Details for: ITPK1

Gene ID: 3705

Symbol: ITPK1

Ensembl ID: ENSG00000100605

Description: inositol-tetrakisphosphate 1-kinase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119,047
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.85
    Marker Score: 39,409
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.69
    Marker Score: 14,498
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.67
    Marker Score: 611
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.66
    Marker Score: 15,811
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.65
    Marker Score: 17,069
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.61
    Marker Score: 6,238
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.58
    Marker Score: 3,725
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.58
    Marker Score: 6,550
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.57
    Marker Score: 23,425
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.49
    Marker Score: 623
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,940
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2,254
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.42
    Marker Score: 458
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53,136
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.39
    Marker Score: 813
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.39
    Marker Score: 435
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.37
    Marker Score: 27,230
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.32
    Marker Score: 5,382
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.32
    Marker Score: 4,692
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.29
    Marker Score: 28,790
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.28
    Marker Score: 6,144
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.24
    Marker Score: 1,549
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2
    Marker Score: 352
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.19
    Marker Score: 43,877
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.13
    Marker Score: 872
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.11
    Marker Score: 10,481
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.11
    Marker Score: 647
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.09
    Marker Score: 299
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.07
    Marker Score: 2,083
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.06
    Marker Score: 337
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.06
    Marker Score: 2,534
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.05
    Marker Score: 8,035
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.04
    Marker Score: 2,818
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.03
    Marker Score: 501
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.03
    Marker Score: 3,230
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.01
    Marker Score: 2,222
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,720
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,945
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.99
    Marker Score: 25,319
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.98
    Marker Score: 55,016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.98
    Marker Score: 644
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.97
    Marker Score: 1,040
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.97
    Marker Score: 256
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.92
    Marker Score: 515
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1,493
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.92
    Marker Score: 1,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,176
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,708
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9
    Marker Score: 3,777
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.9
    Marker Score: 475
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 990
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.87
    Marker Score: 943
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.87
    Marker Score: 352
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.87
    Marker Score: 2,484
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.86
    Marker Score: 2,112
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.85
    Marker Score: 802
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.82
    Marker Score: 1,157
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.81
    Marker Score: 544
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.8
    Marker Score: 400
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.8
    Marker Score: 882
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.8
    Marker Score: 208
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8
    Marker Score: 965
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.78
    Marker Score: 1,318
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.78
    Marker Score: 439
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.78
    Marker Score: 551
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.77
    Marker Score: 196
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.77
    Marker Score: 666
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.77
    Marker Score: 290
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.76
    Marker Score: 775
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.76
    Marker Score: 366
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.75
    Marker Score: 263
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.75
    Marker Score: 1,531
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.74
    Marker Score: 329
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.73
    Marker Score: 1,033
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,030
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.72
    Marker Score: 4,610
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.71
    Marker Score: 173
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.7
    Marker Score: 1,699
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.69
    Marker Score: 4,425
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.69
    Marker Score: 1,711
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 255
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.68
    Marker Score: 256
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.68
    Marker Score: 691
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.67
    Marker Score: 905
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.66
    Marker Score: 2,854
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.66
    Marker Score: 1,663
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.66
    Marker Score: 627

