Details for: GSTA3

Gene ID: 2940

Symbol: GSTA3

Ensembl ID: ENSG00000174156

Description: glutathione S-transferase alpha 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.9487
    Cell Significance Index: -3.7700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.8846
    Cell Significance Index: 75.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7789
    Cell Significance Index: 74.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2457
    Cell Significance Index: 60.1800
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9221
    Cell Significance Index: 4.6000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.7247
    Cell Significance Index: 1.6300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.6616
    Cell Significance Index: 9.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3073
    Cell Significance Index: 7.1000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1767
    Cell Significance Index: 1.9800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1081
    Cell Significance Index: 1.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0894
    Cell Significance Index: 48.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0725
    Cell Significance Index: 1.2400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0378
    Cell Significance Index: 0.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0056
    Cell Significance Index: 2.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0034
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0074
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0101
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -5.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0118
    Cell Significance Index: -4.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0128
    Cell Significance Index: -0.6500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0151
    Cell Significance Index: -3.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0177
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0199
    Cell Significance Index: -3.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0209
    Cell Significance Index: -4.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0223
    Cell Significance Index: -3.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0231
    Cell Significance Index: -3.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0246
    Cell Significance Index: -0.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0259
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0262
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0401
    Cell Significance Index: -4.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0420
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0459
    Cell Significance Index: -5.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0461
    Cell Significance Index: -0.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0584
    Cell Significance Index: -3.0400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0599
    Cell Significance Index: -0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0605
    Cell Significance Index: -7.8100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0610
    Cell Significance Index: -0.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0667
    Cell Significance Index: -0.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0667
    Cell Significance Index: -2.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0681
    Cell Significance Index: -4.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0700
    Cell Significance Index: -4.3000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0820
    Cell Significance Index: -0.7500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0917
    Cell Significance Index: -1.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0978
    Cell Significance Index: -1.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0999
    Cell Significance Index: -4.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1036
    Cell Significance Index: -1.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1050
    Cell Significance Index: -2.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1094
    Cell Significance Index: -8.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1095
    Cell Significance Index: -3.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1113
    Cell Significance Index: -0.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1165
    Cell Significance Index: -4.0800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1175
    Cell Significance Index: -1.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1297
    Cell Significance Index: -7.2800
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.1298
    Cell Significance Index: -0.9400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1321
    Cell Significance Index: -1.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1355
    Cell Significance Index: -4.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1362
    Cell Significance Index: -4.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1389
    Cell Significance Index: -3.7200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1411
    Cell Significance Index: -1.5400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1444
    Cell Significance Index: -1.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1454
    Cell Significance Index: -6.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1456
    Cell Significance Index: -3.7100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1506
    Cell Significance Index: -1.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1584
    Cell Significance Index: -3.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1591
    Cell Significance Index: -4.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1600
    Cell Significance Index: -3.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1682
    Cell Significance Index: -6.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1709
    Cell Significance Index: -1.8500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1725
    Cell Significance Index: -2.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1754
    Cell Significance Index: -1.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1770
    Cell Significance Index: -2.5700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1800
    Cell Significance Index: -2.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1816
    Cell Significance Index: -3.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1827
    Cell Significance Index: -6.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1903
    Cell Significance Index: -2.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1959
    Cell Significance Index: -4.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1960
    Cell Significance Index: -4.7000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2028
    Cell Significance Index: -0.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2036
    Cell Significance Index: -3.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2053
    Cell Significance Index: -4.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2114
    Cell Significance Index: -6.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2125
    Cell Significance Index: -4.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2153
    Cell Significance Index: -4.3800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2177
    Cell Significance Index: -2.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2240
    Cell Significance Index: -4.6800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2243
    Cell Significance Index: -3.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2271
    Cell Significance Index: -4.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2276
    Cell Significance Index: -4.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2291
    Cell Significance Index: -4.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2296
    Cell Significance Index: -2.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2314
    Cell Significance Index: -4.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GSTA3 is a member of the GST family of enzymes, which are characterized by their ability to conjugate glutathione to electrophilic compounds, thereby neutralizing their toxic effects. GSTA3 is a class-alpha GST, which is distinct from other GST classes (e.g., class-μ and class-π) in terms of its substrate specificity and enzymatic activity. GSTA3 is also unique in its ability to interact with the Keap1-Nrf2 pathway, a key regulator of antioxidant and detoxification enzymes. This interaction allows GSTA3 to modulate the activity of Nrf2, a transcription factor that regulates the expression of antioxidant and detoxification genes. **Pathways and Functions** GSTA3 is involved in multiple cellular pathways, including: 1. **Glutathione conjugation**: GSTA3 conjugates glutathione to electrophilic compounds, such as xenobiotics and ROS, thereby neutralizing their toxic effects. 2. **Antioxidant defense**: GSTA3 participates in the antioxidant defense system by conjugating glutathione to ROS, thereby reducing oxidative stress. 3. **Cellular stress response**: GSTA3 is involved in the cellular response to stress, including heat shock, oxidative stress, and chemical stress. 4. **Xenobiotic metabolism**: GSTA3 is involved in the metabolism of xenobiotics, including environmental toxins and carcinogens. 5. **Keap1-Nrf2 pathway**: GSTA3 interacts with the Keap1-Nrf2 pathway, modulating the activity of Nrf2 and regulating the expression of antioxidant and detoxification genes. **Clinical Significance** GSTA3 has significant clinical implications in human health and disease, including: 1. **Cancer**: GSTA3 is overexpressed in various cancers, including lung, breast, and colon cancer, and is associated with tumor progression and metastasis. 2. **Neurodegenerative diseases**: GSTA3 is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, and is associated with oxidative stress and neuronal damage. 3. **Environmental health**: GSTA3 plays a crucial role in detoxifying environmental toxins, including pesticides and heavy metals, and is associated with the risk of environmental diseases. 4. **Immunology**: GSTA3 is expressed in immune cells, including dendritic cells and plasma cells, and is involved in the regulation of immune responses. In conclusion, GSTA3 is a critical enzyme involved in multiple cellular processes, including antioxidant defense, cellular stress response, and xenobiotic metabolism. Its clinical significance is evident in its association with various diseases, including cancer, neurodegenerative diseases, and environmental health. Further research is needed to fully understand the role of GSTA3 in human health and disease, and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 3521019905

