Gene HOXD11 - ENSG00000128713 | NCBI Gene ID: 3237

Details for: HOXD11

Gene ID: 3237

Symbol: HOXD11

Ensembl ID: ENSG00000128713

Description: homeobox D11

Associated with

Developmental biology
(R-HSA-1266738)
Formation of the ureteric bud
(R-HSA-9830674)
Kidney development
(R-HSA-9830369)
Anatomical structure development
(GO:0048856)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dorsal/ventral pattern formation
(GO:0009953)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: microglial cell (CL0000129)
Fold Change: 2.25
Marker Score: 4101
Cell Name: plasma cell (CL0000786)
Fold Change: 1.89
Marker Score: 2115
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4801
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7605
Cell Name: B cell (CL0000236)
Fold Change: 1.06
Marker Score: 1010
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.05
Marker Score: 1296.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.02
Marker Score: 422
Cell Name: decidual cell (CL2000002)
Fold Change: 1
Marker Score: 4316
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1
Marker Score: 676
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71806
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48031
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5340
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.91
Marker Score: 346
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.87
Marker Score: 205
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.87
Marker Score: 1824
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 487
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.82
Marker Score: 827
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.79
Marker Score: 8844.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.67
Marker Score: 707.5
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.65
Marker Score: 790
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.63
Marker Score: 1011
Cell Name: kidney cell (CL1000497)
Fold Change: 0.59
Marker Score: 396
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.59
Marker Score: 1127
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 176
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.55
Marker Score: 931
Cell Name: T cell (CL0000084)
Fold Change: 0.51
Marker Score: 878
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.51
Marker Score: 660
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.49
Marker Score: 469
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.48
Marker Score: 476
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.48
Marker Score: 251
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.47
Marker Score: 121
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.45
Marker Score: 328
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.42
Marker Score: 300
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.42
Marker Score: 169
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.42
Marker Score: 446
Cell Name: supporting cell (CL0000630)
Fold Change: 0.41
Marker Score: 773
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.41
Marker Score: 1035
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.39
Marker Score: 77
Cell Name: stromal cell (CL0000499)
Fold Change: 0.38
Marker Score: 449
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.38
Marker Score: 383
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.38
Marker Score: 532
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.37
Marker Score: 95
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.37
Marker Score: 236
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.35
Marker Score: 845.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.32
Marker Score: 495
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.32
Marker Score: 91
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.31
Marker Score: 4111
Cell Name: pericyte (CL0000669)
Fold Change: 0.31
Marker Score: 181
Cell Name: fibroblast (CL0000057)
Fold Change: 0.3
Marker Score: 289
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.29
Marker Score: 102
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.27
Marker Score: 71
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.25
Marker Score: 199
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.25
Marker Score: 214
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.24
Marker Score: 631
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.23
Marker Score: 545
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.23
Marker Score: 437
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: male germ cell (CL0000015)
Fold Change: 0.22
Marker Score: 62
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.19
Marker Score: 79
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.19
Marker Score: 118
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.19
Marker Score: 312
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.18
Marker Score: 85
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.18
Marker Score: 66
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.18
Marker Score: 366
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.18
Marker Score: 44
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.17
Marker Score: 2733
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.17
Marker Score: 357
Cell Name: neural cell (CL0002319)
Fold Change: 0.17
Marker Score: 83
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.17
Marker Score: 252
Cell Name: muscle cell (CL0000187)
Fold Change: 0.17
Marker Score: 47
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.16
Marker Score: 142
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.15
Marker Score: 39
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.15
Marker Score: 37
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.15
Marker Score: 38.5
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.15
Marker Score: 37
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.14
Marker Score: 66
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.14
Marker Score: 36
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.14
Marker Score: 42
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.14
Marker Score: 44
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.14
Marker Score: 833
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.14
Marker Score: 170
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.13
Marker Score: 42
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.13
Marker Score: 69
Cell Name: club cell (CL0000158)
Fold Change: 0.13
Marker Score: 150
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.13
Marker Score: 43
Cell Name: leukocyte (CL0000738)
Fold Change: 0.13
Marker Score: 72

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**Key characteristics:** * HOXD11 is a protein with a predicted molecular weight of approximately 300 kDa. * It is expressed in a variety of cell types, including microglial cells, plasma cells, enterocytes, goblet cells, B cells, oligodendrocyte precursor cells, transit amplifying cells of the small intestine, decidual cells, and intestinal crypt stem cells. * It is a key regulator of transcription by RNA polymerase II. * Its expression is essential for the development of the urogenital system, including the kidney. **Pathways and functions:** * HOXD11 is involved in the regulation of the development of the urogenital system. * It is a key regulator of ureteric bud morphogenesis, which is the process of forming the tubes that carry urine from the kidneys to the outside of the body. * It is also involved in the regulation of the differentiation of enterocytes, goblet cells, and other cells in the gut. * HOXD11 is also involved in the regulation of the development of the central nervous system. **Clinical significance:** HOXD11 mutations have been linked to a number of human diseases, including kidney cancer, urogenital disorders, and intellectual disability. These mutations can lead to the formation of tumors in the kidneys or other organs in the body. **Additional notes:** * HOXD11 is a highly conserved gene, with a similar gene found in other vertebrates. * It is a member of the HOX family of homeobox genes. * HOXD11 is a key factor in the development of the human kidney.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein Hox-D11

Genular Protein ID: 3631360345

Symbol: HXD11_HUMAN

Name: Homeobox protein Hox-D11

UniProtKB Accession Codes:

P31277 A6NIS4 Q9NS02

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 17236141

Title: Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome.

PubMed ID: 17236141

DOI: 10.1086/511387

Sequence Information:

Length: 338
Mass: 35197
Checksum: 2960C3C983EA9A6A
Sequence:

MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE 
VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA 
EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ 
FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG 
SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS 
RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.