Details for: GRIK4

Gene ID: 2900

Symbol: GRIK4

Ensembl ID: ENSG00000149403

Description: glutamate ionotropic receptor kainate type subunit 4

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Cell projection
    (GO:0042995)
  • Chemical synaptic transmission
    (GO:0007268)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Hippocampal mossy fiber to ca3 synapse
    (GO:0098686)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.3200
    Cell Significance Index: 128.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.1127
    Cell Significance Index: 111.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.9800
    Cell Significance Index: 85.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9608
    Cell Significance Index: 393.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8647
    Cell Significance Index: 125.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8280
    Cell Significance Index: 69.2200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.8031
    Cell Significance Index: 13.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7831
    Cell Significance Index: 78.8700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.7137
    Cell Significance Index: 22.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6780
    Cell Significance Index: 102.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3310
    Cell Significance Index: 28.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3148
    Cell Significance Index: 42.1100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.1846
    Cell Significance Index: 16.5700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.9472
    Cell Significance Index: 10.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9317
    Cell Significance Index: 57.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9091
    Cell Significance Index: 326.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5964
    Cell Significance Index: 113.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5608
    Cell Significance Index: 13.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2430
    Cell Significance Index: 219.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2351
    Cell Significance Index: 46.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2197
    Cell Significance Index: 21.7400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1326
    Cell Significance Index: 1.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1023
    Cell Significance Index: 16.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1006
    Cell Significance Index: 63.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0529
    Cell Significance Index: 5.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0359
    Cell Significance Index: 1.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0327
    Cell Significance Index: 4.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0172
    Cell Significance Index: 32.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0125
    Cell Significance Index: 0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0132
    Cell Significance Index: -20.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0173
    Cell Significance Index: -23.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0220
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0362
    Cell Significance Index: -27.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0382
    Cell Significance Index: -28.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0393
    Cell Significance Index: -1.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0409
    Cell Significance Index: -18.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0490
    Cell Significance Index: -26.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0499
    Cell Significance Index: -28.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0523
    Cell Significance Index: -3.1400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0705
    Cell Significance Index: -0.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0722
    Cell Significance Index: -31.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0766
    Cell Significance Index: -22.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0812
    Cell Significance Index: -14.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0858
    Cell Significance Index: -1.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0901
    Cell Significance Index: -2.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0921
    Cell Significance Index: -1.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0960
    Cell Significance Index: -1.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1138
    Cell Significance Index: -7.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1334
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1353
    Cell Significance Index: -28.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1425
    Cell Significance Index: -24.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1685
    Cell Significance Index: -4.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1737
    Cell Significance Index: -21.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1759
    Cell Significance Index: -24.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2028
    Cell Significance Index: -26.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2029
    Cell Significance Index: -20.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2193
    Cell Significance Index: -25.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2196
    Cell Significance Index: -28.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2203
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2476
    Cell Significance Index: -28.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2538
    Cell Significance Index: -4.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2596
    Cell Significance Index: -27.0300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2680
