Gene ARHGDIG - ENSG00000242173 | NCBI Gene ID: 398

Details for: ARHGDIG

Gene ID: 398

Symbol: ARHGDIG

Ensembl ID: ENSG00000242173

Description: Rho GDP dissociation inhibitor gamma

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Rhob gtpase cycle
(R-HSA-9013026)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rhoh gtpase cycle
(R-HSA-9013407)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Blastocyst hatching
(GO:0001835)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Gtpase activator activity
(GO:0005096)
Membrane
(GO:0016020)
Negative regulation of cell adhesion
(GO:0007162)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of protein localization
(GO:0032880)
Rho gdp-dissociation inhibitor activity
(GO:0005094)
Rho protein signal transduction
(GO:0007266)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.34
Marker Score: 2351.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.93
Marker Score: 4064
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.35
Marker Score: 13907
Cell Name: peptic cell (CL0000155)
Fold Change: 1.13
Marker Score: 473
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.06
Marker Score: 1188
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.06
Marker Score: 9062
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.01
Marker Score: 340
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: neuron (CL0000540)
Fold Change: 0.96
Marker Score: 3904
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5331
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.93
Marker Score: 1441
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.89
Marker Score: 55021
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5285
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.83
Marker Score: 7925
Cell Name: mast cell (CL0000097)
Fold Change: 0.83
Marker Score: 480
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.82
Marker Score: 330
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.78
Marker Score: 3263
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.77
Marker Score: 29191
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.76
Marker Score: 15125
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.71
Marker Score: 2737
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.7
Marker Score: 6573
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.68
Marker Score: 1392
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.65
Marker Score: 24157
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.65
Marker Score: 10124
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 474
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.57
Marker Score: 4391
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.56
Marker Score: 2335
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.56
Marker Score: 529
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.56
Marker Score: 1152
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.55
Marker Score: 1254
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.51
Marker Score: 620
Cell Name: male germ cell (CL0000015)
Fold Change: 0.5
Marker Score: 144
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.49
Marker Score: 757
Cell Name: plasma cell (CL0000786)
Fold Change: 0.44
Marker Score: 488
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.43
Marker Score: 810
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.42
Marker Score: 6262
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.39
Marker Score: 207
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.38
Marker Score: 916
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.36
Marker Score: 1487
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.35
Marker Score: 229
Cell Name: enterocyte (CL0000584)
Fold Change: 0.34
Marker Score: 1643
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.34
Marker Score: 472
Cell Name: motor neuron (CL0000100)
Fold Change: 0.33
Marker Score: 197
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.33
Marker Score: 225
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.33
Marker Score: 524
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.32
Marker Score: 133
Cell Name: oocyte (CL0000023)
Fold Change: 0.32
Marker Score: 78
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.31
Marker Score: 213
Cell Name: germ cell (CL0000586)
Fold Change: 0.31
Marker Score: 534
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.3
Marker Score: 124
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.29
Marker Score: 287
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.29
Marker Score: 596
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.29
Marker Score: 208
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.29
Marker Score: 821
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.28
Marker Score: 277
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.28
Marker Score: 89
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.27
Marker Score: 147
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.26
Marker Score: 133
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.25
Marker Score: 251
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.24
Marker Score: 84
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.24
Marker Score: 99
Cell Name: astrocyte (CL0000127)
Fold Change: 0.24
Marker Score: 205.5
Cell Name: paneth cell (CL0000510)
Fold Change: 0.24
Marker Score: 164
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.23
Marker Score: 141
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.23
Marker Score: 115
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.23
Marker Score: 87
Cell Name: interneuron (CL0000099)
Fold Change: 0.23
Marker Score: 105
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.23
Marker Score: 62
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.22
Marker Score: 214
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.22
Marker Score: 98
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.21
Marker Score: 360
Cell Name: precursor cell (CL0011115)
Fold Change: 0.21
Marker Score: 52
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.21
Marker Score: 604
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.21
Marker Score: 101
Cell Name: microglial cell (CL0000129)
Fold Change: 0.21
Marker Score: 381
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.21
Marker Score: 124
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2
Marker Score: 94
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.2
Marker Score: 211
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.2
Marker Score: 155
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.2
Marker Score: 71
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.2
Marker Score: 62
Cell Name: neural cell (CL0002319)
Fold Change: 0.19
Marker Score: 92
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.19
Marker Score: 101
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.19
Marker Score: 76
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.18
Marker Score: 228
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.18
Marker Score: 1832
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.17
Marker Score: 5842

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**Key characteristics:** * ARHGDIG is a protein of the Rho GDP dissociation inhibitor family. * It is found in a variety of cell types, including blood vessel endothelial cells, pancreatic acinar cells, dopaminergic neurons, and primary sensory neurons. * It is a negative regulator of cell adhesion, as it inhibits the interaction between cells and their extracellular matrix proteins. * It is also involved in regulating the activity of Rho GTPases, which are key regulators of cell signaling. **Pathways and functions:** * ARHGDIG binds to Rho GTPases and prevents them from interacting with their target proteins. * This leads to the release of the Rho GTPases' regulatory subunits, which can then interact with downstream targets and modulate cellular processes. * For example, ARHGDIG can inhibit the activity of RhoA and RhoC GTPases, which are involved in cell proliferation, migration, and differentiation. * It can also inhibit the activity of RhoG, which is involved in cell cycle regulation and apoptosis. * By inhibiting Rho GTPases, ARHGDIG can regulate various cellular processes, including cell migration, proliferation, and differentiation. **Clinical significance:** ARHGDIG is a promising target for cancer therapy. It is often overexpressed in tumors, where it can inhibit the activity of Rho GTPases and promote tumor growth. Inhibition of ARHGDIG can lead to the reactivation of Rho GTPases and the activation of their target proteins, which can result in cell cycle arrest, apoptosis, and tumor regression. **Additional notes:** * ARHGDIG is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a well-characterized protein that has been extensively studied in both physiological and pathological contexts. * It is a promising target for cancer therapy due to its expression in tumors and its ability to inhibit Rho GTPase activity.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Rho GDP-dissociation inhibitor 3

Genular Protein ID: 2131097965

Symbol: GDIR3_HUMAN

Name: Rho GDP-dissociation inhibitor 3

UniProtKB Accession Codes:

Q99819 Q4TT69 Q96S29

Database IDs:

Citations:

PubMed ID: 9113980

Title: RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.

PubMed ID: 9113980

DOI: 10.1073/pnas.94.9.4279

PubMed ID: 9787082

Title: Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3.

PubMed ID: 9787082

DOI: 10.1006/geno.1998.5482

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 225
Mass: 25098
Checksum: AFC4576E6BE0E9BD
Sequence:

MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA PGRKSLLEIR 
QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS EQAPGPVVMD LTGDLAVLKD 
QVFVLKEGVD YRVKISFKVH REIVSGLKCL HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV 
TPVEEAPRGA LVRGPYLVVS LFTDDDRTHH LSWEWGLCIC QDWKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ARHGDIG

Associated with

Cells (max top 100)

Other Information

RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. PubMed ID: 9113980

Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3. PubMed ID: 9787082

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. PubMed ID: 11157797