Details for: CXCR1

Gene ID: 3577

Symbol: CXCR1

Ensembl ID: ENSG00000163464

Description: C-X-C motif chemokine receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 4.2461
    Cell Significance Index: -1.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2473
    Cell Significance Index: 3.5900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1982
    Cell Significance Index: 2.4900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1538
    Cell Significance Index: 2.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0813
    Cell Significance Index: 2.1800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0169
    Cell Significance Index: 0.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0133
    Cell Significance Index: 0.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0018
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0048
    Cell Significance Index: -2.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0078
    Cell Significance Index: -1.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0080
    Cell Significance Index: -1.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0089
    Cell Significance Index: -1.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0112
    Cell Significance Index: -1.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0119
    Cell Significance Index: -0.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0131
    Cell Significance Index: -1.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0158
    Cell Significance Index: -2.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0174
    Cell Significance Index: -1.9900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0191
    Cell Significance Index: -0.1700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0206
    Cell Significance Index: -1.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0222
    Cell Significance Index: -1.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0231
    Cell Significance Index: -1.7700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0245
    Cell Significance Index: -0.2500
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.0254
    Cell Significance Index: -0.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0278
    Cell Significance Index: -1.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0305
    Cell Significance Index: -1.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0308
    Cell Significance Index: -0.7700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0336
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0377
    Cell Significance Index: -0.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0404
    Cell Significance Index: -1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0405
    Cell Significance Index: -1.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0417
    Cell Significance Index: -1.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0419
    Cell Significance Index: -1.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0434
    Cell Significance Index: -2.0400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0438
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0489
    Cell Significance Index: -0.6700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0499
    Cell Significance Index: -0.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0513
    Cell Significance Index: -1.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0522
    Cell Significance Index: -1.4900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0525
    Cell Significance Index: -0.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0531
    Cell Significance Index: -1.6900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0533
    Cell Significance Index: -0.5700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0544
    Cell Significance Index: -0.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0572
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0585
    Cell Significance Index: -1.0000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0590
    Cell Significance Index: -0.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0612
    Cell Significance Index: -1.6400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0629
    Cell Significance Index: -0.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0682
    Cell Significance Index: -1.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0696
    Cell Significance Index: -1.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0696
    Cell Significance Index: -0.9100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0700
    Cell Significance Index: -0.9300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0723
    Cell Significance Index: -1.5100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0771
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0792
    Cell Significance Index: -2.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0799
    Cell Significance Index: -1.5800
  • Cell Name: mature neutrophil (CL0000096)
    Fold Change: -0.0806
    Cell Significance Index: -0.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0810
    Cell Significance Index: -1.1800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0812
    Cell Significance Index: -1.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0815
    Cell Significance Index: -1.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0830
    Cell Significance Index: -2.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0832
    Cell Significance Index: -2.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0839
    Cell Significance Index: -1.6900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0845
    Cell Significance Index: -1.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0847
    Cell Significance Index: -1.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0850
    Cell Significance Index: -1.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0858
    Cell Significance Index: -0.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0868
    Cell Significance Index: -1.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0879
    Cell Significance Index: -1.4800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0880
    Cell Significance Index: -0.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0894
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0920
    Cell Significance Index: -2.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0922
    Cell Significance Index: -2.1300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0930
    Cell Significance Index: -1.8300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0942
    Cell Significance Index: -1.2100
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1006
    Cell Significance Index: -0.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1014
    Cell Significance Index: -1.5200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1029
    Cell Significance Index: -1.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1044
    Cell Significance Index: -1.4200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1058
    Cell Significance Index: -1.4800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1072
    Cell Significance Index: -1.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1073
    Cell Significance Index: -1.3600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1073
    Cell Significance Index: -2.6800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1083
    Cell Significance Index: -1.1500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1085
    Cell Significance Index: -1.3100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1095
    Cell Significance Index: -1.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1106
    Cell Significance Index: -1.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1125
    Cell Significance Index: -1.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1125
    Cell Significance Index: -1.6600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1127
    Cell Significance Index: -1.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1150
    Cell Significance Index: -2.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCR1 is a seven-transmembrane GPCR that belongs to the CXC chemokine receptor family. It is characterized by its ability to bind to its ligand, CXCL8 (also known as IL-8), which is a potent chemokine that attracts neutrophils and other immune cells to sites of inflammation. CXCR1 is also involved in the regulation of calcium ion concentration, which is essential for various cellular processes, including cell signaling and gene expression. Additionally, CXCR1 has been shown to interact with other molecules, such as interleukin-8 (IL-8) and G-proteins, to modulate its signaling activity. **Pathways and Functions** CXCR1 is involved in several signaling pathways that regulate immune responses, inflammation, and cell migration. The primary pathways associated with CXCR1 include: 1. **Chemokine-mediated signaling pathway**: CXCR1 binds to its ligand, CXCL8, which activates a G-protein coupled signaling cascade that regulates various downstream effects, including cell migration, differentiation, and survival. 2. **Calcium-mediated signaling**: CXCR1 activation leads to the regulation of calcium ion concentration, which is essential for various cellular processes, including cell signaling and gene expression. 3. **Immune response**: CXCR1 plays a crucial role in the recruitment and activation of neutrophils and other immune cells, which is essential for the defense against pathogens and inflammation. 4. **Neutrophil chemotaxis**: CXCR1 is involved in the regulation of neutrophil migration, which is essential for the clearance of pathogens and inflammation. **Clinical Significance** CXCR1 has been implicated in various diseases, including: 1. **Inflammatory disorders**: CXCR1 has been shown to play a key role in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis, asthma, and chronic obstructive pulmonary disease (COPD). 2. **Cancer**: CXCR1 has been implicated in the progression and metastasis of various cancers, including lung, breast, and colon cancer. 3. **Neurological disorders**: CXCR1 has been shown to play a role in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Infectious diseases**: CXCR1 has been implicated in the pathogenesis of infectious diseases, such as sepsis and tuberculosis. In conclusion, CXCR1 is a critical component of the immune system that plays a key role in the regulation of immune responses, inflammation, and cell migration. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and therapeutic strategies targeting CXCR1.

