Details for: KRT15

Gene ID: 3866

Symbol: KRT15

Ensembl ID: ENSG00000171346

Description: keratin 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 43.4891
    Cell Significance Index: 31.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 18.1353
    Cell Significance Index: 506.8200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 13.4028
    Cell Significance Index: 39.8600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 11.1556
    Cell Significance Index: 25.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7434
    Cell Significance Index: -28.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 8.3365
    Cell Significance Index: 113.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.1161
    Cell Significance Index: 919.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.9016
    Cell Significance Index: 3051.3500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 6.5486
    Cell Significance Index: 58.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.8218
    Cell Significance Index: 226.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0209
    Cell Significance Index: -8.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.6152
    Cell Significance Index: 255.6900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.4643
    Cell Significance Index: 21.4400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.6408
    Cell Significance Index: 21.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3175
    Cell Significance Index: 35.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9977
    Cell Significance Index: 6.1400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.9459
    Cell Significance Index: 9.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9112
    Cell Significance Index: 173.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7847
    Cell Significance Index: 96.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7714
    Cell Significance Index: 89.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6524
    Cell Significance Index: 48.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6444
    Cell Significance Index: 116.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4464
    Cell Significance Index: 403.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4458
    Cell Significance Index: 44.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3338
    Cell Significance Index: 17.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2211
    Cell Significance Index: 35.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2186
    Cell Significance Index: 9.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1314
    Cell Significance Index: 14.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0610
    Cell Significance Index: 33.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0118
    Cell Significance Index: 0.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0192
    Cell Significance Index: -36.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0307
    Cell Significance Index: -1.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0332
    Cell Significance Index: -1.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0343
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0377
    Cell Significance Index: -23.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0407
    Cell Significance Index: -75.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0416
    Cell Significance Index: -2.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0489
    Cell Significance Index: -75.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0557
    Cell Significance Index: -75.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0612
    Cell Significance Index: -45.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0767
    Cell Significance Index: -27.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0791
    Cell Significance Index: -44.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0836
    Cell Significance Index: -10.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0923
    Cell Significance Index: -26.5500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0950
    Cell Significance Index: -1.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1049
    Cell Significance Index: -7.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1120
    Cell Significance Index: -2.8000
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1138
    Cell Significance Index: -1.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1265
    Cell Significance Index: -2.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1269
    Cell Significance Index: -57.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1377
    Cell Significance Index: -27.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1499
    Cell Significance Index: -30.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1641
    Cell Significance Index: -23.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1883
    Cell Significance Index: -1.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2031
    Cell Significance Index: -12.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2197
    Cell Significance Index: -46.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2230
    Cell Significance Index: -38.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2362
    Cell Significance Index: -27.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2378
    Cell Significance Index: -24.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2381
    Cell Significance Index: -6.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2415
    Cell Significance Index: -3.6400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2486
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2627
    Cell Significance Index: -30.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2826
    Cell Significance Index: -3.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3241
    Cell Significance Index: -44.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3527
    Cell Significance Index: -8.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3695
    Cell Significance Index: -6.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3763
    Cell Significance Index: -23.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3787
    Cell Significance Index: -12.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4158
    Cell Significance Index: -6.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4219
    Cell Significance Index: -27.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4414
    Cell Significance Index: -29.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4495
    Cell Significance Index: -27.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4633
    Cell Significance Index: -9.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5189
    Cell Significance Index: -39.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6317
    Cell Significance Index: -35.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6652
    Cell Significance Index: -24.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7468
    Cell Significance Index: -32.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.7639
    Cell Significance Index: -9.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7822
    Cell Significance Index: -41.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7890
    Cell Significance Index: -23.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7919
    Cell Significance Index: -22.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7921
    Cell Significance Index: -13.5400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.8166
    Cell Significance Index: -8.9500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8486
    Cell Significance Index: -12.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8578
    Cell Significance Index: -30.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8616
    Cell Significance Index: -18.0400
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.8654
    Cell Significance Index: -7.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8889
    Cell Significance Index: -23.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8934
    Cell Significance Index: -22.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8987
    Cell Significance Index: -19.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9215
    Cell Significance Index: -17.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9545
    Cell Significance Index: -8.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9630
    Cell Significance Index: -6.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9711
    Cell Significance Index: -31.8000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9773
    Cell Significance Index: -16.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9934
    Cell Significance Index: -31.6400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.9985
    Cell Significance Index: -10.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT15 is a type I keratin, which is distinct from type II keratins that are more abundant in the epidermis. Type I keratins are typically found in the basal cell layer of stratified epithelia, where they play a crucial role in maintaining cell-cell adhesion and resistance to mechanical stress. KRT15 is specifically expressed in basal epithelial cells of the tracheobronchial tree, prostate epithelium, and other epithelial tissues. Its expression is also observed in stem cells of the epidermis and in certain types of cancer cells. **Pathways and Functions:** KRT15 is involved in several key pathways that regulate epithelial cell function and differentiation. These include: 1. **Cytoskeleton organization**: KRT15 interacts with other intermediate filament proteins to form a stable cytoskeletal network that provides mechanical support to epithelial cells. 2. **Cell-cell adhesion**: KRT15 contributes to the formation of tight junctions between epithelial cells, which is essential for maintaining tissue integrity and regulating the exchange of ions and molecules. 3. **Keratinization**: KRT15 is involved in the process of keratinization, which is the transformation of basal epithelial cells into stratified epithelial cells that have a thickened layer of keratin filaments. 4. **Epithelial-to-mesenchymal transition (EMT)**: KRT15 has been shown to regulate EMT, a process by which epithelial cells undergo a phenotypic transformation to acquire a mesenchymal phenotype. **Clinical Significance:** Dysregulation of KRT15 expression has been implicated in various diseases, including: 1. **Cancer**: Alterations in KRT15 expression have been observed in certain types of cancer, including prostate cancer and squamous cell carcinoma. 2. **Skin disorders**: Mutations in the KRT15 gene have been associated with skin disorders such as epidermolysis bullosa simplex. 3. **Respiratory diseases**: KRT15 is expressed in basal epithelial cells of the tracheobronchial tree, and its dysfunction has been implicated in respiratory diseases such as chronic obstructive pulmonary disease (COPD). 4. **Gastrointestinal disorders**: KRT15 is expressed in epithelial cells of the esophagus and stomach, and its dysfunction has been implicated in gastrointestinal disorders such as esophageal cancer. In conclusion, KRT15 is a crucial protein that plays a vital role in maintaining the structural integrity and function of epithelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of KRT15 function and its role in human disease.

