Details for: IL10RB

Gene ID: 3588

Symbol: IL10RB

Ensembl ID: ENSG00000243646

Description: interleukin 10 receptor subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.2671
    Cell Significance Index: -15.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 40.7333
    Cell Significance Index: -16.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.8678
    Cell Significance Index: -18.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.6566
    Cell Significance Index: -19.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.0989
    Cell Significance Index: -18.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9502
    Cell Significance Index: -17.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9548
    Cell Significance Index: -18.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5467
    Cell Significance Index: -12.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3981
    Cell Significance Index: -17.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4692
    Cell Significance Index: 88.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0680
    Cell Significance Index: 124.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7674
    Cell Significance Index: 83.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7588
    Cell Significance Index: 104.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7586
    Cell Significance Index: 22.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7198
    Cell Significance Index: 15.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6411
    Cell Significance Index: 11.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4969
    Cell Significance Index: 99.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4695
    Cell Significance Index: 12.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4505
    Cell Significance Index: 11.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4412
    Cell Significance Index: 71.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4344
    Cell Significance Index: 78.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4337
    Cell Significance Index: 42.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4307
    Cell Significance Index: 9.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4306
    Cell Significance Index: 29.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4196
    Cell Significance Index: 51.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3453
    Cell Significance Index: 215.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2931
    Cell Significance Index: 160.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2920
    Cell Significance Index: 7.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2592
    Cell Significance Index: 74.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2530
    Cell Significance Index: 2.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2213
    Cell Significance Index: 4.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1878
    Cell Significance Index: 24.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1768
    Cell Significance Index: 7.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1708
    Cell Significance Index: 4.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1656
    Cell Significance Index: 6.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1565
    Cell Significance Index: 56.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1392
    Cell Significance Index: 4.0100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1255
    Cell Significance Index: 0.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1251
    Cell Significance Index: 112.9600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1159
    Cell Significance Index: 1.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0942
    Cell Significance Index: 17.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0887
    Cell Significance Index: 4.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0343
    Cell Significance Index: 0.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0114
    Cell Significance Index: 5.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0020
    Cell Significance Index: 0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0011
    Cell Significance Index: 0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0006
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0136
    Cell Significance Index: -1.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0139
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0164
    Cell Significance Index: -1.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0167
    Cell Significance Index: -0.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0182
    Cell Significance Index: -1.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0210
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0241
    Cell Significance Index: -17.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0263
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0266
    Cell Significance Index: -16.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0320
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0372
    Cell Significance Index: -16.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0377
    Cell Significance Index: -1.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0397
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0425
    Cell Significance Index: -8.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0486
    Cell Significance Index: -5.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0530
    Cell Significance Index: -10.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0582
    Cell Significance Index: -3.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0669
    Cell Significance Index: -2.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0987
    Cell Significance Index: -14.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1012
    Cell Significance Index: -11.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1079
    Cell Significance Index: -5.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1139
    Cell Significance Index: -2.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1142
    Cell Significance Index: -14.7600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1159
    Cell Significance Index: -0.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1260
    Cell Significance Index: -3.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1275
    Cell Significance Index: -3.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1600
    Cell Significance Index: -8.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1623
    Cell Significance Index: -5.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1672
    Cell Significance Index: -17.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1684
    Cell Significance Index: -11.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1785
    Cell Significance Index: -8.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1860
    Cell Significance Index: -13.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1953
    Cell Significance Index: -5.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2090
    Cell Significance Index: -13.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2145
    Cell Significance Index: -5.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2212
    Cell Significance Index: -13.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2345
    Cell Significance Index: -18.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2354
    Cell Significance Index: -15.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2391
    Cell Significance Index: -16.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2420
    Cell Significance Index: -2.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2640
    Cell Significance Index: -5.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3020
    Cell Significance Index: -4.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3119
    Cell Significance Index: -9.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3391
    Cell Significance Index: -11.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3516
    Cell Significance Index: -11.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3602
    Cell Significance Index: -7.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3740
    Cell Significance Index: -13.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Function:** IL10RB is a transmembrane receptor that, when paired with IL10RA, forms a high-affinity receptor for IL-10, enabling the binding of IL-10 and subsequent signaling. 2. **Cellular Expression:** IL10RB is expressed in various cell types, including immune cells (e.g., monocytes, macrophages), placental cells (e.g., trophoblasts), and neurons (e.g., GABAergic interneurons). 3. **Signaling Pathways:** IL10RB is involved in multiple signaling pathways, including cytokine-mediated signaling, defense responses to viruses, and inflammatory responses. 4. **Regulatory Function:** IL10RB regulates the activity of IL-10, a cytokine that promotes anti-inflammatory responses, suppresses pro-inflammatory responses, and supports tissue repair. **Pathways and Functions:** 1. **Cytokine-Mediated Signaling:** IL10RB is involved in the signaling of IL-10, a cytokine that regulates immune responses, inflammation, and tissue repair. 2. **Immune Response:** IL10RB plays a crucial role in modulating immune responses, particularly in the context of chronic inflammation and tissue repair. 3. **Inflammatory Response:** IL10RB regulates the inflammatory response by suppressing the production of pro-inflammatory cytokines and promoting the production of anti-inflammatory cytokines. 4. **Tissue Repair:** IL10RB supports tissue repair by promoting the production of growth factors and other cytokines that facilitate wound healing. 5. **Neuroimmunology:** IL10RB is expressed in neurons and plays a role in regulating the immune response in the central nervous system. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of the IL10RB gene has been implicated in various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. 2. **Cancer:** IL10RB has been shown to promote tumor growth and immune evasion in certain types of cancer, highlighting its potential as a therapeutic target. 3. **Neurological Disorders:** IL10RB is involved in regulating the immune response in the central nervous system, making it a potential therapeutic target for neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Infectious Diseases:** IL10RB plays a role in regulating the immune response to viral infections, highlighting its potential as a therapeutic target for treating viral infections. In conclusion, the IL10RB gene is a critical component of the immune response and plays a multifaceted role in regulating inflammation, tissue repair, and immune responses. Further research is needed to fully elucidate the functional significance of IL10RB and its potential as a therapeutic target for various diseases.

