Details for: KCNN2

Gene ID: 3781

Symbol: KCNN2

Ensembl ID: ENSG00000080709

Description: potassium calcium-activated channel subfamily N member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.4443
    Cell Significance Index: 119.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.5366
    Cell Significance Index: 129.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1728
    Cell Significance Index: 435.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7815
    Cell Significance Index: 136.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7644
    Cell Significance Index: 632.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2547
    Cell Significance Index: 569.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0195
    Cell Significance Index: 12.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9358
    Cell Significance Index: 647.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.7079
    Cell Significance Index: 43.4000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.5567
    Cell Significance Index: 4.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3945
    Cell Significance Index: 17.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3864
    Cell Significance Index: 73.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3015
    Cell Significance Index: 3.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2675
    Cell Significance Index: 10.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2001
    Cell Significance Index: 12.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1800
    Cell Significance Index: 4.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1789
    Cell Significance Index: 8.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1237
    Cell Significance Index: 111.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0748
    Cell Significance Index: 137.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0487
    Cell Significance Index: 2.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0428
    Cell Significance Index: 2.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0396
    Cell Significance Index: 6.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0290
    Cell Significance Index: 3.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0250
    Cell Significance Index: 38.4400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0190
    Cell Significance Index: 0.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0167
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0170
    Cell Significance Index: -0.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0312
    Cell Significance Index: -13.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0325
    Cell Significance Index: -3.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0345
    Cell Significance Index: -21.9300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0349
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0406
    Cell Significance Index: -30.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0424
    Cell Significance Index: -31.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0474
    Cell Significance Index: -35.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0526
    Cell Significance Index: -5.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0543
    Cell Significance Index: -29.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0572
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0572
    Cell Significance Index: -9.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0575
    Cell Significance Index: -32.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0583
    Cell Significance Index: -36.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0834
    Cell Significance Index: -1.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0952
    Cell Significance Index: -27.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1080
    Cell Significance Index: -19.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1093
    Cell Significance Index: -6.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1433
    Cell Significance Index: -3.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1459
    Cell Significance Index: -3.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1510
    Cell Significance Index: -29.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1577
    Cell Significance Index: -33.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1627
    Cell Significance Index: -2.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1643
    Cell Significance Index: -21.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1758
    Cell Significance Index: -12.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1798
    Cell Significance Index: -3.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1816
    Cell Significance Index: -26.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2061
    Cell Significance Index: -5.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2087
    Cell Significance Index: -25.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2128
    Cell Significance Index: -29.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2161
    Cell Significance Index: -7.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2285
    Cell Significance Index: -3.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2349
    Cell Significance Index: -16.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2402
    Cell Significance Index: -5.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2404
    Cell Significance Index: -31.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2618
    Cell Significance Index: -16.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2694
    Cell Significance Index: -8.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2774
    Cell Significance Index: -31.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2823
    Cell Significance Index: -8.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2920
    Cell Significance Index: -29.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2983
    Cell Significance Index: -13.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3023
    Cell Significance Index: -6.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3265
    Cell Significance Index: -14.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4024
    Cell Significance Index: -31.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4155
    Cell Significance Index: -10.6800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4186
    Cell Significance Index: -4.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4307
    Cell Significance Index: -15.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4324
    Cell Significance Index: -32.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4337
    Cell Significance Index: -22.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4489
    Cell Significance Index: -23.5700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4886
    Cell Significance Index: -5.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5437
    Cell Significance Index: -11.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5519
    Cell Significance Index: -28.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5721
    Cell Significance Index: -18.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5749
    Cell Significance Index: -5.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5801
    Cell Significance Index: -14.4700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6055
    Cell Significance Index: -8.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6321
    Cell Significance Index: -29.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6328
    Cell Significance Index: -25.9300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6564
    Cell Significance Index: -13.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6903
    Cell Significance Index: -13.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7279
    Cell Significance Index: -9.7100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7409
    Cell Significance Index: -10.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7572
    Cell Significance Index: -6.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7995
    Cell Significance Index: -15.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8054
    Cell Significance Index: -11.8900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.8071
    Cell Significance Index: -6.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8149
    Cell Significance Index: -14.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8216
    Cell Significance Index: -30.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8935
    Cell Significance Index: -31.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9185
    Cell Significance Index: -25.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Channel Type:** KCNN2 encodes for a small conductance calcium-activated potassium channel, which is activated by increases in intracellular calcium concentrations. 2. **Subcellular Localization:** The channel is predominantly located at the plasma membrane, where it regulates the flow of potassium ions. 3. **Expression Pattern:** KCNN2 is widely expressed in the nervous system, muscle cells, sensory organs, and cardiac tissue. 4. **Channel Properties:** The KCNN2 channel has a fast activation time, a high conductance, and a low voltage dependence, making it an important regulator of neuronal excitability and muscle contraction. **Pathways and Functions:** The KCNN2 channel is involved in various physiological processes, including: 1. **Sensory Perception:** KCNN2 channels in the cochlea and auditory nerve regulate the processing of sound stimuli. 2. **Neuronal Excitability:** KCNN2 channels modulate the excitability of neurons, influencing synaptic transmission and neuronal plasticity. 3. **Muscle Contraction:** KCNN2 channels in muscle cells regulate the contraction of smooth muscle and skeletal muscle. 4. **Cardiac Function:** KCNN2 channels in cardiac tissue contribute to the repolarization of the cardiac action potential. 5. **Regulation of Potassium Ion Transmembrane Transport:** KCNN2 channels regulate the flow of potassium ions across the plasma membrane, influencing various cellular processes. **Clinical Significance:** Dysregulation of the KCNN2 channel has been implicated in various neurological and cardiovascular disorders, including: 1. **Hearing Loss:** Mutations in KCNN2 have been associated with autosomal dominant non-syndromic hearing loss. 2. **Muscle Weakness:** KCNN2 channel dysfunction has been linked to muscle weakness and wasting disorders, such as myasthenia gravis. 3. **Cardiac Arrhythmias:** KCNN2 channel dysregulation has been implicated in the development of cardiac arrhythmias, including atrial fibrillation. 4. **Neurodegenerative Diseases:** KCNN2 channels have been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the KCNN2 gene plays a crucial role in regulating various physiological processes, from sensory perception to cardiac function. Dysregulation of this gene has been implicated in a range of neurological and cardiovascular disorders, highlighting the importance of understanding the molecular mechanisms underlying KCNN2 channel function.