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme activity:** ITPK1 is a phosphodiesterase-like enzyme that catalyzes the phosphorylation of inositol tetrakisphosphate (IP4) to produce IP3 and inositol pentakisphosphate (IP5). 2. **Subcellular localization:** ITPK1 is primarily localized to the cytosol, where it regulates the synthesis of IP3 and IP4. 3. **Expression patterns:** ITPK1 is expressed in various cell types, including hematopoietic cells, neurons, and epithelial cells. 4. **Function:** ITPK1 plays a critical role in regulating cellular signaling pathways, including those involved in blood coagulation, hemostasis, and immune responses. **Pathways and Functions:** 1. **Inositol phosphate metabolism:** ITPK1 is a key enzyme in the synthesis of IP3 and IP4, which are essential signaling molecules that modulate various cellular processes, including calcium signaling, cell proliferation, and differentiation. 2. **Blood coagulation:** ITPK1 has been implicated in the regulation of blood coagulation, particularly in the context of platelet production and function. 3. **Hemostasis:** ITPK1 plays a role in maintaining hemostasis, which is essential for preventing excessive bleeding. 4. **Immune regulation:** ITPK1 has been shown to regulate immune responses, including those involved in inflammation and immune cell activation. 5. **Neuronal function:** ITPK1 has been implicated in neuronal function, particularly in the context of neurotransmitter release and synaptic plasticity. **Clinical Significance:** 1. **Thrombocytopenia:** Mutations in the ITPK1 gene have been associated with thrombocytopenia, a condition characterized by low platelet counts. 2. **Immune disorders:** Abnormalities in ITPK1 expression and function have been linked to various immune disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Cancer:** ITPK1 has been implicated in cancer, particularly in the context of tumor cell proliferation and metastasis. 4. **Neurological disorders:** Abnormalities in ITPK1 expression and function have been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ITPK1 is a critical enzyme involved in inositol phosphate metabolism and immune regulation. Its dysregulation has been implicated in various diseases, including thrombocytopenia, immune disorders, cancer, and neurological disorders. Further research is needed to fully understand the complexities of ITPK1 and its role in human disease.

Genular Protein ID: 1614990404

Symbol: ITPK1_HUMAN

Name: Inositol 1,3,4-trisphosphate 5/6-kinase

UniProtKB Accession Codes:

Q13572 Q9BTL6 Q9H2E7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChEBI 43 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 18 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8662638

Title: Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.

PubMed ID: 8662638

DOI: 10.1074/jbc.271.20.11904

PubMed ID: 11042108

Title: Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.

PubMed ID: 11042108

DOI: 10.1042/bj3510551

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11533064

Title: Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.

PubMed ID: 11533064

DOI: 10.1074/jbc.m106605200

PubMed ID: 11909533

Title: Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.

PubMed ID: 11909533

DOI: 10.1016/s0960-9822(02)00713-3

PubMed ID: 12324474

Title: Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.

PubMed ID: 12324474

DOI: 10.1074/jbc.m208709200

PubMed ID: 12925536

Title: Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.

PubMed ID: 12925536

DOI: 10.1074/jbc.m300674200

PubMed ID: 15762844

Title: The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.

PubMed ID: 15762844

DOI: 10.1042/bj20050297

PubMed ID: 15837423

Title: Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.

PubMed ID: 15837423

DOI: 10.1016/j.molcel.2005.03.016

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22308441

Title: Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation.

PubMed ID: 22308441

DOI: 10.1073/pnas.1119740109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29883610

Title: MLKL requires the inositol phosphate code to execute necroptosis.

PubMed ID: 29883610

DOI: 10.1016/j.molcel.2018.05.010

PubMed ID: 17616525

Title: Integration of inositol phosphate signaling pathways via human ITPK1.

PubMed ID: 17616525

DOI: 10.1074/jbc.m703121200

Sequence Information:

  • Length: 414
  • Mass: 45621
  • Checksum: E89E2EE11971278E
  • Sequence:
    • MQTFLKGKRV GYWLSEKKIK KLNFQAFAEL CRKRGMEVVQ LNLSRPIEEQ GPLDVIIHKL 
TDVILEADQN DSQSLELVHR FQEYIDAHPE TIVLDPLPAI RTLLDRSKSY ELIRKIEAYM 
EDDRICSPPF MELTSLCGDD TMRLLEKNGL TFPFICKTRV AHGTNSHEMA IVFNQEGLNA 
IQPPCVVQNF INHNAVLYKV FVVGESYTVV QRPSLKNFSA GTSDRESIFF NSHNVSKPES 
SSVLTELDKI EGVFERPSDE VIRELSRALR QALGVSLFGI DIIINNQTGQ HAVIDINAFP 
GYEGVSEFFT DLLNHIATVL QGQSTAMAAT GDVALLRHSK LLAEPAGGLV GERTCSASPG 
CCGSMMGQDA PWKAEADAGG TAKLPHQRLG CNAGVSPSFQ QHCVASLATK ASSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.