Details for: HBE1

Gene ID: 3046

Symbol: HBE1

Ensembl ID: ENSG00000213931

Description: hemoglobin subunit epsilon 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.5021
    Cell Significance Index: -4.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.3255
    Cell Significance Index: -6.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6660
    Cell Significance Index: -4.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.0491
    Cell Significance Index: 17.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3101
    Cell Significance Index: 6.4900
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.2477
    Cell Significance Index: 0.7100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1665
    Cell Significance Index: 2.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1509
    Cell Significance Index: 1.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1382
    Cell Significance Index: 2.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0474
    Cell Significance Index: 1.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0394
    Cell Significance Index: 1.0600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0042
    Cell Significance Index: -0.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0065
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0112
    Cell Significance Index: -6.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0191
    Cell Significance Index: -2.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0194
    Cell Significance Index: -3.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0254
    Cell Significance Index: -7.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0289
    Cell Significance Index: -0.3500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0324
    Cell Significance Index: -0.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0354
    Cell Significance Index: -0.9600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0451
    Cell Significance Index: -0.2800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0502
    Cell Significance Index: -0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0557
    Cell Significance Index: -5.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0664
    Cell Significance Index: -4.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0667
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0811
    Cell Significance Index: -9.3000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0823
    Cell Significance Index: -0.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0868
    Cell Significance Index: -1.2600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0990
    Cell Significance Index: -0.6200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1032
    Cell Significance Index: -0.7500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1042
    Cell Significance Index: -1.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1053
    Cell Significance Index: -3.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1071
    Cell Significance Index: -3.5100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1128
    Cell Significance Index: -1.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1184
    Cell Significance Index: -3.7700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1186
    Cell Significance Index: -0.7000
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.1197
    Cell Significance Index: -0.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1303
    Cell Significance Index: -7.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1309
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1445
    Cell Significance Index: -3.6100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1566
    Cell Significance Index: -2.2900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1601
    Cell Significance Index: -0.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1602
    Cell Significance Index: -7.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1616
    Cell Significance Index: -4.2500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1682
    Cell Significance Index: -1.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1855
    Cell Significance Index: -3.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1859
    Cell Significance Index: -5.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1861
    Cell Significance Index: -5.4800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1912
    Cell Significance Index: -2.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2065
    Cell Significance Index: -7.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2067
    Cell Significance Index: -5.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2095
    Cell Significance Index: -5.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2102
    Cell Significance Index: -5.0400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2159
    Cell Significance Index: -2.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2180
    Cell Significance Index: -5.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2203
    Cell Significance Index: -2.8500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2214
    Cell Significance Index: -1.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2290
    Cell Significance Index: -5.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2393
    Cell Significance Index: -5.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2424
    Cell Significance Index: -5.0600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2456
    Cell Significance Index: -3.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2464
    Cell Significance Index: -4.8500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2528
    Cell Significance Index: -1.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2536
    Cell Significance Index: -5.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2554
    Cell Significance Index: -5.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2604
    Cell Significance Index: -3.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2615
    Cell Significance Index: -5.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2779
    Cell Significance Index: -6.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2818
    Cell Significance Index: -5.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2829
    Cell Significance Index: -5.6800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2852
