Details for: CYP2S1

Gene ID: 29785

Symbol: CYP2S1

Ensembl ID: ENSG00000167600

Description: cytochrome P450 family 2 subfamily S member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.3168
    Cell Significance Index: -5.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.6696
    Cell Significance Index: -5.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 9.7165
    Cell Significance Index: -6.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8339
    Cell Significance Index: -5.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2171
    Cell Significance Index: 30.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0833
    Cell Significance Index: 396.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4213
    Cell Significance Index: 165.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3875
    Cell Significance Index: 30.0600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.2436
    Cell Significance Index: 9.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0517
    Cell Significance Index: 63.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9461
    Cell Significance Index: 854.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8296
    Cell Significance Index: 90.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7402
    Cell Significance Index: 33.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5880
    Cell Significance Index: 95.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5216
    Cell Significance Index: 7.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4898
    Cell Significance Index: 33.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4548
    Cell Significance Index: 13.1100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4124
    Cell Significance Index: 4.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4005
    Cell Significance Index: 84.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3974
    Cell Significance Index: 39.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3658
    Cell Significance Index: 7.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3050
    Cell Significance Index: 4.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2743
    Cell Significance Index: 14.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2500
    Cell Significance Index: 5.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2278
    Cell Significance Index: 8.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2243
    Cell Significance Index: 25.6000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1868
    Cell Significance Index: 0.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1854
    Cell Significance Index: 5.1800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1619
    Cell Significance Index: 1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1555
    Cell Significance Index: 4.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1087
    Cell Significance Index: 1.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0962
    Cell Significance Index: 1.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0876
    Cell Significance Index: 2.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0731
    Cell Significance Index: 32.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0636
    Cell Significance Index: 39.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0624
    Cell Significance Index: 2.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0411
    Cell Significance Index: 2.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0397
    Cell Significance Index: 21.6800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0315
    Cell Significance Index: 0.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0266
    Cell Significance Index: 18.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0163
    Cell Significance Index: 5.8400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0146
    Cell Significance Index: 0.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0016
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0002
    Cell Significance Index: 0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0050
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0066
    Cell Significance Index: -1.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0073
    Cell Significance Index: -1.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0086
    Cell Significance Index: -5.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0097
    Cell Significance Index: -2.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0137
    Cell Significance Index: -6.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0165
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0193
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0265
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0279
    Cell Significance Index: -3.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0294
    Cell Significance Index: -3.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0339
    Cell Significance Index: -4.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0364
    Cell Significance Index: -5.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0369
    Cell Significance Index: -2.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0533
    Cell Significance Index: -6.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0571
    Cell Significance Index: -5.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0584
    Cell Significance Index: -2.9500
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0616
    Cell Significance Index: -0.5300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0647
    Cell Significance Index: -0.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0663
    Cell Significance Index: -2.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0794
    Cell Significance Index: -2.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0817
    Cell Significance Index: -1.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0825
    Cell Significance Index: -1.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0846
    Cell Significance Index: -6.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0854
    Cell Significance Index: -3.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0908
    Cell Significance Index: -6.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0913
    Cell Significance Index: -6.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0916
    Cell Significance Index: -5.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0972
    Cell Significance Index: -6.2700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0974
    Cell Significance Index: -0.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0995
    Cell Significance Index: -6.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1077
    Cell Significance Index: -5.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1090
    Cell Significance Index: -5.6800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1150
    Cell Significance Index: -1.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1189
    Cell Significance Index: -6.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1219
    Cell Significance Index: -4.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1278
    Cell Significance Index: -4.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1289
    Cell Significance Index: -6.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1292
    Cell Significance Index: -4.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1318
    Cell Significance Index: -5.8300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1321
    Cell Significance Index: -1.9900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1332
    Cell Significance Index: -1.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1334
    Cell Significance Index: -4.2500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1402
    Cell Significance Index: -0.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1526
    Cell Significance Index: -5.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1832
    Cell Significance Index: -6.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1832
    Cell Significance Index: -4.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1857
    Cell Significance Index: -2.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1950
    Cell Significance Index: -4.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** CYP2S1 exhibits a high degree of substrate specificity, primarily targeting arachidonic acid and icosanoids, which are essential for immune cell function and inflammation regulation. 2. **Cofactor requirements:** This enzyme relies on the presence of reduced flavin or flavoprotein as a cofactor, which is essential for its catalytic activity. 3. **Expression patterns:** CYP2S1 is expressed in various cell types, including immune cells, epithelial cells, and neural cells, indicating its potential role in multiple physiological processes. **Pathways and Functions:** 1. **Arachidonic acid epoxygenation:** CYP2S1 catalyzes the conversion of arachidonic acid to 12-hydroxyheptadecatrienoic acid, a potent anti-inflammatory metabolite. 2. **Prostaglandin metabolic process:** This enzyme participates in the synthesis and degradation of prostaglandins, which play a crucial role in inflammation and immune response regulation. 3. **Icosanoid metabolic process:** CYP2S1 is involved in the synthesis and degradation of icosanoids, which are essential for immune cell function and inflammation regulation. 4. **Cytochrome metabolic process:** This enzyme is involved in the metabolism of cytochromes, which are essential for the regulation of oxidative stress and immune response. **Clinical Significance:** CYP2S1 has been implicated in various immune and metabolic disorders, including: 1. **Inflammatory diseases:** Alterations in CYP2S1 expression and activity have been observed in inflammatory diseases, such as asthma and rheumatoid arthritis. 2. **Cancer:** CYP2S1 has been implicated in the development and progression of certain cancers, including colon cancer. 3. **Neurological disorders:** This enzyme has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders:** CYP2S1 has been implicated in metabolic disorders, such as obesity and type 2 diabetes. In conclusion, CYP2S1 plays a critical role in modulating the immune response and metabolic processes, and its dysregulation has been implicated in various immune and metabolic disorders. Further research is needed to elucidate the mechanisms underlying CYP2S1-mediated immune and metabolic regulation, and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 3324552607

