Details for: HNF4G

Gene ID: 3174

Symbol: HNF4G

Ensembl ID: ENSG00000164749

Description: hepatocyte nuclear factor 4 gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.6225
    Cell Significance Index: -8.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.7408
    Cell Significance Index: -9.3000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.4148
    Cell Significance Index: 74.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.9175
    Cell Significance Index: 58.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.8879
    Cell Significance Index: 84.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7255
    Cell Significance Index: -9.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.0618
    Cell Significance Index: 88.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.8427
    Cell Significance Index: 71.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4627
    Cell Significance Index: 488.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1969
    Cell Significance Index: 99.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.1925
    Cell Significance Index: 33.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1332
    Cell Significance Index: 232.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.7840
    Cell Significance Index: 24.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4576
    Cell Significance Index: -3.1900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2432
    Cell Significance Index: 7.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9987
    Cell Significance Index: 21.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6851
    Cell Significance Index: 11.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6243
    Cell Significance Index: 43.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5310
    Cell Significance Index: 18.6600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.4859
    Cell Significance Index: 1.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4784
    Cell Significance Index: 10.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4697
    Cell Significance Index: 7.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4351
    Cell Significance Index: 26.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4246
    Cell Significance Index: 383.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3510
    Cell Significance Index: 57.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3314
    Cell Significance Index: 9.2600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2750
    Cell Significance Index: 2.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2719
    Cell Significance Index: 3.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2539
    Cell Significance Index: 48.3100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.2439
    Cell Significance Index: 3.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2392
    Cell Significance Index: 1.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2304
    Cell Significance Index: 5.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2259
    Cell Significance Index: 22.3500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1043
    Cell Significance Index: 0.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0745
    Cell Significance Index: 2.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0590
    Cell Significance Index: 1.0200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0502
    Cell Significance Index: 0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0288
    Cell Significance Index: 5.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0244
    Cell Significance Index: 4.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0181
    Cell Significance Index: 0.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0116
    Cell Significance Index: 6.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0034
    Cell Significance Index: 0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0028
    Cell Significance Index: 0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0014
    Cell Significance Index: 0.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0006
    Cell Significance Index: -0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0083
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0133
    Cell Significance Index: -8.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0134
    Cell Significance Index: -8.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0149
    Cell Significance Index: -4.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0179
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0317
    Cell Significance Index: -6.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0433
    Cell Significance Index: -6.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0546
    Cell Significance Index: -5.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0549
    Cell Significance Index: -7.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0734
    Cell Significance Index: -7.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0757
    Cell Significance Index: -9.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0887
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0916
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0935
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1075
    Cell Significance Index: -7.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1097
    Cell Significance Index: -8.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1135
    Cell Significance Index: -6.9600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.1160
    Cell Significance Index: -0.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1165
    Cell Significance Index: -5.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1197
    Cell Significance Index: -8.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1221
    Cell Significance Index: -6.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1225
    Cell Significance Index: -9.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1238
    Cell Significance Index: -7.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1280
    Cell Significance Index: -6.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1397
    Cell Significance Index: -2.3500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1541
    Cell Significance Index: -1.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1546
    Cell Significance Index: -6.8400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1660
    Cell Significance Index: -1.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1684
    Cell Significance Index: -2.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1695
    Cell Significance Index: -2.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1784
    Cell Significance Index: -9.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1788
    Cell Significance Index: -9.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1845
    Cell Significance Index: -7.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1883
    Cell Significance Index: -7.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1901
    Cell Significance Index: -6.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1982
    Cell Significance Index: -6.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2041
    Cell Significance Index: -6.5000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.2075
    Cell Significance Index: -1.4600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2155
    Cell Significance Index: -2.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2179
    Cell Significance Index: -5.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2249
    Cell Significance Index: -5.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2294
    Cell Significance Index: -8.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** HNF4G acts as a transcriptional regulator by binding to specific DNA sequences, modulating the expression of target genes involved in cell differentiation, growth, and development. 2. **Cell Type-Specific Expression:** HNF4G is expressed in various cell types, including hepatocytes, beta-cells, and epithelial cells, underscoring its role in regulating cellular differentiation and function. 3. **DNA-Binding and RNA Polymerase II Interaction:** HNF4G interacts with RNA polymerase II, facilitating the transcriptional activation of target genes and influencing the regulation of gene expression. 4. **Zinc Ion Binding and Nuclear Receptor Activity:** HNF4G binds to zinc ions, which are essential for its nuclear receptor activity, enabling it to regulate transcriptional activity and gene expression. **Pathways and Functions:** 1. **Anatomical Structure Development:** HNF4G participates in the development and patterning of various organs, including the liver, pancreas, and kidney, by regulating the expression of key developmental genes. 2. **Cell Differentiation:** HNF4G regulates the differentiation of various cell types, including beta-cells, hepatocytes, and epithelial cells, by modulating the expression of specific transcription factors and signaling pathways. 3. **Gene Expression (Transcription):** HNF4G influences the regulation of gene expression by binding to specific DNA sequences, modulating the activity of RNA polymerase II, and interacting with other transcriptional regulators. 4. **Regulation of Beta-Cell Development:** HNF4G plays a crucial role in the development and function of beta-cells, modulating the expression of key transcription factors and signaling pathways involved in insulin secretion and glucose homeostasis. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** Dysregulation of HNF4G has been implicated in the development of diabetes and metabolic disorders, such as insulin resistance and beta-cell failure. 2. **Beta-Cell Development and Function:** HNF4G's role in regulating beta-cell development and function highlights its potential as a therapeutic target for disease intervention and cell replacement therapies. 3. **Liver and Kidney Disease:** HNF4G's involvement in the development and function of the liver and kidney underscores its potential as a therapeutic target for disease intervention in these organs. 4. **Cancer and Tumor Suppression:** HNF4G's role in regulating gene expression and cell differentiation suggests its potential as a tumor suppressor gene, highlighting its importance in cancer prevention and treatment. In conclusion, HNF4G is a critical transcriptional regulator that plays a pivotal role in regulating cellular differentiation, gene expression, and transcriptional activity. Its dysregulation has been implicated in several diseases, including diabetes and metabolic disorders. Further research is needed to fully elucidate the mechanisms underlying HNF4G's function and its potential as a therapeutic target for disease intervention.