    Cell Significance Index: -3.2400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.2927
    Cell Significance Index: -1.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2949
    Cell Significance Index: -5.4500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3003
    Cell Significance Index: -3.5700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3014
    Cell Significance Index: -4.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3065
    Cell Significance Index: -5.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3093
    Cell Significance Index: -5.0100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.3168
    Cell Significance Index: -2.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3189
    Cell Significance Index: -4.5700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3200
    Cell Significance Index: -5.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3396
    Cell Significance Index: -5.8200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3398
    Cell Significance Index: -4.6600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3466
    Cell Significance Index: -4.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3537
    Cell Significance Index: -4.5300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3550
    Cell Significance Index: -4.2000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.3550
    Cell Significance Index: -3.6500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3567
    Cell Significance Index: -3.0400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3601
    Cell Significance Index: -4.5500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3631
    Cell Significance Index: -3.5000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3639
    Cell Significance Index: -4.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3655
    Cell Significance Index: -4.7800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3659
    Cell Significance Index: -3.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3685
    Cell Significance Index: -3.8200
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: -0.3709
    Cell Significance Index: -3.3200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3717
    Cell Significance Index: -5.2200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3754
    Cell Significance Index: -4.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Hemoglobin subunit epsilon:** The HBE1 gene encodes for the epsilon subunit of hemoglobin, which is one of the four subunits that constitute the hemoglobin complex. 2. **Oxygen binding and transport:** The HBE1 gene plays a critical role in oxygen binding and transport, facilitating the delivery of oxygen to tissues and organs. 3. **Antioxidant properties:** The HBE1 gene is involved in cellular oxidant detoxification, protecting cells from oxidative damage and maintaining redox homeostasis. 4. **Megakaryocyte development and platelet production:** The HBE1 gene is expressed in cells involved in megakaryocyte development and platelet production, highlighting its role in hematopoiesis. 5. **Widespread expression:** The HBE1 gene is expressed in various cell types, including endothelial cells, epithelial cells, and immune cells, underscoring its importance in maintaining tissue homeostasis. **Pathways and Functions:** 1. **Oxygen binding and transport:** The HBE1 gene is involved in oxygen binding and transport, facilitating the delivery of oxygen to tissues and organs. 2. **Antioxidant properties:** The HBE1 gene is involved in cellular oxidant detoxification, protecting cells from oxidative damage and maintaining redox homeostasis. 3. **Megakaryocyte development and platelet production:** The HBE1 gene is expressed in cells involved in megakaryocyte development and platelet production, highlighting its role in hematopoiesis. 4. **Carbon dioxide transport:** The HBE1 gene is involved in carbon dioxide transport, facilitating the removal of CO2 from tissues and organs. 5. **Hemostasis:** The HBE1 gene is expressed in cells involved in hemostasis, highlighting its role in maintaining blood clotting and preventing excessive bleeding. **Clinical Significance:** 1. **Anemia:** Mutations in the HBE1 gene have been associated with anemia, highlighting the importance of this gene in maintaining normal red blood cell production. 2. **Oxidative stress:** Abnormal expression of the HBE1 gene has been linked to oxidative stress, underscoring the importance of this gene in maintaining cellular redox homeostasis. 3. **Hemoglobinopathies:** The HBE1 gene is involved in the regulation of hemoglobin production, making it a potential target for the development of new therapies for hemoglobinopathies. 4. **Cardiovascular disease:** The HBE1 gene is expressed in endothelial cells, highlighting its potential role in cardiovascular disease, particularly in the development of atherosclerosis. 5. **Cancer:** The HBE1 gene is expressed in various cancer cell types, highlighting its potential role in cancer development and progression. In conclusion, the HBE1 gene plays a critical role in maintaining tissue homeostasis, regulating oxygen binding and transport, and protecting cells from oxidative damage. Its widespread expression in various cell types highlights its importance in maintaining overall health and preventing disease. Further research is needed to fully elucidate the functions and clinical significance of the HBE1 gene.

Genular Protein ID: 1180788288

Symbol: HBE_HUMAN

Name: Hemoglobin subunit epsilon

UniProtKB Accession Codes:

P02100 Q6FH44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6254663

Title: The primary structure of the human epsilon-globin gene.

PubMed ID: 6254663

DOI: 10.1016/0092-8674(80)90425-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6172865

Title: Embryonic hemoglobin: sequence of the epsilon and zeta chains.

PubMed ID: 6172865

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 9665850

Title: Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of Gower II (alpha2 epsilon2) haemoglobin at 2.9-A resolution.

PubMed ID: 9665850

DOI: 10.1006/jmbi.1998.1868

Sequence Information:

  • Length: 147
  • Mass: 16203
  • Checksum: 223388816EDDE8D5
  • Sequence:
    • MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS SPSAILGNPK 
VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD PENFKLLGNV MVIILATHFG 
KEFTPEVQAA WQKLVSAVAI ALAHKYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.