Gene IL10RB - ENSG00000243646 | NCBI Gene ID: 3588

Details for: IL10RB

Gene ID: 3588

Symbol: IL10RB

Ensembl ID: ENSG00000243646

Description: interleukin 10 receptor subunit beta

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin-20 family signaling
(R-HSA-8854691)
Other interleukin signaling
(R-HSA-449836)
Signaling by interleukins
(R-HSA-449147)
Cellular response to virus
(GO:0098586)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response to virus
(GO:0051607)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interleukin-10 receptor activity
(GO:0004920)
Interleukin-28 receptor complex
(GO:0032002)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of cellular respiration
(GO:1901857)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein binding
(GO:0005515)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Type iii interferon-mediated signaling pathway
(GO:0038196)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.97
Marker Score: 7729
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.48
Marker Score: 3689
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.33
Marker Score: 734
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.15
Marker Score: 29343
Cell Name: decidual cell (CL2000002)
Fold Change: 1.08
Marker Score: 4667
Cell Name: plasmablast (CL0000980)
Fold Change: 1.05
Marker Score: 1402
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.02
Marker Score: 1994
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71709
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47933
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.99
Marker Score: 2394
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.99
Marker Score: 1127
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.96
Marker Score: 6155
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2401
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 483
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 438
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2707
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.9
Marker Score: 1389
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5106
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.88
Marker Score: 283.5
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.87
Marker Score: 5293
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5240
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.86
Marker Score: 244
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.86
Marker Score: 8174
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.86
Marker Score: 9652
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.85
Marker Score: 1378
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.85
Marker Score: 47416
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.85
Marker Score: 506
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.85
Marker Score: 52090
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.84
Marker Score: 1290
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.8
Marker Score: 251
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 319
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.79
Marker Score: 1582
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.79
Marker Score: 1938
Cell Name: secretory cell (CL0000151)
Fold Change: 0.78
Marker Score: 1428
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 597
Cell Name: mature T cell (CL0002419)
Fold Change: 0.78
Marker Score: 7689
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.77
Marker Score: 333
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.76
Marker Score: 1968
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.75
Marker Score: 1970
Cell Name: blood cell (CL0000081)
Fold Change: 0.75
Marker Score: 8721
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.74
Marker Score: 189
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.74
Marker Score: 6352
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 378
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.72
Marker Score: 1363.5
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.71
Marker Score: 206
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.71
Marker Score: 714
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.71
Marker Score: 1027
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.71
Marker Score: 582
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.71
Marker Score: 721
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.71
Marker Score: 814
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2958
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.7
Marker Score: 263
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.69
Marker Score: 1098
Cell Name: club cell (CL0000158)
Fold Change: 0.68
Marker Score: 799.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.68
Marker Score: 25247
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 614
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.67
Marker Score: 474
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.66
Marker Score: 14088
Cell Name: microglial cell (CL0000129)
Fold Change: 0.66
Marker Score: 1201
Cell Name: stromal cell (CL0000499)
Fold Change: 0.66
Marker Score: 768.5
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.65
Marker Score: 319
Cell Name: myelocyte (CL0002193)
Fold Change: 0.65
Marker Score: 279
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.64
Marker Score: 366
Cell Name: Unknown (CL0000548)
Fold Change: 0.64
Marker Score: 463
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.63
Marker Score: 138
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.63
Marker Score: 378
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.62
Marker Score: 5426
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.62
Marker Score: 5847
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.62
Marker Score: 132
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.62
Marker Score: 552
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.62
Marker Score: 251
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.61
Marker Score: 740
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.61
Marker Score: 139
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.61
Marker Score: 1442
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.61
Marker Score: 123
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.61
Marker Score: 155
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.61
Marker Score: 4742
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.59
Marker Score: 8827
Cell Name: basophil (CL0000767)
Fold Change: 0.59
Marker Score: 279
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.59
Marker Score: 1618
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.59
Marker Score: 1594
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.58
Marker Score: 4474
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.58
Marker Score: 167.5
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.58
Marker Score: 399
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.58
Marker Score: 515
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.58
Marker Score: 563
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.57
Marker Score: 336
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.57
Marker Score: 131
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.57
Marker Score: 261
Cell Name: paneth cell (CL0000510)
Fold Change: 0.57
Marker Score: 396
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.57
Marker Score: 401
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.57
Marker Score: 228
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.56
Marker Score: 276
Cell Name: centrocyte (CL0009111)
Fold Change: 0.56
Marker Score: 134
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.56
Marker Score: 383
Cell Name: oocyte (CL0000023)
Fold Change: 0.56
Marker Score: 138
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.56
Marker Score: 2316

