Details for: KCNA10

Gene ID: 3744

Symbol: KCNA10

Ensembl ID: ENSG00000143105

Description: potassium voltage-gated channel subfamily A member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.3837
    Cell Significance Index: 22.4100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.7246
    Cell Significance Index: 9.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6402
    Cell Significance Index: 16.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4452
    Cell Significance Index: 7.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3190
    Cell Significance Index: 4.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1206
    Cell Significance Index: 1.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0699
    Cell Significance Index: 0.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0409
    Cell Significance Index: 0.4100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0272
    Cell Significance Index: 0.2900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0194
    Cell Significance Index: 0.2100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0118
    Cell Significance Index: 0.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0083
    Cell Significance Index: 0.0900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0065
    Cell Significance Index: 0.0500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0034
    Cell Significance Index: 0.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0045
    Cell Significance Index: -0.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0045
    Cell Significance Index: -0.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0125
    Cell Significance Index: -0.1300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0185
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0189
    Cell Significance Index: -0.2400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0196
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0279
    Cell Significance Index: -0.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0292
    Cell Significance Index: -0.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0304
    Cell Significance Index: -0.4000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0328
    Cell Significance Index: -0.2100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0368
    Cell Significance Index: -0.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0413
    Cell Significance Index: -1.3100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0447
    Cell Significance Index: -0.6500
  • Cell Name: pre-natural killer cell (CL0000937)
    Fold Change: -0.0461
    Cell Significance Index: -0.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0473
    Cell Significance Index: -0.6300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0502
    Cell Significance Index: -0.6000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0508
    Cell Significance Index: -0.5400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0538
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0560
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0597
    Cell Significance Index: -0.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0599
    Cell Significance Index: -1.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0631
    Cell Significance Index: -0.6400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0737
    Cell Significance Index: -0.4600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0739
    Cell Significance Index: -0.8900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0757
    Cell Significance Index: -0.8300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0809
    Cell Significance Index: -0.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0815
    Cell Significance Index: -1.0700
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0960
    Cell Significance Index: -0.7400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0998
    Cell Significance Index: -0.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1050
    Cell Significance Index: -1.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1115
    Cell Significance Index: -2.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1206
    Cell Significance Index: -1.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1273
    Cell Significance Index: -1.5600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1279
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1326
    Cell Significance Index: -2.4500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1396
    Cell Significance Index: -1.6500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1423
    Cell Significance Index: -1.8000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1456
    Cell Significance Index: -1.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1497
    Cell Significance Index: -1.4100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1731
    Cell Significance Index: -1.9000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1792
    Cell Significance Index: -2.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1935
    Cell Significance Index: -2.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1941
    Cell Significance Index: -2.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1982
    Cell Significance Index: -2.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2106
    Cell Significance Index: -2.1500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2285
    Cell Significance Index: -1.8900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2304
    Cell Significance Index: -2.0300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2374
    Cell Significance Index: -2.5000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2414
    Cell Significance Index: -2.5000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2428
    Cell Significance Index: -2.2300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2505
    Cell Significance Index: -2.1900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2616
    Cell Significance Index: -2.4800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2697
    Cell Significance Index: -2.4500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2847
    Cell Significance Index: -2.4900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3017
    Cell Significance Index: -2.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KCNA10 is a member of the voltage-gated potassium channel family, which is characterized by their ability to respond to changes in membrane potential. The Kv channel complex, of which KCNA10 is a part, is composed of multiple subunits that assemble to form a functional channel. KCNA10 is specifically expressed in various cell types, including pericytes, mononuclear cells, epithelial cells, and renal cells, where it regulates ion transport and cellular excitability. **Pathways and Functions** KCNA10 is involved in several key pathways, including: 1. **Delayed Rectifier Potassium Channel Activity**: KCNA10 plays a crucial role in regulating the delayed rectifier potassium current, which helps to stabilize the resting membrane potential and prevent excessive excitability. 2. **Intracellular Cyclic Nucleotide-Activated Monoatomic Cation Channel Activity**: KCNA10 also participates in the regulation of intracellular cyclic nucleotide-activated cation channels, which are involved in various cellular processes, including cell signaling and differentiation. 3. **Voltage-Gated Potassium Channel Activity**: KCNA10 is a key component of the voltage-gated potassium channel complex, which is essential for regulating the excitability of neurons and other cells. **Functions** The functions of KCNA10 include: 1. **Regulation of Ion Transport**: KCNA10 helps to regulate ion transport across cell membranes, which is essential for maintaining proper cellular function and function. 2. **Cellular Excitability**: KCNA10 plays a crucial role in regulating cellular excitability, including the regulation of action potentials in neurons. 3. **Cell Signaling**: KCNA10 is involved in various cellular signaling pathways, including those involved in cell differentiation, proliferation, and survival. **Clinical Significance** Dysregulation of KCNA10 has been implicated in several diseases, including: 1. **Neurological Disorders**: Mutations in KCNA10 have been associated with neurological disorders, such as epilepsy and anxiety disorders. 2. **Cardiac Arrhythmias**: KCNA10 dysfunction has been implicated in cardiac arrhythmias, including long QT syndrome. 3. **Immunological Disorders**: KCNA10 has been implicated in immunological disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, KCNA10 is a crucial gene that plays a vital role in regulating ion transport and cellular function. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining proper cellular function. Further research is needed to fully understand the functions of KCNA10 and its role in human disease.

Genular Protein ID: 3666990041

Symbol: KCA10_HUMAN

Name: Potassium voltage-gated channel subfamily A member 10

UniProtKB Accession Codes:

Q16322

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 4 Ensembl 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177773

Title: Genomic localization of the human gene for KCNA10, a cGMP-activated K channel.

PubMed ID: 9177773

DOI: 10.1006/geno.1997.4712

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10836990

Title: KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.

PubMed ID: 10836990

DOI: 10.1152/ajprenal.2000.278.6.f1013

PubMed ID: 12060596

Title: Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.

PubMed ID: 12060596

DOI: 10.1152/ajprenal.00258.2001

PubMed ID: 12444201

Title: Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.

PubMed ID: 12444201

DOI: 10.1097/01.asn.0000036866.37886.c5

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 511
  • Mass: 57785
  • Checksum: 1B09B1CD68745F29
  • Sequence:
    • MDVCGWKEME VALVNFDNSD EIQEEPGYAT DFDSTSPKGR PGGSSFSNGK ILISESTNHE 
TAFSKLPGDY ADPPGPEPVV LNEGNQRVII NIAGLRFETQ LRTLSQFPET LLGDREKRMQ 
FFDSMRNEYF FDRNRPSFDG ILYYYQSGGK IRRPANVPID IFADEISFYE LGSEAMDQFR 
EDEGFIKDPE TLLPTNDIHR QFWLLFEYPE SSSAARAVAV VSVLVVVISI TIFCLETLPE 
FREDRELKVV RDPNLNMSKT VLSQTMFTDP FFMVESTCIV WFTFELVLRF VVCPSKTDFF 
RNIMNIIDII SIIPYFATLI TELVQETEPS AQQNMSLAIL RIIRLVRVFR IFKLSRHSKG 
LQILGQTLKA SMRELGLLIF FLFIGVILFS SAVYFAEVDE PESHFSSIPD GFWWAVVTMT 
TVGYGDMCPT TPGGKIVGTL CAIAGVLTIA LPVPVIVSNF NYFYHRETEN EEKQNIPGEI 
ERILNSVGSR MGSTDSLNKT NGGCSTEKSR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.