Details for: ITGB5

Gene ID: 3693

Symbol: ITGB5

Ensembl ID: ENSG00000082781

Description: integrin subunit beta 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.76
    Marker Score: 14,537
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.51
    Marker Score: 1,467
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.5
    Marker Score: 1,455
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.93
    Marker Score: 606
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.69
    Marker Score: 36,021
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.65
    Marker Score: 1,826
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.59
    Marker Score: 23,731
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.49
    Marker Score: 3,037
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.49
    Marker Score: 829
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.49
    Marker Score: 3,507
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.48
    Marker Score: 2,040
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.48
    Marker Score: 737
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.47
    Marker Score: 1,206
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.46
    Marker Score: 337
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.43
    Marker Score: 789
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.41
    Marker Score: 1,710
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.4
    Marker Score: 1,607
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.36
    Marker Score: 5,341
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.36
    Marker Score: 1,824
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.35
    Marker Score: 1,195
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.34
    Marker Score: 1,426
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.32
    Marker Score: 836
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.32
    Marker Score: 374
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.3
    Marker Score: 337
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.3
    Marker Score: 741
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,273
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.24
    Marker Score: 398
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.22
    Marker Score: 1,165
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.2
    Marker Score: 3,206
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.19
    Marker Score: 441
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.16
    Marker Score: 1,244
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.16
    Marker Score: 623
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.16
    Marker Score: 2,225
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.14
    Marker Score: 4,913
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.13
    Marker Score: 331
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1,147
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.06
    Marker Score: 1,118
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 669
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.05
    Marker Score: 2,761
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.03
    Marker Score: 6,635
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.03
    Marker Score: 6,198
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.03
    Marker Score: 1,028
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 387
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1
    Marker Score: 34,154
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,754
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1
    Marker Score: 768
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,979
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.97
    Marker Score: 844
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.96
    Marker Score: 1,083
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.95
    Marker Score: 5,118
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.95
    Marker Score: 355
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.94
    Marker Score: 1,641
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1,498
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.92
    Marker Score: 227
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.91
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,722
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.91
    Marker Score: 2,968
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.91
    Marker Score: 506
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9
    Marker Score: 3,786
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.9
    Marker Score: 1,167
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,888
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.85
    Marker Score: 312
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.84
    Marker Score: 3,116
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.84
    Marker Score: 415
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.83
    Marker Score: 240
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.82
    Marker Score: 571
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.81
    Marker Score: 391
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.79
    Marker Score: 1,119
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.79
    Marker Score: 797
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.77
    Marker Score: 15,358
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 456
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.76
    Marker Score: 441
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 510
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.74
    Marker Score: 16,617
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.74
    Marker Score: 506
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.74
    Marker Score: 8,341
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.73
    Marker Score: 250
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.73
    Marker Score: 397
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,061
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.73
    Marker Score: 1,839
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 702
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.72
    Marker Score: 473
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.71
    Marker Score: 261
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.71
    Marker Score: 257
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.71
    Marker Score: 324
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.7
    Marker Score: 350
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.7
    Marker Score: 182
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7
    Marker Score: 1,586
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7
    Marker Score: 24,107

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** ITGB5 is widely expressed in various cell types, including neural progenitor cells, endothelial cells, and immune cells, such as astrocytes, corneal epithelial cells, and GABAergic cortical interneurons. 2. **Integrin structure:** ITGB5 is a beta subunit that associates with alpha-5 subunit to form the integrin alpha-5/beta-5 complex, which mediates cell adhesion, migration, and signaling. 3. **Function:** ITGB5 participates in various cellular processes, including cell-cell adhesion, cell-matrix adhesion, antigen processing, and cross-presentation, as well as immune system regulation and tissue remodeling. 4. **Signaling pathways:** ITGB5 is involved in multiple signaling pathways, including the integrin-mediated signaling pathway, TGF-beta receptor signaling pathway, and Smad-dependent signaling. **Pathways and Functions:** 1. **Cell-cell adhesion:** ITGB5 mediates cell-cell adhesion through the integrin alpha-5/beta-5 complex, playing a crucial role in tissue organization and remodeling. 2. **Antigen processing and cross-presentation:** ITGB5 is involved in antigen processing and cross-presentation, which is essential for the activation of immune cells, such as dendritic cells and macrophages. 3. **Immune system regulation:** ITGB5 modulates immune responses by regulating the activity of immune cells, including T cells, B cells, and natural killer cells. 4. **Cell migration and differentiation:** ITGB5 participates in cell migration and differentiation, influencing the development and function of various cell types, including endothelial cells, smooth muscle cells, and immune cells. **Clinical Significance:** 1. **Immunological disorders:** ITGB5 dysfunction has been implicated in various immunological disorders, including rheumatoid arthritis, lupus, and multiple sclerosis, where integrin signaling pathways are dysregulated. 2. **Cancer:** ITGB5 expression is altered in various types of cancer, including breast, lung, and colon cancer, where integrin signaling pathways contribute to tumor progression and metastasis. 3. **Neurological disorders:** ITGB5 is involved in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where integrin signaling pathways are dysregulated. 4. **Wound healing:** ITGB5 plays a crucial role in wound healing, influencing the migration and differentiation of endothelial cells, which is essential for tissue repair and remodeling. In conclusion, ITGB5 is a critical component of the integrin alpha-5/beta-5 complex, playing a vital role in cell adhesion, migration, and signaling pathways. Its expression in various cell types and involvement in immune system regulation, antigen processing, and tissue remodeling make it a significant player in numerous physiological and pathological processes. Further studies on ITGB5 are necessary to elucidate its mechanisms of action and its implications in human diseases.

Genular Protein ID: 4147502801

Symbol: ITB5_HUMAN

Name: Integrin beta-5

UniProtKB Accession Codes:

P18084 B0LPF8 B2RD70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 2 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2328726

Title: Cloning, primary structure and properties of a novel human integrin beta subunit.

PubMed ID: 2328726

DOI: 10.1002/j.1460-2075.1990.tb08275.x

PubMed ID: 2371275

Title: Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit.

PubMed ID: 2371275

DOI: 10.1073/pnas.87.14.5354

PubMed ID: 2211615

Title: cDNA sequence of the human integrin beta 5 subunit.

PubMed ID: 2211615

DOI: 10.1016/s0021-9258(17)44878-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15156152

Title: Myosin-X provides a motor-based link between integrins and the cytoskeleton.

PubMed ID: 15156152

DOI: 10.1038/ncb1136

PubMed ID: 15611078

Title: Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.

PubMed ID: 15611078

DOI: 10.1074/jbc.m404903200

PubMed ID: 20615244

Title: Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.

PubMed ID: 20615244

DOI: 10.1186/1743-422x-7-148

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

Sequence Information:

  • Length: 799
  • Mass: 88054
  • Checksum: D7E4727CA310512B
  • Sequence:
    • MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI 
TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP 
GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG 
SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS 
RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC 
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL 
DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD 
TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG 
TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF 
GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ 
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL 
CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA 
MTILLAVVGS ILLVGLALLA IWKLLVTIHD RREFAKFQSE RSRARYEMAS NPLYRKPIST 
HTVDFTFNKF NKSYNGTVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.