Details for: TRAV13 2

Gene ID: 28670

Symbol: TRAV13 2

Ensembl ID: ENSG00000211791

Description: T cell receptor alpha variable 13-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.5437
    Cell Significance Index: -1.6700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5156
    Cell Significance Index: 5.1700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1804
    Cell Significance Index: 2.1800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0789
    Cell Significance Index: 1.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0266
    Cell Significance Index: 1.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0025
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0037
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0060
    Cell Significance Index: -1.0300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0111
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0139
    Cell Significance Index: -2.5100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0200
    Cell Significance Index: -2.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0203
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0218
    Cell Significance Index: -2.9900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0232
    Cell Significance Index: -0.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0260
    Cell Significance Index: -3.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0287
    Cell Significance Index: -2.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0306
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0311
    Cell Significance Index: -1.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0320
    Cell Significance Index: -0.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0366
    Cell Significance Index: -2.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0367
    Cell Significance Index: -1.7100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0373
    Cell Significance Index: -0.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0398
    Cell Significance Index: -2.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0450
    Cell Significance Index: -1.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0541
    Cell Significance Index: -0.5200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0542
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0551
    Cell Significance Index: -1.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0646
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0652
    Cell Significance Index: -0.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0705
    Cell Significance Index: -1.8000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0817
    Cell Significance Index: -0.7100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0833
    Cell Significance Index: -0.7100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0847
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0865
    Cell Significance Index: -1.8100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0872
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0873
    Cell Significance Index: -0.9900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0876
    Cell Significance Index: -0.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0884
    Cell Significance Index: -2.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0910
    Cell Significance Index: -1.1500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0922
    Cell Significance Index: -1.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0943
    Cell Significance Index: -3.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0969
    Cell Significance Index: -2.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0996
    Cell Significance Index: -2.1500
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1010
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1026
    Cell Significance Index: -1.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1031
    Cell Significance Index: -2.0300
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1050
    Cell Significance Index: -1.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1064
    Cell Significance Index: -2.3300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1090
    Cell Significance Index: -1.1300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1111
    Cell Significance Index: -1.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1119
    Cell Significance Index: -1.1400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1142
    Cell Significance Index: -1.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1150
    Cell Significance Index: -1.0900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1195
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1211
    Cell Significance Index: -3.4700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1221
    Cell Significance Index: -1.1900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1235
    Cell Significance Index: -1.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1292
    Cell Significance Index: -1.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1315
    Cell Significance Index: -2.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1358
    Cell Significance Index: -1.1000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1383
    Cell Significance Index: -1.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1389
    Cell Significance Index: -2.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1389
    Cell Significance Index: -2.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1393
    Cell Significance Index: -2.0300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1396
    Cell Significance Index: -1.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1423
    Cell Significance Index: -2.6300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1436
    Cell Significance Index: -2.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1445
    Cell Significance Index: -1.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1451
    Cell Significance Index: -2.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1502
    Cell Significance Index: -2.5300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1510
    Cell Significance Index: -1.9400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1526
    Cell Significance Index: -2.2200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1555
    Cell Significance Index: -1.8300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1556
    Cell Significance Index: -1.6500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1556
    Cell Significance Index: -1.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1557
    Cell Significance Index: -2.1600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1559
    Cell Significance Index: -1.1200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1586
    Cell Significance Index: -1.8400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1600
    Cell Significance Index: -2.0600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1601
    Cell Significance Index: -2.0100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1619
    Cell Significance Index: -1.6000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1625
    Cell Significance Index: -1.2500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1626
    Cell Significance Index: -1.0600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1638
    Cell Significance Index: -2.2500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1648
    Cell Significance Index: -1.6600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1648
    Cell Significance Index: -2.2600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1657
    Cell Significance Index: -1.1000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1659
    Cell Significance Index: -1.4000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1672
    Cell Significance Index: -1.1500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1687
    Cell Significance Index: -2.2200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1690
    Cell Significance Index: -0.5200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1713
    Cell Significance Index: -2.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1725
    Cell Significance Index: -2.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV13-2 is a single nucleotide polymorphism (SNP) located within the TRAV family, which is a subset of genes encoding the variable region of the T cell receptor alpha chain. The unique characteristics of TRAV13-2 include: * **High expression in non-immune cells**: Unlike other TRAV genes, TRAV13-2 is significantly expressed in cells outside the immune system, such as glutamatergic neurons, microglial cells, and blood vessel endothelial cells. * **Tissue-specific expression**: TRAV13-2 is predominantly expressed in the central nervous system (CNS) and peripheral tissues, highlighting its potential role in maintaining immune homeostasis in these environments. * **Diverse cellular expression patterns**: TRAV13-2 is expressed in various cell types, including neoplastic cells, abnormal cells, and absorptive cells, suggesting its involvement in multiple biological processes. **Pathways and Functions:** The TRAV13-2 gene is involved in several key pathways, including: * **Adaptive immune response**: TRAV13-2 is part of the T cell receptor complex, which plays a crucial role in recognizing and responding to antigens. * **Response to bacterium**: TRAV13-2 is significantly expressed in cells involved in the response to bacterial infections, highlighting its potential role in antimicrobial immunity. * **Cell-cell interactions**: TRAV13-2 may participate in cell-cell interactions, particularly in the context of immune responses, where it could influence the activation and regulation of immune cells. **Clinical Significance:** The clinical significance of TRAV13-2 is an area of ongoing research. However, its expression in non-immune cells and diverse cellular expression patterns suggest potential implications for: * **Autoimmune diseases**: Alterations in TRAV13-2 expression may contribute to the development of autoimmune diseases, such as multiple sclerosis, where immune cells are activated in the CNS. * **Cancer**: TRAV13-2 expression in neoplastic cells may influence tumor progression and immune evasion. * **Infectious diseases**: TRAV13-2 may play a role in the response to bacterial infections, particularly in the context of immune cell activation and regulation. In conclusion, the TRAV13-2 gene is a unique member of the TRAV family, with diverse cellular expression patterns and potential implications for various biological processes. Further research is necessary to fully elucidate the role of TRAV13-2 in immune homeostasis and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.