Details for: IGSF3

Gene ID: 3321

Symbol: IGSF3

Ensembl ID: ENSG00000143061

Description: immunoglobulin superfamily member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.86
    Marker Score: 1504.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.51
    Marker Score: 6288
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.29
    Marker Score: 1363
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.26
    Marker Score: 4665
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.17
    Marker Score: 2371
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.16
    Marker Score: 1627
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.15
    Marker Score: 4775
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17783
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2147
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.1
    Marker Score: 21944
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.09
    Marker Score: 41499
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.07
    Marker Score: 36051
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.06
    Marker Score: 2838
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.01
    Marker Score: 389
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48025
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2297
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.97
    Marker Score: 891
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1413
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 260
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5181.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9
    Marker Score: 1574
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.85
    Marker Score: 961
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.84
    Marker Score: 30885
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.83
    Marker Score: 242
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3358
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4819
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.8
    Marker Score: 422
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.79
    Marker Score: 436
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.76
    Marker Score: 812
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 244
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.75
    Marker Score: 1770
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.71
    Marker Score: 325
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 470
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 417
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2891.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.68
    Marker Score: 41643
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.67
    Marker Score: 157
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.67
    Marker Score: 6890
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.63
    Marker Score: 1601
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.63
    Marker Score: 4694
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.62
    Marker Score: 648
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.61
    Marker Score: 1017
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 866
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.6
    Marker Score: 776
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.58
    Marker Score: 2704
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.58
    Marker Score: 5023
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.58
    Marker Score: 696
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.57
    Marker Score: 580
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.57
    Marker Score: 614
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.57
    Marker Score: 1898
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.56
    Marker Score: 113
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.55
    Marker Score: 322
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.55
    Marker Score: 1352
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.54
    Marker Score: 305
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.53
    Marker Score: 444
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.53
    Marker Score: 558
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.52
    Marker Score: 2728
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.51
    Marker Score: 3355
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.5
    Marker Score: 3818
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 230
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.48
    Marker Score: 7693
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.47
    Marker Score: 2795
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.45
    Marker Score: 2370.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 689
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.44
    Marker Score: 491
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.44
    Marker Score: 713
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.44
    Marker Score: 2350
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.44
    Marker Score: 467
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.44
    Marker Score: 196
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 485
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.43
    Marker Score: 1341
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.42
    Marker Score: 396
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.41
    Marker Score: 515
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 143
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.41
    Marker Score: 165
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.4
    Marker Score: 1943
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.4
    Marker Score: 634
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 105
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.4
    Marker Score: 305
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.4
    Marker Score: 1405
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.39
    Marker Score: 646

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Other Information

**Key characteristics:** * IgSF3 is a glycoprotein that is composed of 16 transmembrane domains. * It is expressed in a variety of cell types, including hematopoietic stem cells, GABAergic neurons, kidney cells, and epithelial cells. * It is a key regulator of lacrimal gland development. * It is involved in the regulation of the immune response. **Pathways and functions:** * IGSF3 is involved in the development and maintenance of the lacrimal gland. * It is a key regulator of corneal epithelial cell migration and differentiation. * It is also involved in the regulation of the immune response. **Clinical significance:** * Mutations in the IGSF3 gene have been linked to a number of human diseases, including glaucoma, corneal dystrophy, and kidney disease. * IGSF3 is a potential therapeutic target for these diseases. **Additional notes:** * IGSF3 is a relatively novel protein, with no known human homologs. * It is a highly conserved protein, with a similar sequence found in mice and rats. * It is a promising target for the development of new therapies for eye diseases.

Genular Protein ID: 3086512050

Symbol: IGSF3_HUMAN

Name: Immunoglobulin superfamily member 3

UniProtKB Accession Codes:

O75054 A6NJZ6 A6NMC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 3 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 3 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790749

Title: Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13.

PubMed ID: 9790749

DOI: 10.1006/geno.1998.5439

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11504738

Title: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

PubMed ID: 11504738

DOI: 10.1074/jbc.m107338200

PubMed ID: 14656960

Title: Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution.

PubMed ID: 14656960

DOI: 10.1101/gr.1549503

PubMed ID: 24372406

Title: Identification of an IGSF3 mutation in a family with congenital nasolacrimal duct obstruction.

PubMed ID: 24372406

DOI: 10.1111/cge.12321

Sequence Information:

  • Length: 1194
  • Mass: 135196
  • Checksum: C5E22EDBC81714DD
  • Sequence:
    • MKCFFPVLSC LAVLGVVSAQ RQVTVQEGPL YRTEGSHITI WCNVSGYQGP SEQNFQWSIY 
LPSSPEREVQ IVSTMDSSFP YAIYTQRVRG GKIFIERVQG NSTLLHITDL QARDAGEYEC 
HTPSTDKQYF GSYSAKMNLV VIPDSLQTTA MPQTLHRVEQ DPLELTCEVA SETIQHSHLS 
VAWLRQKVGE KPVEVISLSR DFMLHSSSEY AQRQSLGEVR LDKLGRTTFR LTIFHLQPSD 
QGEFYCEAAE WIQDPDGSWY AMTRKRSEGA VVNVQPTDKE FTVRLETEKR LHTVGEPVEF 
RCILEAQNVP DRYFAVSWAF NSSLIATMGP NAVPVLNSEF AHREARGQLK VAKESDSVFV 
LKIYHLRQED SGKYNCRVTE REKTVTGEFI DKESKRPKNI PIIVLPLKSS ISVEVASNAS 
VILEGEDLRF SCSVRTAGRP QGRFSVIWQL VDRQNRRSNI MWLDRDGTVQ PGSSYWERSS 
FGGVQMEQVQ PNSFSLGIFN SRKEDEGQYE CHVTEWVRAV DGEWQIVGER RASTPISITA 
LEMGFAVTAI SRTPGVTYSD SFDLQCIIKP HYPAWVPVSV TWRFQPVGTV EFHDLVTFTR 
DGGVQWGDRS SSFRTRTAIE KAESSNNVRL SISRASDTEA GKYQCVAELW RKNYNNTWTR 
LAERTSNLLE IRVLQPVTKL QVSKSKRTLT LVENKPIQLN CSVKSQTSQN SHFAVLWYVH 
KPSDADGKLI LKTTHNSAFE YGTYAEEEGL RARLQFERHV SGGLFSLTVQ RAEVSDSGSY 
YCHVEEWLLS PNYAWYKLAE EVSGRTEVTV KQPDSRLRLS QAQGNLSVLE TRQVQLECVV 
LNRTSITSQL MVEWFVWKPN HPERETVARL SRDATFHYGE QAAKNNLKGR LHLESPSPGV 
YRLFIQNVAV QDSGTYSCHV EEWLPSPSGM WYKRAEDTAG QTALTVMRPD ASLQVDTVVP 
NATVSEKAAF QLDCSIVSRS SQDSRFAVAW YSLRTKAGGK RSSPGLEEQE EEREEEEEED 
DDDDDDPTER TALLSVGPDA VFGPEGSPWE GRLRFQRLSP VLYRLTVLQA SPQDTGNYSC 
HVEEWLPSPQ KEWYRLTEEE SAPIGIRVLD TSPTLQSIIC SNDALFYFVF FYPFPIFGIL 
IITILLVRFK SRNSSKNSDG KNGVPLLWIK EPHLNYSPTC LEPPVLSIHP GAID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.