    Cell Significance Index: -2.5500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2752
    Cell Significance Index: -3.2100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2752
    Cell Significance Index: -3.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2795
    Cell Significance Index: -9.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3100
    Cell Significance Index: -23.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3268
    Cell Significance Index: -3.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3460
    Cell Significance Index: -25.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3532
    Cell Significance Index: -7.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3584
    Cell Significance Index: -8.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3667
    Cell Significance Index: -19.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4257
    Cell Significance Index: -27.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4373
    Cell Significance Index: -15.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4471
    Cell Significance Index: -8.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4554
    Cell Significance Index: -25.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4632
    Cell Significance Index: -24.3200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5163
    Cell Significance Index: -7.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5230
    Cell Significance Index: -24.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5240
    Cell Significance Index: -11.1600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5317
    Cell Significance Index: -5.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5722
    Cell Significance Index: -14.2700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5848
    Cell Significance Index: -7.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5919
    Cell Significance Index: -20.5700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6221
    Cell Significance Index: -8.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6507
    Cell Significance Index: -33.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6808
    Cell Significance Index: -31.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6889
    Cell Significance Index: -8.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7199
    Cell Significance Index: -15.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7653
    Cell Significance Index: -22.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7695
    Cell Significance Index: -15.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.7834
    Cell Significance Index: -8.4000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.8183
    Cell Significance Index: -10.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8273
    Cell Significance Index: -30.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8494
    Cell Significance Index: -22.7600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8553
    Cell Significance Index: -17.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8717
    Cell Significance Index: -22.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8786
    Cell Significance Index: -27.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit Structure:** GRIK4 is a subunit of the kainate receptor complex, which is composed of multiple subunits. The specific arrangement of these subunits determines the receptor's properties and functions. 2. **Ionotropic Activity:** Kainate receptors, including those containing GRIK4, are ionotropic receptors that directly permeabilize the cell membrane to ions, including sodium and potassium. 3. **Glutamate Binding:** The binding of glutamate to the kainate receptor complex triggers a conformational change that opens the ion channel, allowing ions to flow through the membrane. 4. **Regulation of Synaptic Transmission:** GRIK4 plays a critical role in regulating synaptic transmission, including the modulation of presynaptic and postsynaptic membrane potentials. **Pathways and Functions:** 1. **Activation of Ca-permeable Kainate Receptor:** The binding of glutamate to GRIK4 triggers the activation of the Ca-permeable kainate receptor, which is involved in the regulation of neuronal excitability. 2. **Activation of Kainate Receptors upon Glutamate Binding:** GRIK4 is a key component of the kainate receptor complex, which is activated upon glutamate binding. 3. **Chemical Synaptic Transmission:** The kainate receptor, including GRIK4, plays a crucial role in chemical synaptic transmission, mediating the excitatory effects of glutamate. 4. **Regulation of Postsynaptic Membrane Potential:** GRIK4 is involved in the regulation of postsynaptic membrane potential, influencing the excitability of neurons. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in kainate receptor function, including those involving GRIK4, have been implicated in various neurological disorders, such as epilepsy, schizophrenia, and Alzheimer's disease. 2. **Cognitive Function:** The kainate receptor, including GRIK4, plays a critical role in regulating synaptic transmission and neuronal excitability, which are essential for cognitive function. 3. **Neuropathic Pain:** GRIK4 has been identified as a potential target for the treatment of neuropathic pain, a chronic pain condition that affects millions of people worldwide. 4. **Neurodevelopmental Disorders:** The kainate receptor, including GRIK4, is involved in the regulation of neuronal development and synaptic plasticity, which are critical for neurodevelopmental disorders, such as autism and schizophrenia. In conclusion, the GRIK4 gene encodes for a critical component of the kainate receptor complex, which plays a pivotal role in regulating synaptic transmission and neuronal excitability in the brain. Further research into the function and regulation of GRIK4 is essential for understanding the underlying mechanisms of neurological disorders and developing novel therapeutic strategies.

