Details for: KCNJ5

Gene ID: 3762

Symbol: KCNJ5

Ensembl ID: ENSG00000120457

Description: potassium inwardly rectifying channel subfamily J member 5

Associated with

  • Activation of gabab receptors
    (R-HSA-991365)
  • Activation of g protein gated potassium channels
    (R-HSA-1296041)
  • Gaba b receptor activation
    (R-HSA-977444)
  • Gaba receptor activation
    (R-HSA-977443)
  • G protein gated potassium channels
    (R-HSA-1296059)
  • Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
    (R-HSA-997272)
  • Inwardly rectifying k+ channels
    (R-HSA-1296065)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Potassium channels
    (R-HSA-1296071)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • G-protein activated inward rectifier potassium channel activity
    (GO:0015467)
  • I(kach) inward rectifier potassium channel complex
    (GO:1990566)
  • Inward rectifier potassium channel activity
    (GO:0005242)
  • Membrane repolarization during atrial cardiac muscle cell action potential
    (GO:0098914)
  • Membrane repolarization during ventricular cardiac muscle cell action potential
    (GO:0098915)
  • Plasma membrane
    (GO:0005886)
  • Potassium ion import across plasma membrane
    (GO:1990573)
  • Potassium ion transmembrane transport
    (GO:0071805)
  • Potassium ion transport
    (GO:0006813)
  • Protein binding
    (GO:0005515)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of monoatomic ion transmembrane transport
    (GO:0034765)
  • Ventricular cardiac muscle cell membrane repolarization
    (GO:0099625)
  • Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
    (GO:0086089)
  • Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
    (GO:1902282)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.0445
    Cell Significance Index: -3.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.8042
    Cell Significance Index: -3.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.2132
    Cell Significance Index: 61.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.3450
    Cell Significance Index: 89.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9947
    Cell Significance Index: 52.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8334
    Cell Significance Index: 58.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7284
    Cell Significance Index: 5.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.7042
    Cell Significance Index: 17.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5064
    Cell Significance Index: 96.3800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3816
    Cell Significance Index: 4.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2579
    Cell Significance Index: 25.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2535
    Cell Significance Index: 228.9000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2467
    Cell Significance Index: 4.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2174
    Cell Significance Index: 11.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1787
    Cell Significance Index: 19.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1560
    Cell Significance Index: 25.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1529
    Cell Significance Index: 9.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1292
    Cell Significance Index: 9.9200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1135
    Cell Significance Index: 1.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1057
    Cell Significance Index: 2.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0973
    Cell Significance Index: 19.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0928
    Cell Significance Index: 6.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0531
    Cell Significance Index: 1.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0273
    Cell Significance Index: 4.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0216
    Cell Significance Index: 39.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0201
    Cell Significance Index: 37.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0196
    Cell Significance Index: 30.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0190
    Cell Significance Index: 0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0170
    Cell Significance Index: 23.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0100
    Cell Significance Index: 3.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0090
    Cell Significance Index: 6.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0088
    Cell Significance Index: 0.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0087
    Cell Significance Index: 0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0079
    Cell Significance Index: 1.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0062
    Cell Significance Index: 0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0036
    Cell Significance Index: 2.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0018
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0031
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0032
    Cell Significance Index: -1.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0044
    Cell Significance Index: -1.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0055
    Cell Significance Index: -0.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0075
    Cell Significance Index: -3.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0075
    Cell Significance Index: -2.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0077
    Cell Significance Index: -0.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0125
    Cell Significance Index: -1.4600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0133
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0166
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0190
    Cell Significance Index: -4.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0192
    Cell Significance Index: -2.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0252
    Cell Significance Index: -3.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0254
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0255
    Cell Significance Index: -0.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0266
    Cell Significance Index: -3.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0303
    Cell Significance Index: -1.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0327
    Cell Significance Index: -3.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0382
    Cell Significance Index: -4.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0390
    Cell Significance Index: -1.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0434
    Cell Significance Index: -3.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0449
    Cell Significance Index: -3.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0462
    Cell Significance Index: -2.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0493
    Cell Significance Index: -3.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0494
    Cell Significance Index: -1.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0501
    Cell Significance Index: -3.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0532
    Cell Significance Index: -1.4200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0538
    Cell Significance Index: -0.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0557
    Cell Significance Index: -1.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0561
    Cell Significance Index: -1.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0568
    Cell Significance Index: -2.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0579
    Cell Significance Index: -3.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0587
    Cell Significance Index: -2.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0612
    Cell Significance Index: -1.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0645
    Cell Significance Index: -3.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0675
    Cell Significance Index: -1.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0782
    Cell Significance Index: -3.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0783
    Cell Significance Index: -1.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0785
    Cell Significance Index: -2.7500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0884
    Cell Significance Index: -1.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0914
    Cell Significance Index: -2.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0958
    Cell Significance Index: -3.3300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0958
    Cell Significance Index: -1.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0959
    Cell Significance Index: -3.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1025
    Cell Significance Index: -3.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1054
    Cell Significance Index: -1.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1111
    Cell Significance Index: -1.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1136
    Cell Significance Index: -4.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1157
    Cell Significance Index: -3.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1207
    Cell Significance Index: -3.4500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1216
    Cell Significance Index: -2.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1242
    Cell Significance Index: -1.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ion Channel Function**: KCNJ5 encodes for a G protein-activated inward rectifier potassium channel, which regulates potassium ion transport across cell membranes. 2. **Cell Type Specificity**: The gene is expressed in various cell types, including cardiac muscle cells, intestinal epithelial cells, immune cells, and stem cells, highlighting its broad functional significance. 3. **Regulatory Mechanism**: The KCNJ5 channel is activated by G proteins, which modulate its activity in response to various physiological signals. 4. **Biophysical Properties**: The channel exhibits inward rectification, allowing potassium ions to flow into the cell during hyperpolarization and out of the cell during depolarization. **Pathways and Functions** 1. **Cardiac Conduction**: KCNJ5 channels play a crucial role in regulating heart rate and cardiac muscle cell membrane repolarization, ensuring proper cardiac function. 2. **Neurotransmitter Signaling**: The channel is involved in neurotransmitter signaling, particularly in the regulation of GABA (gamma-aminobutyric acid) receptors, which modulate neuronal excitability. 3. **Regulation of Heart Rate**: KCNJ5 channels contribute to the regulation of heart rate by controlling the influx of potassium ions into cardiac muscle cells. 4. **Immune Cell Function**: The gene is expressed in immune cells, including innate lymphoid cells and granulocyte-monocyte progenitors, suggesting its involvement in immune responses. **Clinical Significance** 1. **Cardiac Arrhythmias**: Alterations in KCNJ5 channel function or expression have been implicated in various cardiac arrhythmias, including long QT syndrome. 2. **Neurological Disorders**: Dysregulation of KCNJ5 channels has been linked to neurological disorders, such as epilepsy and anxiety disorders. 3. **Intestinal Function**: The gene's expression in intestinal epithelial cells suggests its involvement in maintaining intestinal homeostasis and regulating intestinal function. 4. **Cancer Research**: KCNJ5 has been identified as a potential biomarker for certain types of cancer, including colon cancer, due to its altered expression in tumor cells. In conclusion, the KCNJ5 gene plays a vital role in regulating various physiological processes, including cardiac conduction, neurotransmitter signaling, and immune cell function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying KCNJ5 function.

