Details for: KRT15

Gene ID: 3866

Symbol: KRT15

Ensembl ID: ENSG00000171346

Description: keratin 15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 6.32
    Marker Score: 7165
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.46
    Marker Score: 8454
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.03
    Marker Score: 2684
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.82
    Marker Score: 2966
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.64
    Marker Score: 4335
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.58
    Marker Score: 622
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.52
    Marker Score: 896
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.51
    Marker Score: 18678
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.4
    Marker Score: 1891
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.37
    Marker Score: 803
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.36
    Marker Score: 1243
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.16
    Marker Score: 16828.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.03
    Marker Score: 17453
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.87
    Marker Score: 2413
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.76
    Marker Score: 734
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.65
    Marker Score: 22231
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.53
    Marker Score: 2705
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.53
    Marker Score: 1039
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.48
    Marker Score: 1234
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.24
    Marker Score: 613
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2
    Marker Score: 833
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.13
    Marker Score: 1666
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.03
    Marker Score: 687
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1
    Marker Score: 438
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 289
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5188
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.89
    Marker Score: 589
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.79
    Marker Score: 368
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.78
    Marker Score: 3025
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 908
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.71
    Marker Score: 636
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2908
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.69
    Marker Score: 423
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.68
    Marker Score: 215
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.66
    Marker Score: 167
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.65
    Marker Score: 579
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.63
    Marker Score: 1065
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.57
    Marker Score: 4988
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.57
    Marker Score: 1045
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 357
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.55
    Marker Score: 321
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.52
    Marker Score: 297
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.47
    Marker Score: 172
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.46
    Marker Score: 2252.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.45
    Marker Score: 273
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.42
    Marker Score: 119
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.41
    Marker Score: 453.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.4
    Marker Score: 348
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.4
    Marker Score: 81
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.39
    Marker Score: 885
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.39
    Marker Score: 1430
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.38
    Marker Score: 149
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.38
    Marker Score: 608
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.38
    Marker Score: 95
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.38
    Marker Score: 95
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.38
    Marker Score: 453
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.37
    Marker Score: 1940
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.37
    Marker Score: 113
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.33
    Marker Score: 121
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.33
    Marker Score: 141
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 188
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.27
    Marker Score: 863
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.26
    Marker Score: 484
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.25
    Marker Score: 178
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 145
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.24
    Marker Score: 101
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.24
    Marker Score: 816
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.22
    Marker Score: 7751
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.22
    Marker Score: 1429
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.22
    Marker Score: 209
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.22
    Marker Score: 439
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.21
    Marker Score: 213.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.21
    Marker Score: 1004
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 431
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.21
    Marker Score: 391
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.21
    Marker Score: 175
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2
    Marker Score: 92
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.2
    Marker Score: 56
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.2
    Marker Score: 560

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Other Information

**Key characteristics:** * KRT15 is a type I transmembrane protein, which means that it is a glycoprotein that is anchored in the lipid bilayer of the cell membrane. * It is a highly conserved protein, with a similar sequence in mice and humans. * KRT15 is a key regulator of epithelial cell differentiation and proliferation. * It is involved in the formation of the cornified envelope, a specialized layer of cells that covers the surface of stratified squamous epithelia. * It is also involved in the organization and stability of the intermediate filament, a cytoskeletal protein that connects the keratinous filaments of the cytoskeleton. **Pathways and functions:** * KRT15 is involved in the assembly and maintenance of the cytoskeleton. * It is a key component of the skin barrier, providing structural support and protection against mechanical stress. * It is also involved in the regulation of cell migration and invasion. * It is involved in the development and maintenance of stratified squamous epithelia, including the skin, respiratory tract, and prostate. * It is a potential therapeutic target for a variety of skin disorders, such as psoriasis and skin cancer. **Clinical significance:** * Mutations in the KRT15 gene have been linked to a number of skin disorders, including psoriasis, skin cancer, and esophageal cancer. * KRT15 is a potential therapeutic target for these disorders, as it is a key component of the cytoskeleton that is involved in the structural integrity and stability of epithelial cells. * Studies on animal models have shown that blocking KRT15 can inhibit cell migration and proliferation, and lead to the development of skin tumors. * Clinical trials are currently underway to evaluate the potential of KRT15 inhibitors as a treatment for skin disorders.

Genular Protein ID: 4072973199

Symbol: K1C15_HUMAN

Name: Keratin, type I cytoskeletal 15

UniProtKB Accession Codes:

P19012 B3KQY1 B3KRA2 E0CX14 Q53XV8 Q9BUG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2468493

Title: Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.

PubMed ID: 2468493

PubMed ID: 2452170

Title: Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.

PubMed ID: 2452170

DOI: 10.1083/jcb.106.4.1249

PubMed ID: 10623642

Title: Genomic organization and amplification of the human keratin 15 and 19 genes.

PubMed ID: 10623642

DOI: 10.1006/bbrc.1999.1966

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10084315

Title: Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.

PubMed ID: 10084315

DOI: 10.1046/j.1523-1747.1999.00535.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

Sequence Information:

  • Length: 456
  • Mass: 49212
  • Checksum: 812C1343905EBE41
  • Sequence:
    • MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY 
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL 
DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE 
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL 
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ 
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI 
AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

Genular Protein ID: 1208608366

Symbol: B3KVF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVF5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 456
  • Mass: 49110
  • Checksum: 85C2D47710EFC06D
  • Sequence:
    • MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY 
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL 
GKVRALEEAN ADLEVKIHDW YQKQTPASPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE 
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL 
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ 
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI 
GIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.