Details for: BICRA

Gene ID: 29998

Symbol: BICRA

Ensembl ID: ENSG00000063169

Description: BRD4 interacting chromatin remodeling complex associated protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.7039
    Cell Significance Index: -8.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7093
    Cell Significance Index: -5.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3738
    Cell Significance Index: 261.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8787
    Cell Significance Index: 86.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7414
    Cell Significance Index: 17.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7314
    Cell Significance Index: 660.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5460
    Cell Significance Index: 33.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5085
    Cell Significance Index: 55.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4775
    Cell Significance Index: 77.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4549
    Cell Significance Index: 27.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3973
    Cell Significance Index: 274.8100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3733
    Cell Significance Index: 4.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3519
    Cell Significance Index: 10.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2967
    Cell Significance Index: 18.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2708
    Cell Significance Index: 18.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2609
    Cell Significance Index: 30.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1925
    Cell Significance Index: 38.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1577
    Cell Significance Index: 8.1900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1459
    Cell Significance Index: 2.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1447
    Cell Significance Index: 6.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0795
    Cell Significance Index: 10.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0775
    Cell Significance Index: 27.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0734
    Cell Significance Index: 13.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0731
    Cell Significance Index: 3.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0719
    Cell Significance Index: 31.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0700
    Cell Significance Index: 5.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0582
    Cell Significance Index: 1.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0494
    Cell Significance Index: 0.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0466
    Cell Significance Index: 25.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0455
    Cell Significance Index: 1.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0351
    Cell Significance Index: 4.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0284
    Cell Significance Index: 0.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0246
    Cell Significance Index: 1.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0228
    Cell Significance Index: 2.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0223
    Cell Significance Index: 2.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0105
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0022
    Cell Significance Index: 0.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0012
    Cell Significance Index: -0.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0129
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -8.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0208
    Cell Significance Index: -9.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0267
    Cell Significance Index: -7.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0297
    Cell Significance Index: -3.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0362
    Cell Significance Index: -2.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0377
    Cell Significance Index: -3.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0380
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0464
    Cell Significance Index: -9.7800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0476
    Cell Significance Index: -0.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0492
    Cell Significance Index: -6.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0531
    Cell Significance Index: -3.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0532
    Cell Significance Index: -0.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0607
    Cell Significance Index: -4.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0618
    Cell Significance Index: -8.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0756
    Cell Significance Index: -3.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0910
    Cell Significance Index: -3.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0914
    Cell Significance Index: -2.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0928
    Cell Significance Index: -9.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0933
    Cell Significance Index: -2.4900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0942
    Cell Significance Index: -1.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1072
    Cell Significance Index: -2.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1088
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1093
    Cell Significance Index: -8.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1112
    Cell Significance Index: -3.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1121
    Cell Significance Index: -1.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1140
    Cell Significance Index: -2.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1142
    Cell Significance Index: -3.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1211
    Cell Significance Index: -3.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1253
    Cell Significance Index: -1.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1257
    Cell Significance Index: -7.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1296
    Cell Significance Index: -0.8600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1317
    Cell Significance Index: -1.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1348
    Cell Significance Index: -2.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1410
    Cell Significance Index: -4.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1414
    Cell Significance Index: -7.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1415
    Cell Significance Index: -2.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1473
    Cell Significance Index: -5.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1527
    Cell Significance Index: -3.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1604
    Cell Significance Index: -4.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1629
    Cell Significance Index: -3.5200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1722
    Cell Significance Index: -1.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1788
    Cell Significance Index: -4.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1825
    Cell Significance Index: -3.1600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1893
    Cell Significance Index: -3.9500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1990
    Cell Significance Index: -2.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2013
    Cell Significance Index: -3.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2055
    Cell Significance Index: -3.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2074
    Cell Significance Index: -5.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2111
    Cell Significance Index: -7.7500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2234
    Cell Significance Index: -3.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BICRA is a protein that interacts with the BRD4 complex, a chromatin remodeling complex that plays a pivotal role in regulating gene expression. The BICRA protein is specifically expressed in various cell types, including immature innate lymphoid cells, renal beta-intercalated cells, cardiac endothelial cells, and lymphoid lineage-restricted progenitor cells. Its expression is also observed in developing tissues, such as the cerebral cortex and forebrain, suggesting a role in neural development and maintenance. **Pathways and Functions:** BICRA's involvement in multiple pathways underscores its multifaceted role in regulating cellular processes. The protein is associated with chromatin remodeling, a process that reorganizes chromatin structure to facilitate or inhibit gene expression. BICRA's interaction with the BRD4 complex enables it to regulate transcription by RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. Moreover, BICRA is implicated in the regulation of stem cell population maintenance, positive regulation of DNA-templated transcription, and negative regulation of cell differentiation. **Clinical Significance:** The expression of BICRA in various cell types and its involvement in regulating cellular processes make it an attractive candidate for studying human diseases. Dysregulation of BICRA's functions may contribute to the development of diseases, such as cancer, where chromatin remodeling and transcriptional regulation are often disrupted. For instance, aberrant expression of BICRA has been linked to the development of certain types of cancer, including leukemia and lymphoma. Furthermore, BICRA's role in regulating stem cell populations suggests its potential involvement in diseases characterized by stem cell dysregulation, such as hematological malignancies. In conclusion, BICRA is a protein that plays a critical role in regulating gene expression, cell differentiation, and proliferation. Its involvement in various cellular processes and its expression in different cell types make it an interesting candidate for studying human diseases. Further research is necessary to elucidate the mechanisms underlying BICRA's functions and to explore its potential as a therapeutic target for treating diseases characterized by dysregulated cellular processes. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms underlying BICRA's functions and its interactions with other proteins. 2. Investigating the expression of BICRA in different human tissues and diseases may reveal new insights into its role in human health and disease. 3. The development of specific inhibitors targeting BICRA may provide novel therapeutic strategies for treating diseases characterized by dysregulated cellular processes. By exploring the intricacies of BICRA's functions and its implications in human diseases, we may uncover new avenues for therapeutic intervention and improve our understanding of the complex interactions between genes, proteins, and cellular processes.

