Details for: ACAD9
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 121.7009
Cell Significance Index: -18.9300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 80.7433
Cell Significance Index: -20.4800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 49.6058
Cell Significance Index: -23.4200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 47.3838
Cell Significance Index: -19.2500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.2777
Cell Significance Index: -19.3600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.7784
Cell Significance Index: -21.9200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.7160
Cell Significance Index: -20.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.6766
Cell Significance Index: -22.4000 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 4.3824
Cell Significance Index: 5.6700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.9660
Cell Significance Index: -8.6800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5638
Cell Significance Index: 154.6900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0641
Cell Significance Index: 960.8100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9389
Cell Significance Index: 12.8100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8965
Cell Significance Index: 53.8200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8777
Cell Significance Index: 176.0700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8345
Cell Significance Index: 135.7200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7691
Cell Significance Index: 39.9500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7275
Cell Significance Index: 144.3800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6526
Cell Significance Index: 6.0100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5729
Cell Significance Index: 15.3500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5290
Cell Significance Index: 189.7600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4418
Cell Significance Index: 79.6500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4326
Cell Significance Index: 12.0900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4186
Cell Significance Index: 28.9500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3589
Cell Significance Index: 10.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3400
Cell Significance Index: 26.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3225
Cell Significance Index: 39.6600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2926
Cell Significance Index: 202.3400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2751
Cell Significance Index: 17.3400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2297
Cell Significance Index: 10.4100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2220
Cell Significance Index: 4.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2122
Cell Significance Index: 115.9000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2057
Cell Significance Index: 9.5900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1966
Cell Significance Index: 5.2500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1816
Cell Significance Index: 10.1900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1743
Cell Significance Index: 20.5500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1494
Cell Significance Index: 20.5200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1390
Cell Significance Index: 61.4500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1258
Cell Significance Index: 7.7300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1199
Cell Significance Index: 8.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0930
Cell Significance Index: 1.9800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0779
Cell Significance Index: 14.8200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0739
Cell Significance Index: 2.6000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0637
Cell Significance Index: 8.1600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0633
Cell Significance Index: 2.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0403
Cell Significance Index: 75.8700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0217
Cell Significance Index: 0.8200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0190
Cell Significance Index: 2.4500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0167
Cell Significance Index: 30.7500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0166
Cell Significance Index: 2.8400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0164
Cell Significance Index: 10.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0139
Cell Significance Index: 21.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0096
Cell Significance Index: 4.3700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0086
Cell Significance Index: 0.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0012
Cell Significance Index: -0.0400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0048
Cell Significance Index: -6.4800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0109
Cell Significance Index: -7.9700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0123
Cell Significance Index: -9.1000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0130
Cell Significance Index: -0.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0156
Cell Significance Index: -11.8000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0158
Cell Significance Index: -9.8800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0231
Cell Significance Index: -1.5500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0258
Cell Significance Index: -14.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0269
Cell Significance Index: -3.9100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0381
Cell Significance Index: -3.9000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0556
Cell Significance Index: -3.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0587
Cell Significance Index: -16.8900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0654
Cell Significance Index: -1.6700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0664
Cell Significance Index: -13.9800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0671
Cell Significance Index: -1.3100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0712
Cell Significance Index: -2.2800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0724
Cell Significance Index: -1.2400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0769
Cell Significance Index: -5.7400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0818
Cell Significance Index: -9.5300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0930
Cell Significance Index: -2.3900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0953
Cell Significance Index: -1.6000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1028
Cell Significance Index: -11.7800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1039
Cell Significance Index: -2.1600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1331
Cell Significance Index: -3.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1453
Cell Significance Index: -7.6300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1525
Cell Significance Index: -17.4100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1555
Cell Significance Index: -8.1000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1825
Cell Significance Index: -19.0000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1929
Cell Significance Index: -2.9300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2179
Cell Significance Index: -4.5600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2239
Cell Significance Index: -17.7300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2320
Cell Significance Index: -6.1000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2386
Cell Significance Index: -5.2300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2644
Cell Significance Index: -6.3400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2784
Cell Significance Index: -4.1100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2939
Cell Significance Index: -18.0200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3524
Cell Significance Index: -7.4800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3711
Cell Significance Index: -10.9000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3748
Cell Significance Index: -3.8800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3907
Cell Significance Index: -11.1500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3941
Cell Significance Index: -9.1100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4032
Cell Significance Index: -10.0800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4118
Cell Significance Index: -13.1200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4244
Cell Significance Index: -13.9000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4438
Cell Significance Index: -5.2900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 58737951
Symbol: ACAD9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12359260
Title: Cloning and functional characterization of ACAD-9, a novel member of human acyl-CoA dehydrogenase family.
PubMed ID: 12359260
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16020546
Title: Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids.
PubMed ID: 16020546
PubMed ID: 17564966
Title: A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency.
PubMed ID: 17564966
DOI: 10.1086/519219
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20816094
Title: Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.
PubMed ID: 20816094
PubMed ID: 21057504
Title: Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency.
PubMed ID: 21057504
DOI: 10.1038/ng.706
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21237683
Title: Identification and characterization of new long chain acyl-CoA dehydrogenases.
PubMed ID: 21237683
PubMed ID: 24158852
Title: ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies.
PubMed ID: 24158852
DOI: 10.1093/hmg/ddt521
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 32320651
Title: Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.
PubMed ID: 32320651
PubMed ID: 33753518
Title: TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.
PubMed ID: 33753518
PubMed ID: 20929961
Title: Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene.
PubMed ID: 20929961
DOI: 10.1093/brain/awq273
PubMed ID: 22499348
Title: Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing.
PubMed ID: 22499348
PubMed ID: 23836383
Title: Mitochondrial encephalomyopathy due to a novel mutation in ACAD9.
PubMed ID: 23836383
PubMed ID: 23996478
Title: A patient with complex I deficiency caused by a novel ACAD9 mutation not responding to riboflavin treatment.
PubMed ID: 23996478
PubMed ID: 26741492
Title: A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies.
PubMed ID: 26741492
Sequence Information:
- Length: 621
- Mass: 68760
- Checksum: 064BCE0378877F54
- Sequence:
MSGCGLFLRT TAAARACRGL VVSTANRRLL RTSPPVRAFA KELFLGKIKK KEVFPFPEVS QDELNEINQF LGPVEKFFTE EVDSRKIDQE GKIPDETLEK LKSLGLFGLQ VPEEYGGLGF SNTMYSRLGE IISMDGSITV TLAAHQAIGL KGIILAGTEE QKAKYLPKLA SGEHIAAFCL TEPASGSDAA SIRSRATLSE DKKHYILNGS KVWITNGGLA NIFTVFAKTE VVDSDGSVKD KITAFIVERD FGGVTNGKPE DKLGIRGSNT CEVHFENTKI PVENILGEVG DGFKVAMNIL NSGRFSMGSV VAGLLKRLIE MTAEYACTRK QFNKRLSEFG LIQEKFALMA QKAYVMESMT YLTAGMLDQP GFPDCSIEAA MVKVFSSEAA WQCVSEALQI LGGLGYTRDY PYERILRDTR ILLIFEGTNE ILRMYIALTG LQHAGRILTT RIHELKQAKV STVMDTVGRR LRDSLGRTVD LGLTGNHGVV HPSLADSANK FEENTYCFGR TVETLLLRFG KTIMEEQLVL KRVANILINL YGMTAVLSRA SRSIRIGLRN HDHEVLLANT FCVEAYLQNL FSLSQLDKYA PENLDEQIKK VSQQILEKRA YICAHPLDRT C
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.