Details for: FOXA3

Gene ID: 3171

Symbol: FOXA3

Ensembl ID: ENSG00000170608

Description: forkhead box A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.0044
    Cell Significance Index: -8.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 11.5495
    Cell Significance Index: -7.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.6296
    Cell Significance Index: 209.8500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 4.0009
    Cell Significance Index: 43.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.5932
    Cell Significance Index: 53.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.3587
    Cell Significance Index: 96.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6264
    Cell Significance Index: 56.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3618
    Cell Significance Index: 384.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7736
    Cell Significance Index: 106.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6717
    Cell Significance Index: 181.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.5516
    Cell Significance Index: 54.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4899
    Cell Significance Index: 147.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0973
    Cell Significance Index: 23.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9357
    Cell Significance Index: 64.7100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8585
    Cell Significance Index: 14.4400
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.8407
    Cell Significance Index: 7.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6230
    Cell Significance Index: 19.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5725
    Cell Significance Index: 113.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5041
    Cell Significance Index: 95.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4889
    Cell Significance Index: 441.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3616
    Cell Significance Index: 8.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1436
    Cell Significance Index: 2.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1161
    Cell Significance Index: 1.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0871
    Cell Significance Index: 14.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0579
    Cell Significance Index: 10.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0172
    Cell Significance Index: 2.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0130
    Cell Significance Index: 0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0104
    Cell Significance Index: 0.4500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0055
    Cell Significance Index: 0.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0020
    Cell Significance Index: 0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0105
    Cell Significance Index: -16.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -7.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0161
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0168
    Cell Significance Index: -10.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0192
    Cell Significance Index: -6.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0226
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0234
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0253
    Cell Significance Index: -2.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0256
    Cell Significance Index: -2.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0268
    Cell Significance Index: -7.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0282
    Cell Significance Index: -1.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0315
    Cell Significance Index: -3.8700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0319
    Cell Significance Index: -0.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0325
    Cell Significance Index: -1.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0345
    Cell Significance Index: -6.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0379
    Cell Significance Index: -4.8900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0397
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0443
    Cell Significance Index: -6.4400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0465
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0491
    Cell Significance Index: -10.3500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0516
    Cell Significance Index: -0.2700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0526
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0545
    Cell Significance Index: -5.5700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0557
    Cell Significance Index: -0.4800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0603
    Cell Significance Index: -0.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0617
    Cell Significance Index: -1.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0728
    Cell Significance Index: -0.4900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0740
    Cell Significance Index: -0.5800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0752
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0784
    Cell Significance Index: -10.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0786
    Cell Significance Index: -0.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0787
    Cell Significance Index: -4.0900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0798
    Cell Significance Index: -0.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0850
    Cell Significance Index: -1.1600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0850
    Cell Significance Index: -0.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1039
    Cell Significance Index: -2.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1049
    Cell Significance Index: -7.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1097
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1161
    Cell Significance Index: -2.4300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.1200
    Cell Significance Index: -0.9100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1209
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1209
    Cell Significance Index: -8.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1231
    Cell Significance Index: -6.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1317
    Cell Significance Index: -6.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1326
    Cell Significance Index: -8.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1402
    Cell Significance Index: -3.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1445
    Cell Significance Index: -2.0700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1447
    Cell Significance Index: -1.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1465
    Cell Significance Index: -1.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1545
    Cell Significance Index: -4.1400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1549
    Cell Significance Index: -1.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1614
    Cell Significance Index: -7.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1686
    Cell Significance Index: -10.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1918
    Cell Significance Index: -2.8900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1964
    Cell Significance Index: -2.6700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2150
    Cell Significance Index: -2.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2196
    Cell Significance Index: -7.6300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2238
    Cell Significance Index: -2.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2249
    Cell Significance Index: -12.6200
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.2250
    Cell Significance Index: -2.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2281
    Cell Significance Index: -2.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2329
    Cell Significance Index: -8.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Activity:** FOXA3 acts as a transcription factor, regulating the expression of target genes involved in various cellular processes. 2. **Cell Type-Specific Expression:** FOXA3 is significantly expressed in multiple cell types, including intestinal goblet cells, pancreatic acinar cells, and cardiac endothelial cells. 3. **Regulation of Gene Expression:** FOXA3 regulates the expression of target genes involved in cell differentiation, development, and glucose homeostasis. 4. **Involvement in Immune Cell Function:** FOXA3 plays a crucial role in regulating gene expression in immune cells, including granulocyte-monocyte progenitor cells and stem cells. **Pathways and Functions:** 1. **Cell Differentiation:** FOXA3 regulates the expression of genes involved in cell differentiation, including the development of goblet cells in the intestine. 2. **Developmental Biology:** FOXA3 is involved in the regulation of developmental processes, including spermatogenesis and hematopoiesis. 3. **Glucose Homeostasis:** FOXA3 regulates the expression of genes involved in glucose homeostasis, including those involved in insulin signaling and pancreatic beta-cell development. 4. **Immune Cell Function:** FOXA3 plays a crucial role in regulating gene expression in immune cells, including granulocyte-monocyte progenitor cells and stem cells. **Clinical Significance:** Dysregulation of FOXA3 has been implicated in various diseases, including: 1. **Pancreatic Cancer:** FOXA3 is often downregulated in pancreatic cancer, leading to impaired pancreatic beta-cell function and insulin resistance. 2. **Type 2 Diabetes:** FOXA3 plays a crucial role in regulating pancreatic beta-cell function, and its dysregulation has been implicated in the development of type 2 diabetes. 3. **Immune-Related Disorders:** FOXA3's involvement in immune cell function makes it an important regulator in immune-related disorders, including autoimmune diseases and cancer. In conclusion, FOXA3 is a critical transcription factor that plays a pivotal role in regulating gene expression in various cell types, including immune cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of FOXA3 regulation and its role in maintaining tissue homeostasis and immune system function.

