Details for: GRIN2B
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 7.12
Marker Score: 37,369 - Cell Name: stellate neuron (CL0000122)
Fold Change: 6
Marker Score: 32,228 - Cell Name: granule cell (CL0000120)
Fold Change: 5.24
Marker Score: 39,506 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 4.67
Marker Score: 15,646 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 4.29
Marker Score: 19,861 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.76
Marker Score: 31,826 - Cell Name: macroglial cell (CL0000126)
Fold Change: 3.51
Marker Score: 8,063 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 3.3
Marker Score: 1,916 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.96
Marker Score: 1,422 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.96
Marker Score: 8,434 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.9
Marker Score: 57,653 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.87
Marker Score: 4,819 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.85
Marker Score: 21,852 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.83
Marker Score: 42,298 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.71
Marker Score: 102,972 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.62
Marker Score: 10,850 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.62
Marker Score: 1,524 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.59
Marker Score: 1,453 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.45
Marker Score: 90,367 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.36
Marker Score: 9,112 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.22
Marker Score: 855 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.19
Marker Score: 20,620 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.07
Marker Score: 127,192 - Cell Name: neuron (CL0000540)
Fold Change: 2.03
Marker Score: 8,267 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.99
Marker Score: 20,566 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.99
Marker Score: 892 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,310 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.92
Marker Score: 3,644 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.91
Marker Score: 2,317 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,148 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.77
Marker Score: 2,213 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.73
Marker Score: 723 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.66
Marker Score: 2,055 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.66
Marker Score: 2,557 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.58
Marker Score: 6,599 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.55
Marker Score: 3,155 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,864 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.35
Marker Score: 984 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.23
Marker Score: 738 - Cell Name: microglial cell (CL0000129)
Fold Change: 1.18
Marker Score: 2,144 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,812 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.15
Marker Score: 313 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1
Marker Score: 17,242 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.03
Marker Score: 325 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,814 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,039 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.95
Marker Score: 436 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,301 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.91
Marker Score: 2,148 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.9
Marker Score: 1,034 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.88
Marker Score: 268 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,265 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396 - Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 695 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.76
Marker Score: 361 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.76
Marker Score: 196 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.75
Marker Score: 236 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.75
Marker Score: 16,081 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.72
Marker Score: 432 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.7
Marker Score: 7,095 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.66
Marker Score: 325 - Cell Name: interneuron (CL0000099)
Fold Change: 0.65
Marker Score: 296 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.61
Marker Score: 270 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 470 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.55
Marker Score: 193 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.54
Marker Score: 467 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.53
Marker Score: 2,065 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.53
Marker Score: 149 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.49
Marker Score: 16,611 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.49
Marker Score: 2,924 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.46
Marker Score: 305 - Cell Name: podocyte (CL0000653)
Fold Change: 0.45
Marker Score: 166 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.42
Marker Score: 202 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.42
Marker Score: 150 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4
Marker Score: 813 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.38
Marker Score: 224 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.37
Marker Score: 323 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.36
Marker Score: 489 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.36
Marker Score: 870 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.36
Marker Score: 279 - Cell Name: fat cell (CL0000136)
Fold Change: 0.33
Marker Score: 187 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.32
Marker Score: 130 - Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.32
Marker Score: 90 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.32
Marker Score: 100 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.31
Marker Score: 213 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.3
Marker Score: 273 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.3
Marker Score: 868 - Cell Name: T cell (CL0000084)
Fold Change: 0.3
Marker Score: 515 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.29
Marker Score: 181
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1955559397
Symbol: NMDE2_HUMAN
Name: Glutamate receptor ionotropic, NMDA 2B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7999784
Title: Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein.
PubMed ID: 7999784
PubMed ID: 8768735
Title: Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
PubMed ID: 8768735
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7959773
Title: Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.
PubMed ID: 7959773
PubMed ID: 9547169
Title: mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit.
PubMed ID: 9547169
PubMed ID: 10748157
Title: Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.
PubMed ID: 10748157
PubMed ID: 27458189
Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.
PubMed ID: 27458189
PubMed ID: 20890276
Title: Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
PubMed ID: 20890276
DOI: 10.1038/ng.677
PubMed ID: 26919761
Title: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
PubMed ID: 26919761
PubMed ID: 26875626
Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
PubMed ID: 26875626
PubMed ID: 28130356
Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
PubMed ID: 28130356
PubMed ID: 28126851
Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.
PubMed ID: 28126851
PubMed ID: 26912815
Title: A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
PubMed ID: 26912815
PubMed ID: 22833210
Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
PubMed ID: 22833210
DOI: 10.1038/tp.2011.52
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 23160955
Title: Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
PubMed ID: 23160955
PubMed ID: 24272827
Title: GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.
PubMed ID: 24272827
DOI: 10.1002/ana.24073
PubMed ID: 24863970
Title: Three rare diseases in one sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
PubMed ID: 24863970
PubMed ID: 25356899
Title: De novo mutations in moderate or severe intellectual disability.
PubMed ID: 25356899
PubMed ID: 27839871
Title: Mechanistic insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains.
PubMed ID: 27839871
PubMed ID: 27864847
Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.
PubMed ID: 27864847
DOI: 10.1002/humu.23149
PubMed ID: 28095420
Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.
PubMed ID: 28095420
Sequence Information:
- Length: 1484
- Mass: 166367
- Checksum: 40AEB12BE6E50CEF
- Sequence:
MKPRAECCSP KFWLVLAVLA VSGSRARSQK SPPSIGIAVI LVGTSDEVAI KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI ENSFVGWELE EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI FEVANSVGLT GYGYTWIVPS LVAGDTDTVP AEFPTGLISV SYDEWDYGLP ARVRDGIAII TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS FSEDGYQMHP KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE QEDDHLSIVT LEEAPFVIVE SVDPLSGTCM RNTVPCQKRI VTENKTDEEP GYIKKCCKGF CIDILKKISK SVKFTYDLYL VTNGKHGKKI NGTWNGMIGE VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR SNGTVSPSAF LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL AAFMIQEEYV DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA EMHAYMGKFN QRGVDDALLS LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT IGSGKVFAST GYGIAIQKDS GWKRQVDLAI LQLFGDGEME ELEALWLTGI CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH LFYWQFRHCF MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN NPPCEENLFS DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSASSI DGLYDCDNPP FTTQSRSISK KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS GHDDLIRSDV SDISTHTVTY GNIEGNAAKR RKQQYKDSLK KRPASAKSRR EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK ENSPHWEHVD LTDIYKERSD DFKRDSVSGG GPCTNRSHIK HGTGDKHGVV SGVPAPWEKN LTNVEWEDRS GGNFCRSCPS KLHNYSTTVT GQNSGRQACI RCEACKKAGN LYDISEDNSL QELDQPAAPV AVTSNASTTK YPQSPTNSKA QKKNRNKLRR QHSYDTFVDL QKEEAALAPR SVSLKDKGRF MDGSPYAHMF EMSAGESTFA NNKSSVPTAG HHHHNNPGGG YMLSKSLYPD RVTQNPFIPT FGDDQCLLHG SKSYFFRQPT VAGASKARPD FRALVTNKPV VSALHGAVPA RFQKDICIGN QSNPCVPNNK NPRAFNGSSN GHVYEKLSSI ESDV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.