Details for: ITIH3

Gene ID: 3699

Symbol: ITIH3

Ensembl ID: ENSG00000162267

Description: inter-alpha-trypsin inhibitor heavy chain 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 19.9923
    Cell Significance Index: 336.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.7352
    Cell Significance Index: 79.7700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.5997
    Cell Significance Index: 4.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1921
    Cell Significance Index: 236.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0386
    Cell Significance Index: 15.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0084
    Cell Significance Index: 8.4700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9976
    Cell Significance Index: 5.7500
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.8199
    Cell Significance Index: 6.3000
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.7247
    Cell Significance Index: 7.1500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4108
    Cell Significance Index: 5.2100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.3995
    Cell Significance Index: 1.3900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3752
    Cell Significance Index: 1.0100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2179
    Cell Significance Index: 1.7200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0594
    Cell Significance Index: 0.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0519
    Cell Significance Index: 1.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0122
    Cell Significance Index: 0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0088
    Cell Significance Index: 0.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0052
    Cell Significance Index: 0.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0047
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0028
    Cell Significance Index: -1.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0045
    Cell Significance Index: -1.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0052
    Cell Significance Index: -1.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0053
    Cell Significance Index: -1.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0066
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0093
    Cell Significance Index: -1.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0105
    Cell Significance Index: -1.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0108
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0112
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0114
    Cell Significance Index: -1.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0158
    Cell Significance Index: -1.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0169
    Cell Significance Index: -2.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0171
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0173
    Cell Significance Index: -1.9800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0186
    Cell Significance Index: -0.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0189
    Cell Significance Index: -0.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0191
    Cell Significance Index: -2.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0235
    Cell Significance Index: -1.8000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0268
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0268
    Cell Significance Index: -1.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0279
    Cell Significance Index: -2.0800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0281
    Cell Significance Index: -0.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0285
    Cell Significance Index: -0.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0296
    Cell Significance Index: -1.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0298
    Cell Significance Index: -1.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0303
    Cell Significance Index: -1.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0305
    Cell Significance Index: -1.9700
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: -0.0314
    Cell Significance Index: -0.2100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0314
    Cell Significance Index: -0.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0328
    Cell Significance Index: -1.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0341
    Cell Significance Index: -1.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0354
    Cell Significance Index: -0.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0364
    Cell Significance Index: -0.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0369
    Cell Significance Index: -1.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0396
    Cell Significance Index: -1.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0398
    Cell Significance Index: -0.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0398
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0403
    Cell Significance Index: -1.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0442
    Cell Significance Index: -1.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0452
    Cell Significance Index: -1.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0455
    Cell Significance Index: -1.3400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0458
    Cell Significance Index: -0.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0468
    Cell Significance Index: -0.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0475
    Cell Significance Index: -1.2500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0484
    Cell Significance Index: -0.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0498
    Cell Significance Index: -1.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0502
    Cell Significance Index: -1.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0542
    Cell Significance Index: -1.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0542
    Cell Significance Index: -1.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0555
    Cell Significance Index: -1.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0561
    Cell Significance Index: -1.9500
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0562
    Cell Significance Index: -0.3300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0564
    Cell Significance Index: -0.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0572
    Cell Significance Index: -1.5300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0596
    Cell Significance Index: -0.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0620
    Cell Significance Index: -1.5800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0626
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0628
    Cell Significance Index: -1.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0648
    Cell Significance Index: -1.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0654
    Cell Significance Index: -1.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0669
    Cell Significance Index: -1.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0670
    Cell Significance Index: -2.1200
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0674
    Cell Significance Index: -0.8000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0693
    Cell Significance Index: -0.9500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0700
    Cell Significance Index: -0.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0713
    Cell Significance Index: -1.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0720
    Cell Significance Index: -1.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0744
    Cell Significance Index: -1.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0745
    Cell Significance Index: -1.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ITIH3 is a member of the inter-alpha-trypsin inhibitor family, which consists of three subunits (α1, α2, and α3). The heavy chain of ITIH3 is composed of 58 kDa, with a molecular weight of approximately 25 kDa. This protein exhibits endopeptidase inhibitor activity, specifically targeting serine-type endopeptidases, thereby regulating proteolytic processes in the extracellular environment. ITIH3 also interacts with hyaluronic acid, modulating its metabolic process and influencing cell migration and proliferation. **Pathways and Functions:** ITIH3 is intricately involved in several key signaling pathways, including: 1. **Hemostasis:** ITIH3 regulates platelet activation, degranulation, and aggregation, thereby modulating blood coagulation and preventing excessive thrombosis. 2. **Extracellular Matrix Remodeling:** ITIH3 interacts with hyaluronic acid, influencing cell migration, proliferation, and differentiation, particularly in the context of wound healing and cancer metastasis. 3. **Immune Response:** ITIH3 is expressed in immune cells, such as granulocytes, monocytes, and macrophages, where it modulates inflammatory responses and tissue repair. 4. **Cell Signaling:** ITIH3 interacts with various growth factors and cytokines, influencing cell growth, survival, and differentiation. **Clinical Significance:** ITIH3's involvement in hemostasis, immune response, and tissue remodeling renders it a critical gene in the context of various diseases. Some of the clinical implications of ITIH3 dysregulation include: 1. **Thrombosis and Hemostasis Disorders:** Abnormalities in ITIH3 expression or function may contribute to thrombotic events, such as deep vein thrombosis or pulmonary embolism. 2. **Inflammatory Diseases:** ITIH3's role in modulating immune responses makes it a potential target for the treatment of inflammatory conditions, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer Metastasis:** ITIH3's involvement in extracellular matrix remodeling and cell migration may contribute to cancer progression and metastasis. 4. **Neurological Disorders:** ITIH3's expression in the cerebral cortex suggests its potential involvement in neurological diseases, such as Alzheimer's disease or Parkinson's disease. In conclusion, ITIH3 is a multifunctional protein that plays a critical role in maintaining tissue homeostasis and regulating immune responses. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying ITIH3's functions.

