Details for: GRIN2B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 6.8543
Cell Significance Index: 195.6000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 6.2764
Cell Significance Index: 277.6200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 6.2462
Cell Significance Index: 420.0000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 5.9718
Cell Significance Index: 226.1400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 5.5664
Cell Significance Index: 342.1400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 5.1634
Cell Significance Index: 1852.0200 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 4.8464
Cell Significance Index: 62.8500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.5325
Cell Significance Index: 708.6200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.4604
Cell Significance Index: 82.9900 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 2.9431
Cell Significance Index: 39.2600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.8851
Cell Significance Index: 1995.4100 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.5170
Cell Significance Index: 11.6400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0374
Cell Significance Index: 197.4300 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.9202
Cell Significance Index: 7.4300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6772
Cell Significance Index: 611.4500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.6564
Cell Significance Index: 6.2500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4251
Cell Significance Index: 42.0500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.3449
Cell Significance Index: 531.0300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.1623
Cell Significance Index: 3.2100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1445
Cell Significance Index: 23.5000 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0677
Cell Significance Index: 1.3600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0378
Cell Significance Index: 69.7300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0344
Cell Significance Index: 5.0100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0257
Cell Significance Index: 0.2800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.0141
Cell Significance Index: 0.4600 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.0003
Cell Significance Index: -0.0100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0062
Cell Significance Index: -8.4700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0181
Cell Significance Index: -34.0300 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0250
Cell Significance Index: -0.3100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0575
Cell Significance Index: -2.0200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0611
Cell Significance Index: -0.8800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0679
Cell Significance Index: -49.7800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0704
Cell Significance Index: -44.7200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0753
Cell Significance Index: -8.1900 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0777
Cell Significance Index: -0.9800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0783
Cell Significance Index: -15.5400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0945
Cell Significance Index: -42.8800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0955
Cell Significance Index: -70.7500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1088
Cell Significance Index: -2.3100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1091
Cell Significance Index: -59.5700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1204
Cell Significance Index: -5.4600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1266
Cell Significance Index: -71.4200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1615
Cell Significance Index: -46.4800 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1681
Cell Significance Index: -2.0100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1718
Cell Significance Index: -4.9500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2102
Cell Significance Index: -5.8800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2256
Cell Significance Index: -5.6400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2375
Cell Significance Index: -7.5700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2596
Cell Significance Index: -46.8000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2759
Cell Significance Index: -4.1900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3151
Cell Significance Index: -36.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3378
Cell Significance Index: -71.1500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3639
Cell Significance Index: -62.1400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.3917
Cell Significance Index: -48.1600 - Cell Name: neural cell (CL0002319)
Fold Change: -0.4029
Cell Significance Index: -4.7000 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.4167
Cell Significance Index: -5.8400 - Cell Name: neuron (CL0000540)
Fold Change: -0.4209
Cell Significance Index: -3.9900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4325
Cell Significance Index: -55.8800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.4542
Cell Significance Index: -62.3800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4661
Cell Significance Index: -32.2300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5036
Cell Significance Index: -59.3900 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.5058
Cell Significance Index: -5.5800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.5107
Cell Significance Index: -52.1700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5138
Cell Significance Index: -11.1000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.5360
Cell Significance Index: -23.3100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5360
Cell Significance Index: -13.3700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5479
Cell Significance Index: -9.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5630
Cell Significance Index: -64.5000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5729
Cell Significance Index: -59.6500 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6167
Cell Significance Index: -7.6900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.6326
Cell Significance Index: -37.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7153
Cell Significance Index: -54.8900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.7584
Cell Significance Index: -56.5200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7977
Cell Significance Index: -41.8800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8000
Cell Significance Index: -37.3000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8016
Cell Significance Index: -28.0800 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.8033
Cell Significance Index: -6.3000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8320
Cell Significance Index: -51.0100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.8557
Cell Significance Index: -17.8600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.9180
Cell Significance Index: -6.2200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.9466
Cell Significance Index: -61.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0086
Cell Significance Index: -56.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0177
Cell Significance Index: -53.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.0343
Cell Significance Index: -48.6100 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.1569
Cell Significance Index: -22.7700 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -1.1828
Cell Significance Index: -12.1600 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -1.1830
Cell Significance Index: -23.5900 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -1.1985
Cell Significance Index: -12.0900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.2455
Cell Significance Index: -15.7200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.2790
Cell Significance Index: -46.9500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.3824
Cell Significance Index: -29.9500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.3856
Cell Significance Index: -48.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.4066
Cell Significance Index: -45.0500 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -1.5000
Cell Significance Index: -13.5600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.5052
Cell Significance Index: -38.6900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.5512
Cell Significance Index: -37.5800 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -1.5559
Cell Significance Index: -20.7400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.6117
Cell Significance Index: -18.3100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.6835
Cell Significance Index: -35.9900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.7670
Cell Significance Index: -52.0500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1955559397
Symbol: NMDE2_HUMAN
Name: Glutamate receptor ionotropic, NMDA 2B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7999784
Title: Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein.
