Details for: KCNA10

Gene ID: 3744

Symbol: KCNA10

Ensembl ID: ENSG00000143105

Description: potassium voltage-gated channel subfamily A member 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.9
    Marker Score: 1112.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.36
    Marker Score: 439
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 1.36
    Marker Score: 436
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.32
    Marker Score: 417
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.16
    Marker Score: 422
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.14
    Marker Score: 421
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30381
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1517.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1873.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.91
    Marker Score: 515
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1686
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 730.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.78
    Marker Score: 411
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.78
    Marker Score: 419
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.72
    Marker Score: 400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.71
    Marker Score: 296
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 11022
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 552
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.66
    Marker Score: 411
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 365
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.62
    Marker Score: 410
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.54
    Marker Score: 411
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.54
    Marker Score: 413
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.52
    Marker Score: 231
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 226
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.47
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 273
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2715.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.45
    Marker Score: 236
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.44
    Marker Score: 391
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 409
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.4
    Marker Score: 419
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.35
    Marker Score: 335.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.34
    Marker Score: 422
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 345
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.3
    Marker Score: 421
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 444
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.25
    Marker Score: 293
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.24
    Marker Score: 399
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 233
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.18
    Marker Score: 251
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.18
    Marker Score: 444
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 402
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 296
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 421.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.13
    Marker Score: 358
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.12
    Marker Score: 418
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.11
    Marker Score: 180
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 442
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 198
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.08
    Marker Score: 509
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.04
    Marker Score: 444
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.02
    Marker Score: 422
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 421
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 405

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Other Information

**Key characteristics:** - KCNA10 is a transmembrane protein that is expressed in the plasma membrane of eukaryotic cells. - It is a member of the potassium voltage-gated channel subfamily A, which is responsible for regulating potassium ion flow across cell membranes. - KCNA10 is a tetrameric protein, meaning it consists of four subunits that are arranged in a tetrahedral shape. - Each subunit of KCNA10 is responsible for a single potassium channel. **Pathways and functions:** - KCNA10 is involved in a variety of cellular processes, including: - Delayed rectifier potassium channel activity - Intracellular cyclic nucleotide-activated monoatomic cation channel activity - Neuronal system - Plasma membrane - Potassium channels - Potassium ion transmembrane transport - Potassium ion transport - Dysfunction of KCNA10 has been linked to a number of human diseases, including epilepsy, cardiac arrhythmias, and hyperkalemia. **Clinical significance:** - Mutations in KCNA10 have been linked to a number of human diseases, including epilepsy, cardiac arrhythmias, and hyperkalemia. - These diseases are often treated with potassium channel blockers, which are drugs that can help to correct the abnormal potassium ion flow that is caused by the mutations. - Development of new drugs that target KCNA10 is an active area of research.

Genular Protein ID: 3666990041

Symbol: KCA10_HUMAN

Name: Potassium voltage-gated channel subfamily A member 10

UniProtKB Accession Codes:

Q16322

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 4 EPD 1 Ensembl 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177773

Title: Genomic localization of the human gene for KCNA10, a cGMP-activated K channel.

PubMed ID: 9177773

DOI: 10.1006/geno.1997.4712

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10836990

Title: KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.

PubMed ID: 10836990

DOI: 10.1152/ajprenal.2000.278.6.f1013

PubMed ID: 12060596

Title: Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.

PubMed ID: 12060596

DOI: 10.1152/ajprenal.00258.2001

PubMed ID: 12444201

Title: Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.

PubMed ID: 12444201

DOI: 10.1097/01.asn.0000036866.37886.c5

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 511
  • Mass: 57785
  • Checksum: 1B09B1CD68745F29
  • Sequence:
    • MDVCGWKEME VALVNFDNSD EIQEEPGYAT DFDSTSPKGR PGGSSFSNGK ILISESTNHE 
TAFSKLPGDY ADPPGPEPVV LNEGNQRVII NIAGLRFETQ LRTLSQFPET LLGDREKRMQ 
FFDSMRNEYF FDRNRPSFDG ILYYYQSGGK IRRPANVPID IFADEISFYE LGSEAMDQFR 
EDEGFIKDPE TLLPTNDIHR QFWLLFEYPE SSSAARAVAV VSVLVVVISI TIFCLETLPE 
FREDRELKVV RDPNLNMSKT VLSQTMFTDP FFMVESTCIV WFTFELVLRF VVCPSKTDFF 
RNIMNIIDII SIIPYFATLI TELVQETEPS AQQNMSLAIL RIIRLVRVFR IFKLSRHSKG 
LQILGQTLKA SMRELGLLIF FLFIGVILFS SAVYFAEVDE PESHFSSIPD GFWWAVVTMT 
TVGYGDMCPT TPGGKIVGTL CAIAGVLTIA LPVPVIVSNF NYFYHRETEN EEKQNIPGEI 
ERILNSVGSR MGSTDSLNKT NGGCSTEKSR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.