Details for: MCHR1

Gene ID: 2847

Symbol: MCHR1

Ensembl ID: ENSG00000128285

Description: melanin concentrating hormone receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4863
    Cell Significance Index: 11.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3323
    Cell Significance Index: 4.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1008
    Cell Significance Index: 10.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0559
    Cell Significance Index: 11.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0293
    Cell Significance Index: 0.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0274
    Cell Significance Index: 0.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0177
    Cell Significance Index: 2.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0104
    Cell Significance Index: 3.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0088
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0096
    Cell Significance Index: -5.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0100
    Cell Significance Index: -2.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -5.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0178
    Cell Significance Index: -2.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0218
    Cell Significance Index: -4.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0280
    Cell Significance Index: -5.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0298
    Cell Significance Index: -4.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0352
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0398
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0404
    Cell Significance Index: -6.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0411
    Cell Significance Index: -5.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0482
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0504
    Cell Significance Index: -2.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0535
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0686
    Cell Significance Index: -4.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0726
    Cell Significance Index: -4.4600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0773
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0809
    Cell Significance Index: -6.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0831
    Cell Significance Index: -5.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0832
    Cell Significance Index: -4.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0851
    Cell Significance Index: -4.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0893
    Cell Significance Index: -2.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0923
    Cell Significance Index: -6.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0943
    Cell Significance Index: -2.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0968
    Cell Significance Index: -3.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0973
    Cell Significance Index: -5.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0976
    Cell Significance Index: -2.7300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0979
    Cell Significance Index: -1.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0991
    Cell Significance Index: -5.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1155
    Cell Significance Index: -3.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1203
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1226
    Cell Significance Index: -4.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1249
    Cell Significance Index: -1.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1277
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1309
    Cell Significance Index: -2.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1343
    Cell Significance Index: -2.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1390
    Cell Significance Index: -2.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1429
    Cell Significance Index: -6.3200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1445
    Cell Significance Index: -1.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1446
    Cell Significance Index: -5.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1494
    Cell Significance Index: -4.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1500
    Cell Significance Index: -3.1300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1551
    Cell Significance Index: -2.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1618
    Cell Significance Index: -3.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1640
    Cell Significance Index: -4.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1652
    Cell Significance Index: -2.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1664
    Cell Significance Index: -6.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1735
    Cell Significance Index: -4.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1791
    Cell Significance Index: -2.2700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1806
    Cell Significance Index: -1.5400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1868
    Cell Significance Index: -2.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1873
    Cell Significance Index: -5.0000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1879
    Cell Significance Index: -2.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1903
    Cell Significance Index: -5.1000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1950
    Cell Significance Index: -1.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1955
    Cell Significance Index: -4.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1984
    Cell Significance Index: -4.3500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2045
    Cell Significance Index: -2.2900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2046
    Cell Significance Index: -2.2600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2074
    Cell Significance Index: -2.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2076
    Cell Significance Index: -5.4600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2080
    Cell Significance Index: -2.3600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2106
    Cell Significance Index: -2.1500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2125
    Cell Significance Index: -2.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2141
    Cell Significance Index: -3.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2175
    Cell Significance Index: -3.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2180
    Cell Significance Index: -4.2900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.2200
    Cell Significance Index: -2.3300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2218
    Cell Significance Index: -2.3700
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.2235
    Cell Significance Index: -2.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2250
    Cell Significance Index: -8.2600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2262
    Cell Significance Index: -2.3400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2335
    Cell Significance Index: -3.0000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2367
    Cell Significance Index: -4.0200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2426
    Cell Significance Index: -1.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2436
    Cell Significance Index: -2.4100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2484
    Cell Significance Index: -2.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2496
    Cell Significance Index: -4.8800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.2523
    Cell Significance Index: -2.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2541
    Cell Significance Index: -5.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2557
    Cell Significance Index: -2.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2558
    Cell Significance Index: -5.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2561
    Cell Significance Index: -2.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MCHR1 is a GPCR that belongs to the class A/1 (rhodopsin-like receptors) and exhibits high affinity for melanin-concentrating hormone (MCH), a neuropeptide involved in energy homeostasis and feeding behavior. The receptor is characterized by its ability to inhibit adenylate cyclase activity, leading to a decrease in cAMP levels and subsequent modulation of downstream signaling pathways. MCHR1 is also involved in the regulation of calcium ion transport and cytosolic calcium ion concentration, which is essential for various cellular processes, including cell signaling and gene expression. **Pathways and Functions:** MCHR1 is involved in several signaling pathways, including: 1. **Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway**: MCHR1 inhibits adenylate cyclase activity, leading to a decrease in cAMP levels and activation of downstream signaling pathways. 2. **Bbsome-mediated cargo-targeting to cilium**: MCHR1 is involved in the targeting of cargo proteins to the cilium, a microtubular structure involved in cellular signaling and transport. 3. **G protein-coupled receptor signaling pathway**: MCHR1 activates G proteins, leading to the modulation of downstream signaling pathways, including calcium ion transport and cytosolic calcium ion concentration. 4. **Neuropeptide signaling pathway**: MCHR1 is involved in the regulation of neuropeptide signaling, including the binding of MCH to the receptor. **Clinical Significance:** MCHR1 has been implicated in various diseases and disorders, including: 1. **Obesity and metabolic disorders**: MCHR1 has been shown to play a role in energy homeostasis and feeding behavior, making it a potential target for the treatment of obesity and metabolic disorders. 2. **Immune system disorders**: MCHR1 is expressed in immune cells, including B cells and plasma cells, and has been implicated in the regulation of immune responses, including antibody production and cytokine secretion. 3. **Neurological disorders**: MCHR1 has been shown to play a role in the regulation of neuronal signaling and gene expression, making it a potential target for the treatment of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, MCHR1 is a complex gene that plays a crucial role in various physiological processes, including immune response, energy metabolism, and feeding behavior. Further research is needed to fully elucidate the functional implications of MCHR1 and its potential clinical significance in various diseases and disorders.

Genular Protein ID: 574814931

Symbol: MCHR1_HUMAN

Name: G-protein coupled receptor 24

UniProtKB Accession Codes:

Q99705 B2RBX6 Q5R3J1 Q96S47 Q9BV08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10441476

Title: Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.

PubMed ID: 10441476

DOI: 10.1006/bbrc.1999.1104

PubMed ID: 15941924

Title: Mutation analysis of the MCHR1 gene in human obesity.

PubMed ID: 15941924

DOI: 10.1530/eje.1.01917

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8977118

Title: Characterization of a human gene related to genes encoding somatostatin receptors.

PubMed ID: 8977118

DOI: 10.1016/s0014-5793(96)01160-x

PubMed ID: 10421367

Title: Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.

PubMed ID: 10421367

DOI: 10.1038/22313

PubMed ID: 16945926

Title: Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.

PubMed ID: 16945926

DOI: 10.1074/jbc.m602889200

PubMed ID: 15166293

Title: Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.

PubMed ID: 15166293

DOI: 10.1038/oby.2004.89

PubMed ID: 15340116

Title: Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.

PubMed ID: 15340116

DOI: 10.1038/oby.2004.167

Sequence Information:

  • Length: 353
  • Mass: 38940
  • Checksum: 0C7D692C92667EDC
  • Sequence:
    • MDLEASLLPT GPNASNTSDG PDNLTSAGSP PRTGSISYIN IIMPSVFGTI CLLGIIGNST 
VIFAVVKKSK LHWCNNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT 
AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSVA TLVICLLWAL SFISITPVWL 
YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVR ILQRMTSSVA 
PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG 
YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRAVSNA QTADEERTES KGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.