Details for: HRH1

Gene ID: 3269

Symbol: HRH1

Ensembl ID: ENSG00000196639

Description: histamine receptor H1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.92
    Marker Score: 1539
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.57
    Marker Score: 33448
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3134
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 23031
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168652
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.39
    Marker Score: 436
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 11022
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.27
    Marker Score: 77996
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.25
    Marker Score: 1811
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.16
    Marker Score: 421
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.13
    Marker Score: 1250
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16708
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 669
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.03
    Marker Score: 2540.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.03
    Marker Score: 325
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48020
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1435
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.91
    Marker Score: 953
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5144
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.86
    Marker Score: 8197
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.85
    Marker Score: 470
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.84
    Marker Score: 169
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.83
    Marker Score: 16436
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.82
    Marker Score: 538
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.81
    Marker Score: 698
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.79
    Marker Score: 1069
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 254
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.79
    Marker Score: 1108
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.76
    Marker Score: 859
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 804
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 481
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 550
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.71
    Marker Score: 24018
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.71
    Marker Score: 224
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.71
    Marker Score: 852.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.7
    Marker Score: 1077
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.68
    Marker Score: 6417.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 409
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.68
    Marker Score: 1151
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2841
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.66
    Marker Score: 657
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.66
    Marker Score: 189
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.65
    Marker Score: 272
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.65
    Marker Score: 156
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.63
    Marker Score: 557
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.61
    Marker Score: 1115.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.61
    Marker Score: 609
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 382
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.59
    Marker Score: 150
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.57
    Marker Score: 206
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 497
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 269
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.56
    Marker Score: 190
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.54
    Marker Score: 1705
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.54
    Marker Score: 367
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.52
    Marker Score: 19168
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.51
    Marker Score: 621
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.5
    Marker Score: 651
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 3022
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5
    Marker Score: 340
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.49
    Marker Score: 494
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.48
    Marker Score: 282
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.48
    Marker Score: 1953
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.47
    Marker Score: 1196
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.46
    Marker Score: 923
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.45
    Marker Score: 149
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.43
    Marker Score: 195
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 379
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.42
    Marker Score: 1201
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 794
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.41
    Marker Score: 396
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 142
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.4
    Marker Score: 230
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.4
    Marker Score: 645
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.39
    Marker Score: 439
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.39
    Marker Score: 270
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.39
    Marker Score: 156
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.39
    Marker Score: 1859
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.38
    Marker Score: 145
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.38
    Marker Score: 137
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 359
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367

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Other Information

**Key characteristics:** - HRH1 is a member of the histamine receptor family, which are a large group of GPCRs that are involved in a variety of physiological and pathological processes. - HRH1 is a G protein-coupled receptor that is expressed in high levels in the brain, particularly in the cerebral cortex. - It is a key regulator of vascular permeability and inflammation. **Pathways and functions:** - HRH1 is a key regulator of vascular permeability. It is expressed in endothelial cells of blood vessels and is activated by histamine, a neurotransmitter that is released by immune cells. When HRH1 is activated, it opens G protein-coupled channels, which leads to the influx of calcium ions and the activation of downstream signaling pathways. These pathways include the phospholipase c-activating g protein-coupled receptor (GPCR) signaling pathway and the G protein-coupled serotonin receptor activity pathway. - HRH1 is also involved in the regulation of memory. It is expressed in neurons that are involved in memory formation and retrieval, and it is thought to play a role in the development and maintenance of memory. - HRH1 is a key regulator of inflammatory responses. It is expressed in immune cells and is activated by histamine released by activated macrophages and dendritic cells. HRH1 activation leads to the production of inflammatory cytokines and chemokines, which can recruit immune cells to the site of inflammation. **Clinical significance:** - Mutations in the HRH1 gene have been linked to a number of human diseases, including autism, schizophrenia, and inflammatory bowel disease. - HRH1 is a potential therapeutic target for these diseases.

Genular Protein ID: 3675925376

Symbol: HRH1_HUMAN

Name: Histamine H1 receptor

UniProtKB Accession Codes:

P35367 A8K047 Q6P9E5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 10 EMDB 1 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 8 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8280179

Title: Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor.

PubMed ID: 8280179

DOI: 10.1006/bbrc.1993.2662

PubMed ID: 8003029

Title: Molecular cloning of the human histamine H1 receptor gene.

PubMed ID: 8003029

DOI: 10.1006/bbrc.1994.1786

PubMed ID: 7925364

Title: Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene.

PubMed ID: 7925364

DOI: 10.1111/j.1432-1033.1994.00489.x

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15328002

Title: Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation.

PubMed ID: 15328002

DOI: 10.1016/j.febslet.2004.07.072

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21697825

Title: Structure of the human histamine H1 receptor complex with doxepin.

PubMed ID: 21697825

DOI: 10.1038/nature10236

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 487
  • Mass: 55784
  • Checksum: E5DB418A4C17A985
  • Sequence:
    • MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY AVRSERKLHT 
VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC LFWLSMDYVA STASIFSVFI 
LCIDRYRSVQ QPLRYLKYRT KTRASATILG AWFLSFLWVI PILGWNHFMQ QTSVRREDKC 
ETDFYDVTWF KVMTAIINFY LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR 
PENPKGDAKK PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL 
YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ MLGDSQSFSR 
TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ YVSGLHMNRE RKAAKQLGFI 
MAAFILCWIP YFIFFMVIAF CKNCCNEHLH MFTIWLGYIN STLNPLIYPL CNENFKKTFK 
RILHIRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.