Details for: SNX10

Gene ID: 29887

Symbol: SNX10

Ensembl ID: ENSG00000086300

Description: sorting nexin 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.9743
    Cell Significance Index: -27.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.1409
    Cell Significance Index: -22.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.1742
    Cell Significance Index: -27.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.1848
    Cell Significance Index: -29.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6150
    Cell Significance Index: -27.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3893
    Cell Significance Index: -27.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0343
    Cell Significance Index: -30.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 9.8697
    Cell Significance Index: 158.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4514
    Cell Significance Index: -22.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0552
    Cell Significance Index: -27.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0450
    Cell Significance Index: -13.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.6889
    Cell Significance Index: 68.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.5969
    Cell Significance Index: 55.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5840
    Cell Significance Index: 56.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0944
    Cell Significance Index: 109.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0878
    Cell Significance Index: 418.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.6868
    Cell Significance Index: 245.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4967
    Cell Significance Index: 42.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3411
    Cell Significance Index: 481.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3255
    Cell Significance Index: 252.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0800
    Cell Significance Index: 106.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0163
    Cell Significance Index: 17.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9818
    Cell Significance Index: 20.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7658
    Cell Significance Index: 51.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6726
    Cell Significance Index: 133.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6405
    Cell Significance Index: 75.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6173
    Cell Significance Index: 557.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5544
    Cell Significance Index: 90.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5308
    Cell Significance Index: 23.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5110
    Cell Significance Index: 19.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4852
    Cell Significance Index: 52.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4682
    Cell Significance Index: 323.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3713
    Cell Significance Index: 4.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3540
    Cell Significance Index: 21.2600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3476
    Cell Significance Index: 2.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2912
    Cell Significance Index: 17.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2426
    Cell Significance Index: 5.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1925
    Cell Significance Index: 5.1500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1295
    Cell Significance Index: 0.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0770
    Cell Significance Index: 2.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0554
    Cell Significance Index: 40.6300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0547
    Cell Significance Index: 0.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0542
    Cell Significance Index: 1.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0414
    Cell Significance Index: 0.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0354
    Cell Significance Index: 4.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0329
    Cell Significance Index: 61.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0011
    Cell Significance Index: 0.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0008
    Cell Significance Index: 0.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0025
    Cell Significance Index: -0.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0088
    Cell Significance Index: -3.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0141
    Cell Significance Index: -7.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0218
    Cell Significance Index: -2.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0339
    Cell Significance Index: -25.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0341
    Cell Significance Index: -0.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0365
    Cell Significance Index: -0.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0379
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0558
    Cell Significance Index: -11.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0568
    Cell Significance Index: -3.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0573
    Cell Significance Index: -26.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0604
    Cell Significance Index: -6.9000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0663
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0745
    Cell Significance Index: -21.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0829
    Cell Significance Index: -4.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0915
    Cell Significance Index: -1.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0988
    Cell Significance Index: -6.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1073
    Cell Significance Index: -2.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1123
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1237
    Cell Significance Index: -14.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1289
    Cell Significance Index: -23.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1497
    Cell Significance Index: -9.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1558
    Cell Significance Index: -12.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1635
    Cell Significance Index: -3.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1783
    Cell Significance Index: -23.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1856
    Cell Significance Index: -2.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1945
    Cell Significance Index: -23.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2047
    Cell Significance Index: -12.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2152
    Cell Significance Index: -4.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2316
    Cell Significance Index: -29.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2515
    Cell Significance Index: -11.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2634
    Cell Significance Index: -27.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2685
    Cell Significance Index: -5.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2848
    Cell Significance Index: -7.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2881
    Cell Significance Index: -9.1800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2927
    Cell Significance Index: -3.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3121
    Cell Significance Index: -4.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3239
    Cell Significance Index: -10.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3314
    Cell Significance Index: -25.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3400
    Cell Significance Index: -10.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3652
    Cell Significance Index: -7.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4035
    Cell Significance Index: -21.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4173
    Cell Significance Index: -29.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4337
    Cell Significance Index: -22.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX10 exhibits a unique combination of characteristics that enable it to interact with various cellular components. Some of its key features include: 1. **Cellular localization:** SNX10 is predominantly expressed in cells of the immune system, including alveolar macrophages, classical monocytes, and myeloid leukocytes. Its expression is also detected in other cell types, such as Mueller cells, GABAergic amacrine cells, and kidney distal convoluted tubule epithelial cells. 2. **Protein binding:** SNX10 interacts with a range of proteins, including phosphatidylinositol-binding proteins, ATPases, and other sorting nexins. 3. **Pathway involvement:** SNX10 is implicated in various cellular pathways, including endocytosis, exocytosis, protein localization, and cellular homeostasis. **Pathways and Functions:** SNX10's involvement in various cellular pathways highlights its multifaceted role in maintaining cellular homeostasis. Some of its key functions include: 1. **Endocytosis and exocytosis:** SNX10 regulates the internalization and release of proteins and lipids through its interactions with endocytic and exocytic pathways. 2. **Protein localization:** SNX10 ensures the correct localization of proteins within the cell by regulating their trafficking through the endomembrane system. 3. **Cellular homeostasis:** SNX10 maintains cellular homeostasis by regulating the activity of various cellular components, including ATPases and phosphatidylinositol-binding proteins. 4. **Bone mineralization and resorption:** SNX10 is involved in the regulation of bone mineralization and resorption, highlighting its significance in bone health. 5. **Leukemia inhibitory factor (LIF) signaling:** SNX10 interacts with LIF receptors, regulating the activity of this cytokine and its downstream signaling pathways. **Clinical Significance:** The clinical significance of SNX10 lies in its potential role in various diseases, including: 1. **Bone disorders:** SNX10's involvement in bone mineralization and resorption highlights its potential role in diseases such as osteoporosis and bone cancer. 2. **Immune system disorders:** SNX10's expression in immune cells suggests its potential role in immune system disorders, such as autoimmune diseases and immunodeficiencies. 3. **Neurological disorders:** SNX10's expression in GABAergic amacrine cells and other neuronal cells highlights its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. In conclusion, SNX10 is a complex gene with diverse cellular and physiological implications. Its multifaceted role in various cellular pathways underscores its significance in maintaining cellular homeostasis. Further research is necessary to elucidate the full extent of SNX10's clinical significance and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2888142373

