Details for: TMPRSS11E

Gene ID: 28983

Symbol: TMPRSS11E

Ensembl ID: ENSG00000087128

Description: transmembrane serine protease 11E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.5400
    Cell Significance Index: 145.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.8118
    Cell Significance Index: 198.0100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 3.4285
    Cell Significance Index: 4.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 3.1667
    Cell Significance Index: 47.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2492
    Cell Significance Index: 30.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7903
    Cell Significance Index: 128.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7128
    Cell Significance Index: 42.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6653
    Cell Significance Index: 14.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6650
    Cell Significance Index: 65.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4915
    Cell Significance Index: 93.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3031
    Cell Significance Index: 4.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2856
    Cell Significance Index: 31.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2850
    Cell Significance Index: 17.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2681
    Cell Significance Index: 7.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2332
    Cell Significance Index: 3.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2319
    Cell Significance Index: 10.8100
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.1671
    Cell Significance Index: 0.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1360
    Cell Significance Index: 9.4100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1055
    Cell Significance Index: 0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0621
    Cell Significance Index: 4.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0443
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0437
    Cell Significance Index: 5.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0221
    Cell Significance Index: 3.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0100
    Cell Significance Index: 1.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0097
    Cell Significance Index: 1.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -1.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0026
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0086
    Cell Significance Index: -4.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0101
    Cell Significance Index: -4.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0115
    Cell Significance Index: -4.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0159
    Cell Significance Index: -0.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0174
    Cell Significance Index: -0.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0178
    Cell Significance Index: -3.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0191
    Cell Significance Index: -0.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0193
    Cell Significance Index: -5.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0237
    Cell Significance Index: -3.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0316
    Cell Significance Index: -3.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0323
    Cell Significance Index: -4.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0332
    Cell Significance Index: -3.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0347
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0354
    Cell Significance Index: -4.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0384
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0413
    Cell Significance Index: -0.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0463
    Cell Significance Index: -0.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0466
    Cell Significance Index: -4.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0687
    Cell Significance Index: -1.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0756
    Cell Significance Index: -0.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0763
    Cell Significance Index: -2.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0771
    Cell Significance Index: -3.6300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0873
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0882
    Cell Significance Index: -2.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0951
    Cell Significance Index: -2.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1139
    Cell Significance Index: -6.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1159
    Cell Significance Index: -2.8900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1177
    Cell Significance Index: -1.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1185
    Cell Significance Index: -4.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1224
    Cell Significance Index: -1.6700
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1227
    Cell Significance Index: -1.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1228
    Cell Significance Index: -5.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1249
    Cell Significance Index: -3.6800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1252
    Cell Significance Index: -0.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1310
    Cell Significance Index: -3.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1374
    Cell Significance Index: -4.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1408
    Cell Significance Index: -5.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1422
    Cell Significance Index: -4.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1466
    Cell Significance Index: -3.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1472
    Cell Significance Index: -3.9300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1526
    Cell Significance Index: -1.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1529
    Cell Significance Index: -4.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1619
    Cell Significance Index: -4.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1668
    Cell Significance Index: -1.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1688
    Cell Significance Index: -3.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1754
    Cell Significance Index: -2.9500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1783
    Cell Significance Index: -2.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1864
    Cell Significance Index: -4.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1875
    Cell Significance Index: -5.9300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1881
    Cell Significance Index: -2.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1900
    Cell Significance Index: -4.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1981
    Cell Significance Index: -5.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2138
    Cell Significance Index: -4.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2141
    Cell Significance Index: -2.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2181
    Cell Significance Index: -4.6300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2221
    Cell Significance Index: -2.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2252
    Cell Significance Index: -4.7000
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: -0.2294
    Cell Significance Index: -2.0100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2297
    Cell Significance Index: -4.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane localization**: TMPRSS11E is a transmembrane enzyme, meaning it spans the cell membrane and has extracellular and intracellular domains. 2. **Serine protease activity**: TMPRSS11E is a serine protease, which means it uses a serine residue to catalyze the hydrolysis of peptide bonds in proteins. 3. **Expression in epithelial cells**: TMPRSS11E is expressed in various epithelial cells, including squamous epithelial cells, enterocytes, keratinocytes, and colon goblet cells. 4. **Significant expression in stem cells**: TMPRSS11E is highly expressed in intestinal crypt stem cells and transit amplifying cells, suggesting its role in maintaining epithelial homeostasis. **Pathways and Functions:** 1. **Proteolysis**: TMPRSS11E has been implicated in the proteolytic processing of various proteins, including growth factors, cytokines, and adhesion molecules. 2. **Protein binding**: TMPRSS11E can bind to various proteins, including growth factors, cytokines, and receptors, modulating their activity and signaling. 3. **Extracellular region**: TMPRSS11E is localized to the extracellular region of the cell membrane, where it can interact with other proteins and ligands. 4. **Plasma membrane**: TMPRSS11E is embedded in the plasma membrane, where it can regulate cell signaling and communication. **Clinical Significance:** 1. **Cancer**: TMPRSS11E has been implicated in the development and progression of various cancers, including colorectal cancer, breast cancer, and lung cancer. 2. **Inflammatory disorders**: TMPRSS11E has been associated with inflammatory disorders, including Crohn's disease and ulcerative colitis. 3. **Epithelial barrier dysfunction**: TMPRSS11E dysregulation has been linked to epithelial barrier dysfunction, leading to the development of various diseases, including gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS). 4. **Immunological regulation**: TMPRSS11E may play a role in regulating immune responses, including the activation of immune cells and the production of cytokines. In conclusion, TMPRSS11E is a novel player in the regulation of epithelial homeostasis and immune responses. Its dysregulation has been associated with various diseases, highlighting the importance of its study in the development of new therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 3097477147

Symbol: TM11E_HUMAN

Name: Transmembrane protease serine 11E

UniProtKB Accession Codes:

Q9UL52 A6NL71 Q14DC8 Q6UW31

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11161383

Title: Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck.

PubMed ID: 11161383

DOI: 10.1054/bjoc.2000.1586

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14696115

Title: Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma.

PubMed ID: 14696115

DOI: 10.1002/ijc.11594

PubMed ID: 17388811

Title: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family.

PubMed ID: 17388811

DOI: 10.1111/j.1742-4658.2007.05756.x

Sequence Information:

  • Length: 423
  • Mass: 47696
  • Checksum: EB1476807C0B613D
  • Sequence:
    • MMYRPDVVRA RKRVCWEPWV IGLVIFISLI VLAVCIGLTV HYVRYNQKKT YNYYSTLSFT 
TDKLYAEFGR EASNNFTEMS QRLESMVKNA FYKSPLREEF VKSQVIKFSQ QKHGVLAHML 
LICRFHSTED PETVDKIVQL VLHEKLQDAV GPPKVDPHSV KIKKINKTET DSYLNHCCGT 
RRSKTLGQSL RIVGGTEVEE GEWPWQASLQ WDGSHRCGAT LINATWLVSA AHCFTTYKNP 
ARWTASFGVT IKPSKMKRGL RRIIVHEKYK HPSHDYDISL AELSSPVPYT NAVHRVCLPD 
ASYEFQPGDV MFVTGFGALK NDGYSQNHLR QAQVTLIDAT TCNEPQAYND AITPRMLCAG 
SLEGKTDACQ GDSGGPLVSS DARDIWYLAG IVSWGDECAK PNKPGVYTRV TALRDWITSK 
TGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.