Details for: MDFIC

Gene ID: 29969

Symbol: MDFIC

Ensembl ID: ENSG00000135272

Description: MyoD family inhibitor domain containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 206.6602
    Cell Significance Index: -32.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.6525
    Cell Significance Index: -31.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.4465
    Cell Significance Index: -31.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.1859
    Cell Significance Index: -31.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.8665
    Cell Significance Index: -27.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.0632
    Cell Significance Index: -31.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.4527
    Cell Significance Index: -27.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0715
    Cell Significance Index: -32.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.9483
    Cell Significance Index: -26.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3294
    Cell Significance Index: -30.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5367
    Cell Significance Index: -26.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1575
    Cell Significance Index: -32.1900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 7.5715
    Cell Significance Index: 32.9600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.8262
    Cell Significance Index: 48.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.3959
    Cell Significance Index: 64.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8678
    Cell Significance Index: 36.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7304
    Cell Significance Index: 37.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4253
    Cell Significance Index: 20.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3287
    Cell Significance Index: 74.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9347
    Cell Significance Index: 177.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9294
    Cell Significance Index: 12.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7257
    Cell Significance Index: 55.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7170
    Cell Significance Index: 84.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6924
    Cell Significance Index: 68.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5527
    Cell Significance Index: 5.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5153
    Cell Significance Index: 10.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4785
    Cell Significance Index: 10.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4699
    Cell Significance Index: 21.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4399
    Cell Significance Index: 87.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4042
    Cell Significance Index: 364.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4037
    Cell Significance Index: 72.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4026
    Cell Significance Index: 11.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3914
    Cell Significance Index: 63.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2872
    Cell Significance Index: 31.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2762
    Cell Significance Index: 7.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2742
    Cell Significance Index: 55.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2009
    Cell Significance Index: 25.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1859
    Cell Significance Index: 22.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1451
    Cell Significance Index: 8.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1390
    Cell Significance Index: 7.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1254
    Cell Significance Index: 1.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1160
    Cell Significance Index: 15.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0729
    Cell Significance Index: 2.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0594
    Cell Significance Index: 6.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0581
    Cell Significance Index: 2.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0141
    Cell Significance Index: 26.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0126
    Cell Significance Index: 17.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0104
    Cell Significance Index: 15.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0042
    Cell Significance Index: 1.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0006
    Cell Significance Index: 0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0114
    Cell Significance Index: -7.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0157
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0193
    Cell Significance Index: -12.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0212
    Cell Significance Index: -15.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0224
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0240
    Cell Significance Index: -0.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0378
    Cell Significance Index: -5.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0443
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0453
    Cell Significance Index: -7.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0736
    Cell Significance Index: -26.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0774
    Cell Significance Index: -5.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0781
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0789
    Cell Significance Index: -16.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0797
    Cell Significance Index: -8.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0805
    Cell Significance Index: -2.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0807
    Cell Significance Index: -23.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0931
    Cell Significance Index: -5.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1041
    Cell Significance Index: -1.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1347
    Cell Significance Index: -1.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1745
    Cell Significance Index: -8.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1857
    Cell Significance Index: -21.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1907
    Cell Significance Index: -24.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2194
    Cell Significance Index: -3.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2256
    Cell Significance Index: -3.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2337
    Cell Significance Index: -3.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2416
    Cell Significance Index: -25.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2913
    Cell Significance Index: -20.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3231
    Cell Significance Index: -10.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3281
    Cell Significance Index: -9.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3329
    Cell Significance Index: -7.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3358
    Cell Significance Index: -25.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3381
    Cell Significance Index: -26.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3548
    Cell Significance Index: -18.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3800
    Cell Significance Index: -19.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4244
    Cell Significance Index: -26.7500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4640
    Cell Significance Index: -3.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4650
    Cell Significance Index: -28.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4758
    Cell Significance Index: -12.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4939
    Cell Significance Index: -33.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5030
    Cell Significance Index: -7.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5113
    Cell Significance Index: -16.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5480
    Cell Significance Index: -14.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MDFIC gene is a protein-coding gene that belongs to the MyoD family, which is involved in muscle development and differentiation. The gene is characterized by its unique inhibitor domain, which is responsible for regulating gene expression and transcription. MDFIC is predominantly expressed in cells of neural, muscular, and epithelial lineages, including neural progenitor cells, skeletal muscle satellite stem cells, and Purkinje cells. **Pathways and Functions:** MDFIC is involved in various cellular processes, including: 1. **Transcription Regulation:** MDFIC acts as a negative regulator of DNA-templated transcription, inhibiting the activity of transcription factors such as MyoD and Myf5, which are essential for muscle development and differentiation. 2. **Cellular Differentiation:** MDFIC is involved in the regulation of cellular differentiation, particularly in neural and muscular lineages. It modulates the expression of genes involved in cell fate determination and differentiation. 3. **Signaling Pathways:** MDFIC interacts with various signaling pathways, including the Wnt/β-catenin and JNK cascades, which are crucial for cellular development and differentiation. 4. **Protein Binding:** MDFIC binds to various proteins, including Tat protein and transcription factors, regulating their activity and function. **Clinical Significance:** The MDFIC gene has significant implications for various diseases and conditions, including: 1. **Muscular Dystrophy:** Mutations in the MDFIC gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Neurological Disorders:** MDFIC has been implicated in neurological disorders, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS), where it regulates gene expression and cellular differentiation in neural cells. 3. **Cancer:** MDFIC has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it regulates cell proliferation and differentiation. In conclusion, the MDFIC gene plays a crucial role in regulating gene expression and cellular differentiation, particularly in neural and muscular lineages. Its dysregulation has been implicated in various diseases and conditions, highlighting the need for further research into the functions and significance of this gene. **Recommendations:** Further studies are necessary to fully elucidate the functions and significance of the MDFIC gene. Researchers should focus on: 1. **Molecular Characterization:** Elucidating the molecular mechanisms by which MDFIC regulates gene expression and transcription. 2. **Cellular Differentiation:** Investigating the role of MDFIC in cellular differentiation, particularly in neural and muscular lineages. 3. **Disease Modeling:** Developing disease models to study the impact of MDFIC dysregulation on various diseases and conditions. By advancing our understanding of the MDFIC gene, researchers can uncover new therapeutic strategies for treating diseases and conditions associated with its dysregulation.