Symbol: SNX10_HUMAN

Name: Sorting nexin-10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17012226

Title: Sorting nexin 10 induces giant vacuoles in mammalian cells.

PubMed ID: 17012226

DOI: 10.1074/jbc.m608884200

PubMed ID: 21844891

Title: A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.

PubMed ID: 21844891

DOI: 10.1038/cr.2011.134

PubMed ID: 22174188

Title: SNX10 is required for osteoclast formation and resorption activity.

PubMed ID: 22174188

DOI: 10.1002/jcb.24029

PubMed ID: 23123320

Title: Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia.

PubMed ID: 23123320

DOI: 10.1016/j.ejmg.2012.10.010

PubMed ID: 22499339

Title: An SNX10 mutation causes malignant osteopetrosis of infancy.

PubMed ID: 22499339

DOI: 10.1136/jmedgenet-2011-100520

PubMed ID: 23280965

Title: SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity.

PubMed ID: 23280965

DOI: 10.1002/jbmr.1849

Sequence Information:

  • Length: 201
  • Mass: 23598
  • Checksum: 665B80734D5E5C72
  • Sequence:
  • MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV RRRYREFVWL 
    RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED FLRKVLQNAL LLSDSSLHLF 
    LQSHLNSEDI EACVSGQTKY SVEEAIHKFA LMNRRFPEED EEGKKENDID YDSESSSSGL 
    GHSSDDSSSH GCKVNTAPQE S

Genular Protein ID: 3493846005

Symbol: Q8N5Z3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 201
  • Mass: 23646
  • Checksum: DB4751BE51935C67
  • Sequence:
  • MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV RRRYREFVWL 
    RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED FLRKVLQNAL LLSYSSLHLF 
    LQSHLNSEDI EACVSGQTKY SVEEAIHKFA LMNRRFPEED EEGKKENDID YDSESSSSGL 
    GHSSDDSSSH GCKVNTAPQE S

Genular Protein ID: 2678619654

Symbol: B4DJM0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 227
  • Mass: 26322
  • Checksum: 5E5A5A8D93FEDE2A
  • Sequence:
  • MILMEGIGCM RHSSLTRQPK LPYRSLASAR GGLQEFVSVW VRDPRIQKED FWHSYIDYEI 
    CIHTNSMCFT MKTSCVRRRY REFVWLRQRL QSNALLVQLP ELPSKNLFFN MNNRQHVDQR 
    RQGLEDFLRK VLQNALLLSD SSLHLFLQSH LNSEDIEACV SGQTKYSVEE AIHKFALMNR 
    RFPEEDEEGK KENDIDYDSE SSSSGLGHSS DDSSSHGCKV NTAPQES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.