Details for: HYAL1

Gene ID: 3373

Symbol: HYAL1

Ensembl ID: ENSG00000114378

Description: hyaluronidase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4801
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2202
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16599
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 667.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.97
    Marker Score: 4206
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.93
    Marker Score: 291
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5215
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.89
    Marker Score: 7782
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.88
    Marker Score: 1056
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 515
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.86
    Marker Score: 2174
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.85
    Marker Score: 2289
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.83
    Marker Score: 762
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.81
    Marker Score: 10793
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.79
    Marker Score: 834
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.77
    Marker Score: 666.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.77
    Marker Score: 4162
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.74
    Marker Score: 4785
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.73
    Marker Score: 4665
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.72
    Marker Score: 1039
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.71
    Marker Score: 758.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1280
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1576
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.66
    Marker Score: 1067
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.66
    Marker Score: 329
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.66
    Marker Score: 1314
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3870
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 376
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.58
    Marker Score: 394
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.57
    Marker Score: 3741
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.55
    Marker Score: 576
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.55
    Marker Score: 128
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.54
    Marker Score: 240
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.52
    Marker Score: 143
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.46
    Marker Score: 758
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.45
    Marker Score: 1020
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 198
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.45
    Marker Score: 252
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.44
    Marker Score: 167
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.44
    Marker Score: 1110
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.42
    Marker Score: 467
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.42
    Marker Score: 710
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.42
    Marker Score: 156
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.41
    Marker Score: 1473
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 393
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4
    Marker Score: 293
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.39
    Marker Score: 556
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.39
    Marker Score: 241
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.39
    Marker Score: 346
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.38
    Marker Score: 381
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.37
    Marker Score: 334
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.37
    Marker Score: 161
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.36
    Marker Score: 346
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.35
    Marker Score: 357
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.33
    Marker Score: 349
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.33
    Marker Score: 79
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.32
    Marker Score: 347
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 306
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.32
    Marker Score: 316
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.32
    Marker Score: 2102
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 492
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.31
    Marker Score: 67
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 199
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.29
    Marker Score: 171
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.29
    Marker Score: 443
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 119
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.28
    Marker Score: 140
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.28
    Marker Score: 189
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.26
    Marker Score: 163
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.26
    Marker Score: 5777

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Other Information

**Key characteristics** * HYAL1 is a glycoprotein that is expressed in a variety of cell types, including granulocyte monocyte progenitor cell, enterocyte of epithelium of small intestine, immature innate lymphoid cell, cardiac muscle myoblast, cerebral cortex GABAergic interneuron, forebrain radial glial cell, intestinal crypt stem cell of small intestine, tuft cell of colon, absorptive cell, midzonal region hepatocyte. * It is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a glycoprotein that is synthesized by the liver and secreted by cells in the extracellular matrix. * It is a key regulator of the balance between the synthesis and degradation of hyaluronic acid in the body. **Pathways and functions** * Hyaluronidase 1 is involved in the following pathways and functions: * Carbohydrate metabolic process * Chondroitin hydrolase activity * Chondroitin sulfate/dermatan sulfate metabolism * Cs/ds degradation * Disease * Diseases of carbohydrate metabolism * Diseases of metabolism * Glycosaminoglycan catabolic process * Glycosaminoglycan metabolism * Hyaluronan metabolism * Hyaluronan synthase activity * Hyaluronan uptake and degradation * Hyalurononglucosaminidase activity * Metabolism * Metabolism of carbohydrates **Clinical significance** HYAL1 is a gene that is linked to a number of diseases, including: * Mucopolysaccharidoses * Mps ix - natowicz syndrome * Hyaluronidase inhibitor-induced synovitis HYAL1 is an important target for therapy in these diseases, as it is a key enzyme in the metabolism of hyaluronic acid.

Genular Protein ID: 2412210521

Symbol: HYAL1_HUMAN

Name: Hyaluronidase-1

UniProtKB Accession Codes:

Q12794 Q6FH23 Q6PIZ6 Q7KYU2 Q7LE34 Q8NFK5 Q8NFK6 Q8NFK7 Q8NFK8 Q8NFK9 Q93013 Q9UKD5 Q9UNI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 4 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 14 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8603390

Title: Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG.

