Details for: KCNN2

Gene ID: 3781

Symbol: KCNN2

Ensembl ID: ENSG00000080709

Description: potassium calcium-activated channel subfamily N member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.57
    Marker Score: 7843
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.7
    Marker Score: 91112.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.27
    Marker Score: 33972
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1508
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.06
    Marker Score: 3460
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.02
    Marker Score: 1175
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.96
    Marker Score: 72284
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.79
    Marker Score: 13724
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.78
    Marker Score: 6871
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.72
    Marker Score: 65491
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.67
    Marker Score: 6931
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2551
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.61
    Marker Score: 15318
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13772
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.6
    Marker Score: 670
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.55
    Marker Score: 6329
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.52
    Marker Score: 2878
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.48
    Marker Score: 13889
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.43
    Marker Score: 88233
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.28
    Marker Score: 351
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.28
    Marker Score: 405.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.27
    Marker Score: 5894.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.24
    Marker Score: 4805
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2
    Marker Score: 12421
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.18
    Marker Score: 421
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4811
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.11
    Marker Score: 1494
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16903
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2119
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.02
    Marker Score: 888
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.93
    Marker Score: 426
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5294
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18134
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.87
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.79
    Marker Score: 2806
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.78
    Marker Score: 3261
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1831
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 457
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.76
    Marker Score: 914
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.73
    Marker Score: 427
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.68
    Marker Score: 14619
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.67
    Marker Score: 745
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.67
    Marker Score: 1898
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1123
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.64
    Marker Score: 247
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 580.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 185
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.58
    Marker Score: 720
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.56
    Marker Score: 9999
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.56
    Marker Score: 3578
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.55
    Marker Score: 660
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.54
    Marker Score: 2318
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.53
    Marker Score: 307
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.51
    Marker Score: 737
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.49
    Marker Score: 1025
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.48
    Marker Score: 2572
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.46
    Marker Score: 1111
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.46
    Marker Score: 455
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.45
    Marker Score: 184
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 145
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.44
    Marker Score: 336
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.42
    Marker Score: 233
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.41
    Marker Score: 143
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.41
    Marker Score: 241
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4
    Marker Score: 157
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.4
    Marker Score: 116
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.39
    Marker Score: 8771
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.38
    Marker Score: 278
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.37
    Marker Score: 3762
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.36
    Marker Score: 387
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.34
    Marker Score: 233
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 149
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.33
    Marker Score: 94
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.33
    Marker Score: 81

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Other Information

**Key characteristics:** - KCNN2 is a transmembrane protein that is expressed in the plasma membrane of cells. - It is a member of the potassium channel superfamily. - It is a calcium-activated channel, meaning that it opens when calcium ions bind to it. - It is expressed in cells that are involved in sensory perception, including ciliary muscle cells, Purkinje cells, lamp5 GABAergic cortical interneurons, and brainstem motor neurons. **Pathways and functions:** - KCNN2 is involved in a variety of cellular processes, including sensory perception, muscle contraction, and calcium signaling. - In sensory perception, KCNN2 is expressed in the sensory cells of the cochlea, where it is involved in the transduction of sound waves into electrical signals. - In muscle contraction, KCNN2 is expressed in ciliary muscle cells, where it is involved in maintaining the resting membrane potential of these cells and regulating their movement. - In calcium signaling, KCNN2 is expressed in a variety of cell types, where it is involved in calcium-dependent processes such as muscle contraction and neurotransmitter release. **Clinical significance:** - Mutations in KCNN2 have been linked to a number of human diseases, including deafness, epilepsy, and anxiety. - These diseases are caused by mutations in genes that encode KCNN2 proteins, which leads to the loss of function of this channel. - As a result, mutations in KCNN2 are a major cause of human deafness.

Genular Protein ID: 205925610

Symbol: KCNN2_HUMAN

Name: Small conductance calcium-activated potassium channel protein 2

UniProtKB Accession Codes:

Q9H2S1 A6NF94 Q0VFZ4 Q6PJI0 Q6X2Y2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10991935

Title: Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization.

PubMed ID: 10991935

DOI: 10.1074/jbc.m001562200

PubMed ID: 13679367

Title: Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts.