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**Key characteristics:** - The IL10RB gene is located on chromosome 17q21.1. - It is a member of the interleukin-10 receptor family. - It is a type I transmembrane receptor. - It is expressed in high levels in the placenta during pregnancy. - It is also expressed in low levels in inflammatory tissue. **Pathways and functions:** - The IL10RB gene is primarily involved in the cellular response to virus. - It is a key regulator of the cytokine-mediated signaling pathway. - It is also involved in the regulation of the immune response. - It plays a role in the regulation of inflammation. **Clinical significance:** - Mutations in the IL10RB gene have been linked to several autoimmune diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - Gene therapy approaches targeting the IL10RB gene are being investigated as a potential treatment for these diseases. **Other important points:** - The IL10RB gene is also involved in the regulation of cancer. - It is a potential target for cancer immunotherapy. - The IL10RB gene is a promising target for the development of new therapies for inflammatory and autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-10 receptor subunit beta

Genular Protein ID: 810098670

Symbol: I10R2_HUMAN

Name: Interleukin-10 receptor subunit beta

UniProtKB Accession Codes:

Q08334 Q9BUU4

Database IDs:

Citations:

PubMed ID: 8314576

Title: A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.

PubMed ID: 8314576

DOI: 10.1006/geno.1993.1199

PubMed ID: 7563119

Title: Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.

PubMed ID: 7563119

DOI: 10.1007/bf00186545

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9312047

Title: Identification and functional characterization of a second chain of the interleukin-10 receptor complex.

PubMed ID: 9312047

DOI: 10.1093/emboj/16.19.5894

PubMed ID: 10875937

Title: Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

PubMed ID: 10875937

DOI: 10.1074/jbc.m005304200

PubMed ID: 12469119

Title: IL-28, IL-29 and their class II cytokine receptor IL-28R.

PubMed ID: 12469119

DOI: 10.1038/ni873

PubMed ID: 15123776

Title: The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain.

PubMed ID: 15123776

DOI: 10.1189/jlb.0204117

PubMed ID: 16757563

Title: Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

PubMed ID: 16757563

DOI: 10.1073/pnas.0602800103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19890111

Title: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

PubMed ID: 19890111

DOI: 10.1056/nejmoa0907206

PubMed ID: 20462497

Title: Structure and mechanism of receptor sharing by the IL-10R2 common chain.

PubMed ID: 20462497

DOI: 10.1016/j.str.2010.02.009

Sequence Information:

Length: 325
Mass: 36995
Checksum: E470726619AF54C2
Sequence:

MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR 
IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV 
EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN 
LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG 
CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE 
DSESGKQNPG DSCSLGTPPG QGPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL10RB

Associated with

Cells (max top 100)

Other Information

A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. PubMed ID: 8314576

Structure of the human CRFB4 gene: comparison with its IFNAR neighbor. PubMed ID: 7563119

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Identification and functional characterization of a second chain of the interleukin-10 receptor complex. PubMed ID: 9312047

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. PubMed ID: 10875937

IL-28, IL-29 and their class II cytokine receptor IL-28R. PubMed ID: 12469119

The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. PubMed ID: 15123776

Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. PubMed ID: 16757563

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. PubMed ID: 19890111

Structure and mechanism of receptor sharing by the IL-10R2 common chain. PubMed ID: 20462497