Details for: SNX15

Gene ID: 29907

Symbol: SNX15

Ensembl ID: ENSG00000110025

Description: sorting nexin 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.6459
    Cell Significance Index: -5.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 14.0362
    Cell Significance Index: -7.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.4572
    Cell Significance Index: -6.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7624
    Cell Significance Index: -7.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7814
    Cell Significance Index: 40.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5537
    Cell Significance Index: 60.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4568
    Cell Significance Index: 2.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3283
    Cell Significance Index: 3.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2861
    Cell Significance Index: 19.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2694
    Cell Significance Index: 34.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2693
    Cell Significance Index: 5.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2555
    Cell Significance Index: 46.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2472
    Cell Significance Index: 47.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2360
    Cell Significance Index: 29.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2325
    Cell Significance Index: 209.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2243
    Cell Significance Index: 44.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2189
    Cell Significance Index: 21.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1615
    Cell Significance Index: 26.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1450
    Cell Significance Index: 1.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1274
    Cell Significance Index: 3.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1231
    Cell Significance Index: 44.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1184
    Cell Significance Index: 2.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1058
    Cell Significance Index: 73.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0946
    Cell Significance Index: 4.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0864
    Cell Significance Index: 6.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0458
    Cell Significance Index: 1.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0428
    Cell Significance Index: 2.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0268
    Cell Significance Index: 1.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0253
    Cell Significance Index: 0.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0241
    Cell Significance Index: 1.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0105
    Cell Significance Index: 0.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0092
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0094
    Cell Significance Index: -7.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0103
    Cell Significance Index: -5.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0104
    Cell Significance Index: -4.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0119
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0126
    Cell Significance Index: -7.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0149
    Cell Significance Index: -2.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0201
    Cell Significance Index: -0.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0242
    Cell Significance Index: -6.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0280
    Cell Significance Index: -1.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0297
    Cell Significance Index: -0.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0349
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0358
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0362
    Cell Significance Index: -7.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0384
    Cell Significance Index: -7.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0413
    Cell Significance Index: -7.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0446
    Cell Significance Index: -5.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0453
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0502
    Cell Significance Index: -5.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0511
    Cell Significance Index: -1.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0520
    Cell Significance Index: -5.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0533
    Cell Significance Index: -6.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0541
    Cell Significance Index: -1.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0653
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0669
    Cell Significance Index: -6.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0673
    Cell Significance Index: -2.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0780
    Cell Significance Index: -2.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0789
    Cell Significance Index: -3.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0908
    Cell Significance Index: -6.7700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0910
    Cell Significance Index: -0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0951
    Cell Significance Index: -2.5400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0971
    Cell Significance Index: -0.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0985
    Cell Significance Index: -4.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1017
    Cell Significance Index: -6.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1029
    Cell Significance Index: -2.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1034
    Cell Significance Index: -2.4800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1048
    Cell Significance Index: -1.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1100
    Cell Significance Index: -7.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1160
    Cell Significance Index: -7.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1173
    Cell Significance Index: -6.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1207
    Cell Significance Index: -5.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1227
    Cell Significance Index: -1.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1368
    Cell Significance Index: -7.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1428
    Cell Significance Index: -3.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1488
    Cell Significance Index: -2.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1522
    Cell Significance Index: -2.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1538
    Cell Significance Index: -2.6600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1629
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1631
    Cell Significance Index: -5.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1646
    Cell Significance Index: -1.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1665
    Cell Significance Index: -4.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1684
    Cell Significance Index: -3.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1686
    Cell Significance Index: -4.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1704
    Cell Significance Index: -5.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1749
    Cell Significance Index: -5.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1810
    Cell Significance Index: -6.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1883
    Cell Significance Index: -3.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1892
    Cell Significance Index: -3.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1894
    Cell Significance Index: -7.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1903
    Cell Significance Index: -3.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphatidylinositol binding**: SNX15 interacts with phosphatidylinositol (PI) lipids, which are essential components of cellular membranes. This interaction is crucial for its ability to regulate protein transport. 2. **Intracellular protein transport**: SNX15 is involved in the transport of proteins between the plasma membrane and intracellular vesicles, including endosomes and lysosomes. 3. **Regulation of membrane trafficking**: SNX15 modulates the activity of other proteins involved in membrane trafficking, such as the clathrin-coated pit and the Golgi apparatus. 4. **Cellular localization**: SNX15 is predominantly localized to the plasma membrane and intracellular vesicles, with some expression in the nucleus. **Pathways and Functions:** 1. **Cytoplasmic vesicle membrane**: SNX15 regulates the transport of proteins between the plasma membrane and cytoplasmic vesicles, including endosomes and lysosomes. 2. **Intracellular protein transport**: SNX15 is involved in the transport of proteins between the plasma membrane and intracellular vesicles, including the Golgi apparatus and lysosomes. 3. **Membrane trafficking**: SNX15 modulates the activity of other proteins involved in membrane trafficking, such as the clathrin-coated pit. 4. **Phosphatidylinositol binding**: SNX15 interacts with phosphatidylinositol (PI) lipids, which are essential components of cellular membranes. **Clinical Significance:** 1. **Immunological disorders**: SNX15 has been implicated in various immunological disorders, including multiple sclerosis and rheumatoid arthritis, where it plays a role in regulating immune cell function and protein transport. 2. **Cancer**: SNX15 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological disorders**: SNX15 has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, where it may play a role in regulating protein transport and aggregation. 4. **Metabolic disorders**: SNX15 has been found to be involved in regulating protein transport and lipid metabolism, which may contribute to the development of metabolic disorders, such as obesity and diabetes. In conclusion, SNX15 is a novel sorting nexin that plays a critical role in regulating intracellular protein transport and membrane trafficking. Its involvement in various cellular processes, including immunological, neurological, and metabolic disorders, highlights its importance as a potential therapeutic target for the treatment of these diseases.

Genular Protein ID: 1267597507

Symbol: SNX15_HUMAN

Name: Sorting nexin-15

UniProtKB Accession Codes:

Q9NRS6 E5KQS6 Q9NRS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 48 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11085978

Title: Identification and characterization of snx15, a novel sorting nexin involved in protein trafficking.

PubMed ID: 11085978

DOI: 10.1074/jbc.m004671200

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 342
  • Mass: 38291
  • Checksum: 33F64A79EAF6BBDC
  • Sequence:
    • MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG 
DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK 
EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS 
PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE 
SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH 
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.