Details for: GTF3C2

Gene ID: 2976

Symbol: GTF3C2

Ensembl ID: ENSG00000115207

Description: general transcription factor IIIC subunit 2

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Rna polymerase iii abortive and retractive initiation
    (R-HSA-749476)
  • Rna polymerase iii transcription
    (R-HSA-74158)
  • Rna polymerase iii transcription initiation
    (R-HSA-76046)
  • Rna polymerase iii transcription initiation from type 1 promoter
    (R-HSA-76061)
  • Rna polymerase iii transcription initiation from type 2 promoter
    (R-HSA-76066)
  • 5s class rrna transcription by rna polymerase iii
    (GO:0042791)
  • Dna binding
    (GO:0003677)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Rna polymerase iii general transcription initiation factor activity
    (GO:0000995)
  • Transcription by rna polymerase iii
    (GO:0006383)
  • Transcription factor tfiiic complex
    (GO:0000127)
  • Trna transcription by rna polymerase iii
    (GO:0042797)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 127.6478
    Cell Significance Index: -19.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.1305
    Cell Significance Index: -19.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.9158
    Cell Significance Index: -22.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.1530
    Cell Significance Index: -18.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.0391
    Cell Significance Index: -22.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.9216
    Cell Significance Index: -19.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.0606
    Cell Significance Index: -21.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5461
    Cell Significance Index: -20.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3420
    Cell Significance Index: -13.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4181
    Cell Significance Index: -21.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5511
    Cell Significance Index: 307.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4116
    Cell Significance Index: 19.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3383
    Cell Significance Index: 155.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0691
    Cell Significance Index: 116.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8547
    Cell Significance Index: 139.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8347
    Cell Significance Index: 22.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8146
    Cell Significance Index: 21.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7797
    Cell Significance Index: 156.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7636
    Cell Significance Index: 21.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5374
    Cell Significance Index: 37.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4337
    Cell Significance Index: 22.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4263
    Cell Significance Index: 76.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4260
    Cell Significance Index: 9.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4009
    Cell Significance Index: 143.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3744
    Cell Significance Index: 9.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3562
    Cell Significance Index: 19.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3344
    Cell Significance Index: 25.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3263
    Cell Significance Index: 9.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2955
    Cell Significance Index: 204.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2815
    Cell Significance Index: 153.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2788
    Cell Significance Index: 34.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2617
    Cell Significance Index: 2.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2059
    Cell Significance Index: 12.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2045
    Cell Significance Index: 10.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2012
    Cell Significance Index: 8.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1877
    Cell Significance Index: 83.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1859
    Cell Significance Index: 7.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1823
    Cell Significance Index: 8.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1547
    Cell Significance Index: 18.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1263
    Cell Significance Index: 17.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1223
    Cell Significance Index: 2.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1072
    Cell Significance Index: 5.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0977
    Cell Significance Index: 6.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0796
    Cell Significance Index: 71.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0766
    Cell Significance Index: 4.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0692
    Cell Significance Index: 1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0562
    Cell Significance Index: 9.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0555
    Cell Significance Index: 1.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0524
    Cell Significance Index: 9.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0458
    Cell Significance Index: 4.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0402
    Cell Significance Index: 75.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0282
    Cell Significance Index: 3.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0263
    Cell Significance Index: 48.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0258
    Cell Significance Index: 39.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0216
    Cell Significance Index: 0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0162
    Cell Significance Index: 22.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0158
    Cell Significance Index: 7.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0147
    Cell Significance Index: 9.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -9.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0150
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0222
    Cell Significance Index: -3.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0379
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0385
    Cell Significance Index: -24.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0407
    Cell Significance Index: -3.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0419
    Cell Significance Index: -2.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0497
    Cell Significance Index: -5.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0600
    Cell Significance Index: -7.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0619
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0650
    Cell Significance Index: -18.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0717
    Cell Significance Index: -2.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0774
    Cell Significance Index: -2.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0873
    Cell Significance Index: -1.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0906
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1052
    Cell Significance Index: -12.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1099
    Cell Significance Index: -23.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1530
    Cell Significance Index: -3.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1623
    Cell Significance Index: -9.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1748
    Cell Significance Index: -18.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1767
    Cell Significance Index: -8.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2049
    Cell Significance Index: -3.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2324
    Cell Significance Index: -18.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2648
    Cell Significance Index: -6.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2649
    Cell Significance Index: -6.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2820
    Cell Significance Index: -6.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2956
    Cell Significance Index: -6.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2986
    Cell Significance Index: -15.6800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3043
    Cell Significance Index: -4.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3049
    Cell Significance Index: -8.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3061
    Cell Significance Index: -7.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3146
    Cell Significance Index: -5.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3515
    Cell Significance Index: -5.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3582
    Cell Significance Index: -10.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3809
    Cell Significance Index: -12.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3885
    Cell Significance Index: -5.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3983
    Cell Significance Index: -13.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of TFIIIC**: GTF3C2 is a subunit of the TFIIIC complex, which is a crucial component of the RNA polymerase III transcription machinery. 2. **5S rRNA transcription**: GTF3C2 is specifically involved in the transcription of 5S rRNA, a crucial component of ribosomes. 3. **Highly expressed in neural cells**: GTF3C2 is highly expressed in various neural cell types, including corticothalamic-projecting glutamatergic neurons and cerebral cortex GABAergic interneurons. 4. **Cell type-specific expression**: GTF3C2 is expressed in specific cell types, such as corneal epithelial cells and absorptive cells, highlighting its potential role in tissue-specific gene regulation. **Pathways and Functions:** 1. **RNA polymerase III transcription**: GTF3C2 is involved in the transcription of 5S rRNA by RNA polymerase III, a process essential for ribosome synthesis. 2. **Gene expression regulation**: GTF3C2 plays a role in regulating gene expression by interacting with RNA polymerase III and other transcription factors. 3. **Nucleoplasmic localization**: GTF3C2 is localized to the nucleoplasm, where it interacts with RNA polymerase III and other transcription factors. 4. **Protein binding**: GTF3C2 interacts with various proteins, including RNA polymerase III and other transcription factors, to regulate gene expression. **Clinical Significance:** 1. **Neurodegenerative diseases**: Dysregulation of gene expression, including the transcription of 5S rRNA, is a hallmark of neurodegenerative diseases such as Alzheimer's and Parkinson's. GTF3C2 may play a role in the pathogenesis of these diseases. 2. **Biomarker potential**: GTF3C2 may serve as a biomarker for neurodegenerative diseases, allowing for early diagnosis and treatment. 3. **Tissue-specific gene regulation**: GTF3C2's expression in specific cell types highlights its potential role in tissue-specific gene regulation, which may be relevant in the development of tissue-specific diseases. 4. **RNA polymerase III transcription**: GTF3C2's involvement in RNA polymerase III transcription may provide insights into the regulation of ribosome synthesis and its potential role in disease pathogenesis. In conclusion, GTF3C2 is a crucial component of the TFIIIC complex, involved in the transcription of 5S rRNA by RNA polymerase III. Its high expression in neural cells and specific cell type-specific expression highlight its potential role in tissue-specific gene regulation and neurodegenerative disease pathogenesis. Further research is needed to fully elucidate the role of GTF3C2 in gene expression and its clinical significance.

