Details for: LY6H

Gene ID: 4062

Symbol: LY6H

Ensembl ID: ENSG00000176956

Description: lymphocyte antigen 6 family member H

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.72
    Marker Score: 1015
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.36
    Marker Score: 794
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.29
    Marker Score: 4309
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.01
    Marker Score: 3414
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.99
    Marker Score: 1879
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.66
    Marker Score: 14247
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.61
    Marker Score: 1805
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.59
    Marker Score: 2662
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.58
    Marker Score: 2175
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.56
    Marker Score: 1879.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.51
    Marker Score: 6133
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.49
    Marker Score: 14136
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.38
    Marker Score: 2132
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.3
    Marker Score: 25883
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.28
    Marker Score: 78971
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.27
    Marker Score: 439
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.27
    Marker Score: 553
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.26
    Marker Score: 404
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.24
    Marker Score: 2525
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.21
    Marker Score: 4685
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.17
    Marker Score: 12115
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.16
    Marker Score: 7561
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.14
    Marker Score: 723
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.09
    Marker Score: 2975
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.09
    Marker Score: 5055
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.09
    Marker Score: 41487
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.08
    Marker Score: 1881
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251797
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.04
    Marker Score: 15484
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.03
    Marker Score: 355
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.02
    Marker Score: 7790
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1
    Marker Score: 516.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 441
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.95
    Marker Score: 2706
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.95
    Marker Score: 890
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.94
    Marker Score: 8865
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.92
    Marker Score: 266
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.92
    Marker Score: 226
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.89
    Marker Score: 30005
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.88
    Marker Score: 521
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.88
    Marker Score: 32361
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.86
    Marker Score: 965
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 471
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 782
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.79
    Marker Score: 179
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.74
    Marker Score: 3081
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.71
    Marker Score: 884
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.7
    Marker Score: 9237
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.67
    Marker Score: 1030
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.64
    Marker Score: 303.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.59
    Marker Score: 632
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.59
    Marker Score: 559
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.57
    Marker Score: 2364
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.56
    Marker Score: 1161
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.55
    Marker Score: 144
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.54
    Marker Score: 4686
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.53
    Marker Score: 1831
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.53
    Marker Score: 5305
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.52
    Marker Score: 753
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.52
    Marker Score: 187.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.51
    Marker Score: 336
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.5
    Marker Score: 942
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.48
    Marker Score: 120
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.48
    Marker Score: 876
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.46
    Marker Score: 453
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.43
    Marker Score: 376
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.41
    Marker Score: 164
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4
    Marker Score: 271
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.39
    Marker Score: 210
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.39
    Marker Score: 201
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.39
    Marker Score: 405
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 483
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 445
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.38
    Marker Score: 172
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.37
    Marker Score: 1996
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.36
    Marker Score: 163
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.35
    Marker Score: 171

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Other Information

## Summary The LY6H gene encodes a protein involved in the regulation of acetylcholine receptor signaling in the central nervous system. This protein is expressed in various cell types, including P/D1 enteroendocrine cells, primary sensory neurons, supporting cells, and neurons of the central nervous system. ## Key characteristics * LY6H is a member of the LY6 family of cell surface receptors. * It is expressed in high levels in the central nervous system, particularly in the brain and spinal cord. * LY6H is a ligand for the acetylcholine receptor, a G protein-coupled receptor that is involved in a variety of cellular processes, including learning and memory, cognition, and muscle contraction. * Activation of the acetylcholine receptor by LY6H induces the internalization of the receptor into lysosomes, leading to the degradation of the receptor protein. * This degradation is mediated by the ubiquitin-proteasome pathway, which is a major mechanism for regulating protein turnover in the central nervous system. ## Pathways and functions * LY6H is involved in the regulation of acetylcholine receptor signaling in the central nervous system. * This signaling pathway is critical for a variety of cognitive functions, including learning, memory, and cognition. * LY6H is also involved in the development and maintenance of the enteric nervous system. ## Clinical significance * Mutations in the LY6H gene have been linked to a number of neurological disorders, including Alzheimer's disease, schizophrenia, and autism. * These mutations can lead to a loss of function in the LY6H protein, which can disrupt the normal functioning of the central nervous system. * As a result, LY6H inhibitors are being investigated as potential treatments for these disorders.

Genular Protein ID: 2477893011

Symbol: LY6H_HUMAN

Name: Lymphocyte antigen 6H

UniProtKB Accession Codes:

O94772 B2RAD2 J3KQI0 Q6IAX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 7 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799603

Title: Isolation and characterization of a new member of the human Ly6 gene family (LY6H).

PubMed ID: 9799603

DOI: 10.1006/geno.1998.5462

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 140
  • Mass: 14669
  • Checksum: A9274BFE89B6CBA3
  • Sequence:
    • MLPAAMKGLG LALLAVLLCS APAHGLWCQD CTLTTNSSHC TPKQCQPSDT VCASVRITDP 
SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV DVDCCEKDLC NGAAGAGHSP 
WALAGGLLLS LGPALLWAGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.