Genular Protein ID: 205925610

Symbol: KCNN2_HUMAN

Name: KCa2.2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10991935

Title: Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization.

PubMed ID: 10991935

DOI: 10.1074/jbc.m001562200

PubMed ID: 13679367

Title: Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts.

PubMed ID: 13679367

DOI: 10.1074/jbc.m307508200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9287325

Title: Determinants of apamin and d-tubocurarine block in SK potassium channels.

PubMed ID: 9287325

DOI: 10.1074/jbc.272.37.23195

PubMed ID: 20689065

Title: Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.

PubMed ID: 20689065

DOI: 10.1161/circresaha.109.215269

PubMed ID: 33242881

Title: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders.

PubMed ID: 33242881

DOI: 10.1093/brain/awaa346

PubMed ID: 32212350

Title: KCNN2 mutation in autosomal-dominant tremulous myoclonus-dystonia.

PubMed ID: 32212350

DOI: 10.1111/ene.14228

Sequence Information:

  • Length: 579
  • Mass: 63760
  • Checksum: 2ED87FE13C106183
  • Sequence:
  • MSSCRYNGGV MRPLSNLSAS RRNLHEMDSE AQPLQPPASV GGGGGASSPS AAAAAAAAVS 
    SSAPEIVVSK PEHNNSNNLA LYGTGGGGST GGGGGGGGSG HGSSSGTKSS KKKNQNIGYK 
    LGHRRALFEK RKRLSDYALI FGMFGIVVMV IETELSWGAY DKASLYSLAL KCLISLSTII 
    LLGLIIVYHA REIQLFMVDN GADDWRIAMT YERIFFICLE ILVCAIHPIP GNYTFTWTAR 
    LAFSYAPSTT TADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF 
    VMKTLMTICP GTVLLVFSIS LWIIAAWTVR ACERYHDQQD VTSNFLGAMW LISITFLSIG 
    YGDMVPNTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT KAEKHVHNFM MDTQLTKRVK 
    NAAANVLRET WLIYKNTKLV KKIDHAKVRK HQRKFLQAIH QLRSVKMEQR KLNDQANTLV 
    DLAKTQNIMY DMISDLNERS EDFEKRIVTL ETKLETLIGS IHALPGLISQ TIRQQQRDFI 
    EAQMESYDKH VTYNAERSRS SSRRRRSSST APPTSSESS

Genular Protein ID: 3607899413

Symbol: A0A3F2YNY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 857
  • Mass: 93660
  • Checksum: 47434ABFB98BED28
  • Sequence:
  • MFWRRRKCDV MPIVLVRPTN RTRRLDSTGA GMGPSSHQQQ ESPLPTITHC AGCTTAWSPC 
    SFNSPDMETP LQFQRGFFPE QPPPPPRSSH LHCQQQQQSQ DKPCPPFAPL PHPHHHPHLA 
    HQQPASGGSS PCLRCNSCAS SGAPAAGAGD NLSLLLRTSS PGGAFRTRTS SPLSGSSCCC 
    CCCSSRRGSQ LNVSELTPSS HASALRQQYA QQSAQQSASA SQYHQCHSLQ PAASPTGSLG 
    SLGSGPPLSH HHHHPHPAHH QHHQPQARRE SNPFTEIAMS SCRYNGGVMR PLSNLSASRR 
    NLHEMDSEAQ PLQPPASVGG GGGASSPSAA AAAAAAVSSS APEIVVSKPE HNNSNNLALY 
    GTGGGGSTGG GGGGGGSGHG SSSGTKSSKK KNQNIGYKLG HRRALFEKRK RLSDYALIFG 
    MFGIVVMVIE TELSWGAYDK ASLYSLALKC LISLSTIILL GLIIVYHARE IQLFMVDNGA 
    DDWRIAMTYE RIFFICLEIL VCAIHPIPGN YTFTWTARLA FSYAPSTTTA DVDIILSIPM 
    FLRLYLIARV MLLHSKLFTD ASSRSIGALN KINFNTRFVM KTLMTICPGT VLLVFSISLW 
    IIAAWTVRAC ERYHDQQDVT SNFLGAMWLI SITFLSIGYG DMVPNTYCGK GVCLLTGIMG 
    AGCTALVVAV VARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL IYKNTKLVKK 
    IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM ISDLNERSED 
    FEKRIVTLET KLETLIGSIH ALPGLISQTI RQQQRDFIEA QMESYDKHVT YNAERSRSSS 
    RRRRSSSTAP PTSSESS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.