Genular Protein ID: 810098670

Symbol: I10R2_HUMAN

Name: Interleukin-10 receptor subunit beta

UniProtKB Accession Codes:

Q08334 Q9BUU4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 3 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8314576

Title: A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.

PubMed ID: 8314576

DOI: 10.1006/geno.1993.1199

PubMed ID: 7563119

Title: Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.

PubMed ID: 7563119

DOI: 10.1007/bf00186545

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9312047

Title: Identification and functional characterization of a second chain of the interleukin-10 receptor complex.

PubMed ID: 9312047

DOI: 10.1093/emboj/16.19.5894

PubMed ID: 10875937

Title: Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

PubMed ID: 10875937

DOI: 10.1074/jbc.m005304200

PubMed ID: 12469119

Title: IL-28, IL-29 and their class II cytokine receptor IL-28R.

PubMed ID: 12469119

DOI: 10.1038/ni873

PubMed ID: 15123776

Title: The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain.

PubMed ID: 15123776

DOI: 10.1189/jlb.0204117

PubMed ID: 16757563

Title: Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

PubMed ID: 16757563

DOI: 10.1073/pnas.0602800103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19890111

Title: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

PubMed ID: 19890111

DOI: 10.1056/nejmoa0907206

PubMed ID: 20462497

Title: Structure and mechanism of receptor sharing by the IL-10R2 common chain.

PubMed ID: 20462497

DOI: 10.1016/j.str.2010.02.009

Sequence Information:

  • Length: 325
  • Mass: 36995
  • Checksum: E470726619AF54C2
  • Sequence:
    • MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR 
IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV 
EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN 
LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG 
CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE 
DSESGKQNPG DSCSLGTPPG QGPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.