Details for: CXCR1

Gene ID: 3577

Symbol: CXCR1

Ensembl ID: ENSG00000163464

Description: C-X-C motif chemokine receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2377.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.56
    Marker Score: 654
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.15
    Marker Score: 732.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.03
    Marker Score: 1370
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1409
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 659
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 508
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1491
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1309
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 492
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7420
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.43
    Marker Score: 254
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.38
    Marker Score: 499
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.31
    Marker Score: 178
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1837
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.29
    Marker Score: 151
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.27
    Marker Score: 210
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 122
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.26
    Marker Score: 415
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.25
    Marker Score: 716
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.24
    Marker Score: 103
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.23
    Marker Score: 150
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 128
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.22
    Marker Score: 194
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 317
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 206
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.08
    Marker Score: 97
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.08
    Marker Score: 253
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 424
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.06
    Marker Score: 376
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 112
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.05
    Marker Score: 120
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.05
    Marker Score: 69
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 141
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 167
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.04
    Marker Score: 2069
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 424
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 26

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Other Information

**Key characteristics:** - CXCR1 is a single-pass membrane protein with a molecular weight of approximately 180 kDa. - It is expressed in high levels in endothelial cells, where it is thought to play a role in the migration and retention of immune cells. - CXCR1 is also expressed on macrophages, dendritic cells, and neutrophils, where it is thought to be involved in the recruitment of these cells to sites of inflammation. **Pathways and functions:** CXCR1 is a ligand for the chemokine CXCL1, which is a protein that is produced by endothelial cells and macrophages. When CXCR1 binds to CXCL1, it activates the receptor and recruits the leukocyte to the site of inflammation. **Clinical significance:** Mutations in the CXCR1 gene have been linked to a number of human diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. In these diseases, CXCR1 is thought to be involved in the recruitment of inflammatory cells to sites of injury or infection. **Additional information:** - CXCR1 is a highly conserved protein, with similar sequences found in mammals, birds, and reptiles. - It is a member of the C-C chemokine receptor family, which are a large family of cell surface receptors that are expressed on a variety of immune cells. - CXCR1 is a relatively new protein, with the gene encoding it first described in 1996.

Genular Protein ID: 429145807

Symbol: CXCR1_HUMAN

Name: C-X-C chemokine receptor type 1

UniProtKB Accession Codes:

P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 26 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1840701

Title: Structure and functional expression of a human interleukin-8 receptor.

PubMed ID: 1840701

DOI: 10.1126/science.1840701

PubMed ID: 8384312

Title: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

PubMed ID: 8384312

DOI: 10.1016/0161-5890(93)90065-j

PubMed ID: 8486366

Title: The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor.

PubMed ID: 8486366

DOI: 10.1006/geno.1993.1167

PubMed ID: 7929358

Title: Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.

PubMed ID: 7929358

DOI: 10.1016/s0021-9258(18)47205-5

PubMed ID: 16205979

Title: Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.

PubMed ID: 16205979

DOI: 10.1007/s00239-005-0039-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11196695

Title: Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

PubMed ID: 11196695

DOI: 10.1038/sj.gene.6363682

PubMed ID: 8662698

Title: Physical association of Gi2alpha with interleukin-8 receptors.

PubMed ID: 8662698

DOI: 10.1074/jbc.271.22.12783

PubMed ID: 1379593

Title: Characterization of two high affinity human interleukin-8 receptors.

PubMed ID: 1379593

DOI: 10.1016/s0021-9258(18)41997-7

PubMed ID: 10368283

Title: Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.

PubMed ID: 10368283

DOI: 10.1016/s0969-2126(99)80022-7

Sequence Information:

  • Length: 350
  • Mass: 39791
  • Checksum: 2463E868C0EB0DE2
  • Sequence:
    • MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV 
MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN 
FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP 
NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA 
MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.