Genular Protein ID: 2189698842

Symbol: FOXA3_HUMAN

Name: Hepatocyte nuclear factor 3-gamma

UniProtKB Accession Codes:

P55318 A9LYI5 Q53F16 Q9UMW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8499623

Title: Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells.

PubMed ID: 8499623

PubMed ID: 10899756

Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

PubMed ID: 10899756

DOI: 10.1159/000022943

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9369482

Title: The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation.

PubMed ID: 9369482

DOI: 10.1021/bi9703249

PubMed ID: 12695546

Title: Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma.

PubMed ID: 12695546

DOI: 10.1124/mol.63.5.1180

PubMed ID: 19919681

Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

PubMed ID: 19919681

DOI: 10.1186/gb-2009-10-11-r129

PubMed ID: 19706729

Title: Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.

PubMed ID: 19706729

DOI: 10.1124/mol.109.055699

PubMed ID: 8332212

Title: Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

PubMed ID: 8332212

DOI: 10.1038/364412a0

Sequence Information:

  • Length: 350
  • Mass: 37140
  • Checksum: 07657D41B0867101
  • Sequence:
    • MLGSVKMEAH DLAEWSYYPE AGEVYSPVTP VPTMAPLNSY MTLNPLSSPY PPGGLPASPL 
PSGPLAPPAP AAPLGPTFPG LGVSGGSSSS GYGAPGPGLV HGKEMPKGYR RPLAHAKPPY 
SYISLITMAI QQAPGKMLTL SEIYQWIMDL FPYYRENQQR WQNSIRHSLS FNDCFVKVAR 
SPDKPGKGSY WALHPSSGNM FENGCYLRRQ KRFKLEEKVK KGGSGAATTT RNGTGSAAST 
TTPAATVTSP PQPPPPAPEP EAQGGEDVGA LDCGSPASST PYFTGLELPG ELKLDAPYNF 
NHPFSINNLM SEQTPAPPKL DVGFGGYGAE GGEPGVYYQG LYSRSLLNAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.