Details for: GPR39

Gene ID: 2863

Symbol: GPR39

Ensembl ID: ENSG00000183840

Description: G protein-coupled receptor 39

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.62
    Marker Score: 16399
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.2
    Marker Score: 27057
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.4
    Marker Score: 2296.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.62
    Marker Score: 468
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.58
    Marker Score: 2999
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.5
    Marker Score: 1152
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.42
    Marker Score: 1572
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.37
    Marker Score: 1183
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3150
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.34
    Marker Score: 2715
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.12
    Marker Score: 3216.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.11
    Marker Score: 17789
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71794
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48018
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.98
    Marker Score: 4092
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15180
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.96
    Marker Score: 9909
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.95
    Marker Score: 32132
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1511
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5149
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.87
    Marker Score: 520
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1212
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.8
    Marker Score: 259
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 837
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.75
    Marker Score: 344
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 667
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.71
    Marker Score: 2524.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2956.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.64
    Marker Score: 356
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 546
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 196
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.59
    Marker Score: 628
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.59
    Marker Score: 119
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.59
    Marker Score: 152
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 270
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.55
    Marker Score: 1037
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.54
    Marker Score: 1761
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.53
    Marker Score: 376
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.52
    Marker Score: 2114.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.51
    Marker Score: 347
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.51
    Marker Score: 372
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.51
    Marker Score: 810
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.5
    Marker Score: 132
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.48
    Marker Score: 738
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.46
    Marker Score: 144
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.44
    Marker Score: 9330
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.44
    Marker Score: 568
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.43
    Marker Score: 237
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.42
    Marker Score: 510
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.42
    Marker Score: 198
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.41
    Marker Score: 262
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.4
    Marker Score: 493
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.39
    Marker Score: 1219
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.38
    Marker Score: 112
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.38
    Marker Score: 266
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.38
    Marker Score: 488
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.36
    Marker Score: 134
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.35
    Marker Score: 13396
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.35
    Marker Score: 311
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.34
    Marker Score: 3233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.34
    Marker Score: 205
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 118
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.34
    Marker Score: 99
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.32
    Marker Score: 189
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.32
    Marker Score: 1249
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.31
    Marker Score: 528
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 113
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.3
    Marker Score: 1029
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.3
    Marker Score: 65
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.29
    Marker Score: 369
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.29
    Marker Score: 88
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.29
    Marker Score: 918
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.29
    Marker Score: 553
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.28
    Marker Score: 487
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.28
    Marker Score: 113
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.28
    Marker Score: 2120
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.27
    Marker Score: 429
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.26
    Marker Score: 406
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.26
    Marker Score: 121

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Other Information

**Key characteristics:** * GPR39 is a single-pass membrane protein with seven transmembrane domains. * It is a member of the GPCR superfamily, which is expressed in a variety of cell types. * It is a ligand-gated ion channel that is expressed in the plasma membrane of many cell types. * It is a key regulator of cell growth, differentiation, and survival. **Pathways and functions:** * GPR39 is a G protein-coupled receptor that is expressed on the surface of retinal bipolar neurons. * It is a key regulator of retinal development and function. * It is also expressed in the plasma membrane of cardiac endothelial cells, where it is involved in regulating blood flow. * It is expressed in the plasma membrane of renal principal cells, where it is involved in regulating water and electrolyte homeostasis. * It is expressed in the plasma membrane of corneal epithelial cells, where it is involved in regulating the water balance of the eye. * It is expressed in the plasma membrane of taste receptor cells, where it is involved in taste sensation. **Clinical significance:** * Mutations in GPR39 have been linked to a number of human diseases, including retinal degenerative diseases, cardiovascular disease, and kidney disease. * Inhibition of GPR39 has been shown to improve the symptoms of these diseases. * Therefore, GPR39 is a promising target for the treatment of human diseases that are characterized by abnormal GPCR function.

Genular Protein ID: 1986295059

Symbol: GPR39_HUMAN

Name: G-protein coupled receptor 39

UniProtKB Accession Codes:

O43194 B2RC12 B6V9G4 Q08AS2 Q53R01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9441746

Title: Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.

PubMed ID: 9441746

DOI: 10.1006/geno.1997.5069

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18693759

Title: A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39.

PubMed ID: 18693759

DOI: 10.1021/bi8005016

PubMed ID: 18588883

Title: Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.

PubMed ID: 18588883

DOI: 10.1016/j.febslet.2008.06.030

PubMed ID: 18180304

Title: The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor.

PubMed ID: 18180304

DOI: 10.1074/jbc.m704323200

PubMed ID: 20522546

Title: Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair.

PubMed ID: 20522546

DOI: 10.1074/jbc.m110.107490

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26365466

Title: The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.

PubMed ID: 26365466

DOI: 10.1016/j.bbadis.2015.09.003

Sequence Information:

  • Length: 453
  • Mass: 51329
  • Checksum: 8E3A233420D9021E
  • Sequence:
    • MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA TIRVTQVLQK 
KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY 
ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL 
VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAFVV YLVVLLSVAF 
MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ 
IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC 
CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ 
SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.