Details for: KCNN2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.4443
Cell Significance Index: 119.2100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 4.5366
Cell Significance Index: 129.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1728
Cell Significance Index: 435.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.7815
Cell Significance Index: 136.7100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.7644
Cell Significance Index: 632.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.2547
Cell Significance Index: 569.4900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.0195
Cell Significance Index: 12.6500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9358
Cell Significance Index: 647.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.7079
Cell Significance Index: 43.4000 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.5567
Cell Significance Index: 4.2700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3945
Cell Significance Index: 17.4500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3864
Cell Significance Index: 73.5300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.3015
Cell Significance Index: 3.7600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2675
Cell Significance Index: 10.1300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2001
Cell Significance Index: 12.3000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.1800
Cell Significance Index: 4.3600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1789
Cell Significance Index: 8.1100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1237
Cell Significance Index: 111.6800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0748
Cell Significance Index: 137.9700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0487
Cell Significance Index: 2.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0428
Cell Significance Index: 2.8800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0396
Cell Significance Index: 6.4400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.0290
Cell Significance Index: 3.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0250
Cell Significance Index: 38.4400 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.0190
Cell Significance Index: 0.2400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0167
Cell Significance Index: 0.4000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0034
Cell Significance Index: -0.1200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0037
Cell Significance Index: -6.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0038
Cell Significance Index: -5.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0170
Cell Significance Index: -0.4900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0312
Cell Significance Index: -13.7800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0325
Cell Significance Index: -3.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0345
Cell Significance Index: -21.9300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0349
Cell Significance Index: -0.4500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0406
Cell Significance Index: -30.0900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0424
Cell Significance Index: -31.0900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0474
Cell Significance Index: -35.9100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0526
Cell Significance Index: -5.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0543
Cell Significance Index: -29.6400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0572
Cell Significance Index: -1.4300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0572
Cell Significance Index: -9.7600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0575
Cell Significance Index: -32.4100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0583
Cell Significance Index: -36.3800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0834
Cell Significance Index: -1.7700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0952
Cell Significance Index: -27.4000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1080
Cell Significance Index: -19.4600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1093
Cell Significance Index: -6.5600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1433
Cell Significance Index: -3.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1459
Cell Significance Index: -3.1600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1510
Cell Significance Index: -29.9600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1577
Cell Significance Index: -33.2200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1627
Cell Significance Index: -2.3300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1643
Cell Significance Index: -21.0600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1758
Cell Significance Index: -12.1600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1798
Cell Significance Index: -3.6100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1816
Cell Significance Index: -26.4000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2061
Cell Significance Index: -5.7600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2087
Cell Significance Index: -25.6700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2128
Cell Significance Index: -29.2300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2161
Cell Significance Index: -7.0800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2285
Cell Significance Index: -3.9200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2349
Cell Significance Index: -16.6100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2402
Cell Significance Index: -5.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2404
Cell Significance Index: -31.0600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2618
Cell Significance Index: -16.5000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2694
Cell Significance Index: -8.6300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2774
Cell Significance Index: -31.7800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2823
Cell Significance Index: -8.9900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2920
Cell Significance Index: -29.8300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2983
Cell Significance Index: -13.9100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3023
Cell Significance Index: -6.2700 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3265
Cell Significance Index: -14.2000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4024
Cell Significance Index: -31.8700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4155
Cell Significance Index: -10.6800 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4186
Cell Significance Index: -4.5600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4307
Cell Significance Index: -15.0900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4324
Cell Significance Index: -32.2300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4337
Cell Significance Index: -22.5300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4489
Cell Significance Index: -23.5700 - Cell Name: neural cell (CL0002319)
Fold Change: -0.4886
Cell Significance Index: -5.7000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5437
Cell Significance Index: -11.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5519
Cell Significance Index: -28.7500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5721
Cell Significance Index: -18.1000 - Cell Name: neuron (CL0000540)
Fold Change: -0.5749
Cell Significance Index: -5.4500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5801
Cell Significance Index: -14.4700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.6055
Cell Significance Index: -8.6200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6321
Cell Significance Index: -29.7100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.6328
Cell Significance Index: -25.9300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.6564
Cell Significance Index: -13.7000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6903
Cell Significance Index: -13.6500 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.7279
Cell Significance Index: -9.7100 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.7409
Cell Significance Index: -10.3600 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.7572
Cell Significance Index: -6.2500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.7995
Cell Significance Index: -15.7400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.8054
Cell Significance Index: -11.8900 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.8071
Cell Significance Index: -6.3300 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.8149
Cell Significance Index: -14.0900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8216
Cell Significance Index: -30.1600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8935
Cell Significance Index: -31.0500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.9185
Cell Significance Index: -25.0000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 205925610
Symbol: KCNN2_HUMAN
Name: KCa2.2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10991935
Title: Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization.
