Details for: GSTA3

Gene ID: 2940

Symbol: GSTA3

Ensembl ID: ENSG00000174156

Description: glutathione S-transferase alpha 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1517
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.73
    Marker Score: 6791
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.67
    Marker Score: 1863
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.93
    Marker Score: 714
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.92
    Marker Score: 994
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1740
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 479
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.74
    Marker Score: 605
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.72
    Marker Score: 6219
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1433
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 449
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.65
    Marker Score: 2228
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 505
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9239
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 350
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.57
    Marker Score: 1078
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.55
    Marker Score: 3650
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 314
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.44
    Marker Score: 392
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.39
    Marker Score: 2321
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 219
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.33
    Marker Score: 304
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.32
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.29
    Marker Score: 136
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.24
    Marker Score: 4304
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.23
    Marker Score: 124
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.2
    Marker Score: 277
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2
    Marker Score: 104
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 103.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 349.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.14
    Marker Score: 4846
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 147
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.12
    Marker Score: 217
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.1
    Marker Score: 125
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1
    Marker Score: 1015
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 33.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 126
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 94
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.06
    Marker Score: 375
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 175.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.05
    Marker Score: 139

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Other Information

**Key characteristics:** * GSTA3 is a protein of the GST class-alpha. * It is expressed in a variety of cell types, including conventional dendritic cell, placental villous trophoblast, plasma cell, granulocyte monocyte progenitor cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, intestinal crypt stem cell of colon, transit amplifying cell, and early T lineage precursor. * It is a highly conserved protein, with a sequence that is similar in humans and mice. **Pathways and functions:** * GSTA3 is involved in the glutathione metabolic process, which is a complex network of reactions that helps to protect cells from damage by ROS. * It is responsible for the detoxification of a variety of ROS, including hydrogen peroxide, hydroxyl radicals, and nitric oxide. * It also plays a role in the clearance of oxidized proteins and lipids. * GSTA3 is also involved in the regulation of inflammation and cell death. **Clinical significance:** * Mutations in the GSTA3 gene have been linked to an increased risk of liver disease and cancer. * Drugs that target GSTA3 have been investigated as potential treatments for these diseases. * GSTA3 is a promising target for the prevention and treatment of a variety of diseases, including liver disease, cancer, and neurodegenerative disorders.

Genular Protein ID: 3521019905

Symbol: GSTA3_HUMAN

Name: GST class-alpha member 3

UniProtKB Accession Codes:

Q16772 O43468 Q068V6 Q8WWA8 Q9H415

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8307579

Title: Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes.

PubMed ID: 8307579

DOI: 10.1016/s0888-7543(05)80373-8

PubMed ID: 11418619

Title: Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones.

PubMed ID: 11418619

DOI: 10.1074/jbc.m104539200

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9480897

Title: Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.

PubMed ID: 9480897

DOI: 10.1042/bj3300827

PubMed ID: 15595823

Title: Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity.

PubMed ID: 15595823

DOI: 10.1021/bi048757g

PubMed ID: 20083122

Title: Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.

PubMed ID: 20083122

DOI: 10.1016/j.jmb.2010.01.023

Sequence Information:

  • Length: 222
  • Mass: 25302
  • Checksum: 904AA17519B5343C
  • Sequence:
    • MAGKPKLHYF NGRGRMEPIR WLLAAAGVEF EEKFIGSAED LGKLRNDGSL MFQQVPMVEI 
DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP LCRPEEKDAK 
IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL DSSLISNFPL 
LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF

Genular Protein ID: 3018074633

Symbol: Q5JW85_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JW85

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 EC 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 1 RuleBase 1 SFLD 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 172
  • Mass: 19742
  • Checksum: B66F107BA552D6A5
  • Sequence:
    • MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP 
LCRPEEKDAK IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL 
DSSLISNFPL LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.