Genular Protein ID: 4072973199

Symbol: K1C15_HUMAN

Name: Keratin, type I cytoskeletal 15

UniProtKB Accession Codes:

P19012 B3KQY1 B3KRA2 E0CX14 Q53XV8 Q9BUG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2468493

Title: Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.

PubMed ID: 2468493

PubMed ID: 2452170

Title: Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.

PubMed ID: 2452170

DOI: 10.1083/jcb.106.4.1249

PubMed ID: 10623642

Title: Genomic organization and amplification of the human keratin 15 and 19 genes.

PubMed ID: 10623642

DOI: 10.1006/bbrc.1999.1966

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10084315

Title: Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.

PubMed ID: 10084315

DOI: 10.1046/j.1523-1747.1999.00535.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

Sequence Information:

  • Length: 456
  • Mass: 49212
  • Checksum: 812C1343905EBE41
  • Sequence:
    • MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY 
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL 
DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE 
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL 
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ 
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI 
AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

Genular Protein ID: 1208608366

Symbol: B3KVF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVF5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 3 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 456
  • Mass: 49110
  • Checksum: 85C2D47710EFC06D
  • Sequence:
    • MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY 
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL 
GKVRALEEAN ADLEVKIHDW YQKQTPASPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE 
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL 
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK 
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ 
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI 
GIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.