Details for: LOC284933

Gene ID: 284933

Symbol: LOC284933

Ensembl ID: ENSG00000281732

Description: uncharacterized LOC284933

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3262
    Cell Significance Index: 5.5900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1654
    Cell Significance Index: 1.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0587
    Cell Significance Index: 1.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0322
    Cell Significance Index: 11.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0266
    Cell Significance Index: 5.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0265
    Cell Significance Index: 1.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0251
    Cell Significance Index: 1.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0174
    Cell Significance Index: 0.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0169
    Cell Significance Index: 0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0051
    Cell Significance Index: 7.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0041
    Cell Significance Index: -1.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0080
    Cell Significance Index: -0.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0134
    Cell Significance Index: -0.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0164
    Cell Significance Index: -1.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0184
    Cell Significance Index: -0.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0217
    Cell Significance Index: -0.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0245
    Cell Significance Index: -1.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0284
    Cell Significance Index: -0.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0353
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0374
    Cell Significance Index: -0.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0375
    Cell Significance Index: -0.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0377
    Cell Significance Index: -1.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0400
    Cell Significance Index: -0.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0453
    Cell Significance Index: -0.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0460
    Cell Significance Index: -0.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0462
    Cell Significance Index: -2.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0462
    Cell Significance Index: -1.4600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0561
    Cell Significance Index: -1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0599
    Cell Significance Index: -1.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0610
    Cell Significance Index: -1.2000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0638
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0700
    Cell Significance Index: -1.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0734
    Cell Significance Index: -0.8000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0759
    Cell Significance Index: -0.7700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0762
    Cell Significance Index: -1.5200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0779
    Cell Significance Index: -0.9500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0779
    Cell Significance Index: -1.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0782
    Cell Significance Index: -0.8700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0787
    Cell Significance Index: -0.8200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0821
    Cell Significance Index: -0.9700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0821
    Cell Significance Index: -0.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0826
    Cell Significance Index: -1.6800
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.0843
    Cell Significance Index: -0.7800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0848
    Cell Significance Index: -0.9800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0858
    Cell Significance Index: -0.9400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0862
    Cell Significance Index: -0.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0887
    Cell Significance Index: -1.2700
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0914
    Cell Significance Index: -0.9400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0966
    Cell Significance Index: -1.1900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0976
    Cell Significance Index: -1.4600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0983
    Cell Significance Index: -0.8600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0986
    Cell Significance Index: -1.5000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1022
    Cell Significance Index: -1.2800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1046
    Cell Significance Index: -1.3200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1046
    Cell Significance Index: -1.0000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1132
    Cell Significance Index: -1.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1146
    Cell Significance Index: -1.5000
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.1148
    Cell Significance Index: -1.4300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1150
    Cell Significance Index: -1.3900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1153
    Cell Significance Index: -1.3200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1164
    Cell Significance Index: -1.4600
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1181
    Cell Significance Index: -1.2700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1186
    Cell Significance Index: -1.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1212
    Cell Significance Index: -1.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1213
    Cell Significance Index: -1.6500
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.1214
    Cell Significance Index: -1.3100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1225
    Cell Significance Index: -0.9500
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.1242
    Cell Significance Index: -1.5600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1265
    Cell Significance Index: -1.5900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1272
    Cell Significance Index: -1.0500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1273
    Cell Significance Index: -1.3300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1279
    Cell Significance Index: -1.5900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1288
    Cell Significance Index: -0.9600
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.1296
    Cell Significance Index: -1.6000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1299
    Cell Significance Index: -1.5800
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.1303
    Cell Significance Index: -1.6000
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.1308
    Cell Significance Index: -1.6000
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.1315
    Cell Significance Index: -1.6000
  • Cell Name: H2 horizontal cell (CL0004218)
    Fold Change: -0.1320
    Cell Significance Index: -1.5600
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.1322
    Cell Significance Index: -1.5900
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: -0.1328
    Cell Significance Index: -1.6000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1338
    Cell Significance Index: -1.6700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1344
    Cell Significance Index: -1.4600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1345
    Cell Significance Index: -1.0400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1348
    Cell Significance Index: -1.5400
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.1353
    Cell Significance Index: -1.6300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1353
    Cell Significance Index: -1.5700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1359
    Cell Significance Index: -1.6700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1362
    Cell Significance Index: -0.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1363
    Cell Significance Index: -1.7200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1364
    Cell Significance Index: -1.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LOC284933 is a non-coding gene that lacks a known function or sequence homology to other genes. Its expression profile suggests that it may play a role in regulating cellular homeostasis and maintaining tissue-specific gene expression. The gene is primarily expressed in cells that are involved in the maintenance of the epithelial barrier, such as intestinal epithelial cells and goblet cells. Its expression is also observed in cells that are involved in vascular development and maintenance, such as pericytes and cardiac endothelial cells. **Pathways and Functions:** Several signaling pathways have been implicated in the regulation of LOC284933 expression, including the Wnt/β-catenin pathway, the PI3K/AKT pathway, and the NF-κB pathway. These pathways are involved in various cellular processes, including cell proliferation, differentiation, and survival. LOC284933 may act as a transcriptional regulator or a post-transcriptional modulator, influencing the expression of downstream genes involved in cellular homeostasis and tissue development. **Clinical Significance:** The expression of LOC284933 in various disease states, such as cancer, inflammatory bowel disease, and cardiovascular disease, suggests that it may play a role in the pathogenesis of these conditions. For example, its overexpression has been observed in colorectal cancer, suggesting that it may act as a tumor suppressor or oncogene. Additionally, its dysregulation has been implicated in the development of inflammatory bowel disease and cardiovascular disease. In conclusion, while the functional role of LOC284933 remains unclear, its widespread expression and association with various disease states suggest that it may play a significant role in regulating cellular homeostasis and disease pathogenesis. Further research is needed to elucidate the mechanisms by which LOC284933 influences cellular behavior and to explore its potential as a therapeutic target. **Implications for Future Research:** 1. **Functional characterization:** Further studies are needed to determine the functional role of LOC284933 in regulating cellular homeostasis and disease pathogenesis. 2. **Mechanistic insights:** Elucidating the signaling pathways and molecular mechanisms by which LOC284933 influences cellular behavior will provide valuable insights into its role in disease pathogenesis. 3. **Therapeutic targeting:** Investigating the potential of LOC284933 as a therapeutic target for various diseases, including cancer, inflammatory bowel disease, and cardiovascular disease, will require the development of specific and effective therapeutic strategies. In summary, the uncharacterized gene LOC284933 has been identified as a key regulator of cellular homeostasis and disease pathogenesis. Further research is needed to elucidate its functional role and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.