Details for: TRAV13 2

Gene ID: 28670

Symbol: TRAV13 2

Ensembl ID: ENSG00000211791

Description: T cell receptor alpha variable 13-2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,085
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.43
    Marker Score: 4,416
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.16
    Marker Score: 2,173
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,796
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,727
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,331
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.72
    Marker Score: 635
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 417
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.43
    Marker Score: 196
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 397
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.34
    Marker Score: 484
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.33
    Marker Score: 587
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 187
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.29
    Marker Score: 193
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.26
    Marker Score: 440
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.24
    Marker Score: 261
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.22
    Marker Score: 11,407
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.21
    Marker Score: 414
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.2
    Marker Score: 213
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.19
    Marker Score: 818
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.17
    Marker Score: 125
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.16
    Marker Score: 154
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.16
    Marker Score: 169
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.15
    Marker Score: 117
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.15
    Marker Score: 109
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.15
    Marker Score: 83
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.15
    Marker Score: 330
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.15
    Marker Score: 357
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.14
    Marker Score: 108
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.13
    Marker Score: 114
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.13
    Marker Score: 125
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.13
    Marker Score: 1,272
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1,343
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 137
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 336
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.1
    Marker Score: 293
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.1
    Marker Score: 85
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 74
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 134
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 150
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.09
    Marker Score: 134
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 116
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.09
    Marker Score: 335
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 85
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 91

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV13-2 is a single nucleotide polymorphism (SNP) located within the TRAV family, which is a subset of genes encoding the variable region of the T cell receptor alpha chain. The unique characteristics of TRAV13-2 include: * **High expression in non-immune cells**: Unlike other TRAV genes, TRAV13-2 is significantly expressed in cells outside the immune system, such as glutamatergic neurons, microglial cells, and blood vessel endothelial cells. * **Tissue-specific expression**: TRAV13-2 is predominantly expressed in the central nervous system (CNS) and peripheral tissues, highlighting its potential role in maintaining immune homeostasis in these environments. * **Diverse cellular expression patterns**: TRAV13-2 is expressed in various cell types, including neoplastic cells, abnormal cells, and absorptive cells, suggesting its involvement in multiple biological processes. **Pathways and Functions:** The TRAV13-2 gene is involved in several key pathways, including: * **Adaptive immune response**: TRAV13-2 is part of the T cell receptor complex, which plays a crucial role in recognizing and responding to antigens. * **Response to bacterium**: TRAV13-2 is significantly expressed in cells involved in the response to bacterial infections, highlighting its potential role in antimicrobial immunity. * **Cell-cell interactions**: TRAV13-2 may participate in cell-cell interactions, particularly in the context of immune responses, where it could influence the activation and regulation of immune cells. **Clinical Significance:** The clinical significance of TRAV13-2 is an area of ongoing research. However, its expression in non-immune cells and diverse cellular expression patterns suggest potential implications for: * **Autoimmune diseases**: Alterations in TRAV13-2 expression may contribute to the development of autoimmune diseases, such as multiple sclerosis, where immune cells are activated in the CNS. * **Cancer**: TRAV13-2 expression in neoplastic cells may influence tumor progression and immune evasion. * **Infectious diseases**: TRAV13-2 may play a role in the response to bacterial infections, particularly in the context of immune cell activation and regulation. In conclusion, the TRAV13-2 gene is a unique member of the TRAV family, with diverse cellular expression patterns and potential implications for various biological processes. Further research is necessary to fully elucidate the role of TRAV13-2 in immune homeostasis and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.