Symbol: CP2S1_HUMAN

Name: CYPIIS1

UniProtKB Accession Codes:

Q96SQ9 Q9BZ66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 34 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 20 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11181079

Title: Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).

PubMed ID: 11181079

DOI: 10.1006/bbrc.2001.4390

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12711469

Title: Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

PubMed ID: 12711469

DOI: 10.1016/s0140-6736(03)13081-4

PubMed ID: 21068195

Title: Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.

PubMed ID: 21068195

DOI: 10.1124/dmd.110.035121

Sequence Information:

  • Length: 504
  • Mass: 55817
  • Checksum: 853513370F65E25A
  • Sequence:
    • MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP GALYSGLMRL 
SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG RGTVAMLEGT FDGHGVFFSN 
GERWRQLRKF TMLALRDLGM GKREGEELIQ AEARCLVETF QGTEGRPFDP SLLLAQATSN 
VVCSLLFGLR FSYEDKEFQA VVRAAGGTLL GVSSQGGQTY EMFSWFLRPL PGPHKQLLHH 
VSTLAAFTVR QVQQHQGNLD ASGPARDLVD AFLLKMAQEE QNPGTEFTNK NMLMTVIYLL 
FAGTMTVSTT VGYTLLLLMK YPHVQKWVRE ELNRELGAGQ APSLGDRTRL PYTDAVLHEA 
QRLLALVPMG IPRTLMRTTR FRGYTLPQGT EVFPLLGSIL HDPNIFKHPE EFNPDRFLDA 
DGRFRKHEAF LPFSLGKRVC LGEGLAKAEL FLFFTTILQA FSLESPCPPD TLSLKPTVSG 
LFNIPPAFQL QVRPTDLHST TQTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.