Details for: TRAJ39

Gene ID: 28716

Symbol: TRAJ39

Ensembl ID: ENSG00000211850

Description: T cell receptor alpha joining 39

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 8.2496
    Cell Significance Index: 161.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3710
    Cell Significance Index: 33.2100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.7699
    Cell Significance Index: 9.8900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4357
    Cell Significance Index: 6.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1707
    Cell Significance Index: 2.7700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.0339
    Cell Significance Index: 0.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0032
    Cell Significance Index: -0.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0174
    Cell Significance Index: -0.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0201
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0238
    Cell Significance Index: -0.4100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0245
    Cell Significance Index: -0.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0246
    Cell Significance Index: -0.9300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0397
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0515
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0617
    Cell Significance Index: -0.7500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0686
    Cell Significance Index: -0.9100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0694
    Cell Significance Index: -0.7800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0709
    Cell Significance Index: -0.8600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0728
    Cell Significance Index: -0.8600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0740
    Cell Significance Index: -0.8700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0742
    Cell Significance Index: -1.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0763
    Cell Significance Index: -1.0300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0781
    Cell Significance Index: -0.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0805
    Cell Significance Index: -0.9600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0809
    Cell Significance Index: -0.8700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0828
    Cell Significance Index: -0.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0830
    Cell Significance Index: -0.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0830
    Cell Significance Index: -1.0300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0838
    Cell Significance Index: -0.8500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0843
    Cell Significance Index: -0.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0844
    Cell Significance Index: -0.8000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0862
    Cell Significance Index: -0.8400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0872
    Cell Significance Index: -0.8700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0886
    Cell Significance Index: -0.9500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0893
    Cell Significance Index: -0.9000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0895
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0903
    Cell Significance Index: -1.1100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0905
    Cell Significance Index: -0.9600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0911
    Cell Significance Index: -0.9200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0939
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0952
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0957
    Cell Significance Index: -1.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0968
    Cell Significance Index: -1.2400
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0983
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0986
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0994
    Cell Significance Index: -0.9300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0997
    Cell Significance Index: -0.8600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1001
    Cell Significance Index: -1.0800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1009
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1024
    Cell Significance Index: -0.9300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1053
    Cell Significance Index: -0.9800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1056
    Cell Significance Index: -0.9800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1075
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1076
    Cell Significance Index: -1.0100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1078
    Cell Significance Index: -0.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1104
    Cell Significance Index: -1.5000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1113
    Cell Significance Index: -0.9300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1125
    Cell Significance Index: -1.2300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1127
    Cell Significance Index: -0.9600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1146
    Cell Significance Index: -1.0200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1177
    Cell Significance Index: -1.0600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1192
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1201
    Cell Significance Index: -1.1100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1207
    Cell Significance Index: -0.8300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1219
    Cell Significance Index: -1.0000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1247
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1318
    Cell Significance Index: -1.4200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1344
    Cell Significance Index: -1.0000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1386
    Cell Significance Index: -1.1900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1467
    Cell Significance Index: -0.7900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1495
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1565
    Cell Significance Index: -1.4100
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.1576
    Cell Significance Index: -1.2900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1781
    Cell Significance Index: -1.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1816
    Cell Significance Index: -0.9900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.3216
    Cell Significance Index: -0.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ39 is a gene that encodes a protein essential for the proper assembly and signaling of the TCR complex. It is specifically expressed in various T cell subsets, including CD4+ and CD8+ T cells, alpha-beta thymocytes, and gamma-delta T cells. The TRAJ39 protein is a member of the immunoglobulin superfamily and contains immunoglobulin-like domains that facilitate interactions with other TCR components. **Pathways and Functions:** The TRAJ39 protein plays a critical role in the TCR signaling pathway, which is essential for T cell activation, proliferation, and differentiation. Upon antigen presentation, the TCR complex, including TRAJ39, binds to specific antigens, triggering a cascade of intracellular signaling events that lead to T cell activation. TRAJ39 interacts with other TCR components, such as CD3 and CD4/CD8, to facilitate the transmission of signals from the TCR to downstream signaling molecules. The TRAJ39 protein also regulates the expression of genes involved in T cell differentiation and function, including cytokine production and cell cycle progression. Furthermore, TRAJ39 has been implicated in the regulation of immune responses, including the modulation of T cell activation, proliferation, and apoptosis. **Clinical Significance:** Dysregulation of TRAJ39 has been associated with various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. Alterations in TRAJ39 expression have been observed in these conditions, suggesting a potential role for TRAJ39 in the pathogenesis of these diseases. Additionally, TRAJ39 has been studied in the context of cancer immunotherapy, where it is believed to play a role in the regulation of T cell responses against tumor antigens. Mutations in TRAJ39 have been identified in some cancer types, highlighting its potential as a therapeutic target. In conclusion, TRAJ39 is a critical component of the TCR complex that plays a pivotal role in T cell signaling, differentiation, and function. Its dysregulation has been implicated in various immune-related disorders, and further research is needed to fully elucidate its role in immune homeostasis and disease. **Future Directions:** Further studies are needed to fully understand the mechanisms by which TRAJ39 regulates T cell function and to explore its therapeutic potential in immune-related disorders. Additionally, the development of TRAJ39-targeted therapies may provide new avenues for the treatment of autoimmune diseases and cancer. **References:** * [Insert references to relevant studies on TRAJ39] Note: The references provided should be up-to-date and include studies published in reputable scientific journals. The references should be cited in a consistent citation style, such as APA, MLA, or Chicago.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.