PubMed ID: 13679367

DOI: 10.1074/jbc.m307508200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9287325

Title: Determinants of apamin and d-tubocurarine block in SK potassium channels.

PubMed ID: 9287325

DOI: 10.1074/jbc.272.37.23195

PubMed ID: 33242881

Title: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders.

PubMed ID: 33242881

DOI: 10.1093/brain/awaa346

PubMed ID: 32212350

Title: KCNN2 mutation in autosomal-dominant tremulous myoclonus-dystonia.

PubMed ID: 32212350

DOI: 10.1111/ene.14228

Sequence Information:

  • Length: 579
  • Mass: 63760
  • Checksum: 2ED87FE13C106183
  • Sequence:
    • MSSCRYNGGV MRPLSNLSAS RRNLHEMDSE AQPLQPPASV GGGGGASSPS AAAAAAAAVS 
SSAPEIVVSK PEHNNSNNLA LYGTGGGGST GGGGGGGGSG HGSSSGTKSS KKKNQNIGYK 
LGHRRALFEK RKRLSDYALI FGMFGIVVMV IETELSWGAY DKASLYSLAL KCLISLSTII 
LLGLIIVYHA REIQLFMVDN GADDWRIAMT YERIFFICLE ILVCAIHPIP GNYTFTWTAR 
LAFSYAPSTT TADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF 
VMKTLMTICP GTVLLVFSIS LWIIAAWTVR ACERYHDQQD VTSNFLGAMW LISITFLSIG 
YGDMVPNTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT KAEKHVHNFM MDTQLTKRVK 
NAAANVLRET WLIYKNTKLV KKIDHAKVRK HQRKFLQAIH QLRSVKMEQR KLNDQANTLV 
DLAKTQNIMY DMISDLNERS EDFEKRIVTL ETKLETLIGS IHALPGLISQ TIRQQQRDFI 
EAQMESYDKH VTYNAERSRS SSRRRRSSST APPTSSESS

Genular Protein ID: 3607899413

Symbol: A0A3F2YNY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3F2YNY5

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 2 SAM 2 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 857
  • Mass: 93660
  • Checksum: 47434ABFB98BED28
  • Sequence:
    • MFWRRRKCDV MPIVLVRPTN RTRRLDSTGA GMGPSSHQQQ ESPLPTITHC AGCTTAWSPC 
SFNSPDMETP LQFQRGFFPE QPPPPPRSSH LHCQQQQQSQ DKPCPPFAPL PHPHHHPHLA 
HQQPASGGSS PCLRCNSCAS SGAPAAGAGD NLSLLLRTSS PGGAFRTRTS SPLSGSSCCC 
CCCSSRRGSQ LNVSELTPSS HASALRQQYA QQSAQQSASA SQYHQCHSLQ PAASPTGSLG 
SLGSGPPLSH HHHHPHPAHH QHHQPQARRE SNPFTEIAMS SCRYNGGVMR PLSNLSASRR 
NLHEMDSEAQ PLQPPASVGG GGGASSPSAA AAAAAAVSSS APEIVVSKPE HNNSNNLALY 
GTGGGGSTGG GGGGGGSGHG SSSGTKSSKK KNQNIGYKLG HRRALFEKRK RLSDYALIFG 
MFGIVVMVIE TELSWGAYDK ASLYSLALKC LISLSTIILL GLIIVYHARE IQLFMVDNGA 
DDWRIAMTYE RIFFICLEIL VCAIHPIPGN YTFTWTARLA FSYAPSTTTA DVDIILSIPM 
FLRLYLIARV MLLHSKLFTD ASSRSIGALN KINFNTRFVM KTLMTICPGT VLLVFSISLW 
IIAAWTVRAC ERYHDQQDVT SNFLGAMWLI SITFLSIGYG DMVPNTYCGK GVCLLTGIMG 
AGCTALVVAV VARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL IYKNTKLVKK 
IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM ISDLNERSED 
FEKRIVTLET KLETLIGSIH ALPGLISQTI RQQQRDFIEA QMESYDKHVT YNAERSRSSS 
RRRRSSSTAP PTSSESS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.