Details for: ITIH3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 19.9923
Cell Significance Index: 336.2600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.7352
Cell Significance Index: 79.7700 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 1.5997
Cell Significance Index: 4.2200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1921
Cell Significance Index: 236.5700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.0386
Cell Significance Index: 15.3300 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.0084
Cell Significance Index: 8.4700 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.9976
Cell Significance Index: 5.7500 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.8199
Cell Significance Index: 6.3000 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.7247
Cell Significance Index: 7.1500 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.4108
Cell Significance Index: 5.2100 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.3995
Cell Significance Index: 1.3900 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.3752
Cell Significance Index: 1.0100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.2179
Cell Significance Index: 1.7200 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0594
Cell Significance Index: 0.5700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0519
Cell Significance Index: 1.3900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0122
Cell Significance Index: 0.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0088
Cell Significance Index: 0.9000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0052
Cell Significance Index: 0.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0047
Cell Significance Index: 0.6400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0005
Cell Significance Index: -0.9700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0006
Cell Significance Index: -1.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0010
Cell Significance Index: -1.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0014
Cell Significance Index: -1.9000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0025
Cell Significance Index: -1.8600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0026
Cell Significance Index: -1.9000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0028
Cell Significance Index: -1.2800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0029
Cell Significance Index: -1.8500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0034
Cell Significance Index: -1.9300 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0034
Cell Significance Index: -1.8800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0045
Cell Significance Index: -1.6300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0052
Cell Significance Index: -1.0500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0053
Cell Significance Index: -1.5300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0053
Cell Significance Index: -0.1100 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.0055
Cell Significance Index: -0.0500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0066
Cell Significance Index: -0.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0093
Cell Significance Index: -1.6800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0105
Cell Significance Index: -1.2900 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0108
Cell Significance Index: -0.1500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0109
Cell Significance Index: -1.5900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0112
Cell Significance Index: -2.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0114
Cell Significance Index: -1.9400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0158
Cell Significance Index: -1.8400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0169
Cell Significance Index: -2.1800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0171
Cell Significance Index: -1.7800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0173
Cell Significance Index: -1.9800 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.0186
Cell Significance Index: -0.0700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0189
Cell Significance Index: -0.9800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0191
Cell Significance Index: -2.2500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0235
Cell Significance Index: -1.8000 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0268
Cell Significance Index: -0.3500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0268
Cell Significance Index: -1.8000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0279
Cell Significance Index: -2.0800 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0281
Cell Significance Index: -0.2900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0285
Cell Significance Index: -0.7100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0296
Cell Significance Index: -1.3800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0298
Cell Significance Index: -1.3000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0303
Cell Significance Index: -1.8600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0305
Cell Significance Index: -1.9700 - Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: -0.0314
Cell Significance Index: -0.2100 - Cell Name: muscle cell (CL0000187)
Fold Change: -0.0314
Cell Significance Index: -0.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0328
Cell Significance Index: -1.8400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0341
Cell Significance Index: -1.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0354
Cell Significance Index: -0.9900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0364
Cell Significance Index: -0.6100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0369
Cell Significance Index: -1.9200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0396
Cell Significance Index: -1.7500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0398
Cell Significance Index: -0.5100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0398
Cell Significance Index: -1.6300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0403
Cell Significance Index: -1.9000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0442
Cell Significance Index: -1.5500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0452
Cell Significance Index: -1.7100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0455
Cell Significance Index: -1.3400 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.0458
Cell Significance Index: -0.3900 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0468
Cell Significance Index: -0.6700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0475
Cell Significance Index: -1.2500 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0484
Cell Significance Index: -0.5300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0498
Cell Significance Index: -1.6300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0502
Cell Significance Index: -1.6000 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0542
Cell Significance Index: -1.0800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0542
Cell Significance Index: -1.9900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0555
Cell Significance Index: -1.5100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0561
Cell Significance Index: -1.9500 - Cell Name: theca cell (CL0000503)
Fold Change: -0.0562
Cell Significance Index: -0.3300 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0564
Cell Significance Index: -0.7300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0572
Cell Significance Index: -1.5300 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0596
Cell Significance Index: -0.7700 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0620
Cell Significance Index: -1.5800 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0626
Cell Significance Index: -0.7000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0628
Cell Significance Index: -1.8000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0648
Cell Significance Index: -1.8500 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0654
Cell Significance Index: -1.3300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0669
Cell Significance Index: -1.6700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0670
Cell Significance Index: -2.1200 - Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.0674
Cell Significance Index: -0.8000 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0693
Cell Significance Index: -0.9500 - Cell Name: plasmablast (CL0000980)
Fold Change: -0.0700
Cell Significance Index: -0.6500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0713
Cell Significance Index: -1.7400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0720
Cell Significance Index: -1.8000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0744
Cell Significance Index: -1.6300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0745
Cell Significance Index: -1.9900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3761771970
Symbol: ITIH3_HUMAN
Name: Inter-alpha-trypsin inhibitor heavy chain H3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7681778
Title: Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence.
PubMed ID: 7681778
PubMed ID: 9756925
Title: Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage.
PubMed ID: 9756925
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7522574
Title: Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes.
PubMed ID: 7522574
PubMed ID: 2476436
Title: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.
PubMed ID: 2476436
PubMed ID: 2465147
Title: Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.
PubMed ID: 2465147
PubMed ID: 1898736
Title: Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.
PubMed ID: 1898736
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
Sequence Information:
- Length: 890
- Mass: 99849
- Checksum: 03B2B768784CB440
- Sequence:
MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI NSKVTSRFAH NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT YPGNVKEKEV AKKQYEKAVS QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV TFELTYEELL KRHKGKYEMY LKVQPKQLVK HFEIEVDIFE PQGISMLDAE ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT DSLLNGDFTI TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF VKSMEDKGMT NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV GESRPEKIQE NVRNAIGGKF PLYNLGFGNN LNYNFLENMA LENHGFARRI YEDSDADLQL QGFYEEVANP LLTGVEMEYP ENAILDLTQN TYQHFYDGSE IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME KALQERDYIF GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG DPHFIIQIPE KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS PDSKTRKTYF GKLGIANAQM DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ VWKKHPVHRD FLGFYVVDSH RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK NHQLIVTRGS QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.