Details for: HABP2

Gene ID: 3026

Symbol: HABP2

Ensembl ID: ENSG00000148702

Description: hyaluronan binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.14
    Marker Score: 3301.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1995
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.78
    Marker Score: 935
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.39
    Marker Score: 4539
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.38
    Marker Score: 577
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.26
    Marker Score: 5448
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2149
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.06
    Marker Score: 6804
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.02
    Marker Score: 5470
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1993
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14624
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 410
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.87
    Marker Score: 215
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.87
    Marker Score: 360
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1479
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.69
    Marker Score: 470
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.67
    Marker Score: 743
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.66
    Marker Score: 383
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 409
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.61
    Marker Score: 1386
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.56
    Marker Score: 1383
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 556
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 294
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.48
    Marker Score: 515
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 224
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.47
    Marker Score: 274
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4
    Marker Score: 150
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.39
    Marker Score: 1398
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 259.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.37
    Marker Score: 390.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.36
    Marker Score: 135
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.33
    Marker Score: 220
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.28
    Marker Score: 85
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.27
    Marker Score: 1414
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 114
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 153
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.23
    Marker Score: 330
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.23
    Marker Score: 14180
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.23
    Marker Score: 70
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.23
    Marker Score: 232
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.23
    Marker Score: 230
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.22
    Marker Score: 2071
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.22
    Marker Score: 47
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.21
    Marker Score: 1354
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2
    Marker Score: 7029
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 468
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 70
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.17
    Marker Score: 2299
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.16
    Marker Score: 163.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 53
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 72.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.15
    Marker Score: 257
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 86
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 63
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.13
    Marker Score: 219
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.13
    Marker Score: 99
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.12
    Marker Score: 427
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 135
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.12
    Marker Score: 73.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.12
    Marker Score: 278
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 185

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Other Information

**Key characteristics** * The protein is a glycoprotein with a molecular weight of approximately 160 kDa. * It is expressed in high levels in the enterocytes of the colon and small intestine. * It is also expressed in the hematopoietic stem cell, hepatoblast, and megakaryocyte-erythroid progenitor cell. * It is a transmembrane protein that is localized to the cell surface. * It is a type of hyaluronan-binding protein, which are proteins that bind to hyaluronic acid, a polymer of the sugar hyaluronic acid. **Pathways and functions** The HABP2 protein is involved in a variety of cellular pathways, including: * Cell adhesion: The protein binds to hyaluronic acid, which is a component of the extracellular matrix that holds cells together. This binding is important for cell adhesion and migration. * Signaling: The protein also binds to other proteins that are involved in cell signaling, such as E-cadherin and integrins. This binding allows the protein to signal to downstream targets, which can lead to changes in cell behavior. * Proteolysis: The protein is a serpin, which is an enzyme that cleaves proteins. This activity is important for the regulation of cell adhesion and migration. **Clinical significance** The HABP2 gene has been linked to a number of human diseases, including colorectal cancer, liver disease, and cardiovascular disease. In colorectal cancer, the HABP2 protein is overexpressed in tumors and is thought to play a role in cell migration and invasion. In liver disease, the protein is also overexpressed and is thought to contribute to the development of fibrosis and cirrhosis. In cardiovascular disease, the protein is expressed in cells that line blood vessels and is thought to play a role in the development of atherosclerosis.

Genular Protein ID: 3040405962

Symbol: HABP2_HUMAN

Name: Hyaluronan-binding protein 2

UniProtKB Accession Codes:

Q14520 A8K467 B7Z8U5 F5H5M6 O00663

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 EPD 1 Ensembl 2 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 8 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SABIO-RK 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8827452

Title: Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator.

PubMed ID: 8827452

DOI: 10.1093/oxfordjournals.jbchem.a021362

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10754382

Title: The FVII activating protease cleaves single-chain plasminogen activators.

PubMed ID: 10754382

DOI: 10.1159/000022515

PubMed ID: 11217080

Title: Identification of the substrates for plasma hyaluronan binding protein.

PubMed ID: 11217080

DOI: 10.1248/bpb.24.140

PubMed ID: 12578864

Title: Marburg I polymorphism of factor VII-activating protease: a prominent risk predictor of carotid stenosis.

PubMed ID: 12578864

DOI: 10.1161/01.cir.0000055189.18831.b1

PubMed ID: 26222560

Title: Germline HABP2 mutation causing familial nonmedullary thyroid cancer.

PubMed ID: 26222560

DOI: 10.1056/nejmoa1502449

Sequence Information:

  • Length: 560
  • Mass: 62672
  • Checksum: 5C1907230784ACD4
  • Sequence:
    • MFARMSDLHV LLLMALVGKT ACGFSLMSLL ESLDPDWTPD QYDYSYEDYN QEENTSSTLT 
HAENPDWYYT EDQADPCQPN PCEHGGDCLV HGSTFTCSCL APFSGNKCQK VQNTCKDNPC 
GRGQCLITQS PPYYRCVCKH PYTGPSCSQV VPVCRPNPCQ NGATCSRHKR RSKFTCACPD 
QFKGKFCEIG SDDCYVGDGY SYRGKMNRTV NQHACLYWNS HLLLQENYNM FMEDAETHGI 
GEHNFCRNPD ADEKPWCFIK VTNDKVKWEY CDVSACSAQD VAYPEESPTE PSTKLPGFDS 
CGKTEIAERK IKRIYGGFKS TAGKHPWQAS LQSSLPLTIS MPQGHFCGGA LIHPCWVLTA 
AHCTDIKTRH LKVVLGDQDL KKEEFHEQSF RVEKIFKYSH YNERDEIPHN DIALLKLKPV 
DGHCALESKY VKTVCLPDGS FPSGSECHIS GWGVTETGKG SRQLLDAKVK LIANTLCNSR 
QLYDHMIDDS MICAGNLQKP GQDTCQGDSG GPLTCEKDGT YYVYGIVSWG LECGKRPGVY 
TQVTKFLNWI KATIKSESGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.