Genular Protein ID: 59207568

Symbol: KCNJ5_HUMAN

Name: G protein-activated inward rectifier potassium channel 4

UniProtKB Accession Codes:

P48544 B2R744 Q6DK13 Q6DK14 Q92807

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 13 EMDB 2 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8047164

Title: Cloning and functional expression of a rat heart KATP channel.

PubMed ID: 8047164

DOI: 10.1038/370456a0

PubMed ID: 8524415

Title:

PubMed ID: 8524415

DOI: 10.1038/378792a0

PubMed ID: 8558261

Title: A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels.

PubMed ID: 8558261

DOI: 10.1523/jneurosci.16-03-00930.1996

PubMed ID: 10659995

Title: Co-expression of human Kir3 subunits can yield channels with different functional properties.

PubMed ID: 10659995

DOI: 10.1016/s0898-6568(99)00059-5

PubMed ID: 8834003

Title: Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel.

PubMed ID: 8834003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21311022

Title: K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.

PubMed ID: 21311022

DOI: 10.1126/science.1198785

PubMed ID: 20560207

Title: Identification of a Kir3.4 mutation in congenital long QT syndrome.

PubMed ID: 20560207

DOI: 10.1016/j.ajhg.2010.04.017

PubMed ID: 22315453

Title: Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.

PubMed ID: 22315453

DOI: 10.1210/en.2011-1733

PubMed ID: 22203740

Title: KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism.

PubMed ID: 22203740

DOI: 10.1161/hypertensionaha.111.183996

PubMed ID: 22275527

Title: Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.

PubMed ID: 22275527

DOI: 10.1161/hypertensionaha.111.186478

PubMed ID: 22628607

Title: A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension.

PubMed ID: 22628607

DOI: 10.1210/jc.2012-1334

PubMed ID: 22848660

Title: Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter.

PubMed ID: 22848660

DOI: 10.1371/journal.pone.0041926

PubMed ID: 22308486

Title: Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5.

PubMed ID: 22308486

DOI: 10.1073/pnas.1121407109

PubMed ID: 24037882

Title: a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.

PubMed ID: 24037882

DOI: 10.1210/jc.2013-2428

PubMed ID: 27293068

Title: Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without primary aldosteronism but with ACTH-dependent aldosterone hypersecretion.

PubMed ID: 27293068

DOI: 10.1111/cen.13132

PubMed ID: 27099398

Title: Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production.

PubMed ID: 27099398

DOI: 10.1530/jme-15-0324

Sequence Information:

  • Length: 419
  • Mass: 47668
  • Checksum: 7C14A6B0B7EA0FD4
  • Sequence:
    • MAGDSRNAMN QDMEIGVTPW DPKKIPKQAR DYVPIATDRT RLLAEGKKPR QRYMEKSGKC 
NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTVT WLFFGFIWWL IAYIRGDLDH 
VGDQEWIPCV ENLSGFVSAF LFSIETETTI GYGFRVITEK CPEGIILLLV QAILGSIVNA 
FMVGCMFVKI SQPKKRAETL MFSNNAVISM RDEKLCLMFR VGDLRNSHIV EASIRAKLIK 
SRQTKEGEFI PLNQTDINVG FDTGDDRLFL VSPLIISHEI NQKSPFWEMS QAQLHQEEFE 
VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT FHDTYETNTP 
SCCAKELAEM KREGRLLQYL PSPPLLGGCA EAGLDAEAEQ NEEDEPKGLG GSREARGSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.