Genular Protein ID: 2165039460

Symbol: MDFIC_HUMAN

Name: MyoD family inhibitor domain-containing protein

UniProtKB Accession Codes:

Q9P1T7 Q9P1T6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TCDB 2 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10671520

Title: Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression.

PubMed ID: 10671520

DOI: 10.1074/jbc.275.7.4848

PubMed ID: 16260749

Title: Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity.

PubMed ID: 16260749

DOI: 10.1073/pnas.0503519102

PubMed ID: 11139147

Title: Sequence requirement for the nucleolar localization of human I-mfa domain-containing protein (HIC p40).

PubMed ID: 11139147

DOI: 10.1078/0171-9335-00111

PubMed ID: 12192039

Title: I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.

PubMed ID: 12192039

DOI: 10.1128/mcb.22.18.6393-6405.2002

PubMed ID: 12944466

Title: The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.

PubMed ID: 12944466

DOI: 10.1128/mcb.23.18.6373-6384.2003

Title: The human I-mfa domain containing protein, HIC, interacts with HIV-1 Tat and Rev and sequesters them in the cytoplasm.

DOI: 10.1186/1742-4690-3-S1-S106

PubMed ID: 17289077

Title: Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.

PubMed ID: 17289077

DOI: 10.1016/j.jmb.2007.01.020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35235341

Title: Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.

PubMed ID: 35235341

DOI: 10.1126/scitranslmed.abm4869

Sequence Information:

  • Length: 246
  • Mass: 25788
  • Checksum: B8DAAE9ADF5772A0
  • Sequence:
    • MSGAGEALAP GPVGPQRVAE AGGGQLGSTA QGKCDKDNTE KDITQATNSH FTHGEMQDQS 
IWGNPSDGEL IRTQPQRLPQ LQTSAQVPSG EEIGKIKNGH TGLSNGNGIH HGAKHGSADN 
RKLSAPVSQK MHRKIQSSLS VNSDISKKSK VNAVFSQKTG SSPEDCCVHC ILACLFCEFL 
TLCNIVLGQA SCGICTSEAC CCCCGDEMGD DCNCPCDMDC GIMDACCESS DCLEICMECC 
GICFPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.