Details for: ITGB5

Gene ID: 3693

Symbol: ITGB5

Ensembl ID: ENSG00000082781

Description: integrin subunit beta 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 235.8799
    Cell Significance Index: -36.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.6894
    Cell Significance Index: -31.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.2506
    Cell Significance Index: -29.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2574
    Cell Significance Index: -36.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9024
    Cell Significance Index: 37.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4601
    Cell Significance Index: 289.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2673
    Cell Significance Index: 17.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2572
    Cell Significance Index: 146.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0717
    Cell Significance Index: 54.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9593
    Cell Significance Index: 25.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9353
    Cell Significance Index: 101.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8464
    Cell Significance Index: 64.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5917
    Cell Significance Index: 35.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5904
    Cell Significance Index: 16.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4682
    Cell Significance Index: 32.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4664
    Cell Significance Index: 26.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4636
    Cell Significance Index: 3.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4115
    Cell Significance Index: 559.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3756
    Cell Significance Index: 166.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3711
    Cell Significance Index: 10.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3600
    Cell Significance Index: 64.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3594
    Cell Significance Index: 196.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3543
    Cell Significance Index: 16.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3273
    Cell Significance Index: 7.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3212
    Cell Significance Index: 5.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2987
    Cell Significance Index: 4.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2983
    Cell Significance Index: 40.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2786
    Cell Significance Index: 4.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2267
    Cell Significance Index: 10.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1976
    Cell Significance Index: 19.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1935
    Cell Significance Index: 23.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1923
    Cell Significance Index: 36.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1682
    Cell Significance Index: 4.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1322
    Cell Significance Index: 8.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1201
    Cell Significance Index: 43.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1176
    Cell Significance Index: 181.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1134
    Cell Significance Index: 102.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0866
    Cell Significance Index: 159.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0760
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0735
    Cell Significance Index: 138.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0731
    Cell Significance Index: 46.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0600
    Cell Significance Index: 1.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0563
    Cell Significance Index: 38.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0384
    Cell Significance Index: 4.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0250
    Cell Significance Index: 0.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0209
    Cell Significance Index: 1.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0147
    Cell Significance Index: 1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0288
    Cell Significance Index: -4.1900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0366
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0474
    Cell Significance Index: -21.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0481
    Cell Significance Index: -36.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0519
    Cell Significance Index: -29.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0603
    Cell Significance Index: -10.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0818
    Cell Significance Index: -9.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0998
    Cell Significance Index: -20.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1021
    Cell Significance Index: -10.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1080
    Cell Significance Index: -22.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1155
    Cell Significance Index: -33.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1244
    Cell Significance Index: -16.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1506
    Cell Significance Index: -0.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1535
    Cell Significance Index: -3.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1543
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1801
    Cell Significance Index: -20.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1858
    Cell Significance Index: -9.6500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2462
    Cell Significance Index: -3.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2480
    Cell Significance Index: -3.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3105
    Cell Significance Index: -6.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3112
    Cell Significance Index: -8.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3202
    Cell Significance Index: -33.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3224
    Cell Significance Index: -38.0200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3595
    Cell Significance Index: -5.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3676
    Cell Significance Index: -23.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3797
    Cell Significance Index: -9.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4030
    Cell Significance Index: -31.9200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4054
    Cell Significance Index: -5.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4224
    Cell Significance Index: -25.9600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4476
    Cell Significance Index: -6.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4524
    Cell Significance Index: -14.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5279
    Cell Significance Index: -7.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5478
    Cell Significance Index: -8.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5609
    Cell Significance Index: -36.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5671
    Cell Significance Index: -29.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6029
    Cell Significance Index: -10.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6229
    Cell Significance Index: -38.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6326
    Cell Significance Index: -9.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7079
    Cell Significance Index: -37.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7490
    Cell Significance Index: -32.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7842
    Cell Significance Index: -11.7500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.8088
    Cell Significance Index: -11.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8118
    Cell Significance Index: -17.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8174
    Cell Significance Index: -13.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8431
    Cell Significance Index: -30.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8557
    Cell Significance Index: -37.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8734
    Cell Significance Index: -30.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9219
    Cell Significance Index: -15.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9603
    Cell Significance Index: -33.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9691
    Cell Significance Index: -8.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** ITGB5 is widely expressed in various cell types, including neural progenitor cells, endothelial cells, and immune cells, such as astrocytes, corneal epithelial cells, and GABAergic cortical interneurons. 2. **Integrin structure:** ITGB5 is a beta subunit that associates with alpha-5 subunit to form the integrin alpha-5/beta-5 complex, which mediates cell adhesion, migration, and signaling. 3. **Function:** ITGB5 participates in various cellular processes, including cell-cell adhesion, cell-matrix adhesion, antigen processing, and cross-presentation, as well as immune system regulation and tissue remodeling. 4. **Signaling pathways:** ITGB5 is involved in multiple signaling pathways, including the integrin-mediated signaling pathway, TGF-beta receptor signaling pathway, and Smad-dependent signaling. **Pathways and Functions:** 1. **Cell-cell adhesion:** ITGB5 mediates cell-cell adhesion through the integrin alpha-5/beta-5 complex, playing a crucial role in tissue organization and remodeling. 2. **Antigen processing and cross-presentation:** ITGB5 is involved in antigen processing and cross-presentation, which is essential for the activation of immune cells, such as dendritic cells and macrophages. 3. **Immune system regulation:** ITGB5 modulates immune responses by regulating the activity of immune cells, including T cells, B cells, and natural killer cells. 4. **Cell migration and differentiation:** ITGB5 participates in cell migration and differentiation, influencing the development and function of various cell types, including endothelial cells, smooth muscle cells, and immune cells. **Clinical Significance:** 1. **Immunological disorders:** ITGB5 dysfunction has been implicated in various immunological disorders, including rheumatoid arthritis, lupus, and multiple sclerosis, where integrin signaling pathways are dysregulated. 2. **Cancer:** ITGB5 expression is altered in various types of cancer, including breast, lung, and colon cancer, where integrin signaling pathways contribute to tumor progression and metastasis. 3. **Neurological disorders:** ITGB5 is involved in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where integrin signaling pathways are dysregulated. 4. **Wound healing:** ITGB5 plays a crucial role in wound healing, influencing the migration and differentiation of endothelial cells, which is essential for tissue repair and remodeling. In conclusion, ITGB5 is a critical component of the integrin alpha-5/beta-5 complex, playing a vital role in cell adhesion, migration, and signaling pathways. Its expression in various cell types and involvement in immune system regulation, antigen processing, and tissue remodeling make it a significant player in numerous physiological and pathological processes. Further studies on ITGB5 are necessary to elucidate its mechanisms of action and its implications in human diseases.