Symbol: GSTA3_HUMAN

Name: GST class-alpha member 3

UniProtKB Accession Codes:

Q16772 O43468 Q068V6 Q8WWA8 Q9H415

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8307579

Title: Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes.

PubMed ID: 8307579

DOI: 10.1016/s0888-7543(05)80373-8

PubMed ID: 11418619

Title: Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones.

PubMed ID: 11418619

DOI: 10.1074/jbc.m104539200

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9480897

Title: Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.

PubMed ID: 9480897

DOI: 10.1042/bj3300827

PubMed ID: 15595823

Title: Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity.

PubMed ID: 15595823

DOI: 10.1021/bi048757g

PubMed ID: 20083122

Title: Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.

PubMed ID: 20083122

DOI: 10.1016/j.jmb.2010.01.023

Sequence Information:

  • Length: 222
  • Mass: 25302
  • Checksum: 904AA17519B5343C
  • Sequence:
    • MAGKPKLHYF NGRGRMEPIR WLLAAAGVEF EEKFIGSAED LGKLRNDGSL MFQQVPMVEI 
DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP LCRPEEKDAK 
IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL DSSLISNFPL 
LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF

Genular Protein ID: 3018074633

Symbol: Q5JW85_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JW85

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 8 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 1 RuleBase 1 SFLD 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 172
  • Mass: 19742
  • Checksum: B66F107BA552D6A5
  • Sequence:
    • MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP 
LCRPEEKDAK IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL 
DSSLISNFPL LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.