Details for: HABP2

Gene ID: 3026

Symbol: HABP2

Ensembl ID: ENSG00000148702

Description: hyaluronan binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.8888
    Cell Significance Index: 26.8100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.3503
    Cell Significance Index: 6.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.2335
    Cell Significance Index: 71.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.1603
    Cell Significance Index: 29.6300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.8945
    Cell Significance Index: 7.1400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.3671
    Cell Significance Index: 17.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3281
    Cell Significance Index: 32.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0424
    Cell Significance Index: 17.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7771
    Cell Significance Index: 35.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6709
    Cell Significance Index: 127.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4503
    Cell Significance Index: 9.5900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4490
    Cell Significance Index: 4.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3670
    Cell Significance Index: 36.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3347
    Cell Significance Index: 4.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3195
    Cell Significance Index: 288.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3111
    Cell Significance Index: 6.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3030
    Cell Significance Index: 18.1900
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.2820
    Cell Significance Index: 2.0200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2787
    Cell Significance Index: 1.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2768
    Cell Significance Index: 30.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2500
    Cell Significance Index: 3.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2393
    Cell Significance Index: 47.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2108
    Cell Significance Index: 34.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1817
    Cell Significance Index: 21.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1429
    Cell Significance Index: 9.8800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.1288
    Cell Significance Index: 1.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1225
    Cell Significance Index: 66.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1062
    Cell Significance Index: 10.8500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0786
    Cell Significance Index: 1.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0557
    Cell Significance Index: 11.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0391
    Cell Significance Index: 0.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0177
    Cell Significance Index: 0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0166
    Cell Significance Index: 0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0093
    Cell Significance Index: 1.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0067
    Cell Significance Index: 0.7600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0003
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0008
    Cell Significance Index: -0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0021
    Cell Significance Index: -0.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0044
    Cell Significance Index: -1.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0046
    Cell Significance Index: -0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0055
    Cell Significance Index: -0.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0076
    Cell Significance Index: -0.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0121
    Cell Significance Index: -0.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0158
    Cell Significance Index: -2.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0179
    Cell Significance Index: -0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0184
    Cell Significance Index: -3.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0185
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0237
    Cell Significance Index: -3.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0255
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0274
    Cell Significance Index: -3.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0283
    Cell Significance Index: -2.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0317
    Cell Significance Index: -2.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0324
    Cell Significance Index: -0.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0347
    Cell Significance Index: -0.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0410
    Cell Significance Index: -0.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0430
    Cell Significance Index: -1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0436
    Cell Significance Index: -2.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0441
    Cell Significance Index: -1.1000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0498
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0505
    Cell Significance Index: -4.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0521
    Cell Significance Index: -3.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0522
    Cell Significance Index: -0.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0522
    Cell Significance Index: -2.2700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0581
    Cell Significance Index: -0.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0598
    Cell Significance Index: -0.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0605
    Cell Significance Index: -1.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0655
    Cell Significance Index: -3.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0674
    Cell Significance Index: -3.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0692
    Cell Significance Index: -0.4700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0708
    Cell Significance Index: -1.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0761
    Cell Significance Index: -3.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0782
    Cell Significance Index: -2.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0783
    Cell Significance Index: -0.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0788
    Cell Significance Index: -2.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0799
    Cell Significance Index: -3.5400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0858
    Cell Significance Index: -0.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0860
    Cell Significance Index: -2.8200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0903
    Cell Significance Index: -0.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0907
    Cell Significance Index: -3.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0941
    Cell Significance Index: -3.5700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0981
    Cell Significance Index: -0.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1021
    Cell Significance Index: -3.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1023
    Cell Significance Index: -2.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1031
    Cell Significance Index: -4.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1043
    Cell Significance Index: -2.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HABP2 is a calcium-dependent serine protease that exhibits a unique ability to cleave hyaluronic acid, a major component of the extracellular matrix. This activity is essential for regulating HA levels, which in turn affects cell migration, proliferation, and differentiation. HABP2 is primarily expressed in cells of the hematopoietic system, including hematopoietic stem cells, megakaryocytes, and erythroid progenitor cells, as well as in cells of the epithelium, such as enterocytes and goblet cells. Its expression is also observed in cardiac endothelial cells and hepatocytes. **Pathways and Functions:** The primary function of HABP2 is to regulate HA levels by cleaving it into smaller fragments. This process is crucial for maintaining tissue homeostasis, particularly in the context of inflammatory responses. HABP2's activity is also implicated in the regulation of cell migration and adhesion, which are essential processes in immune cell trafficking and tissue repair. The proteolytic activity of HABP2 is also involved in the regulation of proteolysis, peptidase activity, and glycosaminoglycan binding, highlighting its complex role in maintaining tissue integrity. **Clinical Significance:** HABP2's dysregulation has been implicated in various diseases, including inflammatory bowel disease (IBD), rheumatoid arthritis, and cancer. In IBD, HABP2's ability to regulate HA levels may contribute to the development of intestinal inflammation and tissue damage. In rheumatoid arthritis, HABP2's proteolytic activity may contribute to the degradation of the extracellular matrix, leading to joint damage and inflammation. In cancer, HABP2's expression has been observed in various tumor types, suggesting its potential role in tumor progression and metastasis. In conclusion, HABP2 is a serine protease that plays a crucial role in regulating HA levels and maintaining tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications. As an immunologist, understanding the functions of HABP2 can provide valuable insights into the regulation of immune responses and the development of novel therapeutic strategies for immune-related diseases. **References:** * [Insert relevant references to support the discussion] Note: This article is a hypothetical example, and the references should be replaced with actual scientific literature to support the discussion.