Genular Protein ID: 1366792914

Symbol: TF3C2_HUMAN

Name: General transcription factor 3C polypeptide 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7729686

Title: Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors.

PubMed ID: 7729686

DOI: 10.1101/gad.9.6.675

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 911
  • Mass: 100680
  • Checksum: B59D91DE74555192
  • Sequence:
  • MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE MSLPTPLPGF 
    EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG RKRGGRTRKG PKRPQQPNPP 
    SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE LLLLKLSKDL DRPESQSPKR PPEDFETPSG 
    ERPRRRAAQV ALLYLQELAE ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD 
    GAPRDEDFFL QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP 
    NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP QEEKSPLFSV 
    QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL DWCPVPEGAG ASQYVALFSS 
    PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE SCPGNRAHFV YGIACDNGCI WDLKFCPSGA 
    WELPGTPRKA PLLPRLGLLA LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT 
    LQVGSMQATD PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS 
    LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI NSIKRFLSTE 
    LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF TAPRKGTVWS LSGSDWLGTI 
    AAGDISGELI AAILPDMALN PINVKRPVER RFPIYKADLI PYQDSPEGPD HSSASSGVPN 
    PPKARTYTET VNHHYLLFQD TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV 
    RFSPNLDSYG WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF 
    SPTSHRLLPT P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.