Details for: HRH1

Gene ID: 3269

Symbol: HRH1

Ensembl ID: ENSG00000196639

Description: histamine receptor H1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.7433
    Cell Significance Index: -20.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.1982
    Cell Significance Index: -17.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8089
    Cell Significance Index: -18.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.9487
    Cell Significance Index: 42.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7472
    Cell Significance Index: 90.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6726
    Cell Significance Index: 22.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.5893
    Cell Significance Index: 12.9600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.5611
    Cell Significance Index: 19.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2345
    Cell Significance Index: 55.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1893
    Cell Significance Index: 34.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1888
    Cell Significance Index: 226.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7306
    Cell Significance Index: 10.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7094
    Cell Significance Index: 15.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6391
    Cell Significance Index: 63.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6166
    Cell Significance Index: 123.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5886
    Cell Significance Index: 16.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5406
    Cell Significance Index: 488.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5402
    Cell Significance Index: 8.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5398
    Cell Significance Index: 14.4400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.5201
    Cell Significance Index: 5.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4852
    Cell Significance Index: 9.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4767
    Cell Significance Index: 28.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4725
    Cell Significance Index: 7.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4484
    Cell Significance Index: 15.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4154
    Cell Significance Index: 45.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3680
    Cell Significance Index: 59.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2948
    Cell Significance Index: 36.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2772
    Cell Significance Index: 7.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2562
    Cell Significance Index: 5.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2121
    Cell Significance Index: 14.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1770
    Cell Significance Index: 2.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1604
    Cell Significance Index: 4.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1585
    Cell Significance Index: 28.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1472
    Cell Significance Index: 101.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1198
    Cell Significance Index: 65.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0965
    Cell Significance Index: 6.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0654
    Cell Significance Index: 1.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0615
    Cell Significance Index: 1.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0612
    Cell Significance Index: 1.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0571
    Cell Significance Index: 2.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0494
    Cell Significance Index: 91.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0465
    Cell Significance Index: 16.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0453
    Cell Significance Index: 0.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0411
    Cell Significance Index: 0.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0253
    Cell Significance Index: 39.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0022
    Cell Significance Index: 0.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0053
    Cell Significance Index: -0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0230
    Cell Significance Index: -3.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0280
    Cell Significance Index: -21.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0310
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0346
    Cell Significance Index: -15.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0371
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0390
    Cell Significance Index: -4.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0430
    Cell Significance Index: -24.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0487
    Cell Significance Index: -9.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0529
    Cell Significance Index: -15.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0684
    Cell Significance Index: -8.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0862
    Cell Significance Index: -6.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0874
    Cell Significance Index: -12.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1104
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1214
    Cell Significance Index: -25.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1257
    Cell Significance Index: -21.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1303
    Cell Significance Index: -13.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1522
    Cell Significance Index: -17.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1537
    Cell Significance Index: -3.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1563
    Cell Significance Index: -11.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1666
    Cell Significance Index: -4.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1672
    Cell Significance Index: -2.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1967
    Cell Significance Index: -6.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2010
    Cell Significance Index: -7.6100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2141
    Cell Significance Index: -2.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2214
    Cell Significance Index: -15.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2249
    Cell Significance Index: -25.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2288
    Cell Significance Index: -10.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2466
    Cell Significance Index: -15.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2800
    Cell Significance Index: -14.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2981
    Cell Significance Index: -14.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3060
    Cell Significance Index: -5.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3149
    Cell Significance Index: -10.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3298
    Cell Significance Index: -7.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3335
    Cell Significance Index: -10.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3348
    Cell Significance Index: -21.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3371
    Cell Significance Index: -8.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3750
    Cell Significance Index: -10.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3760
    Cell Significance Index: -21.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4083
    Cell Significance Index: -3.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4178
    Cell Significance Index: -11.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4223
    Cell Significance Index: -8.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4476
    Cell Significance Index: -8.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4527
    Cell Significance Index: -15.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4545
    Cell Significance Index: -15.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4768
    Cell Significance Index: -10.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4813
    Cell Significance Index: -17.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4834
    Cell Significance Index: -22.5400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4841
    Cell Significance Index: -6.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HRH1 gene is a member of the G protein-coupled receptor family, specifically classified as a histamine receptor. It is expressed in various cell types, including hematopoietic stem cells, astrocytes, and endothelial cells, which highlights its widespread involvement in maintaining tissue homeostasis. The HRH1 receptor is characterized by its high affinity for histamine, a neurotransmitter involved in immune responses, arousal, and regulation of the vascular system. **Pathways and Functions:** The HRH1 receptor is activated by histamine, leading to the activation of Gq proteins, which in turn initiate a signaling cascade involving phospholipase C, inositol trisphosphate, and diacylglycerol. This pathway is implicated in various physiological processes, including: 1. **Inflammatory response:** Histamine release from mast cells triggers the activation of HRH1 receptors, leading to the production of pro-inflammatory cytokines and the recruitment of immune cells to sites of inflammation. 2. **Vascular permeability:** Histamine-induced HRH1 receptor activation causes vasoconstriction, increased vascular permeability, and the recruitment of immune cells to the site of inflammation. 3. **Neurotransmitter regulation:** Histamine's interaction with HRH1 receptors modulates the release of neurotransmitters, such as glutamate and GABA, influencing synaptic plasticity and learning. 4. **Immune cell regulation:** HRH1 receptors are expressed on the surface of immature innate lymphoid cells, regulating their activation and proliferation. **Clinical Significance:** The HRH1 gene has significant implications in various diseases and conditions, including: 1. **Allergic disorders:** Overexpression of HRH1 receptors has been linked to allergic reactions, such as asthma, rhinitis, and atopic dermatitis. 2. **Inflammatory diseases:** The activation of HRH1 receptors contributes to the development of inflammatory diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Neurological disorders:** Histamine's interaction with HRH1 receptors may play a role in the pathophysiology of neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression. 4. **Cancer:** The expression of HRH1 receptors has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting a potential role in tumor growth and metastasis. In conclusion, the HRH1 gene plays a critical role in regulating histamine's effects on the immune system, inflammation, and various physiological processes. Further research into the molecular mechanisms of HRH1 receptor activation and its clinical significance will provide valuable insights into the development of novel therapeutic strategies for diseases and conditions associated with histamine dysregulation.