PubMed ID: 8603390

PubMed ID: 9223416

Title: Purification, cloning, and expression of human plasma hyaluronidase.

PubMed ID: 9223416

DOI: 10.1006/bbrc.1997.6773

PubMed ID: 10702795

Title: HYAL1(LUCA-1), a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA.

PubMed ID: 10702795

DOI: 10.1038/sj.onc.1203317

PubMed ID: 12084718

Title: Regulation of hyaluronidase activity by alternative mRNA splicing.

PubMed ID: 12084718

DOI: 10.1074/jbc.m203821200

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17503783

Title: Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis.

PubMed ID: 17503783

DOI: 10.1021/bi700382g

PubMed ID: 10339581

Title: Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.

PubMed ID: 10339581

DOI: 10.1073/pnas.96.11.6296

Sequence Information:

  • Length: 435
  • Mass: 48368
  • Checksum: 9C2B2D8DB361E0BB
  • Sequence:
    • MAAHLLPICA LFLTLLDMAQ GFRGPLLPNR PFTTVWNANT QWCLERHGVD VDVSVFDVVA 
NPGQTFRGPD MTIFYSSQLG TYPYYTPTGE PVFGGLPQNA SLIAHLARTF QDILAAIPAP 
DFSGLAVIDW EAWRPRWAFN WDTKDIYRQR SRALVQAQHP DWPAPQVEAV AQDQFQGAAR 
AWMAGTLQLG RALRPRGLWG FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR 
ALYPSIYMPA VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHFLPL 
DELEHSLGES AAQGAAGVVL WVSWENTRTK ESCQAIKEYM DTTLGPFILN VTSGALLCSQ 
ALCSGHGRCV RRTSHPKALL LLNPASFSIQ LTPGGGPLSL RGALSLEDQA QMAVEFKCRC 
YPGWQAPWCE RKSMW

Genular Protein ID: 2933080740

Symbol: A0A0S2Z3Q0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3Q0

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EC 1 EMBL 4 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 GlyCosmos 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 405
  • Mass: 45145
  • Checksum: C24DAD360D9CF032
  • Sequence:
    • MAAHLLPICA LFLTLLDMAQ GFRGPLLPNR PFTTVWNANT QWCLERHGVD VDVSVFDVVA 
NPGQTFRGPD MTIFYSSQLG TYPYYTPTGE PVFGGLPQNA SLIAHLARTF QDILAAIPAP 
DFSGLAVIDW EAWRPRWAFN WDTKDIYRQR SRALVQAQHP DWPAPQVEAV AQDQFQGAAR 
AWMAGTLQLG RALRPRGLWG FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR 
ALYPSIYMPA VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHFLPL 
ESCQAIKEYM DTTLGPFILN VTSGALLCSQ ALCSGHGRCV RRTSHPKALL LLNPASFSIQ 
LTPGGGPLSL RGALSLEDQA QMAVEFKCRC YPGWQAPWCE RKSMW

Genular Protein ID: 2017390509

Symbol: B3KUI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KUI5

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EC 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 3 PRINTS 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 435
  • Mass: 48282
  • Checksum: C5B9AC2622FED6DA
  • Sequence:
    • MAAHLLPICA LFLTLLDMAQ GFRGPLLPNR PFTTVWNANT QWCLERHGVD VDVSVFDVVA 
NPGQTFRGPD MTIFYSSQLG TYPYYTPTGE PVFGGLPQNA SLIAHLARTF QGILAAIPAP 
DFSGLAAIDW EAWRPRWAFN WDTKDIYRQR SRALVQAQHP DWPAPQVEAV AQDQFQGAAR 
AWMAGTLQLG RALRPRGLWG FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR 
ALYPSIYMPA VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHFLPL 
DELEHSLGES AAQGAAGVVL WVSWENTRTK ESCQAIKEYM DTTLGPFILN VTSGALLCSQ 
ALCSGHGRCV RRTSHPKALL LLNPASFSIQ LTPGGGPLSL RGALSLEDQA QMAVEFKCRC 
YPGWQAPWCE RKSMW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.