Details for: SNX15

Gene ID: 29907

Symbol: SNX15

Ensembl ID: ENSG00000110025

Description: sorting nexin 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.93
    Marker Score: 1,391
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 3.84
    Marker Score: 2,970
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.9
    Marker Score: 1,884
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.39
    Marker Score: 2,872
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7,607
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1
    Marker Score: 707
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1,816
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.95
    Marker Score: 989
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,319
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.92
    Marker Score: 559
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 620
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13,485
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1,707
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7
    Marker Score: 6,136
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,855
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.59
    Marker Score: 190
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 334
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.55
    Marker Score: 4,741
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 249
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.51
    Marker Score: 343
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.49
    Marker Score: 213
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.46
    Marker Score: 418
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.45
    Marker Score: 451
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.44
    Marker Score: 448
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 140
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.43
    Marker Score: 4,111
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.43
    Marker Score: 26,449
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.43
    Marker Score: 429
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.42
    Marker Score: 647
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 984
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.4
    Marker Score: 201
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 121
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.38
    Marker Score: 222
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.37
    Marker Score: 269
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.37
    Marker Score: 3,494
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 153
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.34
    Marker Score: 166
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.32
    Marker Score: 255
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.31
    Marker Score: 1,181
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.3
    Marker Score: 366
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.29
    Marker Score: 131
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 166
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.27
    Marker Score: 312
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.27
    Marker Score: 458
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.26
    Marker Score: 716
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.25
    Marker Score: 9,459
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.24
    Marker Score: 3,651
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.24
    Marker Score: 8,956
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.24
    Marker Score: 1,036
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.24
    Marker Score: 8,211
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 104
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.24
    Marker Score: 616
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 151
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.23
    Marker Score: 97
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.23
    Marker Score: 4,534
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.22
    Marker Score: 4,754
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.22
    Marker Score: 541
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.21
    Marker Score: 1,613
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.21
    Marker Score: 179
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.19
    Marker Score: 785
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.18
    Marker Score: 150
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.18
    Marker Score: 860
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 73
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 184
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.16
    Marker Score: 109
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.15
    Marker Score: 371
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.15
    Marker Score: 62

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphatidylinositol binding**: SNX15 interacts with phosphatidylinositol (PI) lipids, which are essential components of cellular membranes. This interaction is crucial for its ability to regulate protein transport. 2. **Intracellular protein transport**: SNX15 is involved in the transport of proteins between the plasma membrane and intracellular vesicles, including endosomes and lysosomes. 3. **Regulation of membrane trafficking**: SNX15 modulates the activity of other proteins involved in membrane trafficking, such as the clathrin-coated pit and the Golgi apparatus. 4. **Cellular localization**: SNX15 is predominantly localized to the plasma membrane and intracellular vesicles, with some expression in the nucleus. **Pathways and Functions:** 1. **Cytoplasmic vesicle membrane**: SNX15 regulates the transport of proteins between the plasma membrane and cytoplasmic vesicles, including endosomes and lysosomes. 2. **Intracellular protein transport**: SNX15 is involved in the transport of proteins between the plasma membrane and intracellular vesicles, including the Golgi apparatus and lysosomes. 3. **Membrane trafficking**: SNX15 modulates the activity of other proteins involved in membrane trafficking, such as the clathrin-coated pit. 4. **Phosphatidylinositol binding**: SNX15 interacts with phosphatidylinositol (PI) lipids, which are essential components of cellular membranes. **Clinical Significance:** 1. **Immunological disorders**: SNX15 has been implicated in various immunological disorders, including multiple sclerosis and rheumatoid arthritis, where it plays a role in regulating immune cell function and protein transport. 2. **Cancer**: SNX15 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological disorders**: SNX15 has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, where it may play a role in regulating protein transport and aggregation. 4. **Metabolic disorders**: SNX15 has been found to be involved in regulating protein transport and lipid metabolism, which may contribute to the development of metabolic disorders, such as obesity and diabetes. In conclusion, SNX15 is a novel sorting nexin that plays a critical role in regulating intracellular protein transport and membrane trafficking. Its involvement in various cellular processes, including immunological, neurological, and metabolic disorders, highlights its importance as a potential therapeutic target for the treatment of these diseases.

Genular Protein ID: 1267597507

Symbol: SNX15_HUMAN

Name: Sorting nexin-15

UniProtKB Accession Codes:

Q9NRS6 E5KQS6 Q9NRS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 DMDM 1 DNASU 1 EMBL 48 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11085978

Title: Identification and characterization of snx15, a novel sorting nexin involved in protein trafficking.

PubMed ID: 11085978

DOI: 10.1074/jbc.m004671200

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 342
  • Mass: 38291
  • Checksum: 33F64A79EAF6BBDC
  • Sequence:
    • MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG 
DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK 
EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS 
PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE 
SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH 
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.