Genular Protein ID: 3675925376

Symbol: HRH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35367 A8K047 Q6P9E5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 10 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8280179

Title: Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor.

PubMed ID: 8280179

DOI: 10.1006/bbrc.1993.2662

PubMed ID: 8003029

Title: Molecular cloning of the human histamine H1 receptor gene.

PubMed ID: 8003029

DOI: 10.1006/bbrc.1994.1786

PubMed ID: 7925364

Title: Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene.

PubMed ID: 7925364

DOI: 10.1111/j.1432-1033.1994.00489.x

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15328002

Title: Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation.

PubMed ID: 15328002

DOI: 10.1016/j.febslet.2004.07.072

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21697825

Title: Structure of the human histamine H1 receptor complex with doxepin.

PubMed ID: 21697825

DOI: 10.1038/nature10236

PubMed ID: 33828102

Title: Cryo-EM structure of the human histamine H1 receptor/Gq complex.

PubMed ID: 33828102

DOI: 10.1038/s41467-021-22427-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 487
  • Mass: 55784
  • Checksum: E5DB418A4C17A985
  • Sequence:
    • MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY AVRSERKLHT 
VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC LFWLSMDYVA STASIFSVFI 
LCIDRYRSVQ QPLRYLKYRT KTRASATILG AWFLSFLWVI PILGWNHFMQ QTSVRREDKC 
ETDFYDVTWF KVMTAIINFY LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR 
PENPKGDAKK PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL 
YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ MLGDSQSFSR 
TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ YVSGLHMNRE RKAAKQLGFI 
MAAFILCWIP YFIFFMVIAF CKNCCNEHLH MFTIWLGYIN STLNPLIYPL CNENFKKTFK 
RILHIRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.