Genular Protein ID: 4147502801

Symbol: ITB5_HUMAN

Name: Integrin beta-5

UniProtKB Accession Codes:

P18084 B0LPF8 B2RD70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 2 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2328726

Title: Cloning, primary structure and properties of a novel human integrin beta subunit.

PubMed ID: 2328726

DOI: 10.1002/j.1460-2075.1990.tb08275.x

PubMed ID: 2371275

Title: Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit.

PubMed ID: 2371275

DOI: 10.1073/pnas.87.14.5354

PubMed ID: 2211615

Title: cDNA sequence of the human integrin beta 5 subunit.

PubMed ID: 2211615

DOI: 10.1016/s0021-9258(17)44878-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15156152

Title: Myosin-X provides a motor-based link between integrins and the cytoskeleton.

PubMed ID: 15156152

DOI: 10.1038/ncb1136

PubMed ID: 15611078

Title: Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.

PubMed ID: 15611078

DOI: 10.1074/jbc.m404903200

PubMed ID: 20615244

Title: Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.

PubMed ID: 20615244

DOI: 10.1186/1743-422x-7-148

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

Sequence Information:

  • Length: 799
  • Mass: 88054
  • Checksum: D7E4727CA310512B
  • Sequence:
    • MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI 
TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP 
GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG 
SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS 
RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC 
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL 
DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD 
TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG 
TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF 
GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ 
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL 
CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA 
MTILLAVVGS ILLVGLALLA IWKLLVTIHD RREFAKFQSE RSRARYEMAS NPLYRKPIST 
HTVDFTFNKF NKSYNGTVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.