Genular Protein ID: 3040405962

Symbol: HABP2_HUMAN

Name: Hyaluronan-binding protein 2

UniProtKB Accession Codes:

Q14520 A8K467 B7Z8U5 F5H5M6 O00663

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 Ensembl 2 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SABIO-RK 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8827452

Title: Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator.

PubMed ID: 8827452

DOI: 10.1093/oxfordjournals.jbchem.a021362

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10754382

Title: The FVII activating protease cleaves single-chain plasminogen activators.

PubMed ID: 10754382

DOI: 10.1159/000022515

PubMed ID: 11217080

Title: Identification of the substrates for plasma hyaluronan binding protein.

PubMed ID: 11217080

DOI: 10.1248/bpb.24.140

PubMed ID: 12578864

Title: Marburg I polymorphism of factor VII-activating protease: a prominent risk predictor of carotid stenosis.

PubMed ID: 12578864

DOI: 10.1161/01.cir.0000055189.18831.b1

PubMed ID: 26222560

Title: Germline HABP2 mutation causing familial nonmedullary thyroid cancer.

PubMed ID: 26222560

DOI: 10.1056/nejmoa1502449

Sequence Information:

  • Length: 560
  • Mass: 62672
  • Checksum: 5C1907230784ACD4
  • Sequence:
    • MFARMSDLHV LLLMALVGKT ACGFSLMSLL ESLDPDWTPD QYDYSYEDYN QEENTSSTLT 
HAENPDWYYT EDQADPCQPN PCEHGGDCLV HGSTFTCSCL APFSGNKCQK VQNTCKDNPC 
GRGQCLITQS PPYYRCVCKH PYTGPSCSQV VPVCRPNPCQ NGATCSRHKR RSKFTCACPD 
QFKGKFCEIG SDDCYVGDGY SYRGKMNRTV NQHACLYWNS HLLLQENYNM FMEDAETHGI 
GEHNFCRNPD ADEKPWCFIK VTNDKVKWEY CDVSACSAQD VAYPEESPTE PSTKLPGFDS 
CGKTEIAERK IKRIYGGFKS TAGKHPWQAS LQSSLPLTIS MPQGHFCGGA LIHPCWVLTA 
AHCTDIKTRH LKVVLGDQDL KKEEFHEQSF RVEKIFKYSH YNERDEIPHN DIALLKLKPV 
DGHCALESKY VKTVCLPDGS FPSGSECHIS GWGVTETGKG SRQLLDAKVK LIANTLCNSR 
QLYDHMIDDS MICAGNLQKP GQDTCQGDSG GPLTCEKDGT YYVYGIVSWG LECGKRPGVY 
TQVTKFLNWI KATIKSESGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.