Details for: ITPK1

Gene ID: 3705

Symbol: ITPK1

Ensembl ID: ENSG00000100605

Description: inositol-tetrakisphosphate 1-kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.5211
    Cell Significance Index: -32.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.9499
    Cell Significance Index: -32.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.1211
    Cell Significance Index: -34.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.7003
    Cell Significance Index: -27.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.9295
    Cell Significance Index: -32.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.8478
    Cell Significance Index: -34.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.3796
    Cell Significance Index: -28.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8298
    Cell Significance Index: -33.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6206
    Cell Significance Index: -31.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4439
    Cell Significance Index: -33.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0221
    Cell Significance Index: -13.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7748
    Cell Significance Index: 356.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2649
    Cell Significance Index: 75.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1940
    Cell Significance Index: 91.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0910
    Cell Significance Index: 391.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8793
    Cell Significance Index: 19.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8671
    Cell Significance Index: 141.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7070
    Cell Significance Index: 488.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6361
    Cell Significance Index: 574.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4673
    Cell Significance Index: 26.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4439
    Cell Significance Index: 88.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3973
    Cell Significance Index: 18.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3145
    Cell Significance Index: 56.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3141
    Cell Significance Index: 59.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3053
    Cell Significance Index: 21.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2425
    Cell Significance Index: 132.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2143
    Cell Significance Index: 9.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1954
    Cell Significance Index: 5.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1951
    Cell Significance Index: 19.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1925
    Cell Significance Index: 7.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1756
    Cell Significance Index: 24.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1145
    Cell Significance Index: 72.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1062
    Cell Significance Index: 18.1300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0942
    Cell Significance Index: 0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0823
    Cell Significance Index: 111.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0821
    Cell Significance Index: 1.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0777
    Cell Significance Index: 146.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0561
    Cell Significance Index: 86.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0540
    Cell Significance Index: 1.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0456
    Cell Significance Index: 20.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0455
    Cell Significance Index: 5.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0330
    Cell Significance Index: 14.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0287
    Cell Significance Index: 52.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0251
    Cell Significance Index: 1.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0100
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0133
    Cell Significance Index: -8.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0196
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0285
    Cell Significance Index: -20.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0296
    Cell Significance Index: -22.4300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0343
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0414
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0460
    Cell Significance Index: -0.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0522
    Cell Significance Index: -0.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0849
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0883
    Cell Significance Index: -10.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0899
    Cell Significance Index: -18.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0972
    Cell Significance Index: -27.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0979
    Cell Significance Index: -1.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1060
    Cell Significance Index: -7.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1206
    Cell Significance Index: -14.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1251
    Cell Significance Index: -18.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1296
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1446
    Cell Significance Index: -16.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1616
    Cell Significance Index: -2.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1752
    Cell Significance Index: -22.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1836
    Cell Significance Index: -23.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2067
    Cell Significance Index: -5.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2198
    Cell Significance Index: -2.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2224
    Cell Significance Index: -14.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2265
    Cell Significance Index: -26.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2279
    Cell Significance Index: -4.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2418
    Cell Significance Index: -12.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2463
    Cell Significance Index: -12.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2570
    Cell Significance Index: -3.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2723
    Cell Significance Index: -28.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3200
    Cell Significance Index: -15.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3430
    Cell Significance Index: -11.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3561
    Cell Significance Index: -28.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3650
    Cell Significance Index: -9.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3730
    Cell Significance Index: -6.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3797
    Cell Significance Index: -19.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3849
    Cell Significance Index: -27.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3884
    Cell Significance Index: -12.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3930
    Cell Significance Index: -4.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4043
    Cell Significance Index: -18.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4595
    Cell Significance Index: -28.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4828
    Cell Significance Index: -12.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4972
    Cell Significance Index: -7.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5066
    Cell Significance Index: -13.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5229
    Cell Significance Index: -6.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5371
    Cell Significance Index: -11.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5472
    Cell Significance Index: -19.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5802
    Cell Significance Index: -15.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6000
    Cell Significance Index: -5.0400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6117
    Cell Significance Index: -8.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6157
    Cell Significance Index: -12.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6171
    Cell Significance Index: -12.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme activity:** ITPK1 is a phosphodiesterase-like enzyme that catalyzes the phosphorylation of inositol tetrakisphosphate (IP4) to produce IP3 and inositol pentakisphosphate (IP5). 2. **Subcellular localization:** ITPK1 is primarily localized to the cytosol, where it regulates the synthesis of IP3 and IP4. 3. **Expression patterns:** ITPK1 is expressed in various cell types, including hematopoietic cells, neurons, and epithelial cells. 4. **Function:** ITPK1 plays a critical role in regulating cellular signaling pathways, including those involved in blood coagulation, hemostasis, and immune responses. **Pathways and Functions:** 1. **Inositol phosphate metabolism:** ITPK1 is a key enzyme in the synthesis of IP3 and IP4, which are essential signaling molecules that modulate various cellular processes, including calcium signaling, cell proliferation, and differentiation. 2. **Blood coagulation:** ITPK1 has been implicated in the regulation of blood coagulation, particularly in the context of platelet production and function. 3. **Hemostasis:** ITPK1 plays a role in maintaining hemostasis, which is essential for preventing excessive bleeding. 4. **Immune regulation:** ITPK1 has been shown to regulate immune responses, including those involved in inflammation and immune cell activation. 5. **Neuronal function:** ITPK1 has been implicated in neuronal function, particularly in the context of neurotransmitter release and synaptic plasticity. **Clinical Significance:** 1. **Thrombocytopenia:** Mutations in the ITPK1 gene have been associated with thrombocytopenia, a condition characterized by low platelet counts. 2. **Immune disorders:** Abnormalities in ITPK1 expression and function have been linked to various immune disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Cancer:** ITPK1 has been implicated in cancer, particularly in the context of tumor cell proliferation and metastasis. 4. **Neurological disorders:** Abnormalities in ITPK1 expression and function have been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ITPK1 is a critical enzyme involved in inositol phosphate metabolism and immune regulation. Its dysregulation has been implicated in various diseases, including thrombocytopenia, immune disorders, cancer, and neurological disorders. Further research is needed to fully understand the complexities of ITPK1 and its role in human disease.