Genular Protein ID: 1826508454

Symbol: BICRA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10708517

Title: A transcript map of the chromosome 19q-Arm glioma tumor suppressor region.

PubMed ID: 10708517

DOI: 10.1006/geno.1999.6101

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21555454

Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

PubMed ID: 21555454

DOI: 10.1128/mcb.01341-10

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29374058

Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

PubMed ID: 29374058

DOI: 10.1074/jbc.ra117.001065

PubMed ID: 33232675

Title: BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.

PubMed ID: 33232675

DOI: 10.1016/j.ajhg.2020.11.003

Sequence Information:

  • Length: 1560
  • Mass: 158490
  • Checksum: 32453B35C9219462
  • Sequence:
  • MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG LHVQEASGNH 
    LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP CDILQQSLQE ANITEQTLEA 
    EAELDLGPFQ LPTLQPADGG AGPTGAGGAA AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA 
    LVPPQDVVNK ALSVQPFLQP VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ 
    PVMALNTPTS QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT 
    LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP IQPKPAGVLP 
    PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM AAGKAGQNVV LSGFPAPALQ 
    ANVFKQPPAT TTGAAPPQPP GALSKPMSVH LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV 
    QLPQQLSALP ANVGGQILAA AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH 
    ILSAAPIQVG QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD 
    GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA PTPQAAAPPQ 
    ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL PQERSQQPLS AEGPHLSVPA 
    SVIVSAPPPA QDPAPATPVA KGAGLGPQAP DSQASPAPAP QIPAAAPLKG PGPSSSPSLP 
    HQAPLGDSPH LPSPHPTRPP SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ 
    LGVPPPASNP APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA 
    PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF PALPQPKALL 
    ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL VSGQAPSGTP TAPSHAPAPA 
    PMAATGLPPL LPAENKAFAS NLPTLNVAKA ASSGPGKPSG LQYESKLSGL KKPPTLQPSK 
    EACFLEHLHK HQGSVLHPDY KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV 
    STQLLKRTQA MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE 
    YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH GGAGGSPSVT 
    WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY EARSRIGLKL KIKQEAGLSK 
    VVHNTALDPV HQPPPPPATL KVAEPPPRPP PPPPPTGQMN GTVDHPPPAA PERKPLGTAP 
    HCPRLPLRKT YRENVGGPGA PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY 
    QRMLKGPPPE PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH 
    LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN GGLGARTLTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.