Details for: ARHGDIG

Gene ID: 398

Symbol: ARHGDIG

Ensembl ID: ENSG00000242173

Description: Rho GDP dissociation inhibitor gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.9703
    Cell Significance Index: -14.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.3022
    Cell Significance Index: -12.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.8836
    Cell Significance Index: -14.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6951
    Cell Significance Index: 77.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9262
    Cell Significance Index: 91.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8210
    Cell Significance Index: 741.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7295
    Cell Significance Index: 146.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6296
    Cell Significance Index: 13.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5787
    Cell Significance Index: 34.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5734
    Cell Significance Index: 62.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4989
    Cell Significance Index: 10.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4988
    Cell Significance Index: 81.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4878
    Cell Significance Index: 10.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3935
    Cell Significance Index: 141.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3478
    Cell Significance Index: 18.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3364
    Cell Significance Index: 9.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3028
    Cell Significance Index: 20.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3014
    Cell Significance Index: 4.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2482
    Cell Significance Index: 16.6900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.1267
    Cell Significance Index: 1.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1227
    Cell Significance Index: 23.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0918
    Cell Significance Index: 5.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0813
    Cell Significance Index: 13.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0543
    Cell Significance Index: 37.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0368
    Cell Significance Index: 0.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0207
    Cell Significance Index: 0.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0053
    Cell Significance Index: 0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0035
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0064
    Cell Significance Index: -11.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0158
    Cell Significance Index: -11.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0187
    Cell Significance Index: -0.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0195
    Cell Significance Index: -1.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0201
    Cell Significance Index: -5.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0208
    Cell Significance Index: -15.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0228
    Cell Significance Index: -12.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0235
    Cell Significance Index: -14.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0303
    Cell Significance Index: -13.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0363
    Cell Significance Index: -0.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0369
    Cell Significance Index: -0.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0388
    Cell Significance Index: -0.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0440
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0629
    Cell Significance Index: -13.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0660
    Cell Significance Index: -13.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0725
    Cell Significance Index: -1.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0782
    Cell Significance Index: -1.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0823
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0839
    Cell Significance Index: -9.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0869
    Cell Significance Index: -5.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0880
    Cell Significance Index: -1.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0901
    Cell Significance Index: -1.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0925
    Cell Significance Index: -12.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0940
    Cell Significance Index: -3.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0997
    Cell Significance Index: -12.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1020
    Cell Significance Index: -3.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1020
    Cell Significance Index: -2.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1024
    Cell Significance Index: -12.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1037
    Cell Significance Index: -15.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1118
    Cell Significance Index: -13.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1295
    Cell Significance Index: -3.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1366
    Cell Significance Index: -14.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1556
    Cell Significance Index: -15.8900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1656
    Cell Significance Index: -1.5700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1680
    Cell Significance Index: -2.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1719
    Cell Significance Index: -13.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1772
    Cell Significance Index: -2.6700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1820
    Cell Significance Index: -2.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1860
    Cell Significance Index: -8.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1932
    Cell Significance Index: -15.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1988
    Cell Significance Index: -4.9600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1989
    Cell Significance Index: -2.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2067
    Cell Significance Index: -7.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2155
    Cell Significance Index: -13.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2172
    Cell Significance Index: -12.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2271
    Cell Significance Index: -4.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2386
    Cell Significance Index: -4.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2441
    Cell Significance Index: -2.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2520
    Cell Significance Index: -3.1300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2701
    Cell Significance Index: -2.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2705
    Cell Significance Index: -14.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2732
    Cell Significance Index: -12.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2919
    Cell Significance Index: -7.2900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2927
    Cell Significance Index: -3.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2945
    Cell Significance Index: -13.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2988
    Cell Significance Index: -10.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3071
    Cell Significance Index: -11.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3098
    Cell Significance Index: -4.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3424
    Cell Significance Index: -3.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3562
    Cell Significance Index: -7.0100
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -0.3671
    Cell Significance Index: -2.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3756
    Cell Significance Index: -11.8800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3880
    Cell Significance Index: -4.6400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.4016
    Cell Significance Index: -3.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4120
    Cell Significance Index: -5.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4283
    Cell Significance Index: -8.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARHGDIG is a member of the Rho GDP-dissociation inhibitor family, which regulates the activity of Rho GTPases by facilitating the exchange of GDP for GTP. This process is essential for the activation of downstream effectors, leading to various cellular responses, including cell migration, adhesion, and morphology. The gene is characterized by its ability to bind to Rho GTPases, specifically Rhob, Rhoc, and Rho, and inhibit their GDP-dissociation activity. This inhibition is crucial for regulating the duration and intensity of Rho GTPase signaling, which in turn modulates cellular processes. **Pathways and Functions:** ARHGDIG is involved in various signaling pathways, including: 1. **Blastocyst hatching:** ARHGDIG regulates the Rho GTPase cycle during blastocyst hatching, ensuring proper implantation of the embryo. 2. **Cdc42 GTPase cycle:** ARHGDIG modulates the activity of Cdc42, a key Rho GTPase involved in cell migration and adhesion. 3. **Cytoplasmic vesicle formation:** ARHGDIG regulates the formation of cytoplasmic vesicles, which is essential for cellular processes such as endocytosis and exocytosis. 4. **Negative regulation of cell adhesion:** ARHGDIG inhibits cell adhesion by regulating the activity of Rho GTPases, which is crucial for maintaining tissue homeostasis. 5. **Regulation of protein localization:** ARHGDIG regulates the localization of proteins within the cell, ensuring proper cellular processes. **Clinical Significance:** Dysregulation of ARHGDIG has been implicated in various diseases, including: 1. **Cancer:** Overexpression of ARHGDIG has been observed in various types of cancer, including colon cancer and pancreatic cancer, suggesting its potential as a therapeutic target. 2. **Neurological disorders:** ARHGDIG has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where dysregulation of Rho GTPase signaling contributes to disease pathology. 3. **Cardiovascular disease:** ARHGDIG has been shown to play a crucial role in maintaining vascular homeostasis, and its dysregulation has been implicated in cardiovascular disease. In conclusion, ARHGDIG is a critical regulator of Rho GTPase signaling, and its dysregulation has been implicated in various diseases. Further research is necessary to fully elucidate the role of ARHGDIG in maintaining tissue homeostasis and to explore its potential as a therapeutic target.

Genular Protein ID: 2131097965

Symbol: GDIR3_HUMAN

Name: Rho GDP-dissociation inhibitor 3

UniProtKB Accession Codes:

Q99819 Q4TT69 Q96S29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9113980

Title: RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.

PubMed ID: 9113980

DOI: 10.1073/pnas.94.9.4279

PubMed ID: 9787082

Title: Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3.

PubMed ID: 9787082

DOI: 10.1006/geno.1998.5482

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 225
  • Mass: 25098
  • Checksum: AFC4576E6BE0E9BD
  • Sequence:
    • MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA PGRKSLLEIR 
QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS EQAPGPVVMD LTGDLAVLKD 
QVFVLKEGVD YRVKISFKVH REIVSGLKCL HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV 
TPVEEAPRGA LVRGPYLVVS LFTDDDRTHH LSWEWGLCIC QDWKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.