Genular Protein ID: 2210262386

Symbol: GRIK4_HUMAN

Name: Glutamate receptor ionotropic, kainate 4

UniProtKB Accession Codes:

Q16099 A8K9L1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 3 Ensembl 3 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8263508

Title: Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit.

PubMed ID: 8263508

DOI: 10.1046/j.1471-4159.1994.62010001.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 956
  • Mass: 107246
  • Checksum: B7CBEA402A79397A
  • Sequence:
    • MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 
KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 
VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 
QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 
YTYIFTNLEF SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY LRMVELEGLT 
GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM DSHLYASNIS DTLFNTTLVV 
TTILENPYLM LKGNHQEMEG NDRYEGFCVD MLKELAEILR FNYKIRLVGD GVYGVPEANG 
TWTGMVGELI ARKADLAVAG LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL 
DPFSPGVWLF MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD VPIESVDDLA 
DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS VFVKSTEEGI ARVLNSNYAF 
LLESTMNEYY RQRNCNLTQI GGLLDTKGYG IGMPVGSVFR DEFDLAILQL QENNRLEILK 
RKWWEGGKCP KEEDHRAKGL GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS 
VCQEMVTELR SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT NSSEPE

Genular Protein ID: 3181136559

Symbol: B2RAP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RAP6

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 6 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 2 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 956
  • Mass: 107229
  • Checksum: DAC32868761C8F41
  • Sequence:
    • MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 
KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 
VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 
QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 
YTYIFTNPEF SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY LRMVELEGLT 
GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM DSHLYASNIS DTLFNTTLVV 
TTILENPYLM LKGNHQEMEG NDRYEGFCVD MLKELAEILR FNYKIRLVGD GVYGVPEANG 
TWTGMVGELI ARKADLAVAG LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL 
DPFSPGVWLF MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD VPIESVDDLA 
DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS VFVKSTEEGI ARVLNSNYAF 
LLESTMNEYY RQRNCNLTQI GGLLDTKGYG IGMPVGSVFR DEFDLAILQL QENNRLEILK 
RKWWEGGKCP KEEDHRAKGL GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS 
VCQEMVTELR SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 
LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT NSSEPE

Genular Protein ID: 3271995787

Symbol: A6H8K8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6H8K8

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 GO 7 Gene3D 3 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SMART 4 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 765
  • Mass: 85719
  • Checksum: D2CB3062FFA273A9
  • Sequence:
    • MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 
KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 
VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 
QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 
YTYIFTNLEF SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 
PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY LRMVELEGLT 
GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM DSHLYASNIS DTLFNTTLVV 
TTILENPYLM LKGNHQEMEG NDRYEGFCVD MLKELAEILR FNYKIRLVGD GVYGVPEANG 
TWTGMVGELI ARKADLAVAG LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL 
DPFSPGVWLF MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 
VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD VPIESVDDLA 
DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS VFVKSTEEGI ARVLNSNYAF 
LLESTMNEYY RQRNCNLTQI GGLLDTKGYG IGMPVGMRER NSLFG

Genular Protein ID: 2750334240

Symbol: A0A8D9UJ88_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8D9UJ88

Database IDs:

ARBA 12 CDD 1 CTD 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Citations:

PubMed ID: 34100982

Title: Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.

PubMed ID: 34100982

DOI: 10.1007/s00018-021-03865-z

Sequence Information:

  • Length: 902
  • Mass: 101014
  • Checksum: BD09BD894069E586
  • Sequence:
    • MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 
KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 
VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 
QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 
YTYIFTNLLS SALLFDAVYA VVTAVQELNR SQEIGVKPLS CGSAQIWQHG TSLMNYLRMV 
ELEGLTGHIE FNSKGQRSNY ALKILQFTRN GFRQIGQWHV AEGLSMDSHL YASNISDTLF 
NTTLVVTTIL ENPYLMLKGN HQEMEGNDRY EGFCVDMLKE LAEILRFNYK IRLVGDGVYG 
VPEANGTWTG MVGELIARKA DLAVAGLTIT AEREKVIDFS KPFMTLGISI LYRVHMGRKP 
GYFSFLDPFS PGVWLFMLLA YLAVSCVLFL VARLTPYEWY SPHPCAQGRC NLLVNQYSLG 
NSLWFPVGGF MQQGSTIAPR ALSTRCVSGV WWAFTLIIIS SYTANLAAFL TVQRMDVPIE 
SVDDLADQTA IEYGTIHGGS SMTFFQNSRY QTYQRMWNYM YSKQPSVFVK STEEGIARVL 
NSNYAFLLES TMNEYYRQRN CNLTQIGGLL DTKGYGIGMP VGSVFRDEFD LAILQLQENN 
RLEILKRKWW EGGKCPKEED HRAKGLGMEN IGGIFVVLIC GLIVAIFMAM LEFLWTLRHS 
EATEVSVCQE MVTELRSIIL CQDSIHPRRR RAAVPPPRPP IPEERRPRGT ATLSNGKLCG 
AGEPDQLAQR LAQEAALVAR GCTHIRVCPE CRRFQGLRAR PSPARSEESL EWEKTTNSSE 
PE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.