Genular Protein ID: 1614990404

Symbol: ITPK1_HUMAN

Name: Inositol 1,3,4-trisphosphate 5/6-kinase

UniProtKB Accession Codes:

Q13572 Q9BTL6 Q9H2E7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChEBI 43 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 18 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8662638

Title: Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.

PubMed ID: 8662638

DOI: 10.1074/jbc.271.20.11904

PubMed ID: 11042108

Title: Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.

PubMed ID: 11042108

DOI: 10.1042/bj3510551

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11533064

Title: Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.

PubMed ID: 11533064

DOI: 10.1074/jbc.m106605200

PubMed ID: 11909533

Title: Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.

PubMed ID: 11909533

DOI: 10.1016/s0960-9822(02)00713-3

PubMed ID: 12324474

Title: Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.

PubMed ID: 12324474

DOI: 10.1074/jbc.m208709200

PubMed ID: 12925536

Title: Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.

PubMed ID: 12925536

DOI: 10.1074/jbc.m300674200

PubMed ID: 15762844

Title: The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.

PubMed ID: 15762844

DOI: 10.1042/bj20050297

PubMed ID: 15837423

Title: Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.

PubMed ID: 15837423

DOI: 10.1016/j.molcel.2005.03.016

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22308441

Title: Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation.

PubMed ID: 22308441

DOI: 10.1073/pnas.1119740109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29883610

Title: MLKL requires the inositol phosphate code to execute necroptosis.

PubMed ID: 29883610

DOI: 10.1016/j.molcel.2018.05.010

PubMed ID: 17616525

Title: Integration of inositol phosphate signaling pathways via human ITPK1.

PubMed ID: 17616525

DOI: 10.1074/jbc.m703121200

Sequence Information:

  • Length: 414
  • Mass: 45621
  • Checksum: E89E2EE11971278E
  • Sequence:
    • MQTFLKGKRV GYWLSEKKIK KLNFQAFAEL CRKRGMEVVQ LNLSRPIEEQ GPLDVIIHKL 
TDVILEADQN DSQSLELVHR FQEYIDAHPE TIVLDPLPAI RTLLDRSKSY ELIRKIEAYM 
EDDRICSPPF MELTSLCGDD TMRLLEKNGL TFPFICKTRV AHGTNSHEMA IVFNQEGLNA 
IQPPCVVQNF INHNAVLYKV FVVGESYTVV QRPSLKNFSA GTSDRESIFF NSHNVSKPES 
SSVLTELDKI EGVFERPSDE VIRELSRALR QALGVSLFGI DIIINNQTGQ HAVIDINAFP 
GYEGVSEFFT DLLNHIATVL QGQSTAMAAT GDVALLRHSK LLAEPAGGLV GERTCSASPG 
CCGSMMGQDA PWKAEADAGG TAKLPHQRLG CNAGVSPSFQ QHCVASLATK ASSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.