Details for: LY6H

Gene ID: 4062

Symbol: LY6H

Ensembl ID: ENSG00000176956

Description: lymphocyte antigen 6 family member H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.8359
    Cell Significance Index: -25.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.8636
    Cell Significance Index: -24.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9337
    Cell Significance Index: 87.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8632
    Cell Significance Index: 40.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4910
    Cell Significance Index: 19.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2600
    Cell Significance Index: 27.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8378
    Cell Significance Index: 300.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8250
    Cell Significance Index: 744.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7473
    Cell Significance Index: 149.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6203
    Cell Significance Index: 32.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4065
    Cell Significance Index: 66.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3228
    Cell Significance Index: 10.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2626
    Cell Significance Index: 28.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2492
    Cell Significance Index: 47.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0796
    Cell Significance Index: 7.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0350
    Cell Significance Index: 2.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0282
    Cell Significance Index: 0.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0146
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0066
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0219
    Cell Significance Index: -33.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0326
    Cell Significance Index: -24.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0338
    Cell Significance Index: -25.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0410
    Cell Significance Index: -26.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0462
    Cell Significance Index: -26.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0462
    Cell Significance Index: -25.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0556
    Cell Significance Index: -34.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0709
    Cell Significance Index: -32.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0744
    Cell Significance Index: -21.4000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0841
    Cell Significance Index: -0.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0900
    Cell Significance Index: -2.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1052
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1137
    Cell Significance Index: -23.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1236
    Cell Significance Index: -6.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1263
    Cell Significance Index: -25.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1276
    Cell Significance Index: -23.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1359
    Cell Significance Index: -8.1600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1382
    Cell Significance Index: -1.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1402
    Cell Significance Index: -4.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1415
    Cell Significance Index: -2.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1457
    Cell Significance Index: -2.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1684
    Cell Significance Index: -3.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1778
    Cell Significance Index: -25.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1850
    Cell Significance Index: -21.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1937
    Cell Significance Index: -23.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1970
    Cell Significance Index: -33.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2039
    Cell Significance Index: -28.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2154
    Cell Significance Index: -6.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2307
    Cell Significance Index: -3.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2394
    Cell Significance Index: -5.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2434
    Cell Significance Index: -31.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2543
    Cell Significance Index: -25.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2656
    Cell Significance Index: -30.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2695
    Cell Significance Index: -3.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2785
    Cell Significance Index: -5.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3284
    Cell Significance Index: -18.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3288
    Cell Significance Index: -8.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3475
    Cell Significance Index: -12.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3655
    Cell Significance Index: -9.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3952
    Cell Significance Index: -24.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4145
    Cell Significance Index: -31.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4149
    Cell Significance Index: -18.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4221
    Cell Significance Index: -8.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4263
    Cell Significance Index: -31.7700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4404
    Cell Significance Index: -4.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4498
    Cell Significance Index: -11.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4809
    Cell Significance Index: -21.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4859
    Cell Significance Index: -5.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5068
    Cell Significance Index: -19.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5280
    Cell Significance Index: -11.2500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5297
    Cell Significance Index: -6.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5706
    Cell Significance Index: -11.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6245
    Cell Significance Index: -32.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6659
    Cell Significance Index: -10.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7220
    Cell Significance Index: -33.9400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.7260
    Cell Significance Index: -6.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7315
    Cell Significance Index: -21.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7342
    Cell Significance Index: -34.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7434
    Cell Significance Index: -19.8900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7659
    Cell Significance Index: -4.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8160
    Cell Significance Index: -8.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8371
    Cell Significance Index: -30.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8391
    Cell Significance Index: -14.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8420
    Cell Significance Index: -21.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8513
    Cell Significance Index: -10.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8527
    Cell Significance Index: -17.3500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.8731
    Cell Significance Index: -5.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8897
    Cell Significance Index: -26.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8904
    Cell Significance Index: -15.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8987
    Cell Significance Index: -12.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9222
    Cell Significance Index: -24.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9267
    Cell Significance Index: -18.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9344
    Cell Significance Index: -23.3000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9480
    Cell Significance Index: -9.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9572
    Cell Significance Index: -25.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0514
    Cell Significance Index: -26.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0592
    Cell Significance Index: -28.8300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0691
    Cell Significance Index: -18.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular Expression**: LY6H is expressed in a wide range of cell types, including P/D1 enteroendocrine cells, primary sensory neurons, supporting cells, mesenchymal cells, enterocytes, glycinergic amacrine cells, L6b glutamatergic cortical neurons, peripheral nervous system neurons, colon goblet cells, and pyramidal neurons. 2. **Protein Structure**: The LY6H protein has a unique structure, consisting of two extracellular domains and a transmembrane domain. The extracellular domains are rich in cysteine residues, which are involved in disulfide bond formation and protein-protein interactions. 3. **Expression Patterns**: LY6H expression is tissue-specific, with varying levels of expression in different cell types and tissues. For instance, LY6H is highly expressed in lymphocytes, while its expression is lower in neurons and epithelial cells. **Pathways and Functions** 1. **Cell Signaling**: LY6H has been implicated in cell signaling pathways, including the acetylcholine receptor signaling pathway. The protein interacts with various receptors and ligands, modulating cellular responses to external stimuli. 2. **Protein Modification**: LY6H is involved in post-translational protein modification, including glycosylation and protein synthesis. The protein helps regulate the synthesis of GPI-anchored proteins, which are crucial for cell membrane trafficking and signaling. 3. **Immune Homeostasis**: LY6H has been shown to regulate immune homeostasis by modulating lymphocyte signaling and activation. The protein interacts with immune cells, influencing their function and behavior. **Clinical Significance** 1. **Autoimmune Diseases**: LY6H has been implicated in various autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and lupus. The protein's role in regulating immune homeostasis suggests that it may be a potential therapeutic target for these diseases. 2. **Cancer**: LY6H has been found to be overexpressed in certain types of cancer, including breast, lung, and colon cancer. The protein's involvement in cell signaling and protein modification may contribute to cancer progression and metastasis. 3. **Neurological Disorders**: LY6H has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). The protein's role in regulating neuronal signaling and protein modification may contribute to disease pathogenesis. In conclusion, LY6H is a novel immunological player that regulates lymphocyte signaling and immune homeostasis. Its unique structure and function make it a potential therapeutic target for various diseases, including autoimmune disorders, cancer, and neurological disorders. Further research is necessary to fully elucidate the mechanisms of LY6H and its role in human disease.

Genular Protein ID: 2477893011

Symbol: LY6H_HUMAN

Name: Lymphocyte antigen 6H

UniProtKB Accession Codes:

O94772 B2RAD2 J3KQI0 Q6IAX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 7 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799603

Title: Isolation and characterization of a new member of the human Ly6 gene family (LY6H).

PubMed ID: 9799603

DOI: 10.1006/geno.1998.5462

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 140
  • Mass: 14669
  • Checksum: A9274BFE89B6CBA3
  • Sequence:
    • MLPAAMKGLG LALLAVLLCS APAHGLWCQD CTLTTNSSHC TPKQCQPSDT VCASVRITDP 
SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV DVDCCEKDLC NGAAGAGHSP 
WALAGGLLLS LGPALLWAGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.