Genular Protein ID: 379399498

Symbol: HNF4G_HUMAN

Name: Hepatocyte nuclear factor 4-gamma

UniProtKB Accession Codes:

Q14541 Q7Z2V9 Q9UH81 Q9UIS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8622695

Title: Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.

PubMed ID: 8622695

DOI: 10.1128/mcb.16.3.925

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10512380

Title: Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes.

PubMed ID: 10512380

DOI: 10.2337/diabetes.48.10.2099

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12220494

Title: Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.

PubMed ID: 12220494

DOI: 10.1016/s0969-2126(02)00829-8

Sequence Information:

  • Length: 408
  • Mass: 45877
  • Checksum: C75410E10251AE9F
  • Sequence:
    • MNTTDNGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK 
RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTFDGSN IPSINTLAQA EVRSRQISVS 
SPGSSTDINV KKIASIGDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL 
LLGATKRSMM YKDILLLGNN YVIHRNSCEV EISRVANRVL DELVRPFQEI QIDDNEYACL 
KAIVFFDPDA KGLSDPVKIK NMRFQVQIGL EDYINDRQYD SRGRFGELLL LLPTLQSITW 
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAS NDGSHLHHPM HPHLSQDPLT GQTILLGPMS 
TLVHADQIST PETPLPSPPQ GSGQEQYKIA ANQASVISHQ HLSKQKQL

Genular Protein ID: 2439970754

Symbol: F1D8Q4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1D8Q4

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 445
  • Mass: 50041
  • Checksum: CA8F19E4AF99E81B
  • Sequence:
    • MDMANYSEVL DPTYTTLEFE TMQILYNSSD SSAPETSMNT TDNGVNCLCA ICGDRATGKH 
YGASSCDGCK GFFRRSIRKS HVYSCRFSRQ CVVDKDKRNQ CRYCRLRKCF RAGMKKEAVQ 
NERDRISTRR STFDGSNIPS INTLAQAEVR SRQISVSSPG SSTDINVKKI ASIGDVCESM 
KQQLLVLVEW AKYIPAFCEL PLDDQVALLR AHAGEHLLLG ATKRSMMYKD ILLLGNNYVI 
HRNSCEVEIS RVANRVLDEL VRPFQEIQID DNEYACLKAI VFFDPDAKGL SDPVKIKNMR 
FQVQIGLEDY INDRQYDSRG RFGELLLLLP TLQSITWQMI EQIQFVKLFG MVKIDNLLQE 
MLLGGASNDG SHLHHPMHPH LSQDPLTGQT ILLGPMSTLV HADQISTPET PLPSPPQGSG 
QEQYKIAANQ ASVISHQHLS KQKQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.