Genular Protein ID: 429145807

Symbol: CXCR1_HUMAN

Name: C-X-C chemokine receptor type 1

UniProtKB Accession Codes:

P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 26 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1840701

Title: Structure and functional expression of a human interleukin-8 receptor.

PubMed ID: 1840701

DOI: 10.1126/science.1840701

PubMed ID: 8384312

Title: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

PubMed ID: 8384312

DOI: 10.1016/0161-5890(93)90065-j

PubMed ID: 8486366

Title: The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor.

PubMed ID: 8486366

DOI: 10.1006/geno.1993.1167

PubMed ID: 7929358

Title: Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.

PubMed ID: 7929358

DOI: 10.1016/s0021-9258(18)47205-5

PubMed ID: 16205979

Title: Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.

PubMed ID: 16205979

DOI: 10.1007/s00239-005-0039-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11196695

Title: Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

PubMed ID: 11196695

DOI: 10.1038/sj.gene.6363682

PubMed ID: 8662698

Title: Physical association of Gi2alpha with interleukin-8 receptors.

PubMed ID: 8662698

DOI: 10.1074/jbc.271.22.12783

PubMed ID: 1379593

Title: Characterization of two high affinity human interleukin-8 receptors.

PubMed ID: 1379593

DOI: 10.1016/s0021-9258(18)41997-7

PubMed ID: 10368283

Title: Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.

PubMed ID: 10368283

DOI: 10.1016/s0969-2126(99)80022-7

Sequence Information:

  • Length: 350
  • Mass: 39791
  • Checksum: 2463E868C0EB0DE2
  • Sequence:
    • MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV 
MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN 
FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP 
NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA 
MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.