Details for: HCRTR2

Gene ID: 3062

Symbol: HCRTR2

Ensembl ID: ENSG00000137252

Description: hypocretin receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.28
    Marker Score: 2299.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.52
    Marker Score: 2886
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170186
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.46
    Marker Score: 1631.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.22
    Marker Score: 2529
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2442
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.14
    Marker Score: 687
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.04
    Marker Score: 8904
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.03
    Marker Score: 10601
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6455
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.97
    Marker Score: 435
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14907
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.94
    Marker Score: 3647
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.92
    Marker Score: 699
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.9
    Marker Score: 523
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.8
    Marker Score: 3261
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.79
    Marker Score: 7460
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.69
    Marker Score: 241
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 445
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.64
    Marker Score: 1482
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.62
    Marker Score: 197
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 347
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 258
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.52
    Marker Score: 236
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 258
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.43
    Marker Score: 248
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 136
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.42
    Marker Score: 3234
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.34
    Marker Score: 2895
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 149
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.32
    Marker Score: 2975
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.31
    Marker Score: 1053
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 689
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.29
    Marker Score: 1201
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 167
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.23
    Marker Score: 7697
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.23
    Marker Score: 1702
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.22
    Marker Score: 214
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.22
    Marker Score: 639
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.22
    Marker Score: 85
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.21
    Marker Score: 973
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1236
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 164
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.19
    Marker Score: 507
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 169
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.18
    Marker Score: 403
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.18
    Marker Score: 94
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 282
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 187
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.16
    Marker Score: 290
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 196
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 34
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 259
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 227
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.15
    Marker Score: 780
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.14
    Marker Score: 192
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.13
    Marker Score: 63
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 143
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.11
    Marker Score: 593
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.11
    Marker Score: 4215
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.11
    Marker Score: 2192
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 6637
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.11
    Marker Score: 33.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.11
    Marker Score: 51

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Other Information

**Key characteristics:** * HCRTR2 is a type a/1 GPCR, which are characterized by the presence of a single extracellular domain that is homologous to the extracellular domain of rhodopsin. * It is expressed in a variety of cell types, including blood vessel endothelial cells, cardiac endothelial cells, mural cells, plasma cells, granulocyte monocyte progenitor cells, kidney proximal convoluted tubule epithelial cells, immature innate lymphoid cells, lymphoid lineage restricted progenitor cells, and L6b glutamatergic cortical neurons. * The protein is a ligand for orexin, a neuropeptide that is involved in circadian sleep/wake cycles. **Pathways and functions:** * Orexin binds to its receptor, orexin receptor type 2 (OX2R_HUMAN), and activates it. * Activation of orexin receptor downstream signaling pathways, including the G alpha (q) signaling pathway and the Gpcr downstream signaling pathway, leads to the inhibition of adenylate cyclase and the subsequent increase in cyclic GMP levels. * Cyclic GMP then activates protein kinases, including protein kinase B and MAPK, which regulate various cellular processes, including sleep/wake cycles. **Clinical significance:** * Mutations in the HCRTR2 gene have been linked to a variety of human diseases, including narcolepsy, insomnia, and circadian rhythm disorders. * Studies of HCRTR2 mutations have also been used to develop drugs that are used to treat these disorders.

Genular Protein ID: 1262419969

Symbol: OX2R_HUMAN

Name: Orexin receptor type 2

UniProtKB Accession Codes:

O43614 Q5VTM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 5 EMDB 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 11 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9491897

Title: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

PubMed ID: 9491897

DOI: 10.1016/s0092-8674(00)80949-6

PubMed ID: 11723285

Title: Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

PubMed ID: 11723285

DOI: 10.1212/wnl.57.10.1896

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 11340621

Title: Hypocretin/orexin, sleep and narcolepsy.

PubMed ID: 11340621

DOI: 10.1002/bies.1058

PubMed ID: 11283317

Title: To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

PubMed ID: 11283317

DOI: 10.1146/annurev.neuro.24.1.429

PubMed ID: 26950369

Title: Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

PubMed ID: 26950369

DOI: 10.1038/nsmb.3183

PubMed ID: 25533960

Title: Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.

PubMed ID: 25533960

DOI: 10.1038/nature14035

PubMed ID: 33547286

Title: Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.

PubMed ID: 33547286

DOI: 10.1038/s41467-021-21087-6

Sequence Information:

  • Length: 444
  • Mass: 50694
  • Checksum: C4C9A153D42254C6
  • Sequence:
    • MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG 
YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW 
FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS 
CIIMIPQAIV MECSTVFPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV 
LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR 
KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH WLVYANSAAN 
PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNISKL 
SEQVVLTSIS TLPAANGAGP LQNW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.