Details for: TRAV19

Gene ID: 28664

Symbol: TRAV19

Ensembl ID: ENSG00000211799

Description: T cell receptor alpha variable 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6034
    Cell Significance Index: 3.2900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3834
    Cell Significance Index: 4.2900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0160
    Cell Significance Index: 0.1600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0125
    Cell Significance Index: 0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0099
    Cell Significance Index: -1.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0155
    Cell Significance Index: -2.8000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0165
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0171
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0241
    Cell Significance Index: -2.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0243
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0335
    Cell Significance Index: -3.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0353
    Cell Significance Index: -0.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0372
    Cell Significance Index: -0.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0400
    Cell Significance Index: -2.0800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0412
    Cell Significance Index: -0.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0427
    Cell Significance Index: -2.0100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0430
    Cell Significance Index: -0.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0432
    Cell Significance Index: -1.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0599
    Cell Significance Index: -2.2000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0601
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0609
    Cell Significance Index: -0.8900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0825
    Cell Significance Index: -1.0200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0857
    Cell Significance Index: -0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0888
    Cell Significance Index: -4.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0983
    Cell Significance Index: -2.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1050
    Cell Significance Index: -3.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1056
    Cell Significance Index: -3.1100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1125
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1158
    Cell Significance Index: -1.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1209
    Cell Significance Index: -3.0800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1221
    Cell Significance Index: -1.0400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1301
    Cell Significance Index: -1.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1305
    Cell Significance Index: -3.1600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1328
    Cell Significance Index: -2.2900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1331
    Cell Significance Index: -1.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1336
    Cell Significance Index: -2.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1375
    Cell Significance Index: -2.0300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1383
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1403
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1497
    Cell Significance Index: -1.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1499
    Cell Significance Index: -2.9300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1521
    Cell Significance Index: -1.7900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1534
    Cell Significance Index: -1.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1585
    Cell Significance Index: -2.9300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1610
    Cell Significance Index: -0.6700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1623
    Cell Significance Index: -2.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1634
    Cell Significance Index: -1.7800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1640
    Cell Significance Index: -1.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1644
    Cell Significance Index: -1.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1655
    Cell Significance Index: -2.5600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1678
    Cell Significance Index: -2.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1727
    Cell Significance Index: -2.8900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1729
    Cell Significance Index: -2.8000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1732
    Cell Significance Index: -2.9600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1764
    Cell Significance Index: -1.8200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1768
    Cell Significance Index: -1.8800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1785
    Cell Significance Index: -2.6700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1787
    Cell Significance Index: -1.3900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1804
    Cell Significance Index: -2.9000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1811
    Cell Significance Index: -1.8300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1840
    Cell Significance Index: -2.3600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1897
    Cell Significance Index: -2.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1902
    Cell Significance Index: -2.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1905
    Cell Significance Index: -2.2100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1918
    Cell Significance Index: -1.5900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1929
    Cell Significance Index: -1.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1930
    Cell Significance Index: -2.5400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1932
    Cell Significance Index: -1.6300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1950
    Cell Significance Index: -2.3700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1964
    Cell Significance Index: -1.7000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1969
    Cell Significance Index: -2.4200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1971
    Cell Significance Index: -2.4000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1985
    Cell Significance Index: -2.1400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1988
    Cell Significance Index: -2.6500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1996
    Cell Significance Index: -2.2900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1998
    Cell Significance Index: -2.2700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2006
    Cell Significance Index: -1.3800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2011
    Cell Significance Index: -2.3900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2025
    Cell Significance Index: -2.5300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2044
    Cell Significance Index: -2.2700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2054
    Cell Significance Index: -2.6900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2055
    Cell Significance Index: -2.5000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2066
    Cell Significance Index: -2.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2086
    Cell Significance Index: -2.6800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2094
    Cell Significance Index: -1.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2097
    Cell Significance Index: -2.9800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2100
    Cell Significance Index: -2.6900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2113
    Cell Significance Index: -2.0600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2119
    Cell Significance Index: -2.1700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2130
    Cell Significance Index: -1.9700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2131
    Cell Significance Index: -2.3200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2156
    Cell Significance Index: -1.9600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2168
    Cell Significance Index: -2.6000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2174
    Cell Significance Index: -2.4500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2195
    Cell Significance Index: -2.3800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.2202
    Cell Significance Index: -0.5900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2212
    Cell Significance Index: -2.5500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2240
    Cell Significance Index: -2.9300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2241
    Cell Significance Index: -2.3800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2242
    Cell Significance Index: -2.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Type-Specific Expression:** TRAV19 is expressed in a diverse range of cell types, including T cells, plasma cells, endothelial cells, and cells of the nervous system (glutamatergic neurons and oligodendrocyte precursor cells). 2. **T Cell Receptor Complex:** TRAV19 is integral to the TCR complex, which recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules. 3. **Signaling Pathways:** TRAV19 is involved in multiple signaling pathways, including downstream TCR signaling, costimulation by the CD28 family, and phospholysis of CD3 and TCR zeta chains. 4. **MHC Protein Binding:** TRAV19 interacts with MHC molecules, facilitating antigen recognition and T cell activation. **Pathways and Functions:** 1. **Downstream TCR Signaling:** TRAV19 is involved in the downstream signaling events triggered by TCR engagement, including the activation of Zap-70 and the phosphorylation of TCR zeta chains. 2. **Costimulation by the CD28 Family:** TRAV19 interacts with the CD28 family of costimulatory molecules, enhancing T cell activation and proliferation. 3. **Phosphorylation of CD3 and TCR Zeta Chains:** TRAV19 is responsible for the phosphorylation of CD3 and TCR zeta chains, which is essential for T cell activation and signaling. 4. **Immune Response Modulation:** TRAV19 plays a role in regulating immune responses, including the production of immunoglobulins and the interaction between lymphoid and non-lymphoid cells. **Clinical Significance:** 1. **Immunological Diseases:** Dysregulation of TRAV19 expression or function may contribute to the pathogenesis of immunological diseases, such as autoimmune disorders and cancer. 2. **Cancer Immunotherapy:** Targeting TRAV19 may provide a novel therapeutic approach for cancer treatment, particularly in the context of T cell-based immunotherapy. 3. **Immunoregulatory Interactions:** Understanding the role of TRAV19 in immune regulation may shed light on the mechanisms underlying immune tolerance and the development of immunotherapies for autoimmune diseases. 4. **Neurological Disorders:** The expression of TRAV19 in neural cells may have implications for the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, TRAV19 is a critical component of the T cell receptor complex, playing a multifaceted role in the adaptive immune response. Further research on the functions and clinical significance of TRAV19 will provide valuable insights into the intricacies of the immune system and potential therapeutic applications in immunological diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.