Details for: HSD17B4

Gene ID: 3295

Symbol: HSD17B4

Ensembl ID: ENSG00000133835

Description: hydroxysteroid 17-beta dehydrogenase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 333.0864
    Cell Significance Index: -51.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.5318
    Cell Significance Index: -53.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 144.8242
    Cell Significance Index: -59.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.4470
    Cell Significance Index: -57.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.9456
    Cell Significance Index: -47.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.3017
    Cell Significance Index: -54.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.0239
    Cell Significance Index: -47.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.4518
    Cell Significance Index: -56.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4154
    Cell Significance Index: -54.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.6526
    Cell Significance Index: -57.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0424
    Cell Significance Index: -19.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.5524
    Cell Significance Index: 76.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1548
    Cell Significance Index: 626.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2930
    Cell Significance Index: 413.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1021
    Cell Significance Index: 28.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0229
    Cell Significance Index: 405.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9797
    Cell Significance Index: 18.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9456
    Cell Significance Index: 51.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7534
    Cell Significance Index: 628.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7475
    Cell Significance Index: 90.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7326
    Cell Significance Index: 213.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4169
    Cell Significance Index: 1279.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3544
    Cell Significance Index: 103.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2486
    Cell Significance Index: 135.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1636
    Cell Significance Index: 32.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0393
    Cell Significance Index: 29.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9764
    Cell Significance Index: 158.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7026
    Cell Significance Index: 43.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6484
    Cell Significance Index: 29.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6258
    Cell Significance Index: 432.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5942
    Cell Significance Index: 324.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5909
    Cell Significance Index: 27.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5402
    Cell Significance Index: 74.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4237
    Cell Significance Index: 187.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3464
    Cell Significance Index: 9.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2982
    Cell Significance Index: 56.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2879
    Cell Significance Index: 7.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2757
    Cell Significance Index: 19.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2374
    Cell Significance Index: 17.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2122
    Cell Significance Index: 4.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2109
    Cell Significance Index: 9.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1913
    Cell Significance Index: 32.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1904
    Cell Significance Index: 12.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1853
    Cell Significance Index: 18.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1744
    Cell Significance Index: 328.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1704
    Cell Significance Index: 9.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1307
    Cell Significance Index: 4.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0857
    Cell Significance Index: 54.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0764
    Cell Significance Index: 3.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0676
    Cell Significance Index: 8.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0612
    Cell Significance Index: 46.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0506
    Cell Significance Index: 22.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0267
    Cell Significance Index: 49.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0236
    Cell Significance Index: 36.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0195
    Cell Significance Index: 14.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0160
    Cell Significance Index: 21.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0287
    Cell Significance Index: -21.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0504
    Cell Significance Index: -6.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0616
    Cell Significance Index: -34.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0649
    Cell Significance Index: -6.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0661
    Cell Significance Index: -1.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0730
    Cell Significance Index: -1.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1118
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1639
    Cell Significance Index: -34.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1644
    Cell Significance Index: -19.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1667
    Cell Significance Index: -47.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1752
    Cell Significance Index: -25.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1775
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2421
    Cell Significance Index: -27.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2627
    Cell Significance Index: -16.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2728
    Cell Significance Index: -31.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2807
    Cell Significance Index: -8.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3100
    Cell Significance Index: -7.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3462
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3533
    Cell Significance Index: -40.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3642
    Cell Significance Index: -18.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4180
    Cell Significance Index: -43.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4311
    Cell Significance Index: -27.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4356
    Cell Significance Index: -7.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4463
    Cell Significance Index: -10.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4645
    Cell Significance Index: -7.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4711
    Cell Significance Index: -37.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5442
    Cell Significance Index: -17.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6075
    Cell Significance Index: -21.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6759
    Cell Significance Index: -35.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6839
    Cell Significance Index: -41.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6929
    Cell Significance Index: -42.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7426
    Cell Significance Index: -16.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7449
    Cell Significance Index: -15.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8772
    Cell Significance Index: -23.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9375
    Cell Significance Index: -47.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9460
    Cell Significance Index: -25.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0000
    Cell Significance Index: -29.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0029
    Cell Significance Index: -31.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0400
    Cell Significance Index: -34.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0612
    Cell Significance Index: -7.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0792
    Cell Significance Index: -27.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0987
    Cell Significance Index: -22.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B4 is a member of the 17-beta-hydroxysteroid dehydrogenase family, which consists of enzymes responsible for the interconversion of steroids. This enzyme exhibits a broad substrate specificity, allowing it to catalyze the reduction of 17-hydroxyprogesterone to 11-deoxycortisol, as well as the oxidation of various fatty acids. The enzyme is highly expressed in various tissues, including the liver, brain, and adrenal gland, and plays a critical role in maintaining hormonal balance and lipid metabolism. **Pathways and Functions:** HSD17B4 is involved in several key metabolic pathways, including: 1. **Steroid Biosynthesis:** HSD17B4 is essential for the conversion of 17-hydroxyprogesterone to 11-deoxycortisol, a critical step in the biosynthesis of cortisol. 2. **Fatty Acid Metabolism:** HSD17B4 is implicated in the metabolism of alpha-linolenic acid, a polyunsaturated fatty acid that plays a crucial role in various physiological processes. 3. **Lipid Metabolism:** HSD17B4 is involved in the beta-oxidation of fatty acids, a process that is essential for energy production and lipid homeostasis. 4. **Androgen Metabolism:** HSD17B4 is also involved in the metabolism of androgens, such as testosterone and dihydrotestosterone. 5. **Estrogen Metabolism:** HSD17B4 is implicated in the metabolism of estrogens, including estradiol and estriol. **Clinical Significance:** Dysregulation of HSD17B4 has been implicated in various diseases, including: 1. **Metabolic Disorders:** HSD17B4 has been linked to obesity, type 2 diabetes, and metabolic syndrome. 2. **Cancer:** HSD17B4 is overexpressed in several types of cancer, including breast, prostate, and colon cancer. 3. **Neurological Conditions:** HSD17B4 has been implicated in the pathogenesis of Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Hypertension:** HSD17B4 has been linked to hypertension, a condition characterized by elevated blood pressure. In conclusion, HSD17B4 is a multifaceted enzyme that plays a critical role in various metabolic pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying its function and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 1709670036

