubMed ID: 15340116

Title: Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.

PubMed ID: 15340116

DOI: 10.1038/oby.2004.167

Sequence Information:

  • Length: 353
  • Mass: 38940
  • Checksum: 0C7D692C92667EDC
  • Sequence:
    • MDLEASLLPT GPNASNTSDG PDNLTSAGSP PRTGSISYIN IIMPSVFGTI CLLGIIGNST 
VIFAVVKKSK LHWCNNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT 
AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSVA TLVICLLWAL SFISITPVWL 
YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVR ILQRMTSSVA 
PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG 
YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRAVSNA QTADEERTES KGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.