PubMed ID: 7999784
PubMed ID: 8768735
Title: Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
PubMed ID: 8768735
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7959773
Title: Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.
PubMed ID: 7959773
PubMed ID: 9547169
Title: mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit.
PubMed ID: 9547169
PubMed ID: 10748157
Title: Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.
PubMed ID: 10748157
PubMed ID: 27458189
Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.
PubMed ID: 27458189
PubMed ID: 20890276
Title: Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
PubMed ID: 20890276
DOI: 10.1038/ng.677
PubMed ID: 26919761
Title: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
PubMed ID: 26919761
PubMed ID: 26875626
Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
PubMed ID: 26875626
PubMed ID: 28130356
Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
PubMed ID: 28130356
PubMed ID: 28126851
Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.
PubMed ID: 28126851
PubMed ID: 26912815
Title: A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
PubMed ID: 26912815
PubMed ID: 22833210
Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
PubMed ID: 22833210
DOI: 10.1038/tp.2011.52
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 23160955
Title: Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
PubMed ID: 23160955
PubMed ID: 24272827
Title: GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.
PubMed ID: 24272827
DOI: 10.1002/ana.24073
PubMed ID: 24863970
Title: Three rare diseases in one sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
PubMed ID: 24863970
PubMed ID: 25356899
Title: De novo mutations in moderate or severe intellectual disability.
PubMed ID: 25356899
PubMed ID: 27839871
Title: Mechanistic insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains.
PubMed ID: 27839871
PubMed ID: 27864847
Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.
PubMed ID: 27864847
DOI: 10.1002/humu.23149
PubMed ID: 28095420
Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.
PubMed ID: 28095420
PubMed ID: 38538865
Title: De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
PubMed ID: 38538865
Sequence Information:
- Length: 1484
- Mass: 166367
- Checksum: 40AEB12BE6E50CEF
- Sequence:
MKPRAECCSP KFWLVLAVLA VSGSRARSQK SPPSIGIAVI LVGTSDEVAI KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI ENSFVGWELE EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI FEVANSVGLT GYGYTWIVPS LVAGDTDTVP AEFPTGLISV SYDEWDYGLP ARVRDGIAII TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS FSEDGYQMHP KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE QEDDHLSIVT LEEAPFVIVE SVDPLSGTCM RNTVPCQKRI VTENKTDEEP GYIKKCCKGF CIDILKKISK SVKFTYDLYL VTNGKHGKKI NGTWNGMIGE VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR SNGTVSPSAF LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL AAFMIQEEYV DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA EMHAYMGKFN QRGVDDALLS LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT IGSGKVFAST GYGIAIQKDS GWKRQVDLAI LQLFGDGEME ELEALWLTGI CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH LFYWQFRHCF MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN NPPCEENLFS DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSASSI DGLYDCDNPP FTTQSRSISK KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS GHDDLIRSDV SDISTHTVTY GNIEGNAAKR RKQQYKDSLK KRPASAKSRR EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK ENSPHWEHVD LTDIYKERSD DFKRDSVSGG GPCTNRSHIK HGTGDKHGVV SGVPAPWEKN LTNVEWEDRS GGNFCRSCPS KLHNYSTTVT GQNSGRQACI RCEACKKAGN LYDISEDNSL QELDQPAAPV AVTSNASTTK YPQSPTNSKA QKKNRNKLRR QHSYDTFVDL QKEEAALAPR SVSLKDKGRF MDGSPYAHMF EMSAGESTFA NNKSSVPTAG HHHHNNPGGG YMLSKSLYPD RVTQNPFIPT FGDDQCLLHG SKSYFFRQPT VAGASKARPD FRALVTNKPV VSALHGAVPA RFQKDICIGN QSNPCVPNNK NPRAFNGSSN GHVYEKLSSI ESDV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.