Details for: TRAV19

Gene ID: 28664

Symbol: TRAV19

Ensembl ID: ENSG00000211799

Description: T cell receptor alpha variable 19

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,074
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,271
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,173
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.81
    Marker Score: 2,026
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,802
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.44
    Marker Score: 1,269
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,566
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3,626
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.06
    Marker Score: 1,006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,716
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,047
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,307
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.87
    Marker Score: 768
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 734
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,188
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.67
    Marker Score: 384
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.55
    Marker Score: 1,694
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 506
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.43
    Marker Score: 288
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 382
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.4
    Marker Score: 313
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.39
    Marker Score: 668
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.35
    Marker Score: 294
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.27
    Marker Score: 297
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.27
    Marker Score: 195
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 145
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.26
    Marker Score: 456
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.25
    Marker Score: 483
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.2
    Marker Score: 498
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.2
    Marker Score: 548
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.18
    Marker Score: 258
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.16
    Marker Score: 127
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.16
    Marker Score: 176
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.15
    Marker Score: 646
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.15
    Marker Score: 218
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.14
    Marker Score: 106
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.12
    Marker Score: 92
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.12
    Marker Score: 6,591
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.12
    Marker Score: 86
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 197
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.11
    Marker Score: 91
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1
    Marker Score: 1,192
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1
    Marker Score: 85
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1
    Marker Score: 956
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.09
    Marker Score: 193
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 139
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 110
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 154
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: T-helper 2 cell (CL0000546)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 84
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 60

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Type-Specific Expression:** TRAV19 is expressed in a diverse range of cell types, including T cells, plasma cells, endothelial cells, and cells of the nervous system (glutamatergic neurons and oligodendrocyte precursor cells). 2. **T Cell Receptor Complex:** TRAV19 is integral to the TCR complex, which recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules. 3. **Signaling Pathways:** TRAV19 is involved in multiple signaling pathways, including downstream TCR signaling, costimulation by the CD28 family, and phospholysis of CD3 and TCR zeta chains. 4. **MHC Protein Binding:** TRAV19 interacts with MHC molecules, facilitating antigen recognition and T cell activation. **Pathways and Functions:** 1. **Downstream TCR Signaling:** TRAV19 is involved in the downstream signaling events triggered by TCR engagement, including the activation of Zap-70 and the phosphorylation of TCR zeta chains. 2. **Costimulation by the CD28 Family:** TRAV19 interacts with the CD28 family of costimulatory molecules, enhancing T cell activation and proliferation. 3. **Phosphorylation of CD3 and TCR Zeta Chains:** TRAV19 is responsible for the phosphorylation of CD3 and TCR zeta chains, which is essential for T cell activation and signaling. 4. **Immune Response Modulation:** TRAV19 plays a role in regulating immune responses, including the production of immunoglobulins and the interaction between lymphoid and non-lymphoid cells. **Clinical Significance:** 1. **Immunological Diseases:** Dysregulation of TRAV19 expression or function may contribute to the pathogenesis of immunological diseases, such as autoimmune disorders and cancer. 2. **Cancer Immunotherapy:** Targeting TRAV19 may provide a novel therapeutic approach for cancer treatment, particularly in the context of T cell-based immunotherapy. 3. **Immunoregulatory Interactions:** Understanding the role of TRAV19 in immune regulation may shed light on the mechanisms underlying immune tolerance and the development of immunotherapies for autoimmune diseases. 4. **Neurological Disorders:** The expression of TRAV19 in neural cells may have implications for the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, TRAV19 is a critical component of the T cell receptor complex, playing a multifaceted role in the adaptive immune response. Further research on the functions and clinical significance of TRAV19 will provide valuable insights into the intricacies of the immune system and potential therapeutic applications in immunological diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.