PubMed ID: 10991935
PubMed ID: 13679367
Title: Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts.
PubMed ID: 13679367
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9287325
Title: Determinants of apamin and d-tubocurarine block in SK potassium channels.
PubMed ID: 9287325
PubMed ID: 20689065
Title: Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.
PubMed ID: 20689065
PubMed ID: 33242881
Title: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders.
PubMed ID: 33242881
PubMed ID: 32212350
Title: KCNN2 mutation in autosomal-dominant tremulous myoclonus-dystonia.
PubMed ID: 32212350
DOI: 10.1111/ene.14228
Sequence Information:
- Length: 579
- Mass: 63760
- Checksum: 2ED87FE13C106183
- Sequence:
MSSCRYNGGV MRPLSNLSAS RRNLHEMDSE AQPLQPPASV GGGGGASSPS AAAAAAAAVS SSAPEIVVSK PEHNNSNNLA LYGTGGGGST GGGGGGGGSG HGSSSGTKSS KKKNQNIGYK LGHRRALFEK RKRLSDYALI FGMFGIVVMV IETELSWGAY DKASLYSLAL KCLISLSTII LLGLIIVYHA REIQLFMVDN GADDWRIAMT YERIFFICLE ILVCAIHPIP GNYTFTWTAR LAFSYAPSTT TADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF VMKTLMTICP GTVLLVFSIS LWIIAAWTVR ACERYHDQQD VTSNFLGAMW LISITFLSIG YGDMVPNTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT KAEKHVHNFM MDTQLTKRVK NAAANVLRET WLIYKNTKLV KKIDHAKVRK HQRKFLQAIH QLRSVKMEQR KLNDQANTLV DLAKTQNIMY DMISDLNERS EDFEKRIVTL ETKLETLIGS IHALPGLISQ TIRQQQRDFI EAQMESYDKH VTYNAERSRS SSRRRRSSST APPTSSESS
Genular Protein ID: 3607899413
Symbol: A0A3F2YNY5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 857
- Mass: 93660
- Checksum: 47434ABFB98BED28
- Sequence:
MFWRRRKCDV MPIVLVRPTN RTRRLDSTGA GMGPSSHQQQ ESPLPTITHC AGCTTAWSPC SFNSPDMETP LQFQRGFFPE QPPPPPRSSH LHCQQQQQSQ DKPCPPFAPL PHPHHHPHLA HQQPASGGSS PCLRCNSCAS SGAPAAGAGD NLSLLLRTSS PGGAFRTRTS SPLSGSSCCC CCCSSRRGSQ LNVSELTPSS HASALRQQYA QQSAQQSASA SQYHQCHSLQ PAASPTGSLG SLGSGPPLSH HHHHPHPAHH QHHQPQARRE SNPFTEIAMS SCRYNGGVMR PLSNLSASRR NLHEMDSEAQ PLQPPASVGG GGGASSPSAA AAAAAAVSSS APEIVVSKPE HNNSNNLALY GTGGGGSTGG GGGGGGSGHG SSSGTKSSKK KNQNIGYKLG HRRALFEKRK RLSDYALIFG MFGIVVMVIE TELSWGAYDK ASLYSLALKC LISLSTIILL GLIIVYHARE IQLFMVDNGA DDWRIAMTYE RIFFICLEIL VCAIHPIPGN YTFTWTARLA FSYAPSTTTA DVDIILSIPM FLRLYLIARV MLLHSKLFTD ASSRSIGALN KINFNTRFVM KTLMTICPGT VLLVFSISLW IIAAWTVRAC ERYHDQQDVT SNFLGAMWLI SITFLSIGYG DMVPNTYCGK GVCLLTGIMG AGCTALVVAV VARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL IYKNTKLVKK IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM ISDLNERSED FEKRIVTLET KLETLIGSIH ALPGLISQTI RQQQRDFIEA QMESYDKHVT YNAERSRSSS RRRRSSSTAP PTSSESS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.