Details for: ITIH3

Gene ID: 3699

Symbol: ITIH3

Ensembl ID: ENSG00000162267

Description: inter-alpha-trypsin inhibitor heavy chain 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.31
    Marker Score: 10,848
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.93
    Marker Score: 15,756
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.04
    Marker Score: 8,804
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.97
    Marker Score: 12,697
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.44
    Marker Score: 1,541
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.34
    Marker Score: 415
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7,604
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2,579
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.96
    Marker Score: 280
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.84
    Marker Score: 571
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.75
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.68
    Marker Score: 148
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.66
    Marker Score: 182
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.58
    Marker Score: 581
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.53
    Marker Score: 1,107
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.52
    Marker Score: 195
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.39
    Marker Score: 109
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.37
    Marker Score: 234
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 649
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 305
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.29
    Marker Score: 544
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.27
    Marker Score: 4,272
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 142
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 503
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.22
    Marker Score: 87
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.21
    Marker Score: 158
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2
    Marker Score: 56
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 97
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 335
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.12
    Marker Score: 111
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.09
    Marker Score: 292
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 132
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.07
    Marker Score: 170
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 196
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.06
    Marker Score: 104
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 104
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 91
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 94
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 42

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ITIH3 is a member of the inter-alpha-trypsin inhibitor family, which consists of three subunits (α1, α2, and α3). The heavy chain of ITIH3 is composed of 58 kDa, with a molecular weight of approximately 25 kDa. This protein exhibits endopeptidase inhibitor activity, specifically targeting serine-type endopeptidases, thereby regulating proteolytic processes in the extracellular environment. ITIH3 also interacts with hyaluronic acid, modulating its metabolic process and influencing cell migration and proliferation. **Pathways and Functions:** ITIH3 is intricately involved in several key signaling pathways, including: 1. **Hemostasis:** ITIH3 regulates platelet activation, degranulation, and aggregation, thereby modulating blood coagulation and preventing excessive thrombosis. 2. **Extracellular Matrix Remodeling:** ITIH3 interacts with hyaluronic acid, influencing cell migration, proliferation, and differentiation, particularly in the context of wound healing and cancer metastasis. 3. **Immune Response:** ITIH3 is expressed in immune cells, such as granulocytes, monocytes, and macrophages, where it modulates inflammatory responses and tissue repair. 4. **Cell Signaling:** ITIH3 interacts with various growth factors and cytokines, influencing cell growth, survival, and differentiation. **Clinical Significance:** ITIH3's involvement in hemostasis, immune response, and tissue remodeling renders it a critical gene in the context of various diseases. Some of the clinical implications of ITIH3 dysregulation include: 1. **Thrombosis and Hemostasis Disorders:** Abnormalities in ITIH3 expression or function may contribute to thrombotic events, such as deep vein thrombosis or pulmonary embolism. 2. **Inflammatory Diseases:** ITIH3's role in modulating immune responses makes it a potential target for the treatment of inflammatory conditions, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer Metastasis:** ITIH3's involvement in extracellular matrix remodeling and cell migration may contribute to cancer progression and metastasis. 4. **Neurological Disorders:** ITIH3's expression in the cerebral cortex suggests its potential involvement in neurological diseases, such as Alzheimer's disease or Parkinson's disease. In conclusion, ITIH3 is a multifunctional protein that plays a critical role in maintaining tissue homeostasis and regulating immune responses. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying ITIH3's functions.

Genular Protein ID: 3761771970

Symbol: ITIH3_HUMAN

Name: Inter-alpha-trypsin inhibitor heavy chain H3

UniProtKB Accession Codes:

Q06033 Q3B7H5 Q53F06 Q6LAM2 Q99085

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7681778

Title: Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence.

PubMed ID: 7681778

DOI: 10.1111/j.1432-1033.1993.tb17717.x

PubMed ID: 9756925

Title: Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage.

PubMed ID: 9756925

DOI: 10.1074/jbc.273.41.26809

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7522574

Title: Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes.

PubMed ID: 7522574

DOI: 10.1016/0167-4781(94)90087-6

PubMed ID: 2476436

Title: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.

PubMed ID: 2476436

DOI: 10.1016/s0021-9258(18)71575-5

PubMed ID: 2465147

Title: Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.

PubMed ID: 2465147

DOI: 10.1111/j.1432-1033.1989.tb14532.x

PubMed ID: 1898736

Title: Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.

PubMed ID: 1898736

DOI: 10.1016/s0021-9258(17)35235-3

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 890
  • Mass: 99849
  • Checksum: 03B2B768784CB440
  • Sequence:
    • MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI NSKVTSRFAH 
NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT YPGNVKEKEV AKKQYEKAVS 
QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV TFELTYEELL KRHKGKYEMY LKVQPKQLVK 
HFEIEVDIFE PQGISMLDAE ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT 
DSLLNGDFTI TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL 
EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF VKSMEDKGMT 
NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV GESRPEKIQE NVRNAIGGKF 
PLYNLGFGNN LNYNFLENMA LENHGFARRI YEDSDADLQL QGFYEEVANP LLTGVEMEYP 
ENAILDLTQN TYQHFYDGSE IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME 
KALQERDYIF GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS 
MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG DPHFIIQIPE 
KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS PDSKTRKTYF GKLGIANAQM 
DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ 
VWKKHPVHRD FLGFYVVDSH RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK 
NHQLIVTRGS QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.