Details for: IGSF3

Gene ID: 3321

Symbol: IGSF3

Ensembl ID: ENSG00000143061

Description: immunoglobulin superfamily member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.6875
    Cell Significance Index: -20.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.1992
    Cell Significance Index: -17.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.0931
    Cell Significance Index: -21.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4164
    Cell Significance Index: 459.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1585
    Cell Significance Index: 29.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8178
    Cell Significance Index: 94.4300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.6657
    Cell Significance Index: 23.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3938
    Cell Significance Index: 1258.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.2117
    Cell Significance Index: 9.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1815
    Cell Significance Index: 33.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9262
    Cell Significance Index: 20.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8501
    Cell Significance Index: 138.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8076
    Cell Significance Index: 94.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7693
    Cell Significance Index: 83.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7411
    Cell Significance Index: 45.5500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.6964
    Cell Significance Index: 1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6842
    Cell Significance Index: 137.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6082
    Cell Significance Index: 16.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5216
    Cell Significance Index: 11.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5103
    Cell Significance Index: 23.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5053
    Cell Significance Index: 30.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4629
    Cell Significance Index: 83.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4453
    Cell Significance Index: 10.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4188
    Cell Significance Index: 12.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3041
    Cell Significance Index: 2.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2943
    Cell Significance Index: 36.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2776
    Cell Significance Index: 122.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2635
    Cell Significance Index: 18.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2548
    Cell Significance Index: 176.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2184
    Cell Significance Index: 21.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2068
    Cell Significance Index: 5.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1865
    Cell Significance Index: 101.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1501
    Cell Significance Index: 6.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1019
    Cell Significance Index: 7.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0669
    Cell Significance Index: 1.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0662
    Cell Significance Index: 1.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0660
    Cell Significance Index: 13.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0578
    Cell Significance Index: 2.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0554
    Cell Significance Index: 19.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0544
    Cell Significance Index: 2.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0372
    Cell Significance Index: 23.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0165
    Cell Significance Index: 0.5800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0097
    Cell Significance Index: 0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0075
    Cell Significance Index: 5.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0052
    Cell Significance Index: 0.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -13.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -24.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0387
    Cell Significance Index: -6.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0391
    Cell Significance Index: -2.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0471
    Cell Significance Index: -21.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0562
    Cell Significance Index: -2.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0563
    Cell Significance Index: -16.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0564
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0578
    Cell Significance Index: -6.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0640
    Cell Significance Index: -9.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0706
    Cell Significance Index: -1.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0801
    Cell Significance Index: -10.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0852
    Cell Significance Index: -9.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0995
    Cell Significance Index: -12.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1044
    Cell Significance Index: -5.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1253
    Cell Significance Index: -17.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1268
    Cell Significance Index: -12.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1274
    Cell Significance Index: -4.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1410
    Cell Significance Index: -2.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1491
    Cell Significance Index: -2.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1826
    Cell Significance Index: -21.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1842
    Cell Significance Index: -13.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1998
    Cell Significance Index: -20.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2379
    Cell Significance Index: -18.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2551
    Cell Significance Index: -5.0500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2558
    Cell Significance Index: -2.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2644
    Cell Significance Index: -3.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2723
    Cell Significance Index: -5.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3046
    Cell Significance Index: -19.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3168
    Cell Significance Index: -20.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3343
    Cell Significance Index: -20.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3496
    Cell Significance Index: -3.6500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3513
    Cell Significance Index: -2.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3565
    Cell Significance Index: -4.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3649
    Cell Significance Index: -19.1600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4484
    Cell Significance Index: -6.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4590
    Cell Significance Index: -15.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4653
    Cell Significance Index: -16.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4735
    Cell Significance Index: -17.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4776
    Cell Significance Index: -7.8700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4957
    Cell Significance Index: -4.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5177
    Cell Significance Index: -16.9500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5475
    Cell Significance Index: -5.1900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5537
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5648
    Cell Significance Index: -16.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5650
    Cell Significance Index: -15.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5761
    Cell Significance Index: -16.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGSF3 is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by its ability to interact with other proteins and cell surfaces. The gene is expressed in multiple cell types, including: * Hematopoietic stem cells, where it may play a role in hematopoiesis and immune development * GABAergic neurons, where it could influence neurotransmission and synaptic plasticity * Epithelial cells of the lower respiratory tract, where it may contribute to airway development and function * Other cell types, such as chromaffin cells, cardiac muscle myoblasts, and cardiac endothelial cells IGSF3 is involved in various cellular processes, including: * Cell surface interactions and adhesion * Development and morphogenesis * Signaling pathways and protein-protein interactions **Pathways and Functions:** IGSF3 is implicated in several signaling pathways and cellular processes, including: * Cell surface interactions: IGSF3 interacts with other proteins and cell surfaces, influencing cell adhesion, migration, and signaling. * Development and morphogenesis: IGSF3 is involved in the development of various tissues, including the hematopoietic system, nervous system, and epithelial tissues. * Signaling pathways: IGSF3 is linked to various signaling pathways, including the Notch and Wnt/β-catenin pathways, which regulate cellular differentiation, proliferation, and survival. The functions of IGSF3 are not yet fully understood, but it is believed to play a role in: * Modulating immune responses and hematopoiesis * Regulating neural development and function * Influencing epithelial development and function **Clinical Significance:** The IGSF3 gene has been associated with various diseases and disorders, including: * Immune-related disorders, such as autoimmune diseases and immunodeficiencies * Neurological disorders, such as epilepsy and autism spectrum disorder * Respiratory disorders, such as asthma and chronic obstructive pulmonary disease (COPD) Further research is needed to elucidate the role of IGSF3 in human disease and to identify potential therapeutic targets. As our understanding of this gene and its functions evolves, it is likely to reveal new avenues for the treatment and management of various diseases. In conclusion, IGSF3 is a gene of ongoing research and clinical significance, with implications for our understanding of immune function, neural development, and epithelial development. Further studies are necessary to fully elucidate the functions of this gene and its role in human disease.

