Details for: HOXD11

Gene ID: 3237

Symbol: HOXD11

Ensembl ID: ENSG00000128713

Description: homeobox D11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 8.9770
    Cell Significance Index: 76.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.7918
    Cell Significance Index: 120.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.2337
    Cell Significance Index: 148.7700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 3.1249
    Cell Significance Index: 35.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.2847
    Cell Significance Index: 57.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1343
    Cell Significance Index: 31.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7425
    Cell Significance Index: 37.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6714
    Cell Significance Index: 102.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1898
    Cell Significance Index: 17.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8199
    Cell Significance Index: 28.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6773
    Cell Significance Index: 30.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6764
    Cell Significance Index: 35.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6302
    Cell Significance Index: 15.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5887
    Cell Significance Index: 4.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4321
    Cell Significance Index: 82.2400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3437
    Cell Significance Index: 4.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3423
    Cell Significance Index: 7.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3399
    Cell Significance Index: 33.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2673
    Cell Significance Index: 241.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2414
    Cell Significance Index: 6.5700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2242
    Cell Significance Index: 2.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2052
    Cell Significance Index: 12.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1923
    Cell Significance Index: 20.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1821
    Cell Significance Index: 29.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0977
    Cell Significance Index: 6.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0756
    Cell Significance Index: 13.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0707
    Cell Significance Index: 0.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0465
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0092
    Cell Significance Index: 1.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0104
    Cell Significance Index: -0.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0110
    Cell Significance Index: -1.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0265
    Cell Significance Index: -7.6300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0343
    Cell Significance Index: -0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0368
    Cell Significance Index: -7.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0425
    Cell Significance Index: -1.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0501
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0549
    Cell Significance Index: -0.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0553
    Cell Significance Index: -7.1400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0635
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0661
    Cell Significance Index: -7.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0961
    Cell Significance Index: -7.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0993
    Cell Significance Index: -4.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1028
    Cell Significance Index: -8.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1397
    Cell Significance Index: -7.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1468
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1518
    Cell Significance Index: -1.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1571
    Cell Significance Index: -2.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1652
    Cell Significance Index: -1.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1728
    Cell Significance Index: -5.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1781
    Cell Significance Index: -2.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1796
    Cell Significance Index: -3.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1864
    Cell Significance Index: -3.1200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1923
    Cell Significance Index: -1.8600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2061
    Cell Significance Index: -2.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2089
    Cell Significance Index: -7.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2121
    Cell Significance Index: -6.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2308
    Cell Significance Index: -6.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2363
    Cell Significance Index: -4.6200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2514
    Cell Significance Index: -2.1600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2517
    Cell Significance Index: -2.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2570
    Cell Significance Index: -2.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2578
    Cell Significance Index: -5.1400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2744
    Cell Significance Index: -3.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2775
    Cell Significance Index: -7.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2859
    Cell Significance Index: -7.6600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2870
    Cell Significance Index: -3.1500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2959
    Cell Significance Index: -7.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3041
    Cell Significance Index: -7.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3080
    Cell Significance Index: -5.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3095
    Cell Significance Index: -7.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3322
    Cell Significance Index: -5.8700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3337
    Cell Significance Index: -3.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3345
    Cell Significance Index: -7.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3398
    Cell Significance Index: -7.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3452
    Cell Significance Index: -6.9300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3479
    Cell Significance Index: -4.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3629
    Cell Significance Index: -7.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3709
    Cell Significance Index: -5.0600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4002
    Cell Significance Index: -4.3600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4096
    Cell Significance Index: -4.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4135
    Cell Significance Index: -5.6700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.4229
    Cell Significance Index: -6.8000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4294
    Cell Significance Index: -4.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4294
    Cell Significance Index: -8.3800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.4296
    Cell Significance Index: -4.1100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4392
    Cell Significance Index: -4.5300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4397
    Cell Significance Index: -4.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4438
    Cell Significance Index: -6.7400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.4493
    Cell Significance Index: -6.1100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4550
    Cell Significance Index: -3.9800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4600
    Cell Significance Index: -5.8200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4652
    Cell Significance Index: -5.4700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4728
    Cell Significance Index: -2.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4754
    Cell Significance Index: -4.9300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4785
    Cell Significance Index: -7.7500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.4813
    Cell Significance Index: -5.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** HOXD11 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes involved in developmental processes. 2. **Hox gene family member:** HOXD11 is a member of the Hox gene family, which is a group of homeobox-containing genes that play a crucial role in embryonic development and tissue patterning. 3. **Widespread expression:** HOXD11 is expressed in a diverse range of cell types, including microglial cells, plasma cells, enterocytes, goblet cells, B cells, oligodendrocyte precursor cells, and intestinal crypt stem cells. 4. **Developmental importance:** HOXD11 is involved in various developmental processes, including organogenesis, cell differentiation, and tissue morphogenesis. **Pathways and Functions:** 1. **Anatomical structure development:** HOXD11 plays a crucial role in the development of various anatomical structures, including the kidney, ureteric bud, and nervous system. 2. **Branching involved in ureteric bud morphogenesis:** HOXD11 is involved in the branching morphogenesis of the ureteric bud, a critical process in kidney development. 3. **Dorsal/ventral pattern formation:** HOXD11 regulates the dorsal/ventral patterning of the embryo, which is essential for the proper formation of various tissues and organs. 4. **Regulation of transcription by RNA polymerase II:** HOXD11 interacts with RNA polymerase II to regulate the expression of target genes involved in developmental processes. **Clinical Significance:** 1. **Kidney development disorders:** Mutations in the HOXD11 gene have been associated with kidney development disorders, including renal agenesis and ureteric bud dysgenesis. 2. **Neurological disorders:** Alterations in HOXD11 expression have been linked to various neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer:** HOXD11 has been implicated in the development and progression of certain cancers, including breast cancer and colon cancer. 4. **Immune system disorders:** Dysregulation of HOXD11 expression has been associated with immune system disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, the HOXD11 gene plays a critical role in various developmental processes, including organogenesis, cell differentiation, and tissue patterning. Its dysregulation has been implicated in a range of diseases, including kidney development disorders, neurological disorders, cancer, and immune system disorders. Further research is needed to fully elucidate the functions and clinical significance of the HOXD11 gene.

Genular Protein ID: 3631360345

Symbol: HXD11_HUMAN

Name: Homeobox protein Hox-D11

UniProtKB Accession Codes:

P31277 A6NIS4 Q9NS02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 17236141

Title: Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome.

PubMed ID: 17236141

DOI: 10.1086/511387

Sequence Information:

  • Length: 338
  • Mass: 35197
  • Checksum: 2960C3C983EA9A6A
  • Sequence:
    • MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE 
VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA 
EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ 
FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG 
SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS 
RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.