Details for: GTF3C2

Gene ID: 2976

Symbol: GTF3C2

Ensembl ID: ENSG00000115207

Description: general transcription factor IIIC subunit 2

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Rna polymerase iii abortive and retractive initiation
    (R-HSA-749476)
  • Rna polymerase iii transcription
    (R-HSA-74158)
  • Rna polymerase iii transcription initiation
    (R-HSA-76046)
  • Rna polymerase iii transcription initiation from type 1 promoter
    (R-HSA-76061)
  • Rna polymerase iii transcription initiation from type 2 promoter
    (R-HSA-76066)
  • 5s class rrna transcription by rna polymerase iii
    (GO:0042791)
  • Dna binding
    (GO:0003677)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Rna polymerase iii general transcription initiation factor activity
    (GO:0000995)
  • Transcription by rna polymerase iii
    (GO:0006383)
  • Transcription factor tfiiic complex
    (GO:0000127)
  • Trna transcription by rna polymerase iii
    (GO:0042797)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.25
    Marker Score: 1383
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10578
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.09
    Marker Score: 1686
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.06
    Marker Score: 9985.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.04
    Marker Score: 8970
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62676
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71724
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47948
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.98
    Marker Score: 897
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3874.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.93
    Marker Score: 544
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.93
    Marker Score: 34312
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.89
    Marker Score: 9189
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1436
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4894
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.85
    Marker Score: 3305
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.83
    Marker Score: 718
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.83
    Marker Score: 1037.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.82
    Marker Score: 12256.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.79
    Marker Score: 895
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15589
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.78
    Marker Score: 325
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 836
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.77
    Marker Score: 29174
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.76
    Marker Score: 219
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.75
    Marker Score: 1657
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11775.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.73
    Marker Score: 5627
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.73
    Marker Score: 886
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.73
    Marker Score: 426
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.72
    Marker Score: 1382
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2964
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.69
    Marker Score: 239
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.69
    Marker Score: 2840
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.68
    Marker Score: 252
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.68
    Marker Score: 330
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1601
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.68
    Marker Score: 11999.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.67
    Marker Score: 981
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.66
    Marker Score: 2751
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.65
    Marker Score: 838
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.64
    Marker Score: 240
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.62
    Marker Score: 3989
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.62
    Marker Score: 709
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.61
    Marker Score: 13055
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.61
    Marker Score: 1286
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.6
    Marker Score: 149
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.6
    Marker Score: 848
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.6
    Marker Score: 607
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6
    Marker Score: 804
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.59
    Marker Score: 162
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.59
    Marker Score: 846
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 389
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 710
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.59
    Marker Score: 620
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.59
    Marker Score: 616
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.59
    Marker Score: 237
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.58
    Marker Score: 2071
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 305
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.58
    Marker Score: 698
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.58
    Marker Score: 2488
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.57
    Marker Score: 2259
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.57
    Marker Score: 321
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.57
    Marker Score: 596
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.57
    Marker Score: 315
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.57
    Marker Score: 389
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.57
    Marker Score: 381
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.57
    Marker Score: 756
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.57
    Marker Score: 708
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.57
    Marker Score: 384
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.57
    Marker Score: 353
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.56
    Marker Score: 1926
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.56
    Marker Score: 430
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.56
    Marker Score: 227.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.56
    Marker Score: 465
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.56
    Marker Score: 560
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.55
    Marker Score: 276
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.55
    Marker Score: 582
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.55
    Marker Score: 1367
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.55
    Marker Score: 287
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.54
    Marker Score: 2268
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.54
    Marker Score: 377
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.54
    Marker Score: 574
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.54
    Marker Score: 18720
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.54
    Marker Score: 12013.5

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Other Information

**Key characteristics:** - GTF3C2 is a protein of the RPA family of transcription factors. - It is expressed in a wide range of brain cells, including neurons, glial cells, and epithelial cells. - It is a key regulator of gene expression in the developing brain. - It is involved in the regulation of a variety of cellular processes, including development, differentiation, proliferation, and apoptosis. - It is a key regulator of the expression of genes involved in cell cycle regulation, apoptosis, and differentiation. **Pathways and functions:** - GTF3C2 is a key regulator of the expression of genes involved in cell cycle regulation, apoptosis, and differentiation. - It is involved in the development of the central nervous system by regulating the expression of genes involved in neural differentiation and survival. - It is also involved in the regulation of synaptic plasticity and learning and memory. **Clinical significance:** - Mutations in GTF3C2 have been linked to a number of neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. - These mutations can lead to changes in gene expression that disrupt the normal functioning of neurons and glial cells. - As a result, GTF3C2 is a promising target for the treatment of neurodevelopmental disorders. **Additional notes:** - GTF3C2 is a highly conserved protein with a similar sequence in mice and humans. - It is a heterodimeric protein that consists of two subunits, TF3C1 and TF3C2. - TF3C1 and TF3C2 are both required for full activity.

Genular Protein ID: 1366792914

Symbol: TF3C2_HUMAN

Name: General transcription factor 3C polypeptide 2

UniProtKB Accession Codes:

Q8WUA4 D6W557 Q16632 Q9BWI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7729686

Title: Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors.

PubMed ID: 7729686

DOI: 10.1101/gad.9.6.675

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 911
  • Mass: 100680
  • Checksum: B59D91DE74555192
  • Sequence:
    • MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE MSLPTPLPGF 
EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG RKRGGRTRKG PKRPQQPNPP 
SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE LLLLKLSKDL DRPESQSPKR PPEDFETPSG 
ERPRRRAAQV ALLYLQELAE ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD 
GAPRDEDFFL QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP 
NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP QEEKSPLFSV 
QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL DWCPVPEGAG ASQYVALFSS 
PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE SCPGNRAHFV YGIACDNGCI WDLKFCPSGA 
WELPGTPRKA PLLPRLGLLA LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT 
LQVGSMQATD PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS 
LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI NSIKRFLSTE 
LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF TAPRKGTVWS LSGSDWLGTI 
AAGDISGELI AAILPDMALN PINVKRPVER RFPIYKADLI PYQDSPEGPD HSSASSGVPN 
PPKARTYTET VNHHYLLFQD TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV 
RFSPNLDSYG WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF 
SPTSHRLLPT P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.