Genular Protein ID: 3086512050

Symbol: IGSF3_HUMAN

Name: Immunoglobulin superfamily member 3

UniProtKB Accession Codes:

O75054 A6NJZ6 A6NMC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SMART 3 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790749

Title: Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13.

PubMed ID: 9790749

DOI: 10.1006/geno.1998.5439

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11504738

Title: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

PubMed ID: 11504738

DOI: 10.1074/jbc.m107338200

PubMed ID: 14656960

Title: Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution.

PubMed ID: 14656960

DOI: 10.1101/gr.1549503

PubMed ID: 24372406

Title: Identification of an IGSF3 mutation in a family with congenital nasolacrimal duct obstruction.

PubMed ID: 24372406

DOI: 10.1111/cge.12321

Sequence Information:

  • Length: 1194
  • Mass: 135196
  • Checksum: C5E22EDBC81714DD
  • Sequence:
    • MKCFFPVLSC LAVLGVVSAQ RQVTVQEGPL YRTEGSHITI WCNVSGYQGP SEQNFQWSIY 
LPSSPEREVQ IVSTMDSSFP YAIYTQRVRG GKIFIERVQG NSTLLHITDL QARDAGEYEC 
HTPSTDKQYF GSYSAKMNLV VIPDSLQTTA MPQTLHRVEQ DPLELTCEVA SETIQHSHLS 
VAWLRQKVGE KPVEVISLSR DFMLHSSSEY AQRQSLGEVR LDKLGRTTFR LTIFHLQPSD 
QGEFYCEAAE WIQDPDGSWY AMTRKRSEGA VVNVQPTDKE FTVRLETEKR LHTVGEPVEF 
RCILEAQNVP DRYFAVSWAF NSSLIATMGP NAVPVLNSEF AHREARGQLK VAKESDSVFV 
LKIYHLRQED SGKYNCRVTE REKTVTGEFI DKESKRPKNI PIIVLPLKSS ISVEVASNAS 
VILEGEDLRF SCSVRTAGRP QGRFSVIWQL VDRQNRRSNI MWLDRDGTVQ PGSSYWERSS 
FGGVQMEQVQ PNSFSLGIFN SRKEDEGQYE CHVTEWVRAV DGEWQIVGER RASTPISITA 
LEMGFAVTAI SRTPGVTYSD SFDLQCIIKP HYPAWVPVSV TWRFQPVGTV EFHDLVTFTR 
DGGVQWGDRS SSFRTRTAIE KAESSNNVRL SISRASDTEA GKYQCVAELW RKNYNNTWTR 
LAERTSNLLE IRVLQPVTKL QVSKSKRTLT LVENKPIQLN CSVKSQTSQN SHFAVLWYVH 
KPSDADGKLI LKTTHNSAFE YGTYAEEEGL RARLQFERHV SGGLFSLTVQ RAEVSDSGSY 
YCHVEEWLLS PNYAWYKLAE EVSGRTEVTV KQPDSRLRLS QAQGNLSVLE TRQVQLECVV 
LNRTSITSQL MVEWFVWKPN HPERETVARL SRDATFHYGE QAAKNNLKGR LHLESPSPGV 
YRLFIQNVAV QDSGTYSCHV EEWLPSPSGM WYKRAEDTAG QTALTVMRPD ASLQVDTVVP 
NATVSEKAAF QLDCSIVSRS SQDSRFAVAW YSLRTKAGGK RSSPGLEEQE EEREEEEEED 
DDDDDDPTER TALLSVGPDA VFGPEGSPWE GRLRFQRLSP VLYRLTVLQA SPQDTGNYSC 
HVEEWLPSPQ KEWYRLTEEE SAPIGIRVLD TSPTLQSIIC SNDALFYFVF FYPFPIFGIL 
IITILLVRFK SRNSSKNSDG KNGVPLLWIK EPHLNYSPTC LEPPVLSIHP GAID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.