Genular Protein ID: 3761771970

Symbol: ITIH3_HUMAN

Name: Inter-alpha-trypsin inhibitor heavy chain H3

UniProtKB Accession Codes:

Q06033 Q3B7H5 Q53F06 Q6LAM2 Q99085

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7681778

Title: Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence.

PubMed ID: 7681778

DOI: 10.1111/j.1432-1033.1993.tb17717.x

PubMed ID: 9756925

Title: Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage.

PubMed ID: 9756925

DOI: 10.1074/jbc.273.41.26809

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7522574

Title: Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes.

PubMed ID: 7522574

DOI: 10.1016/0167-4781(94)90087-6

PubMed ID: 2476436

Title: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.

PubMed ID: 2476436

DOI: 10.1016/s0021-9258(18)71575-5

PubMed ID: 2465147

Title: Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.

PubMed ID: 2465147

DOI: 10.1111/j.1432-1033.1989.tb14532.x

PubMed ID: 1898736

Title: Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.

PubMed ID: 1898736

DOI: 10.1016/s0021-9258(17)35235-3

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 890
  • Mass: 99849
  • Checksum: 03B2B768784CB440
  • Sequence:
    • MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI NSKVTSRFAH 
NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT YPGNVKEKEV AKKQYEKAVS 
QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV TFELTYEELL KRHKGKYEMY LKVQPKQLVK 
HFEIEVDIFE PQGISMLDAE ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT 
DSLLNGDFTI TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL 
EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF VKSMEDKGMT 
NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV GESRPEKIQE NVRNAIGGKF 
PLYNLGFGNN LNYNFLENMA LENHGFARRI YEDSDADLQL QGFYEEVANP LLTGVEMEYP 
ENAILDLTQN TYQHFYDGSE IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME 
KALQERDYIF GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS 
MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG DPHFIIQIPE 
KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS PDSKTRKTYF GKLGIANAQM 
DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ 
VWKKHPVHRD FLGFYVVDSH RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK 
NHQLIVTRGS QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.