Symbol: DHB4_HUMAN

Name: 17-beta-hydroxysteroid dehydrogenase 4

UniProtKB Accession Codes:

P51659 B4DNV1 B4DVS5 E9PB82 F5HE57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 2 CTD 1 ChEBI 60 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 26 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 Rhea 24 SABIO-RK 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7487879

Title: Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV.

PubMed ID: 7487879

DOI: 10.1042/bj3110437

PubMed ID: 9089413

Title: Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.

PubMed ID: 9089413

DOI: 10.1093/oxfordjournals.jbchem.a021596

PubMed ID: 9880674

Title: Structure of the gene for the human 17beta-hydroxysteroid dehydrogenase type IV.

PubMed ID: 9880674

DOI: 10.1007/s003359900921

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8902629

Title: Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase.

PubMed ID: 8902629

DOI: 10.1093/oxfordjournals.jbchem.a021458

PubMed ID: 10671535

Title: Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity.

PubMed ID: 10671535

DOI: 10.1074/jbc.275.7.4965

PubMed ID: 10706581

Title: Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method.

PubMed ID: 10706581

PubMed ID: 15060085

Title: Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids.

PubMed ID: 15060085

DOI: 10.1194/jlr.m300512-jlr200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11700068

Title: Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 A resolution.

PubMed ID: 11700068

DOI: 10.1006/jmbi.2001.5084

PubMed ID: 15644212

Title: Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2.

PubMed ID: 15644212

DOI: 10.1016/j.jmb.2004.11.009

PubMed ID: 9482850

Title: Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency.

PubMed ID: 9482850

DOI: 10.1073/pnas.95.5.2128

PubMed ID: 10400999

Title: Enoyl-CoA hydratase deficiency: identification of a new type of D-bifunctional protein deficiency.

PubMed ID: 10400999

DOI: 10.1093/hmg/8.8.1509

PubMed ID: 11743515

Title: D-bifunctional protein deficiency with fetal ascites, polyhydramnios, and contractures of hands and toes.

PubMed ID: 11743515

DOI: 10.1067/mpd.2001.119170

PubMed ID: 20673864

Title: Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome.

PubMed ID: 20673864

DOI: 10.1016/j.ajhg.2010.07.007

PubMed ID: 25956234

Title: Exome analysis identified a novel missense mutation in the CLPP gene in a consanguineous Saudi family expanding the clinical spectrum of Perrault Syndrome type-3.

PubMed ID: 25956234

DOI: 10.1016/j.jns.2015.04.038

Sequence Information:

  • Length: 736
  • Mass: 79686
  • Checksum: 7B11E02483328BCE
  • Sequence:
    • MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE 
EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH 
RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI 
EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG 
AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS 
KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD 
LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA 
GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV 
AVAIPNRPPD AVLTDTTSLN QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS 
ARRVLQQFAD NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN 
AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI 
GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI 
MLSQKLQMIL KDYAKL

Genular Protein ID: 3560650955

Symbol: B2R659_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R659

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 4 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 7 RefSeq 4 SMART 1 SUPFAM 3 UniPathway 1

Sequence Information:

  • Length: 736
  • Mass: 79612
  • Checksum: 1DFFAE2214257B9E
  • Sequence:
    • MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE 
EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH 
RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI 
EGRKSNIHCN TIAPNAGSRM TQTVTPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG 
AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS 
KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD 
LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA 
GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV 
AVAIPNRPPD AVLTDTTSLN QAALYRLSGD RNPLHIDPNF ASLAGFDKPI LHGLCTFGFS 
ARRVLQQFAD NDVSRFKAVK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN 
AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI 
GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI 
MLSQKLQMIL KDYAKL

Genular Protein ID: 2675507292

Symbol: B3KSP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSP2

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 4 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 7 RefSeq 1 SUPFAM 3 UniPathway 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 596
  • Mass: 64592
  • Checksum: 187FDF6AEF006596
  • Sequence:
    • MKKQKIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI EGRKSNIHCN TIAPNAGSRM 
TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG AGWIGKLRWE RTLGAIVRQK 
NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS KIDSEGGVSA NHTSRATSTA 
TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD LKFIYEGSSD FSCLPTFGVI 
IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA GKLKCEAVVA DVLDKGSGVV 
IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV AVAIPNRPPD AVLTDTTSLN 
QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS ARRVLQQFAD NDVSRFKAIK 
ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN AYVDLAPTSG TSAKTPSEGG 
KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI GAKWTIDLKS GSGKVYQGPA 
KGAADTTIIL SDENFMEVVL GKLDPQKAFF SGRLKARGNI MLSQKLQMIL KDYAKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.