Details for: FOXA3

Gene ID: 3171

Symbol: FOXA3

Ensembl ID: ENSG00000170608

Description: forkhead box A3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.23
    Marker Score: 2142
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.96
    Marker Score: 12488
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.72
    Marker Score: 3560
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.68
    Marker Score: 3805
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.42
    Marker Score: 593
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.11
    Marker Score: 2629
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1935
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.02
    Marker Score: 2151
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1
    Marker Score: 316
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.95
    Marker Score: 5764
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.93
    Marker Score: 2932
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.89
    Marker Score: 333
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1383
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12443
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1606
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.78
    Marker Score: 268
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.73
    Marker Score: 732
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.69
    Marker Score: 150
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.68
    Marker Score: 2223
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.67
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2738
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.65
    Marker Score: 471
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.62
    Marker Score: 201
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.61
    Marker Score: 229
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.56
    Marker Score: 139
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 334
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 227
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.52
    Marker Score: 2252
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.51
    Marker Score: 645
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.49
    Marker Score: 2329.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1141
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.48
    Marker Score: 138
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.47
    Marker Score: 328
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.44
    Marker Score: 228
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.42
    Marker Score: 3592
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.41
    Marker Score: 201
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4
    Marker Score: 175
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.39
    Marker Score: 2112
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.39
    Marker Score: 275
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.39
    Marker Score: 144
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.38
    Marker Score: 398
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.38
    Marker Score: 2449
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.38
    Marker Score: 85
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 164
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.32
    Marker Score: 147
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.32
    Marker Score: 168
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.31
    Marker Score: 215
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.31
    Marker Score: 80
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.29
    Marker Score: 936
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.29
    Marker Score: 285
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.28
    Marker Score: 70
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.28
    Marker Score: 83
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.25
    Marker Score: 365
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.25
    Marker Score: 102
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.25
    Marker Score: 353
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 126
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 120.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.18
    Marker Score: 322
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.17
    Marker Score: 64
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.17
    Marker Score: 41

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Other Information

**Key characteristics:** - FOXA3 is a transcription factor belonging to the forkhead box A (FOXA) family. - It is highly expressed in the developing and mature pancreas. - It is involved in the regulation of beta-cell development and function through various pathways. **Pathways and functions:** - FOXA3 is a key regulator of beta-cell development. It is required for the survival, proliferation, and differentiation of beta-cell precursors in the pancreas. - It is also involved in the regulation of beta-cell function, including insulin secretion, glucagon release, and lipolysis. - FOXA3 is a key regulator of pancreatic cancer. It is frequently mutated in cancer cells, leading to the development of pancreatic cancer. **Clinical significance:** - Mutations in the FOXA3 gene have been linked to the development of various pancreatic diseases, including islet cell tumors and pancreatitis. - Targeting FOXA3 has emerged as a promising therapeutic strategy for the treatment of these diseases. **Other relevant information:** - FOXA3 is also involved in the regulation of other cellular processes, including embryonic development, cell differentiation, and metabolism. - It is a well-studied gene with a significant impact on human health. - FOXA3 is a target for therapeutic interventions in various diseases, including cancer and diabetes.

Genular Protein ID: 2189698842

Symbol: FOXA3_HUMAN

Name: Hepatocyte nuclear factor 3-gamma

UniProtKB Accession Codes:

P55318 A9LYI5 Q53F16 Q9UMW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8499623

Title: Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells.

PubMed ID: 8499623

PubMed ID: 10899756

Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

PubMed ID: 10899756

DOI: 10.1159/000022943

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9369482

Title: The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation.

PubMed ID: 9369482

DOI: 10.1021/bi9703249

PubMed ID: 12695546

Title: Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma.

PubMed ID: 12695546

DOI: 10.1124/mol.63.5.1180

PubMed ID: 19919681

Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

PubMed ID: 19919681

DOI: 10.1186/gb-2009-10-11-r129

PubMed ID: 19706729

Title: Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.

PubMed ID: 19706729

DOI: 10.1124/mol.109.055699

PubMed ID: 8332212

Title: Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

PubMed ID: 8332212

DOI: 10.1038/364412a0

Sequence Information:

  • Length: 350
  • Mass: 37140
  • Checksum: 07657D41B0867101
  • Sequence:
    • MLGSVKMEAH DLAEWSYYPE AGEVYSPVTP VPTMAPLNSY MTLNPLSSPY PPGGLPASPL 
PSGPLAPPAP AAPLGPTFPG LGVSGGSSSS GYGAPGPGLV HGKEMPKGYR RPLAHAKPPY 
SYISLITMAI QQAPGKMLTL SEIYQWIMDL FPYYRENQQR WQNSIRHSLS FNDCFVKVAR 
SPDKPGKGSY WALHPSSGNM FENGCYLRRQ KRFKLEEKVK KGGSGAATTT RNGTGSAAST 
TTPAATVTSP PQPPPPAPEP EAQGGEDVGA LDCGSPASST PYFTGLELPG ELKLDAPYNF 
NHPFSINNLM SEQTPAPPKL DVGFGGYGAE GGEPGVYYQG LYSRSLLNAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.